CA3184067A1 - Single-chain trail-receptor agonist proteins - Google Patents

Single-chain trail-receptor agonist proteins

Info

Publication number
CA3184067A1
CA3184067A1 CA3184067A CA3184067A CA3184067A1 CA 3184067 A1 CA3184067 A1 CA 3184067A1 CA 3184067 A CA3184067 A CA 3184067A CA 3184067 A CA3184067 A CA 3184067A CA 3184067 A1 CA3184067 A1 CA 3184067A1
Authority
CA
Canada
Prior art keywords
trail
receptor agonist
trail receptor
cell
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3184067A
Other languages
English (en)
French (fr)
Inventor
Oliver Hill
Christian Gieffers
Meinolf Thiemann
Fritz G. Buchanan
Darren C. Phillips
Susan E. Lappe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Apogenix AG
AbbVie Inc
Original Assignee
Apogenix AG
AbbVie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Apogenix AG, AbbVie Inc filed Critical Apogenix AG
Publication of CA3184067A1 publication Critical patent/CA3184067A1/en
Pending legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
CA3184067A 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins Pending CA3184067A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461983152P 2014-04-23 2014-04-23
US61/983,152 2014-04-23
CA2946402A CA2946402C (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2946402A Division CA2946402C (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins

Publications (1)

Publication Number Publication Date
CA3184067A1 true CA3184067A1 (en) 2015-10-29

Family

ID=53055121

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3184067A Pending CA3184067A1 (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins
CA2946402A Active CA2946402C (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2946402A Active CA2946402C (en) 2014-04-23 2015-04-23 Single-chain trail-receptor agonist proteins

Country Status (38)

Country Link
US (5) US9908927B2 (cg-RX-API-DMAC7.html)
EP (2) EP3134430B1 (cg-RX-API-DMAC7.html)
JP (2) JP6523331B2 (cg-RX-API-DMAC7.html)
KR (2) KR102079919B1 (cg-RX-API-DMAC7.html)
CN (2) CN106459221B (cg-RX-API-DMAC7.html)
AR (1) AR100168A1 (cg-RX-API-DMAC7.html)
AU (3) AU2015249649B2 (cg-RX-API-DMAC7.html)
BR (1) BR112016024515B1 (cg-RX-API-DMAC7.html)
CA (2) CA3184067A1 (cg-RX-API-DMAC7.html)
CL (1) CL2016002683A1 (cg-RX-API-DMAC7.html)
CR (1) CR20160516A (cg-RX-API-DMAC7.html)
CY (1) CY1120281T1 (cg-RX-API-DMAC7.html)
DK (1) DK3134430T3 (cg-RX-API-DMAC7.html)
DO (1) DOP2016000284A (cg-RX-API-DMAC7.html)
EC (1) ECSP16089579A (cg-RX-API-DMAC7.html)
ES (1) ES2672368T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20180950T1 (cg-RX-API-DMAC7.html)
HU (1) HUE038914T2 (cg-RX-API-DMAC7.html)
IL (2) IL248244B (cg-RX-API-DMAC7.html)
LT (1) LT3134430T (cg-RX-API-DMAC7.html)
MA (2) MA45069A (cg-RX-API-DMAC7.html)
MX (2) MX2016013858A (cg-RX-API-DMAC7.html)
MY (1) MY181986A (cg-RX-API-DMAC7.html)
NO (1) NO2776305T3 (cg-RX-API-DMAC7.html)
PE (1) PE20170299A1 (cg-RX-API-DMAC7.html)
PH (2) PH12020500377A1 (cg-RX-API-DMAC7.html)
PL (1) PL3134430T3 (cg-RX-API-DMAC7.html)
PT (1) PT3134430T (cg-RX-API-DMAC7.html)
RS (1) RS57153B1 (cg-RX-API-DMAC7.html)
RU (1) RU2699285C2 (cg-RX-API-DMAC7.html)
SG (3) SG11201608767XA (cg-RX-API-DMAC7.html)
SI (1) SI3134430T1 (cg-RX-API-DMAC7.html)
SM (1) SMT201800286T1 (cg-RX-API-DMAC7.html)
TR (1) TR201806912T4 (cg-RX-API-DMAC7.html)
TW (2) TWI747178B (cg-RX-API-DMAC7.html)
UA (1) UA118286C2 (cg-RX-API-DMAC7.html)
UY (1) UY36095A (cg-RX-API-DMAC7.html)
WO (1) WO2015164588A1 (cg-RX-API-DMAC7.html)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112017023646A2 (pt) 2015-05-04 2018-07-17 Apogenix Ag proteínas agonistas de receptor de cd40 de cadeia simples
CA3002602C (en) 2015-10-23 2021-11-02 Apogenix Ag Single-chain cd27-receptor agonist proteins
CA3002587A1 (en) 2015-10-23 2017-04-27 Apogenix Ag Single-chain light receptor agonist proteins
CN108473549A (zh) * 2015-10-23 2018-08-31 阿珀吉科吉尼科斯股份公司 单链gitr受体激动剂蛋白
WO2017102010A1 (en) * 2015-12-17 2017-06-22 Biontech Rna Pharmaceuticals Gmbh Novel cytokine fusion proteins
JP7091248B2 (ja) 2016-03-01 2022-06-27 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 低減されたl-グルタミナーゼ活性および増強された安定性を有するl-アスパラギナーゼ変異体および融合タンパク質
KR20180127407A (ko) * 2016-03-16 2018-11-28 메리맥 파마슈티컬즈, 인크. 암 요법용 조작된 trail
US10501744B2 (en) 2016-05-04 2019-12-10 Indiana University Research And Technology Corporation Presentation of bioactive proteins
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
AU2017283487A1 (en) * 2016-06-13 2018-11-22 Merrimack Pharmaceuticals, Inc. Methods for selecting and treating patients with a trail-based therapeutic or death receptor agonist
EP3360898A1 (en) 2017-02-14 2018-08-15 Boehringer Ingelheim International GmbH Bispecific anti-tnf-related apoptosis-inducing ligand receptor 2 and anti-cadherin 17 binding molecules for the treatment of cancer
WO2019032952A1 (en) * 2017-08-11 2019-02-14 The Board Of Trustees Of The University Of Illinois TRUNCATED VARIANTS OF INDIA PIG ASPARAGINASE AND METHODS OF USE
TW202002952A (zh) 2018-03-15 2020-01-16 美商艾伯維有限公司 用於治療胰臟癌之abbv-621與抗癌劑之組合
WO2019178438A1 (en) 2018-03-15 2019-09-19 Abbvie Inc. Abbv-621 in combination with anti-cancer agents for the treatment of cancer
CN115836084A (zh) 2020-05-15 2023-03-21 阿珀吉尼科斯股份公司 多特异性免疫调节剂
CA3217894A1 (en) 2021-05-28 2022-12-01 Gernot Stuhler Recombinant proteinaceous binding molecules
WO2023088876A1 (en) 2021-11-16 2023-05-25 Apogenix Ag Multi-specific immune modulators

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR025984A1 (es) 1999-10-07 2002-12-26 Maxygen Aps Polipeptidos oligomericos de cadena simple
DE19963859A1 (de) 1999-12-30 2001-07-12 Apotech Res & Dev Ltd Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen
CA2314199A1 (en) 2000-07-21 2002-01-21 Robert Simoneau C-chip
ATE406384T1 (de) 2000-12-07 2008-09-15 Lilly Co Eli Glp-1 fusion proteine
US7317091B2 (en) 2002-03-01 2008-01-08 Xencor, Inc. Optimized Fc variants
AU2003234274A1 (en) 2002-04-26 2003-11-10 California Institute Of Technology D1-1 nucleic acids, polypeptides and related methods
DE102004014983A1 (de) 2004-03-26 2005-10-20 Univ Stuttgart Rekombinante Polypeptide der Mitglieder der TNF Ligandenfamilie und deren Verwendung
US20060188498A1 (en) * 2005-02-18 2006-08-24 Genentech, Inc. Methods of using death receptor agonists and EGFR inhibitors
US8388962B2 (en) 2005-04-15 2013-03-05 Rappaport Family Institute For Research In The Medical Sciences Molecules and methods of using same for treating MCP-1/CCR2 associated diseases
WO2006116260A2 (en) 2005-04-26 2006-11-02 Medimmune, Inc. Modulation of antibody effector function by hinge domain engineering
EP1894940A1 (en) 2006-08-28 2008-03-05 Apogenix GmbH TNF superfamily fusion proteins
ES2560871T3 (es) 2007-07-10 2016-02-23 Apogenix Gmbh Proteínas de fusión de colectina de la superfamilia de TNF
SG191639A1 (en) 2008-06-03 2013-07-31 Abbott Lab Dual variable domain immunoglobulins and uses thereof
JP5674155B2 (ja) * 2008-07-21 2015-02-25 アポゲニクス ゲゼルシャフト ミット ベシュレンクテル ハフツングApogenix GmbH Tnfsf一本鎖分子
CA2737280A1 (en) * 2008-09-22 2010-03-25 Amgen Inc. Method of treatment
EP2379585A2 (en) * 2008-10-10 2011-10-26 Anaphore, Inc. Polypeptides that bind trail-ri and trail-r2
EP2829550B1 (en) 2009-01-09 2016-11-16 Apogenix AG Fusion proteins forming trimers
JP2012515556A (ja) * 2009-01-23 2012-07-12 バイオジェン・アイデック・エムエイ・インコーポレイテッド 低下したエフェクタ機能を有する安定化Fcポリペプチドおよび使用方法
TW201130511A (en) 2009-12-22 2011-09-16 Novartis Ag Soluble proteins for use as therapeutics
AU2011240620A1 (en) 2010-04-13 2012-10-18 Medimmune, Llc Fibronectin type III domain-based multimeric scaffolds
US9717803B2 (en) * 2011-12-23 2017-08-01 Innate Pharma Enzymatic conjugation of polypeptides
CA2878992C (en) 2012-07-18 2020-09-22 Apogenix Gmbh Composition comprising a mixture of cd95-fc isoforms

Also Published As

Publication number Publication date
AR100168A1 (es) 2016-09-14
RS57153B1 (sr) 2018-07-31
JP2017513503A (ja) 2017-06-01
PL3134430T3 (pl) 2018-08-31
RU2699285C2 (ru) 2019-09-04
RU2016145608A3 (cg-RX-API-DMAC7.html) 2018-12-26
CA2946402C (en) 2023-02-28
CA2946402A1 (en) 2015-10-29
IL272612A (en) 2020-03-31
US20240174731A1 (en) 2024-05-30
MA39770A (fr) 2015-10-29
EP3366699A1 (en) 2018-08-29
US20250145688A1 (en) 2025-05-08
EP3134430A1 (en) 2017-03-01
IL248244B (en) 2020-03-31
RU2016145608A (ru) 2018-05-28
JP2019162114A (ja) 2019-09-26
SG10202111785VA (en) 2021-12-30
CN106459221B (zh) 2020-09-01
TWI747178B (zh) 2021-11-21
PE20170299A1 (es) 2017-05-06
PH12016502079A1 (en) 2016-12-19
MX2016013858A (es) 2017-08-02
ES2672368T3 (es) 2018-06-14
LT3134430T (lt) 2018-05-10
SMT201800286T1 (it) 2018-07-17
KR20190135546A (ko) 2019-12-06
JP6523331B2 (ja) 2019-05-29
MX2019013587A (es) 2020-01-13
MY181986A (en) 2021-01-18
BR112016024515B1 (pt) 2020-03-31
PH12020500377A1 (en) 2022-11-14
US20180222962A1 (en) 2018-08-09
SG10201806465TA (en) 2018-08-30
AU2015249649A1 (en) 2016-11-10
AU2020202247A1 (en) 2020-04-23
TW202024123A (zh) 2020-07-01
UY36095A (es) 2015-10-30
BR112016024515A2 (pt) 2017-10-10
AU2018271369B2 (en) 2020-01-02
CN111718424A (zh) 2020-09-29
AU2015249649B2 (en) 2018-10-04
TR201806912T4 (tr) 2018-06-21
KR20170012257A (ko) 2017-02-02
US20150337027A1 (en) 2015-11-26
HUE038914T2 (hu) 2018-12-28
EP3134430B1 (en) 2018-03-21
TWI683825B (zh) 2020-02-01
NO2776305T3 (cg-RX-API-DMAC7.html) 2018-01-27
NZ725476A (en) 2023-09-29
CR20160516A (es) 2017-05-10
KR102079919B1 (ko) 2020-02-24
SG11201608767XA (en) 2016-11-29
US9908927B2 (en) 2018-03-06
JP6714751B2 (ja) 2020-06-24
UA118286C2 (uk) 2018-12-26
SI3134430T1 (en) 2018-05-31
CL2016002683A1 (es) 2017-07-07
TW201620928A (zh) 2016-06-16
ECSP16089579A (es) 2018-05-31
HRP20180950T1 (hr) 2018-08-10
CY1120281T1 (el) 2019-07-10
WO2015164588A1 (en) 2015-10-29
PH12016502079B1 (en) 2016-12-19
AU2018271369A1 (en) 2018-12-20
DOP2016000284A (es) 2017-02-15
DK3134430T3 (en) 2018-05-22
PT3134430T (pt) 2018-04-20
CN106459221A (zh) 2017-02-22
US20210040178A1 (en) 2021-02-11
MA45069A (fr) 2019-04-03
IL248244A0 (en) 2016-11-30

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