CA3177480A1 - Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model - Google Patents

Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Info

Publication number
CA3177480A1
CA3177480A1 CA3177480A CA3177480A CA3177480A1 CA 3177480 A1 CA3177480 A1 CA 3177480A1 CA 3177480 A CA3177480 A CA 3177480A CA 3177480 A CA3177480 A CA 3177480A CA 3177480 A1 CA3177480 A1 CA 3177480A1
Authority
CA
Canada
Prior art keywords
tumor
ink
bio
tissue
stromal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3177480A
Other languages
English (en)
French (fr)
Inventor
Shelby Marie King
Deborah Lynn Greene Nguyen
Vivian A. Gorgen
Benjamin R. Shepherd
Sharon C. Presnell
Rosalie SEARS
Brittany ALLEN-PETERSEN
Ellen LANGER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oregon Health and Science University
Organovo Inc
Original Assignee
Oregon Health and Science University
Organovo Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oregon Health and Science University, Organovo Inc filed Critical Oregon Health and Science University
Publication of CA3177480A1 publication Critical patent/CA3177480A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0656—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0697—Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5011—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing antineoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1305—Adipocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1323—Adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
    • C12N2502/1352—Mesenchymal stem cells
    • C12N2502/1358—Bone marrow mesenchymal stem cells (BM-MSC)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/28—Vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/00—3D culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • General Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Rheumatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3177480A 2014-04-04 2014-06-06 Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model Pending CA3177480A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461975640P 2014-04-04 2014-04-04
US61/975,640 2014-04-04
US201461976895P 2014-04-08 2014-04-08
US61/976,895 2014-04-08
CA2944723A CA2944723C (en) 2014-04-04 2014-06-06 Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2944723A Division CA2944723C (en) 2014-04-04 2014-06-06 Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Publications (1)

Publication Number Publication Date
CA3177480A1 true CA3177480A1 (en) 2015-10-08

Family

ID=54208710

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3177480A Pending CA3177480A1 (en) 2014-04-04 2014-06-06 Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
CA2944723A Active CA2944723C (en) 2014-04-04 2014-06-06 Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2944723A Active CA2944723C (en) 2014-04-04 2014-06-06 Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Country Status (10)

Country Link
US (5) US20170023550A1 (enExample)
EP (2) EP3126490B1 (enExample)
JP (1) JP2017518070A (enExample)
KR (1) KR20170013865A (enExample)
CN (1) CN106536720B (enExample)
AU (1) AU2014389440A1 (enExample)
CA (2) CA3177480A1 (enExample)
DK (1) DK3126490T3 (enExample)
IL (1) IL248164A0 (enExample)
WO (1) WO2015152954A1 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8241905B2 (en) 2004-02-24 2012-08-14 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
KR101711354B1 (ko) 2008-06-24 2017-02-28 더 큐레이터스 오브 더 유니버시티 오브 미주리 자가-조립가능 다세포체 및 이들을 이용하여 3차원 생물학적 구조체를 생산하는 방법
WO2011140441A2 (en) 2010-05-06 2011-11-10 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
EP2629975B1 (en) 2010-10-21 2022-03-09 Organovo, Inc. Devices for the fabrication of tissue
US20140099709A1 (en) * 2012-06-19 2014-04-10 Organovo, Inc. Engineered three-dimensional connective tissue constructs and methods of making the same
CA3177480A1 (en) 2014-04-04 2015-10-08 Organovo, Inc. Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model
EP3712254A1 (en) 2014-05-28 2020-09-23 Children's Hospital Medical Center Methods and systems for converting precursor cells into gastric tissues through directed differentiation
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
US11529436B2 (en) 2014-11-05 2022-12-20 Organovo, Inc. Engineered three-dimensional skin tissues, arrays thereof, and methods of making the same
WO2017083402A1 (en) 2015-11-09 2017-05-18 Organovo, Inc. Improved methods for tissue fabrication
KR101803618B1 (ko) * 2015-12-10 2017-12-01 포항공과대학교 산학협력단 종양 조직 배양 장치 및 종양 조직 배양 방법
WO2017123722A1 (en) * 2016-01-12 2017-07-20 Cleveland State University 3d-printed miniature biological constructs
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
US10345208B2 (en) 2016-07-12 2019-07-09 Deka Products Limited Partnership System and method for applying force to a device
US11254901B2 (en) 2016-07-12 2022-02-22 Deka Products Limited Partnership System and method for printing tissue
EP4478049A3 (en) * 2016-08-03 2024-12-25 Wake Forest University Health Sciences Cancer modeling platforms and methods of using the same
JP2019530435A (ja) * 2016-08-15 2019-10-24 オルガノボ インコーポレイテッド 薬物試験のための三次元バイオプリント腫瘍モデル
SG11201903697WA (en) 2016-11-04 2019-05-30 Childrens Hospital Med Ct Liver organoid compositions and methods of making and using same
GB2555787A (en) 2016-11-07 2018-05-16 Landberg Goran Diagnostic methods
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
EP3538643A4 (en) * 2016-11-10 2020-07-08 Organovo, Inc. GENETICALLY MODIFIED INTESTINAL TISSUE AND USES THEREOF
CA3043708A1 (en) 2016-11-17 2018-05-24 Cleveland State University Chip platforms for microarray 3d bioprinting
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
IL249977A0 (en) 2017-01-08 2017-04-30 Ramot At Tel-Aviv Univ Ltd 3D models of crops, methods for their preparation and their uses
EP3609997A4 (en) 2017-04-14 2021-03-03 Children's Hospital Medical Center COMPOSITIONS OF STEM CELLS FROM MULTIPLE DONOR CELLS AND THEIR PREPARATION PROCEDURES
WO2019002912A1 (en) * 2017-06-27 2019-01-03 ETH Zürich NANOCOMPOSITE MATERIALS COMPRISING CATIONIC NANOPARTICLES AND ANIONIC POLYMERS USEFUL IN METHODS FOR THEIR 3D PRINTING
US12297416B2 (en) 2017-07-12 2025-05-13 Deka Products Limited Partneship System and method for transferring tissue
US10570362B2 (en) 2017-07-12 2020-02-25 Deka Products Limited Partnership System and method for transferring tissue
CN111051495A (zh) * 2017-08-21 2020-04-21 凸版印刷株式会社 原代培养方法
JP6915692B2 (ja) * 2017-08-21 2021-08-04 凸版印刷株式会社 抗がん効果の評価方法、及びがん免疫療法の奏効性予測方法
US12297457B2 (en) 2017-10-10 2025-05-13 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
US11262349B2 (en) 2017-10-11 2022-03-01 Cleveland State University Multiplexed immune cell assays on a micropillar/microwell chip platform
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
CA3089127A1 (en) 2018-02-02 2019-08-08 Wake Forest University Health Sciences Organoids related to immunotherapy and methods of preparing and using the same
CN108396007B (zh) * 2018-03-15 2021-07-23 东北农业大学 体外构建奶牛血乳屏障三维模型的方法
US12421500B2 (en) 2018-07-26 2025-09-23 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
TWI732132B (zh) * 2018-09-05 2021-07-01 國立臺灣大學 製造模擬血管新生的細胞球的方法及其應用
JP2021535753A (ja) 2018-09-12 2021-12-23 チルドレンズ ホスピタル メディカル センター 造血幹細胞およびその派生体の生成のためのオルガノイド組成物
WO2020092887A2 (en) * 2018-11-01 2020-05-07 North Carolina State University Adipocyte mediated delivery of anticancer therapeutics
WO2020160371A1 (en) 2019-02-01 2020-08-06 The University Of Hong Kong Innervated organoid compositions and methods of making same
CA3141814A1 (en) 2019-05-31 2020-12-03 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
CN114174494A (zh) 2019-05-31 2022-03-11 儿童医院医学中心 产生和扩增造血干细胞的方法
US12019040B2 (en) 2019-09-30 2024-06-25 Cornell University System and devices for monitoring cell-containing materials and methods of their use
KR102214911B1 (ko) * 2019-11-18 2021-02-10 한국생산기술연구원 3d 프린터로 제작된 몰드를 이용한 유방 및 종양 모형 제조방법
KR102263745B1 (ko) * 2019-12-05 2021-06-09 포항공과대학교 산학협력단 흑색종 모델 및 이의 제조방법
DE102020004900A1 (de) 2020-08-12 2022-02-17 Universitätsmedizin Der Johannes Gutenberg-Universität Mainz Autologe prävaskulisierte 3D-Druckverfahren-erzeugte Brustgewebe-Konstrukte und Verfahren zu deren Herstellung
WO2022125585A1 (en) * 2020-12-07 2022-06-16 The Regents Of The University Of California Tissue organoid bioprinting and high-throughput screening methodology
WO2022125652A1 (en) * 2020-12-08 2022-06-16 Cornell University Methods of inducing an immunomodulatory tumor response
US12014830B2 (en) * 2021-04-18 2024-06-18 Mary Hitchcock Memorial Hospital, For Itself And On Behalf Of Dartmouth-Hitchcock Clinic System and method for automation of surgical pathology processes using artificial intelligence
CN113444691A (zh) * 2021-06-21 2021-09-28 河南省人民医院 一种模拟乳腺癌放疗后血管再生的体外细胞模型及其制备方法和应用
TW202306575A (zh) * 2021-06-23 2023-02-16 日商Ａｄｅｋａ股份有限公司 去細胞化細胞結構體
EP4680717A1 (en) * 2023-03-14 2026-01-21 The University Of Hong Kong 3d bioprinting of tumor tissue for mechanistic study and drug screening
EP4674952A1 (en) * 2023-03-30 2026-01-07 Toppan Holdings Inc. Three-dimensional mammary gland model and method for producing same

Family Cites Families (114)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4759764A (en) 1985-05-24 1988-07-26 Clayton Foundation For Research Peripheral nerve regeneration
US4808435A (en) 1987-04-06 1989-02-28 International Business Machines Corporation Screen printing method for producing lines of uniform width and height
US5099090A (en) 1988-05-11 1992-03-24 Ariel Electronics, Inc. Circuit writer
EP2075015B1 (en) 1997-07-03 2015-03-11 Massachusetts Institute of Technology Tissue-engineered constructs
US6401795B1 (en) 1997-10-28 2002-06-11 Sandia Corporation Method for freeforming objects with low-binder slurry
US6316153B1 (en) 1998-04-21 2001-11-13 The University Of Connecticut Free-form fabricaton using multi-photon excitation
US6697694B2 (en) 1998-08-26 2004-02-24 Electronic Materials, L.L.C. Apparatus and method for creating flexible circuits
US7338798B2 (en) 1998-09-15 2008-03-04 The Regents Of The University Of Michigan System and method for forming a cardiac muscle construct
DE69907397T2 (de) 1999-02-17 2004-01-22 Hewlett-Packard Co. (N.D.Ges.D.Staates Delaware), Palo Alto Druckvorrichtung
US6979670B1 (en) 1999-03-10 2005-12-27 Biora Bioex Ab Matrix protein compositions for grafting
US6642243B1 (en) 1999-07-22 2003-11-04 Ashkan Imanzahrai Migraine medicine and method for treating same
JP2001145956A (ja) 1999-11-19 2001-05-29 Meiko:Kk 光硬化性樹脂三次元造形物の積層造形装置及びその積層造形方法
US6503273B1 (en) 1999-11-22 2003-01-07 Cyograft Tissue Engineering, Inc. Tissue engineered blood vessels and methods and apparatus for their manufacture
US6454972B1 (en) 1999-11-24 2002-09-24 Sandia Corporation Solid freeform fabrication using chemically reactive suspensions
US6520997B1 (en) 1999-12-08 2003-02-18 Baxter International Inc. Porous three dimensional structure
US6315469B1 (en) 2000-01-19 2001-11-13 Hewlett-Packard Company Tool and method for adjustment of printhead to platen spacing in a printer
DE10013223C2 (de) 2000-03-13 2002-07-18 Co Don Ag Verfahren zur in vitro-Herstellung von dreidimensionalem, vitalem Knorpel- oder Knochengewebe und dessen Verwendung als Transplantationsmaterial
US20050091576A1 (en) 2003-10-24 2005-04-28 Microsoft Corporation Programming interface for a computer platform
DE10018987A1 (de) 2000-04-17 2001-10-31 Envision Technologies Gmbh Vorrichtung und Verfahren zum Herstellen von dreidimensionalen Objekten
WO2002004113A2 (en) 2000-07-11 2002-01-17 The Johns Hopkins University School Of Medicine Methods of patterning protein and cell adhesivity
US7998735B2 (en) 2000-08-21 2011-08-16 Victorian Tissue Engineering Centre Pty. Ltd. Vascularized tissue graft
US6561607B1 (en) 2000-10-05 2003-05-13 Eastman Kodak Company Apparatus and method for maintaining a substantially constant closely spaced working distance between an inkjet printhead and a printing receiver
US6939489B2 (en) 2001-03-23 2005-09-06 Ivoclar Vivadent Ag Desktop process for producing dental products by means of 3-dimensional plotting
AU2002305201A1 (en) 2001-04-19 2002-11-05 Case Western Reserve University Fabrication of a polymeric prosthetic implant
DE10127225A1 (de) 2001-05-22 2002-11-28 Zeiss Carl Ultraviolettlicht-Abschwächungsfilter
US20030049839A1 (en) 2001-08-01 2003-03-13 The University Of Texas System Transparent multi-channel cell scaffold that creates a cellular and/or molecular gradient
AU2002324775A1 (en) 2001-08-23 2003-03-10 Sciperio, Inc. Architecture tool and methods of use
US6934600B2 (en) 2002-03-14 2005-08-23 Auburn University Nanotube fiber reinforced composite materials and method of producing fiber reinforced composites
US20100254900A1 (en) 2002-03-18 2010-10-07 Campbell Phil G Biocompatible polymers and Methods of use
WO2003079985A2 (en) 2002-03-18 2003-10-02 Carnegie Mellon University Method and apparatus for preparing biomimetic scaffold
US6907307B2 (en) 2002-07-02 2005-06-14 3D Systems, Inc. Support volume calculation for a CAD model
WO2004006840A2 (en) 2002-07-12 2004-01-22 The Regents Of The University Of California Three dimensional cell patterned bioploymer scaffolds and method of making the same
US6998264B2 (en) 2002-11-19 2006-02-14 Huntington Medical Research Institutes Replication of biological tissue
US7641898B2 (en) 2003-03-21 2010-01-05 Materials Evolution And Development Usa, Inc. Keratinocyte-fibrocyte concomitant grafting for wound healing
US20040197375A1 (en) 2003-04-02 2004-10-07 Alireza Rezania Composite scaffolds seeded with mammalian cells
US7051654B2 (en) 2003-05-30 2006-05-30 Clemson University Ink-jet printing of viable cells
CA2528134C (en) 2003-06-04 2015-05-12 University Of South Carolina Tissue scaffold having aligned fibrils, apparatus and method for producing the same, and artificial tissue and methods of use thereof
JP4474858B2 (ja) 2003-07-07 2010-06-09 セイコーエプソン株式会社 ギャップ調整装置、これに使用されるキャリブレーション用治具、およびギャップ調整装置を備えた液滴吐出装置、並びに電気光学装置の製造方法
US20050074877A1 (en) 2003-07-28 2005-04-07 Mao Jeremy Jian Biological engineering of articular structures containing both cartilage and bone
US8043614B2 (en) 2004-03-09 2011-10-25 Ahlfors Jan-Eric W Autogenic living scaffolds and living tissue matrices: methods and uses thereof
FR2859128B1 (fr) 2003-08-29 2006-03-10 Centre Nat Rech Scient Procede et dispositif de fabrication d'un composant multimateriaux tridimensionnel par impression du type jet d'encre
DE10353281A1 (de) 2003-11-14 2005-06-16 Bayer Cropscience Ag Wirkstoffkombination mit insektiziden und akariziden Eigenschaften
US20050276791A1 (en) 2004-02-20 2005-12-15 The Ohio State University Multi-layer polymer scaffolds
US8241905B2 (en) * 2004-02-24 2012-08-14 The Curators Of The University Of Missouri Self-assembling cell aggregates and methods of making engineered tissue using the same
US20090142307A1 (en) 2004-07-09 2009-06-04 Athanasiou Kyriacos A Shape-Based Approach for Scaffoldless Tissue Engineering
WO2006020685A2 (en) 2004-08-11 2006-02-23 Cornell Research Foundation, Inc. Modular fabrication systems and methods
US7651665B2 (en) 2004-09-07 2010-01-26 Hewlett-Packard Development Company, L.P. Microtray for handling biosubstances
US7767446B2 (en) 2004-09-16 2010-08-03 Becton, Dickinson And Company Perfusion bioreactors for culturing cells
KR100606457B1 (ko) 2004-11-11 2006-11-23 한국기계연구원 3차원 프린팅 조형시스템
JP4539316B2 (ja) 2004-12-08 2010-09-08 セイコーエプソン株式会社 ヘッド位置補正方法およびヘッド位置補正装置、並びに液滴吐出装置、電気光学装置の製造方法
US7568904B2 (en) 2005-03-03 2009-08-04 Laser Solutions Co., Ltd. Stereolithography apparatus
JP4729948B2 (ja) 2005-03-09 2011-07-20 ブラザー工業株式会社 液体供給装置、この液体供給装置を備えたインクジェット記録装置
US7780897B2 (en) 2005-04-22 2010-08-24 Board Of Regents, The University Of Texas System Hydrogel constructs using stereolithography
JP2008545410A (ja) 2005-05-24 2008-12-18 ザ レジェンツ オブ ザ ユニヴァースティ オブ カリフォルニア 微小規模のマイクロパターン化インビトロ操作・作製組織
CA2616865C (en) 2005-07-28 2014-07-08 Carnegie Mellon University Biocompatible polymers and methods of use
US8690957B2 (en) 2005-12-21 2014-04-08 Warsaw Orthopedic, Inc. Bone graft composition, method and implant
US20070200276A1 (en) 2006-02-24 2007-08-30 Micron Technology, Inc. Method for rapid printing of near-field and imprint lithographic features
US7680555B2 (en) 2006-04-03 2010-03-16 Stratasys, Inc. Auto tip calibration in an extrusion apparatus
US20070231787A1 (en) 2006-04-04 2007-10-04 Voelker Mark A Methods and devices for imaging and manipulating biological samples
CA2648648A1 (en) 2006-04-05 2007-11-29 William Marsh Rice University Dermis-derived cells for tissue engineering applications
WO2007124481A2 (en) 2006-04-21 2007-11-01 Drexel University Bioprinting three-dimensional structures onto microscale tissue analog devices for pharmacokinetic study and other uses
US20090208466A1 (en) 2006-04-21 2009-08-20 James Yoo Ink-jet printing of tissues
JP4051077B2 (ja) 2006-04-28 2008-02-20 シャープ株式会社 液滴塗布装置、液滴吐出部のギャップ測定方法、および、液滴吐出部のギャップ調整方法
FR2901143B1 (fr) 2006-05-16 2008-10-03 Centre Nat Rech Scient "methode de construction de materiaux vivants fonctionnels, materiaux obtenus et applications"
US7959942B2 (en) 2006-10-20 2011-06-14 Orbusneich Medical, Inc. Bioabsorbable medical device with coating
DE102006053121B3 (de) 2006-11-10 2007-12-27 Eos Gmbh Electro Optical Systems Vorrichtung und Verfahren zum Herstellen eines dreidimensionalen Objektes mittels eines Beschichters für pulverförmiges Aufbaumaterial
US8764828B2 (en) 2007-02-02 2014-07-01 The Regents Of The University Of Michigan System and method for forming bone, ligament, and bone-ligament constructs
US8343740B2 (en) 2007-03-29 2013-01-01 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Micro-organ device
AU2008262331B2 (en) 2007-06-07 2013-10-17 Wake Forest University Health Sciences Inkjet gene printing
EP2664443B1 (en) 2007-07-25 2021-08-25 Stratasys Ltd. Solid freeform fabrication using a plurality of modeling materials
CA2696386C (en) 2007-08-29 2012-12-18 Vito Nv Method for producing a three-dimensional macroporous filament construct based on phase inversion and construct thereby obtained
US20090076531A1 (en) 2007-09-18 2009-03-19 Richardson Charles L Method and apparatus for bypass graft
AU2008311957A1 (en) 2007-10-15 2009-04-23 Wake Forest University Methods and compositions for printing biologically compatible nanotube composites of autologous tissue
KR100922232B1 (ko) 2008-02-13 2009-10-16 연세대학교 산학협력단 전기수력학 프린팅 기법을 이용한 살아있는 세포의 직접패터닝 방법 및 장치
EP2090584A1 (en) 2008-02-13 2009-08-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Identification of a novel cysteine-rich cell penetrating peptide
US8691274B2 (en) 2008-02-14 2014-04-08 Wake Forest University Health Sciences Inkjet printing of tissues and cells
US20090248145A1 (en) 2008-03-28 2009-10-01 Nanyang Technological University Method of forming a three-dimensional structure of unidirectionally aligned cells
US8876513B2 (en) 2008-04-25 2014-11-04 3D Systems, Inc. Selective deposition modeling using CW UV LED curing
US9303245B2 (en) 2008-06-20 2016-04-05 Universiteit Maastricht Self-assembling tissue modules
KR101711354B1 (ko) 2008-06-24 2017-02-28 더 큐레이터스 오브 더 유니버시티 오브 미주리 자가-조립가능 다세포체 및 이들을 이용하여 3차원 생물학적 구조체를 생산하는 방법
US9097702B2 (en) * 2008-07-29 2015-08-04 Cornell University Pathologically relevant tumor microenvironments for high-throughput drug screening
US20110212501A1 (en) 2008-09-12 2011-09-01 The Brigham And Women's Hospital, Inc. 3-dimensional multi-layered hydrogels and methods of making the same
WO2010060080A1 (en) 2008-11-24 2010-05-27 Immunotrex Corporation Three dimensional tissue generation
WO2010087912A1 (en) * 2009-01-30 2010-08-05 University Of Utah Research Foundation Hydrogels crosslinked with gold nanoparticles and methods of making and using thereof
EP2450707B1 (en) * 2010-11-04 2016-04-27 University of Pécs Lung tissue model
US8691974B2 (en) 2009-09-28 2014-04-08 Virginia Tech Intellectual Properties, Inc. Three-dimensional bioprinting of biosynthetic cellulose (BC) implants and scaffolds for tissue engineering
US8409603B2 (en) 2009-10-01 2013-04-02 University Of South Carolina Compositions and methods for tissue engineering, tissue regeneration and wound healing
US20110177590A1 (en) 2009-12-11 2011-07-21 Drexel University Bioprinted Nanoparticles and Methods of Use
EP2521587B1 (en) 2010-01-08 2020-04-08 Wake Forest University Health Sciences Delivery system
EP2523656A4 (en) 2010-01-15 2013-12-11 Univ Utah Res Found RETICULATED HYDROGELS AND METHODS OF MAKING AND USING THE SAME
CA2788514A1 (en) 2010-02-02 2011-08-11 Gabor Forgacs Engineered biological nerve graft fabrication and application thereof
ES2671594T3 (es) 2010-03-04 2018-06-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Puesto de bioimpresión, ensamblaje que comprende dicho puesto de bioimpresión y método de bioimpresión
GB2478801B (en) 2010-03-16 2012-05-30 Organovo Inc Multilayered vascular tubes
US9012415B2 (en) 2010-03-26 2015-04-21 Stemmatters, Biotecnologia E Medicina Regenerativa S.A. Photo-crosslinked gellan gum-based hydrogels: preparation methods and uses thereof
WO2012003465A2 (en) 2010-07-01 2012-01-05 The Regents Of The University Of Michigan Scaffold-free three dimensional nerve fibroblast constructs
US20120089238A1 (en) 2010-10-06 2012-04-12 Hyun-Wook Kang Integrated organ and tissue printing methods, system and apparatus
EP2629975B1 (en) 2010-10-21 2022-03-09 Organovo, Inc. Devices for the fabrication of tissue
DE202011003443U1 (de) 2011-03-02 2011-12-23 Bego Medical Gmbh Vorrichtung zur generativen Herstellung dreidimensionaler Bauteile
EP2683328B1 (en) 2011-03-07 2017-11-08 Wake Forest University Health Sciences Delivery system
GB201105226D0 (en) * 2011-03-29 2011-05-11 Univ Leiden Methods
JP5599356B2 (ja) 2011-03-31 2014-10-01 富士フイルム株式会社 シミュレーション方法、プログラムおよびそれを記録した記録媒体、並びに、それらを利用した液滴配置パターンの作成方法、ナノインプリント方法、パターン化基板の製造方法およびインクジェット装置。
RU2623303C2 (ru) 2011-09-12 2017-06-23 Органово, Инк. Платформа для инженерии имплантируемых тканей и органов и способы создания (биофабрикации) этих тканей и органов
CN108619572A (zh) * 2011-09-12 2018-10-09 奥加诺沃公司 用于体外研究用途的工程化组织、其阵列及其制备方法
US10059056B2 (en) 2012-02-01 2018-08-28 Nscrypt, Inc. Micro-dispensing multi-layered 3D objects with curing steps
WO2013130823A1 (en) 2012-02-29 2013-09-06 Massachusetts Institute Of Technology Inverse patterning process for three-dimensional multi-compartmental micro-organization of multiple cell types
CN104271168A (zh) * 2012-03-06 2015-01-07 Uab研究基金会 三维的预血管化的工程化的组织建造物、制造以及使用组织建造物的方法
US9499779B2 (en) * 2012-04-20 2016-11-22 Organovo, Inc. Devices, systems, and methods for the fabrication of tissue utilizing UV cross-linking
US20140099709A1 (en) * 2012-06-19 2014-04-10 Organovo, Inc. Engineered three-dimensional connective tissue constructs and methods of making the same
US20140042657A1 (en) 2012-08-08 2014-02-13 Makerbot Industries, Llc Printed circuit board with integrated temperature sensing
US9442105B2 (en) 2013-03-15 2016-09-13 Organovo, Inc. Engineered liver tissues, arrays thereof, and methods of making the same
CN105188993A (zh) 2013-03-15 2015-12-23 麦特法布公司 用于增材制造装置的料盒和方法
US9802360B2 (en) 2013-06-04 2017-10-31 Stratsys, Inc. Platen planarizing process for additive manufacturing system
KR20160036619A (ko) 2013-07-31 2016-04-04 오가노보, 인크. 조직을 제작하기 위한 자동화 장치, 시스템 및 방법
CA3177480A1 (en) 2014-04-04 2015-10-08 Organovo, Inc. Engineered three-dimensional breast tissue, adipose tissue, and tumor disease model

Also Published As

Publication number Publication date
EP3808838A1 (en) 2021-04-21
AU2014389440A1 (en) 2016-10-20
US20170023550A1 (en) 2017-01-26
EP3126490B1 (en) 2020-09-30
EP3808838B1 (en) 2024-04-10
IL248164A0 (en) 2016-11-30
US11789011B2 (en) 2023-10-17
KR20170013865A (ko) 2017-02-07
CA2944723C (en) 2023-03-14
US20150282885A1 (en) 2015-10-08
DK3126490T3 (da) 2021-01-04
CN106536720B (zh) 2021-04-30
EP3126490A4 (en) 2017-09-13
US20180196034A1 (en) 2018-07-12
EP3126490A1 (en) 2017-02-08
JP2017518070A (ja) 2017-07-06
CA2944723A1 (en) 2015-10-08
CN106536720A (zh) 2017-03-22
US20200116702A1 (en) 2020-04-16
US9983195B2 (en) 2018-05-29
WO2015152954A1 (en) 2015-10-08
US20240168010A1 (en) 2024-05-23

Similar Documents

Publication Publication Date Title
US20240168010A1 (en) Engineered Three-Dimensional Breast Tissue, Adipose Tissue, and Tumor Disease Model
AU2019203265B2 (en) Engineered liver tissues, arrays thereof, and methods of making the same
US20160040132A1 (en) Three-dimensional bioprinted pancreatic tumor model
KR20180056767A (ko) 인 비트로 암 전이 모델링을 위한 방법 및 장치
CN108619572A (zh) 用于体外研究用途的工程化组织、其阵列及其制备方法
US20240026261A1 (en) Engineering of organoid culture for enhanced organogenesis in a dish
US20170067025A1 (en) Tumor model for breast cancer cell migration studies and related methods
Schmid et al. A vascularized in vivo melanoma model suitable for metastasis research of different tumor stages using fundamentally different bioinks
ES3024481T3 (en) Methods and systems for generating three-dimensional biological structures
Tröndle Fabrication of hollow 3D tissue models with drop-on-demand bioprinting and controlled cellular self-assembly

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220929

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-P100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT RECEIVED - RESPONSE TO EXAMINER'S REQUISITION

Effective date: 20240715

B12 Application deemed to be withdrawn, abandoned or lapsed

Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION

Effective date: 20240912

W00 Other event occurred

Free format text: ST27 STATUS EVENT CODE: N-6-6-W10-W00-W111 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: CORRESPONDENT DETERMINED COMPLIANT

Effective date: 20240926

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: N-6-6-P10-P11-P102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: AMENDMENT DETERMINED COMPLIANT

Effective date: 20250208

P13 Application amended

Free format text: ST27 STATUS EVENT CODE: N-6-6-P10-P13-X000 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: APPLICATION AMENDED

Effective date: 20250208

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 11TH ANNIV.) - STANDARD

Year of fee payment: 11

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: N-6-6-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20250507

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: N-6-6-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20250507

D15 Examination report completed

Free format text: ST27 STATUS EVENT CODE: A-2-2-D10-D15-D126 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: EXAMINER'S REPORT

Effective date: 20250708

B12 Application deemed to be withdrawn, abandoned or lapsed

Free format text: ST27 STATUS EVENT CODE: N-2-6-B10-B12-B303 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: DEEMED ABANDONED - FAILURE TO RESPOND TO AN EXAMINER'S REQUISITION

Effective date: 20251110

MFA Maintenance fee for application paid

Free format text: FEE DESCRIPTION TEXT: MF (APPLICATION, 12TH ANNIV.) - STANDARD

Year of fee payment: 12

U00 Fee paid

Free format text: ST27 STATUS EVENT CODE: N-6-6-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED

Effective date: 20260409

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: N-6-6-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL

Effective date: 20260409