CA3149284A1 - Implants and biodegradable fiducial markers - Google Patents

Implants and biodegradable fiducial markers

Info

Publication number
CA3149284A1
CA3149284A1 CA3149284A CA3149284A CA3149284A1 CA 3149284 A1 CA3149284 A1 CA 3149284A1 CA 3149284 A CA3149284 A CA 3149284A CA 3149284 A CA3149284 A CA 3149284A CA 3149284 A1 CA3149284 A1 CA 3149284A1
Authority
CA
Canada
Prior art keywords
hydrogel
spacer
tissue
precursor
functional groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3149284A
Other languages
English (en)
French (fr)
Inventor
Patrick Campbell
Amarpreet S. Sawhney
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incept LLC
Original Assignee
Incept LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incept LLC filed Critical Incept LLC
Publication of CA3149284A1 publication Critical patent/CA3149284A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA3149284A 2009-12-15 2010-12-15 Implants and biodegradable fiducial markers Pending CA3149284A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28645009P 2009-12-15 2009-12-15
US61/286450 2009-12-15
CA3042067A CA3042067C (en) 2009-12-15 2010-12-15 Implants and biodegradable fiducial markers

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA3042067A Division CA3042067C (en) 2009-12-15 2010-12-15 Implants and biodegradable fiducial markers

Publications (1)

Publication Number Publication Date
CA3149284A1 true CA3149284A1 (en) 2011-07-14

Family

ID=44143217

Family Applications (3)

Application Number Title Priority Date Filing Date
CA3149284A Pending CA3149284A1 (en) 2009-12-15 2010-12-15 Implants and biodegradable fiducial markers
CA2782899A Active CA2782899C (en) 2009-12-15 2010-12-15 Implants and biodegradable fiducial markers
CA3042067A Active CA3042067C (en) 2009-12-15 2010-12-15 Implants and biodegradable fiducial markers

Family Applications After (2)

Application Number Title Priority Date Filing Date
CA2782899A Active CA2782899C (en) 2009-12-15 2010-12-15 Implants and biodegradable fiducial markers
CA3042067A Active CA3042067C (en) 2009-12-15 2010-12-15 Implants and biodegradable fiducial markers

Country Status (8)

Country Link
US (12) US8383161B2 (enExample)
EP (3) EP3960215B1 (enExample)
JP (1) JP5820815B2 (enExample)
CN (1) CN102844054B (enExample)
AU (1) AU2010340067B2 (enExample)
CA (3) CA3149284A1 (enExample)
IN (1) IN2012DN05177A (enExample)
WO (1) WO2011084465A2 (enExample)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10675298B2 (en) * 2006-07-27 2020-06-09 Boston Scientific Scimed Inc. Particles
EP3960215B1 (en) * 2009-12-15 2024-10-16 Incept, LLC Implants and biodegradable fiducial markers
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
EP3613413A1 (en) 2011-12-05 2020-02-26 Incept, LLC Medical organogel processes and compositions
EP3797801A1 (en) * 2012-01-24 2021-03-31 LifeCell Corporation Elongated tissue matrices
US9798856B2 (en) * 2012-03-21 2017-10-24 Koninklijke Philips N.V. Clinical workstation integrating medical imaging and biopsy data and methods using same
US9220807B2 (en) * 2012-11-04 2015-12-29 Miba Medical Inc. Non-toxic cross-linker for hyaluronic acid
US9226797B2 (en) * 2012-11-04 2016-01-05 Miba Medical Inc. Computer aided implantation of body implants
EP2968884B1 (en) * 2013-03-15 2018-10-03 Boston Scientific Corporation Device for delivering medicaments
KR20160032000A (ko) 2013-03-15 2016-03-23 매튜 알. 드레허 이미지화 가능한 색전성 마이크로스피어
WO2014187962A1 (en) 2013-05-24 2014-11-27 Danmarks Tekniske Universitet Gel formulations for guiding radiotherapy
MA38709A1 (fr) 2013-06-20 2018-05-31 Nanobiotix Compositions et procédés pour une utilisation en diagnostic médical
AU2014283232B2 (en) * 2013-06-20 2019-03-28 Nanobiotix Compositions and methods for use in oncology
US10842969B2 (en) 2013-10-25 2020-11-24 Mercator Medsystems, Inc. Systems and methods of treating malacia by local delivery of hydrogel to augment tissue
US10743909B2 (en) 2014-04-03 2020-08-18 Corbin Clinical Resources, Llc Transperineal prostate biopsy device, systems, and methods of use
US12144519B2 (en) * 2014-04-03 2024-11-19 Corbin Clinical Resources, Llc Transperineal prostate biopsy and treatment methods
US10022475B2 (en) * 2014-05-01 2018-07-17 Bao Tran Body augmentation device
US9561095B1 (en) * 2015-10-12 2017-02-07 Phi Nguyen Body augmentation device
US9636210B2 (en) 2014-05-19 2017-05-02 Mentor Worldwide Llc Injection zone markers for biomedical implants
US9678022B2 (en) * 2014-09-05 2017-06-13 The Boeing Company Nonaqueous radiopaque fluid and associated imaging system and method
KR101555358B1 (ko) * 2014-10-21 2015-09-24 사회복지법인 삼성생명공익재단 생분해성 다중블록 공중합체를 이용한 표적 표지자
WO2016065245A1 (en) 2014-10-24 2016-04-28 Incept, Llc Extra luminal scaffold
EP3858329A1 (en) 2014-12-10 2021-08-04 Incept, LLC Hydrogel drug delivery implants
EP3233058A1 (en) 2014-12-15 2017-10-25 The Johns Hopkins University Sunitinib formulations and methods for use thereof in treatment of glaucoma
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
CN107921237A (zh) 2015-04-27 2018-04-17 反射医学公司 交感神经心肺神经调节系统和方法
EP4279064A3 (en) 2015-05-12 2024-02-28 Incept, LLC Drug delivery from hydrogels
EA201792560A1 (ru) 2015-05-28 2018-06-29 Нанобиотикс Наночастицы для применения в качестве терапевтической вакцины
US20170103184A1 (en) * 2015-10-12 2017-04-13 Phi Nguyen Injectable filler
CN108367079B (zh) 2015-11-12 2022-11-22 灰色视觉公司 用于治疗的聚集性微粒
EP3373870A4 (en) 2015-11-12 2019-07-10 University Of Virginia Patent Foundation COMPOSITIONS AND METHODS FOR VAS OCCLUSAL CONSUMER PREVENTION AND THEIR REVERSAL
WO2017091749A1 (en) 2015-11-25 2017-06-01 Incept, Llc Shape changing drug delivery devices and methods
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
CN110035754A (zh) 2016-06-29 2019-07-19 图拉维治疗股份有限公司 通过自主神经系统的局部神经调节治疗败血症及相关炎性病况
US20220249366A1 (en) * 2016-07-07 2022-08-11 University Of Virginia Patent Foundation Thiol-michael addition hydrogel-based brachytherapy system and methods comprising the same
EP3481373A4 (en) * 2016-07-07 2020-04-01 University of Virginia Patent Foundation THIOL-MICHAEL-ADDED HYDROGEL-BASED CURIETHERAPY SYSTEM AND METHODS COMPRISING SAME
CN106334213B (zh) * 2016-08-31 2019-07-26 安疗生命科学（武汉）有限公司 一种血管栓塞材料、其制备方法及在药物制备中的用途
JP7430529B2 (ja) 2016-09-23 2024-02-13 インセプト・リミテッド・ライアビリティ・カンパニー 前房内薬物送達デポ
CN110022789B (zh) * 2016-11-23 2022-07-12 霍罗吉克公司 活检部位标记物
CN110381854A (zh) 2017-01-05 2019-10-25 考恩特兰有限公司 用于植入和逆转刺激响应性植入物的方法
US12383421B2 (en) 2017-01-05 2025-08-12 Contraline, Inc. Contraceptive devices
US20180289467A1 (en) * 2017-04-05 2018-10-11 Ernesto Andrade Dispensing device, kit, and method for tissue augmentation
EP3621654A4 (en) 2017-05-10 2021-02-17 Graybug Vision, Inc. PROLONGED-RELEASE MICROPARTICLES AND SUSPENSIONS OF THESE INTENDED FOR MEDICAL THERAPY
CN107307922A (zh) * 2017-07-06 2017-11-03 刘志光 一种人体植入填充颗粒的制作方法
EP3648675A1 (en) * 2017-07-07 2020-05-13 Shadwell Endoscopic, Inc. System and method for marking and subsequently locating sites of biopsies using rfid technology
KR102673196B1 (ko) 2017-09-05 2024-06-10 삼성전자주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물
CN111432807A (zh) 2017-10-06 2020-07-17 铸造疗法股份有限公司 用于控制释放治疗剂的可植入贮库
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
WO2019136490A1 (en) 2018-01-08 2019-07-11 Foundry Therapeutics, Inc. Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents
WO2019169445A1 (en) * 2018-03-07 2019-09-12 Margin-Clear Pty Ltd A topical brachytherapy device and a method of treatment of malignant cancer cells
EP3793536A1 (en) 2018-05-12 2021-03-24 Foundry Therapeutics, Inc. Implantable polymer depots for the controlled release of therapeutic agents
CN112384256A (zh) 2018-05-15 2021-02-19 因赛普特有限责任公司 栓塞组合物及方法
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
AU2019299519B2 (en) 2018-07-02 2025-03-06 Incept Llc Methods and devices for in situ formed nerve cap
EP3843710A1 (en) 2018-08-28 2021-07-07 Foundry Therapeutics, Inc. Polymer implants
USD896383S1 (en) 2018-09-13 2020-09-15 Allergan, Inc. Tissue expansion device
US11160630B2 (en) 2018-09-13 2021-11-02 Allergan, Inc. Tissue expansion device
CA3117577A1 (en) 2018-11-13 2020-05-22 Contraline, Inc. Systems and methods for delivering biomaterials
JP2022530895A (ja) * 2019-05-03 2022-07-04 パレット ライフ サイエンシーズ，インク． 改善された組織スペーサー
JP7281563B2 (ja) 2019-06-12 2023-05-25 ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ ペルオキシエステルを生成するためのプロセス
HUE063796T2 (hu) 2019-06-12 2024-01-28 Nouryon Chemicals Int Bv Eljárás diacil-peroxidok elõállítására
US11976035B2 (en) 2019-06-12 2024-05-07 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
JP7281564B2 (ja) 2019-06-12 2023-05-25 ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ 過酸化ジアシルを生成するためのプロセス
JP7355858B2 (ja) * 2019-06-12 2023-10-03 ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ 水性側流からカルボン酸を単離するための方法
WO2021041225A1 (en) 2019-08-28 2021-03-04 Boston Scientific Scimed, Inc. Multi-armed polymers comprising free-radical-polymerizable monomers
US11820868B2 (en) 2019-08-28 2023-11-21 Boston Scientific Scimed, Inc. Multifunctional nitroxide-mediated polymerization initiators and multi-armed polymers and hydrogels formed therefrom
US12178888B2 (en) 2019-08-28 2024-12-31 Boston Scientific Scimed, Inc. Reactive multi-arm polymers having branched end groups
EP4021513B1 (en) 2019-08-28 2025-11-26 Boston Scientific Scimed Inc. Radiopaque multi-armed polymers and compositions, systems and methods pertaining to the same
US11878092B2 (en) 2019-08-28 2024-01-23 Boston Scientific Scimed, Inc. Medical compositions based on crosslinkable hydrophilic polymers
WO2021041222A1 (en) 2019-08-28 2021-03-04 Boston Scientific Scimed, Inc. Multi-armed polyoxazolines and compositions, systems and methods pertaining to the same
EP4074349A4 (en) * 2020-01-14 2024-02-07 Mochida Pharmaceutical Co., Ltd. COMBINATION AND METHOD FOR TREATING SUBJECTS WITH ALGIC ACID SALT
US12016969B2 (en) 2020-02-04 2024-06-25 Boston Scientific Scimed, Inc. Injectable in vivo crosslinking materials for use as soft tissue fillers
CN111905155B (zh) * 2020-07-23 2021-10-15 北京诺康达医药科技股份有限公司 一种封闭水凝胶及其制备方法和应用
US12343454B2 (en) 2020-11-12 2025-07-01 Pramand LLC Hydrogels formed in situ and composition design for intrauterine use
CA3234635A1 (en) 2021-10-25 2023-05-04 Boston Scientific Scimed Inc. Iodine labeled hydrogels and precursors thereof with improved radiopacity
EP4464339A1 (en) * 2022-01-13 2024-11-20 National Cancer Center Biocompatible composition for labeling target lesion, and preparation method therefor
KR20240144322A (ko) 2022-02-02 2024-10-02 보스톤 싸이엔티픽 싸이메드 인코포레이티드 아이오딘화된 화합물 및 이로 형성된 하이드로겔
CN114344554A (zh) * 2022-02-11 2022-04-15 上海益思妙医疗器械有限公司 一种peg化合物作为制备栓塞剂的应用
US11701451B1 (en) 2022-03-11 2023-07-18 Carbon Medical Technologies, Inc. Soft tissue filler and methods
US12251466B2 (en) 2022-04-20 2025-03-18 Pramand LLC Single solution hydrogels with covalent bonding formed in situ, composition design and medical procedures using the hydrogels
US12440599B2 (en) 2022-05-06 2025-10-14 Pramand LLC Water activated hydrogel-based medical patches, and methods of making and using such patches
US20250360172A1 (en) * 2022-05-25 2025-11-27 Cedars-Sinai Medical Center Microgel-encapsulated ipsc-derived notochordal cells for treatment of intervertebral disc degeneration and discogenic pain
AU2023325229A1 (en) 2022-08-17 2025-01-23 Boston Scientific Scimed, Inc. Iodine labeled hydrogels and precursors thereof with improved properties
US20240174597A1 (en) 2022-11-21 2024-05-30 Boston Scientific Scimed, Inc. Iodine labeled hydrogels and crosslinking agents for forming the same
WO2024182598A1 (en) 2023-03-02 2024-09-06 Boston Scientific Scimed, Inc. Polyamino iodinated compounds and radiopaque hydrogels formed therefrom
US20240293572A1 (en) 2023-03-02 2024-09-05 Boston Scientific Scimed, Inc. Therapeutic-agent-releasing hydrogels and precursors thereof
DE102023108039A1 (de) 2023-03-29 2024-10-02 Dwi - Leibniz-Institut Für Interaktive Materialien E.V. Ein System zur Herstellung eines degradierbaren Hydrogels
CN121127280A (zh) * 2023-04-28 2025-12-12 波士顿科学医学有限公司 不透射线的交联水凝胶颗粒在含有生物相容性亲水性聚合物的载体流体中的悬浮液
WO2025096930A1 (en) 2023-11-01 2025-05-08 Boston Scientific Scimed, Inc. Amino-acid- and amino-alcohol-based polyamine compounds and medical hydrogels formed therefrom
US20250228774A1 (en) * 2024-01-11 2025-07-17 Boston Scientific Scimed, Inc. Systems and methods for accelerated hydrolysis of polysaccharide-based hydrogels

Family Cites Families (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3640741A (en) 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3865108A (en) 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US3872856A (en) 1971-06-09 1975-03-25 Ralph S Clayton Apparatus for treating the walls and floor of the pelvic cavity with radiation
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
DE2437629C3 (de) 1974-08-05 1978-09-21 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4193813A (en) 1976-09-07 1980-03-18 Medi-Coll, Inc. Method for making collagen sponge
US4207893A (en) 1977-08-29 1980-06-17 Alza Corporation Device using hydrophilic polymer for delivering drug to biological environment
CA1295796C (en) 1984-03-27 1992-02-18 Conrad Whyne Biodegradable matrix and methods for producing same
US4697575A (en) 1984-11-21 1987-10-06 Henry Ford Hospital Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member
US4714074A (en) 1985-06-28 1987-12-22 Centre National De La Recherche Scientifique Method for protecting human or animal organs against radiation
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
US4741872A (en) 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
IL82834A (en) 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
US5306500A (en) 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5550187A (en) 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
IL90193A (en) 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
EP0560934B2 (en) 1990-12-06 1999-11-10 W.L. Gore & Associates, Inc. Implantable bioabsorbable article
FR2672713A1 (fr) * 1991-02-13 1992-08-14 Inst Nat Polytech Grenoble Composant d'alimentation du type carte de credit.
US5629008A (en) 1992-06-02 1997-05-13 C.R. Bard, Inc. Method and device for long-term delivery of drugs
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US6592859B1 (en) 1992-08-20 2003-07-15 Ethicon, Inc. Controlled expansion sphincter augmentation media
AU683022B2 (en) 1992-09-10 1997-10-30 Children's Medical Center Corporation Biodegradable polymer matrices for sustained delivery of local anesthetic agents
ES2119201T3 (es) 1993-04-28 1998-10-01 Focal Inc Aparato, producto y uso relacionados con la fototermoconformacion intraluminal.
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5499994A (en) 1993-07-30 1996-03-19 American Medical Systems, Inc. Dilation device for the urethra
CA2188464C (en) 1994-04-27 2006-08-08 Michael Roreger Collagen preparation for the controlled release of active substances
DE4414755C2 (de) 1994-04-27 2000-11-16 Lohmann Therapie Syst Lts Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
DE69637198T2 (de) 1995-03-23 2008-05-08 Genzyme Corp., Cambridge Redox und photoinitiatorsystem zur grundierung von verbesserter adhäsion von gelen zu substraten
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
AU6403196A (en) 1995-06-30 1997-02-05 Baylor University Polyester/carboxylic acid composite materials
US6201065B1 (en) 1995-07-28 2001-03-13 Focal, Inc. Multiblock biodegradable hydrogels for drug delivery and tissue treatment
US5759583A (en) 1995-08-30 1998-06-02 Syntex (U.S.A.) Inc. Sustained release poly (lactic/glycolic) matrices
US5733316A (en) 1995-10-27 1998-03-31 Dornier Medical Systems, Inc. Organ separation for thermal therapy
US5863984A (en) 1995-12-01 1999-01-26 Universite Laval, Cite Universitaire Biostable porous material comprising composite biopolymers
EP1704878B1 (en) 1995-12-18 2013-04-10 AngioDevice International GmbH Crosslinked polymer compositions and methods for their use
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US7049346B1 (en) 1996-08-20 2006-05-23 Menlo Care Div Of Ethicon, Inc. Swollen hydrogel for sphincter augmentation
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US7009034B2 (en) 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US5932539A (en) 1996-10-15 1999-08-03 The Board Of Trustees Of The University Of Illinois Biodegradable polymer matrix for tissue repair
JP3092531B2 (ja) 1996-11-05 2000-09-25 日本油脂株式会社 コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法
JP3092530B2 (ja) 1996-11-05 2000-09-25 日本油脂株式会社 コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6271278B1 (en) 1997-05-13 2001-08-07 Purdue Research Foundation Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties
IL121861A (en) 1997-09-29 2003-07-31 Moshe Ein Gal Prostate radiotherapy apparatus
US8288745B2 (en) 1997-10-10 2012-10-16 Senorx, Inc. Method of utilizing an implant for targeting external beam radiation
JP2001519203A (ja) 1997-10-10 2001-10-23 ジョン・ディ・コービット・ジュニア 胸部インプラント
WO1999021512A1 (en) 1997-10-27 1999-05-06 The Regents Of The University Of California Methods and pharmaceutical compositions for the closure of retinal breaks
US6475477B1 (en) * 1997-11-07 2002-11-05 Rutgers, The State University Radio-opaque polymer biomaterials
US6375634B1 (en) 1997-11-19 2002-04-23 Oncology Innovations, Inc. Apparatus and method to encapsulate, kill and remove malignancies, including selectively increasing absorption of x-rays and increasing free-radical damage to residual tumors targeted by ionizing and non-ionizing radiation therapy
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
US6428978B1 (en) 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
US6066856A (en) 1998-05-18 2000-05-23 Children's Medical Center Corporation Radiation protective device
US6280742B1 (en) * 1998-06-17 2001-08-28 Zonagen, Inc. Methods and materials for the treatment of prostatic carcinoma
US6206930B1 (en) 1998-08-10 2001-03-27 Charlotte-Mecklenburg Hospital Authority Absorbable tissue expander
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
AU5560899A (en) 1998-08-14 2000-03-06 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
ATE264674T1 (de) 1998-10-22 2004-05-15 Bioniche Life Sciences Inc Verwendung von hyaluronsäure zur behandlung der bestrahlungs-blasenentzündung
US6899889B1 (en) 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US8802146B2 (en) * 1998-11-06 2014-08-12 Neomend, Inc. Systems, methods, and compositions for prevention of tissue adhesion
WO2000028919A1 (en) 1998-11-12 2000-05-25 Canadian Prostate Centre, Inc. Apparatus and method of separating organs to enable aggressive thermal therapy
US6110484A (en) 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
AU2707500A (en) 1998-12-04 2000-06-26 Incept Llc Biocompatible crosslinked polymers
US20080114092A1 (en) 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
TW392930U (en) * 1998-12-28 2000-06-01 Hon Hai Prec Ind Co Ltd Electric connector
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
KR100845769B1 (ko) * 1999-02-03 2008-07-11 파우더젝트 리서치 리미티드 하이드로겔 입자 제제
US6177514B1 (en) 1999-04-09 2001-01-23 Sulzer Carbomedics Inc. Blocked functional reagants for cross-linking biological tissues
DK1168934T3 (da) 1999-04-12 2008-05-13 Cornell Res Foundation Inc Hydrogeldannende system med hydrofobe og hydrofile komponenter
US6268405B1 (en) 1999-05-04 2001-07-31 Porex Surgical, Inc. Hydrogels and methods of making and using same
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
US6428785B1 (en) 1999-10-28 2002-08-06 Immunolytics Inc. Method and composition for treating prostate cancer
AU1658601A (en) 1999-11-15 2001-05-30 The Texas A & M University System Wound sealant formed in situ
US6479079B1 (en) 1999-12-13 2002-11-12 Sulzer Carbomedics Inc. Anticalcification treatments for fixed biomaterials
WO2003031388A1 (en) 2000-06-12 2003-04-17 Dainihon Jochugiku Co., Ltd Propargylbenzyl alcohol ester derivative, process for producing the same, and insecticide/insectifuge containing the same
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US9314339B2 (en) * 2000-03-27 2016-04-19 Formae, Inc. Implants for replacing cartilage, with negatively-charged hydrogel surfaces and flexible matrix reinforcement
ES2391763T3 (es) 2000-04-07 2012-11-29 Collagen Matrix, Inc. Dispositivo de embolización
US6599448B1 (en) * 2000-05-10 2003-07-29 Hydromer, Inc. Radio-opaque polymeric compositions
US6383344B1 (en) 2000-07-19 2002-05-07 Genzyme Corporation Molecular weight reduction of polymer using irradiation treatment
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US6596471B2 (en) 2000-12-21 2003-07-22 Carbomedics Inc. Method of cross-linking tissue with a bis-maleimide compound
CA2438193A1 (en) 2001-02-26 2002-09-06 Duke University Novel dendritic polymers and their biomedical uses
JP4123856B2 (ja) 2001-07-31 2008-07-23 日油株式会社 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法
US20070264227A1 (en) * 2001-11-07 2007-11-15 Eidgenossische Technische Hochschule Zurich Synthetic Matrix for Controlled Cell Ingrowth and Tissue Regeneration
US20040131582A1 (en) 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
US7341716B2 (en) * 2002-04-12 2008-03-11 Boston Scientific Scimed, Inc. Occlusive composition
AU2003243755A1 (en) 2002-06-24 2004-01-06 William R. Noyes Fillers and methods for displacing tissues to improve radiological outcomes
US7351430B2 (en) 2002-11-06 2008-04-01 Uluru Inc. Shape-retentive hydrogel particle aggregates and their uses
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
US20050033157A1 (en) * 2003-07-25 2005-02-10 Klein Dean A. Multi-modality marking material and method
US7790141B2 (en) 2003-08-11 2010-09-07 Pathak Holdings, Llc Radio-opaque compounds, compositions containing same and methods of their synthesis and use
EP1673109B1 (en) 2003-09-25 2019-03-20 Rutgers, The State University of New Jersey Inherently radiopaque polymeric products for embolotherapy
CN105147342B (zh) 2004-06-23 2018-04-17 直空间有限公司 用于组织移除或分离的设备系统和方法
FR2872262B1 (fr) 2004-06-29 2010-11-26 Air Liquide Procede et installation de fourniture de secours d'un gaz sous pression
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
EP1778761B1 (en) 2004-08-13 2021-09-29 Reva Medical, Inc. Inherently radiopaque bioresorbable polymers for multiple uses
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
EP1796693A2 (en) 2004-08-26 2007-06-20 Chandrashekhar P. Pathak Implantable tissue compositions and method
WO2006078770A2 (en) 2005-01-21 2006-07-27 Civco Medical Instruments Co., Inc. Creating temporary space between body tissues
US7963287B2 (en) * 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
WO2007005249A2 (en) 2005-06-29 2007-01-11 Hyperbranch Medical Technology, Inc. Nanoparticles and dendritic-polymer-based hydrogels comprising them
DE102005051366A1 (de) * 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
WO2007082061A2 (en) 2006-01-11 2007-07-19 Hyperbranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
JP6075930B2 (ja) 2006-04-24 2017-02-08 インセプト エルエルシー タンパク質架橋剤、架橋方法及びその用途
US7872068B2 (en) 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
JP2010519183A (ja) 2007-02-06 2010-06-03 インセプト エルエルシー 生理溶液の溶出のためのタンパク質の沈殿を用いる重合
US20100104625A1 (en) 2007-02-16 2010-04-29 Cornell University Biodegradable compositions and materials
US20080220047A1 (en) * 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
US9987221B2 (en) 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
CA2707649A1 (en) 2007-11-02 2009-05-07 Genzyme Corporation Methods of augmenting or repairing soft tissue
EP2247645B1 (en) 2008-02-13 2017-12-06 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
CN101724144A (zh) 2008-11-03 2010-06-09 北京键凯科技有限公司 新型的多臂聚乙二醇及其制备方法和应用
WO2010062783A2 (en) 2008-11-03 2010-06-03 Cornell University Polymer compositions of dihydroxyacetone and uses thereof
EP3960215B1 (en) 2009-12-15 2024-10-16 Incept, LLC Implants and biodegradable fiducial markers
US8734930B2 (en) 2010-05-27 2014-05-27 Covidien Lp Hydrogel implants with varying degrees of crosslinking
AU2014214841B2 (en) 2013-02-08 2018-02-22 Endoshape, Inc. Radiopaque polymers for medical devices
US9789073B2 (en) 2013-03-14 2017-10-17 Pathak Holdings, Llc Compositions, methods and devices for local drug delivery
CN107759783A (zh) 2013-12-02 2018-03-06 北京键凯科技股份有限公司 炔基多臂聚乙二醇衍生物
CN106146325B (zh) 2015-04-24 2019-01-29 北京键凯科技股份有限公司 一种y型多缩乙二醇衍生物及其制备方法
WO2019053269A1 (en) * 2017-09-15 2019-03-21 Université De Strasbourg INJECTABLE HYBRID ALGINATE HYDROGELS AND USES THEREOF

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