JP5820815B2 - インプラントおよび生体分解性基準マーカー - Google Patents

インプラントおよび生体分解性基準マーカー Download PDF

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JP5820815B2
JP5820815B2 JP2012544750A JP2012544750A JP5820815B2 JP 5820815 B2 JP5820815 B2 JP 5820815B2 JP 2012544750 A JP2012544750 A JP 2012544750A JP 2012544750 A JP2012544750 A JP 2012544750A JP 5820815 B2 JP5820815 B2 JP 5820815B2
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hydrogel
particles
precursor
agent
tissue
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JP2013514152A5 (enExample
JP2013514152A (ja
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パトリック・キャンベル
アマルプリート・エス・ソーニー
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442—Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18—Materials at least partially X-ray or laser opaque
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Prostheses (AREA)
JP2012544750A 2009-12-15 2010-12-15 インプラントおよび生体分解性基準マーカー Active JP5820815B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28645009P 2009-12-15 2009-12-15
US61/286,450 2009-12-15
PCT/US2010/060474 WO2011084465A2 (en) 2009-12-15 2010-12-15 Implants and biodegradable fiducial markers

Publications (3)

Publication Number Publication Date
JP2013514152A JP2013514152A (ja) 2013-04-25
JP2013514152A5 JP2013514152A5 (enExample) 2014-02-06
JP5820815B2 true JP5820815B2 (ja) 2015-11-24

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JP2012544750A Active JP5820815B2 (ja) 2009-12-15 2010-12-15 インプラントおよび生体分解性基準マーカー

Country Status (8)

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US (12) US8383161B2 (enExample)
EP (3) EP3960215B1 (enExample)
JP (1) JP5820815B2 (enExample)
CN (1) CN102844054B (enExample)
AU (1) AU2010340067B2 (enExample)
CA (3) CA3042067C (enExample)
IN (1) IN2012DN05177A (enExample)
WO (1) WO2011084465A2 (enExample)

Families Citing this family (95)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10675298B2 (en) * 2006-07-27 2020-06-09 Boston Scientific Scimed Inc. Particles
EP3960215B1 (en) 2009-12-15 2024-10-16 Incept, LLC Implants and biodegradable fiducial markers
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
US9205150B2 (en) 2011-12-05 2015-12-08 Incept, Llc Medical organogel processes and compositions
CA2861048C (en) * 2012-01-24 2021-01-12 Lifecell Corporation Elongated tissue matrices
US9798856B2 (en) * 2012-03-21 2017-10-24 Koninklijke Philips N.V. Clinical workstation integrating medical imaging and biopsy data and methods using same
US9226797B2 (en) * 2012-11-04 2016-01-05 Miba Medical Inc. Computer aided implantation of body implants
WO2014169301A1 (en) * 2013-04-12 2014-10-16 Bui The Duy Systems and methods for delivering cross-linked halyuronic acid into a patient
WO2014152488A2 (en) 2013-03-15 2014-09-25 Dreher Matthew R Imageable embolic microsphere
WO2014145397A1 (en) * 2013-03-15 2014-09-18 Herskovic Arnold M Device and method for delivering medicaments
CA2913100C (en) * 2013-05-24 2021-10-26 Danmarks Tekniske Universitet Gel formulations for guiding radiotherapy
WO2014202738A1 (en) * 2013-06-20 2014-12-24 Nanobiotix Compositions and methods for use in oncology
AU2014283217A1 (en) * 2013-06-20 2015-12-24 Nanobiotix Compositions and methods for use in medical diagnosis
US10842969B2 (en) 2013-10-25 2020-11-24 Mercator Medsystems, Inc. Systems and methods of treating malacia by local delivery of hydrogel to augment tissue
US12144519B2 (en) * 2014-04-03 2024-11-19 Corbin Clinical Resources, Llc Transperineal prostate biopsy and treatment methods
US10743909B2 (en) 2014-04-03 2020-08-18 Corbin Clinical Resources, Llc Transperineal prostate biopsy device, systems, and methods of use
US9561095B1 (en) * 2015-10-12 2017-02-07 Phi Nguyen Body augmentation device
US10022475B2 (en) * 2014-05-01 2018-07-17 Bao Tran Body augmentation device
US9636210B2 (en) 2014-05-19 2017-05-02 Mentor Worldwide Llc Injection zone markers for biomedical implants
US9678022B2 (en) * 2014-09-05 2017-06-13 The Boeing Company Nonaqueous radiopaque fluid and associated imaging system and method
KR101555358B1 (ko) * 2014-10-21 2015-09-24 사회복지법인 삼성생명공익재단 생분해성 다중블록 공중합체를 이용한 표적 표지자
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
AU2015360469B2 (en) 2014-12-10 2021-03-25 Incept, Llc Hydrogel drug delivery implants
MX2017007873A (es) 2014-12-15 2017-11-06 Univ Johns Hopkins Formulaciones de sunitinib y metodos para uso de las mismas en el tratamiento de trastornos oculares.
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
EP3288626B8 (en) 2015-04-27 2025-12-10 Tulavi Therapeutics, Inc. Substances and compositions for use in blocking nerve regeneration
WO2016183296A1 (en) 2015-05-12 2016-11-17 Incept, Llc Drug delivery from hydrogels
JP2018516256A (ja) 2015-05-28 2018-06-21 ナノビオティックスＮａｎｏｂｉｏｔｉｘ 治療用ワクチンとしての使用のためのナノ粒子
US20170103184A1 (en) * 2015-10-12 2017-04-13 Phi Nguyen Injectable filler
US10441548B2 (en) 2015-11-12 2019-10-15 Graybug Vision, Inc. Aggregating microparticles for medical therapy
US20170136144A1 (en) 2015-11-12 2017-05-18 John C. Herr Compositions and methods for vas-occlusive contraception
AU2016361579B2 (en) 2015-11-25 2022-08-04 Incept, Llc Shape changing drug delivery devices and methods
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
AU2017290353B2 (en) 2016-06-29 2023-05-18 Tulavi Therapeutics, Inc. Treatment of sepsis and related inflammatory conditions by local neuromodulation of the autonomic nervous system
US12702639B2 (en) * 2016-07-07 2026-08-11 University Of Virginia Patent Foundation Thiol-michael addition hydrogel-based brachytherapy system and methods comprising the same
CA3029806A1 (en) * 2016-07-07 2018-01-11 University Of Virginia Patent Foundation Thiol-michael addition hydrogel-based brachytherapy system and methods comprising the same
CN106334213B (zh) * 2016-08-31 2019-07-26 安疗生命科学（武汉）有限公司 一种血管栓塞材料、其制备方法及在药物制备中的用途
KR102814241B1 (ko) 2016-09-23 2025-05-29 인셉트, 엘엘씨 전안방내 약물 전달 데포
ES2905695T3 (es) * 2016-11-23 2022-04-11 Hologic Inc Marcador de sitio de biopsia
EP3565484B1 (en) 2017-01-05 2024-04-03 Contraline, Inc. Compositions for implanting and reversing stimuli-responsive implants
US12383421B2 (en) 2017-01-05 2025-08-12 Contraline, Inc. Contraceptive devices
US20180289467A1 (en) * 2017-04-05 2018-10-11 Ernesto Andrade Dispensing device, kit, and method for tissue augmentation
MX2019013363A (es) 2017-05-10 2020-01-13 Graybug Vision Inc Microparticulas de liberacion extendida y suspensiones de las mismas para terapia medica.
CN107307922A (zh) * 2017-07-06 2017-11-03 刘志光 一种人体植入填充颗粒的制作方法
WO2019010007A1 (en) * 2017-07-07 2019-01-10 Hindsite, Llc SYSTEM AND METHOD FOR MARKING AND FOLLOWING LOCATION OF BIOPSY SITES USING RFID TECHNOLOGY
KR102673196B1 (ko) 2017-09-05 2024-06-10 삼성전자주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물
EP3691618A1 (en) 2017-10-06 2020-08-12 Foundry Therapeutics, Inc. Implantable depots for the controlled release of therapeutic agents
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
CN116650732A (zh) 2018-01-08 2023-08-29 铸造疗法股份有限公司 经由治疗剂的控制递送用于治疗腔内癌症的装置、系统和方法
JP2021517165A (ja) 2018-03-07 2021-07-15 マージン−クリア ピーティーワイ リミテッド 局所小線源療法装置及び悪性がん細胞の治療の方法
US12458589B2 (en) 2018-05-12 2025-11-04 Foundry Therapeutics, Inc. Implantable polymer depots for the controlled release of therapeutic agents
US11730865B2 (en) 2018-05-15 2023-08-22 Incept, Llc Embolic compositions and methods
AU2019299519B2 (en) 2018-07-02 2025-03-06 Incept Llc Methods and devices for in situ formed nerve cap
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
EP3843710A1 (en) 2018-08-28 2021-07-07 Foundry Therapeutics, Inc. Polymer implants
CA3112634A1 (en) 2018-09-13 2020-03-19 Allergan, Inc. Tissue expansion device
USD896383S1 (en) 2018-09-13 2020-09-15 Allergan, Inc. Tissue expansion device
AU2019380413B2 (en) 2018-11-13 2025-04-17 Contraline, Inc. Systems and methods for delivering biomaterials
AU2020269368B2 (en) * 2019-05-03 2025-07-10 Palette Life Sciences, Inc. Improved tissue spacers
ES2963356T3 (es) * 2019-06-12 2024-03-26 Nouryon Chemicals Int Bv Método para aislar ácido carboxílico a partir de una corriente lateral acuosa
US11976035B2 (en) 2019-06-12 2024-05-07 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
JP7335362B2 (ja) 2019-06-12 2023-08-29 ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ 過酸化ジアシルを生成するためのプロセス
JP7281564B2 (ja) 2019-06-12 2023-05-25 ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ 過酸化ジアシルを生成するためのプロセス
JP7281563B2 (ja) 2019-06-12 2023-05-25 ヌーリオン ケミカルズ インターナショナル ベスローテン フェノーツハップ ペルオキシエステルを生成するためのプロセス
CN114269393A (zh) 2019-08-28 2022-04-01 波士顿科学医学有限公司 具有支化端基的反应性多臂聚合物
AU2020337329B2 (en) 2019-08-28 2024-07-11 Boston Scientific Scimed, Inc. Radiopaque multi-armed polymers and compositions, systems and methods pertaining to the same
WO2021041222A1 (en) 2019-08-28 2021-03-04 Boston Scientific Scimed, Inc. Multi-armed polyoxazolines and compositions, systems and methods pertaining to the same
US11326022B2 (en) 2019-08-28 2022-05-10 Boston Scientific Scimed, Inc. Multi-armed polymers comprising free-radical-polymerizable monomers and compositions, systems and methods pertaining to the same
US11878092B2 (en) 2019-08-28 2024-01-23 Boston Scientific Scimed, Inc. Medical compositions based on crosslinkable hydrophilic polymers
US11820868B2 (en) 2019-08-28 2023-11-21 Boston Scientific Scimed, Inc. Multifunctional nitroxide-mediated polymerization initiators and multi-armed polymers and hydrogels formed therefrom
AU2021206966A1 (en) * 2020-01-14 2022-08-04 Mochida Pharmaceutical Co., Ltd. Combination and method for treating subject using alginic acid salt
CN115052641A (zh) 2020-02-04 2022-09-13 波士顿科学国际有限公司 用作软组织填充物的可注射体内交联材料
WO2021207181A1 (en) * 2020-04-06 2021-10-14 Corbin Clinical Resources, Llc Transperineal prostate biopsy and treatment methods
CN111905155B (zh) * 2020-07-23 2021-10-15 北京诺康达医药科技股份有限公司 一种封闭水凝胶及其制备方法和应用
US12343454B2 (en) 2020-11-12 2025-07-01 Pramand LLC Hydrogels formed in situ and composition design for intrauterine use
US20220142653A1 (en) 2020-11-12 2022-05-12 Pramand LLC Transcervical access systems for intrauterine fluid exchange, such as placement of hydrogels formed in situ
EP4312983A4 (en) * 2021-03-30 2025-01-22 Tulavi Therapeutics, Inc. METHODS AND COMPOSITIONS FOR ABLATION OF NERVES
EP4422596A1 (en) 2021-10-25 2024-09-04 Boston Scientific Scimed Inc. Iodine labeled hydrogels and precursors thereof with improved radiopacity
EP4464339A4 (en) * 2022-01-13 2026-08-05 Nat Cancer Ct BIOCOMPATIBLE COMPOSITION FOR MARKING A TARGET LESION, AND ITS PREPARATION PROCESS
JP7744528B2 (ja) 2022-02-02 2025-09-25 ボストン サイエンティフィック サイムド，インコーポレイテッド ヨウ素化化合物及びこれから形成されるヒドロゲル
CN114344554A (zh) * 2022-02-11 2022-04-15 上海益思妙医疗器械有限公司 一种peg化合物作为制备栓塞剂的应用
US11701451B1 (en) 2022-03-11 2023-07-18 Carbon Medical Technologies, Inc. Soft tissue filler and methods
US12251466B2 (en) 2022-04-20 2025-03-18 Pramand LLC Single solution hydrogels with covalent bonding formed in situ, composition design and medical procedures using the hydrogels
US12440599B2 (en) 2022-05-06 2025-10-14 Pramand LLC Water activated hydrogel-based medical patches, and methods of making and using such patches
US20250360172A1 (en) * 2022-05-25 2025-11-27 Cedars-Sinai Medical Center Microgel-encapsulated ipsc-derived notochordal cells for treatment of intervertebral disc degeneration and discogenic pain
CN119731240A (zh) 2022-08-17 2025-03-28 波士顿科学医学有限公司 具有改进性能的碘标记水凝胶及其前体
EP4623020A1 (en) 2022-11-21 2025-10-01 Boston Scientific Scimed Inc. Iodine labeled hydrogels and crosslinking agents for forming the same
US20240181139A1 (en) * 2022-12-06 2024-06-06 Pramand LLC Chemical tissue ablation with hydrogel matrix and corresponding medical applications
US20240301179A1 (en) 2023-03-02 2024-09-12 Boston Scientific Scimed, Inc. Polyamino iodinated compounds and radiopaque hydrogels formed therefrom
WO2024182523A1 (en) 2023-03-02 2024-09-06 Boston Scientific Scimed, Inc. Therapeutic-agent-releasing hydrogels and precursors thereof
DE102023108039A1 (de) 2023-03-29 2024-10-02 Dwi - Leibniz-Institut Für Interaktive Materialien E.V. Ein System zur Herstellung eines degradierbaren Hydrogels
WO2024227165A1 (en) * 2023-04-28 2024-10-31 Boston Scientific Scimed, Inc. Suspensions of radiopaque crosslinked hydrogel particles in carrier fluids containing biocompatible hydrophilic polymers
WO2025059725A1 (en) 2023-09-20 2025-03-27 Margin-Clear Pty Ltd Improved brachytherapy device
CN122122219A (zh) 2023-11-01 2026-05-29 波士顿科学医学有限公司 基于氨基酸和氨基醇的多胺化合物以及由其形成的医用水凝胶
US20250228774A1 (en) * 2024-01-11 2025-07-17 Boston Scientific Scimed, Inc. Systems and methods for accelerated hydrolysis of polysaccharide-based hydrogels

Family Cites Families (156)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3640741A (en) 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3865108A (en) 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US3872856A (en) 1971-06-09 1975-03-25 Ralph S Clayton Apparatus for treating the walls and floor of the pelvic cavity with radiation
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
DE2437629C3 (de) 1974-08-05 1978-09-21 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4193813A (en) 1976-09-07 1980-03-18 Medi-Coll, Inc. Method for making collagen sponge
US4207893A (en) 1977-08-29 1980-06-17 Alza Corporation Device using hydrophilic polymer for delivering drug to biological environment
IL74715A0 (en) 1984-03-27 1985-06-30 Univ New Jersey Med Biodegradable matrix and methods for producing same
US4697575A (en) 1984-11-21 1987-10-06 Henry Ford Hospital Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member
US4674488A (en) 1985-03-04 1987-06-23 American Hospital Supply Corporation Method of treating bone fractures to reduce formation of fibrous adhesions
US4714074A (en) 1985-06-28 1987-12-22 Centre National De La Recherche Scientifique Method for protecting human or animal organs against radiation
US4706652A (en) 1985-12-30 1987-11-17 Henry Ford Hospital Temporary radiation therapy
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
US4741872A (en) 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
IL82834A (en) 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
US5550187A (en) 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5306500A (en) 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
IL90193A (en) 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
CA2094908C (en) 1990-12-06 2000-02-08 Byron Kent Hayes Implantable bioabsorbable article
FR2672713A1 (fr) * 1991-02-13 1992-08-14 Inst Nat Polytech Grenoble Composant d'alimentation du type carte de credit.
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
US5629008A (en) 1992-06-02 1997-05-13 C.R. Bard, Inc. Method and device for long-term delivery of drugs
US5514379A (en) 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US6592859B1 (en) 1992-08-20 2003-07-15 Ethicon, Inc. Controlled expansion sphincter augmentation media
DE69331387T2 (de) 1992-09-10 2002-08-22 Childrens Medical Center Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika
DE69412474T2 (de) 1993-04-28 1998-12-17 Focal, Inc., Lexington, Mass. Vorrichtung, produkt und verwendung betreffend die intraluminale photothermoformgebung
US5709854A (en) 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5499994A (en) 1993-07-30 1996-03-19 American Medical Systems, Inc. Dilation device for the urethra
CA2188464C (en) 1994-04-27 2006-08-08 Michael Roreger Collagen preparation for the controlled release of active substances
DE4414755C2 (de) 1994-04-27 2000-11-16 Lohmann Therapie Syst Lts Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung
BR9607977A (pt) 1995-03-23 1998-01-13 Univ Texas Sistemas de preparação fotoiniciados e redox para a obtenção de aderência melhorada de géis a substratos
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
AU6403196A (en) 1995-06-30 1997-02-05 Baylor University Polyester/carboxylic acid composite materials
US5827937A (en) 1995-07-17 1998-10-27 Q Med Ab Polysaccharide gel composition
WO1997005185A2 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatment agents
RU2177332C2 (ru) 1995-08-29 2001-12-27 Фидиа Адвансд Биополимерз, С.Р.Л. Биоматериал для предотвращения послеоперационных спаек, включающий производные гиалуроновой кислоты (варианты) и способ предотвращения послеоперационных спаек ткани
US5759583A (en) 1995-08-30 1998-06-02 Syntex (U.S.A.) Inc. Sustained release poly (lactic/glycolic) matrices
US5733316A (en) 1995-10-27 1998-03-31 Dornier Medical Systems, Inc. Organ separation for thermal therapy
US5863984A (en) 1995-12-01 1999-01-26 Universite Laval, Cite Universitaire Biostable porous material comprising composite biopolymers
WO1997022371A1 (en) 1995-12-18 1997-06-26 Collagen Corporation Crosslinked polymer compositions and methods for their use
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
US6060534A (en) * 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US7049346B1 (en) 1996-08-20 2006-05-23 Menlo Care Div Of Ethicon, Inc. Swollen hydrogel for sphincter augmentation
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US7009034B2 (en) 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US5932539A (en) 1996-10-15 1999-08-03 The Board Of Trustees Of The University Of Illinois Biodegradable polymer matrix for tissue repair
JP3092530B2 (ja) 1996-11-05 2000-09-25 日本油脂株式会社 コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法
JP3092531B2 (ja) 1996-11-05 2000-09-25 日本油脂株式会社 コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6271278B1 (en) 1997-05-13 2001-08-07 Purdue Research Foundation Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties
IL121861A (en) 1997-09-29 2003-07-31 Moshe Ein Gal Prostate radiotherapy apparatus
JP2001519203A (ja) 1997-10-10 2001-10-23 ジョン・ディ・コービット・ジュニア 胸部インプラント
US8288745B2 (en) 1997-10-10 2012-10-16 Senorx, Inc. Method of utilizing an implant for targeting external beam radiation
IL135800A0 (en) 1997-10-27 2001-05-20 Univ California Methods and pharmaceutical compositions for the closure of retinal breaks
JP4465105B2 (ja) * 1997-11-07 2010-05-19 ルトガーズ、ザ ステイト ユニバーシティ オブ ニュージャージー 放射線不透過性ポリマー生体適合材料
US6375634B1 (en) 1997-11-19 2002-04-23 Oncology Innovations, Inc. Apparatus and method to encapsulate, kill and remove malignancies, including selectively increasing absorption of x-rays and increasing free-radical damage to residual tumors targeted by ionizing and non-ionizing radiation therapy
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
US6428978B1 (en) 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
US6066856A (en) 1998-05-18 2000-05-23 Children's Medical Center Corporation Radiation protective device
US6280742B1 (en) * 1998-06-17 2001-08-28 Zonagen, Inc. Methods and materials for the treatment of prostatic carcinoma
US6206930B1 (en) 1998-08-10 2001-03-27 Charlotte-Mecklenburg Hospital Authority Absorbable tissue expander
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
ATE502670T1 (de) 1998-08-14 2011-04-15 Incept Llc Apparat für die in-situ-bildung von hydrogelen
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
ES2219070T3 (es) 1998-10-22 2004-11-16 Bioniche Life Sciences Inc. Uso de acido haluronico en el tratamiento de la cistitis por radiacion.
US8802146B2 (en) * 1998-11-06 2014-08-12 Neomend, Inc. Systems, methods, and compositions for prevention of tissue adhesion
US6899889B1 (en) 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
JP4551563B2 (ja) 1998-11-10 2010-09-29 電気化学工業株式会社 ヒアルロン酸ゲルの製造方法及び医用材料
WO2000028919A1 (en) 1998-11-12 2000-05-25 Canadian Prostate Centre, Inc. Apparatus and method of separating organs to enable aggressive thermal therapy
US6110484A (en) 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
EP1137373A4 (en) 1998-12-04 2004-05-19 Chandrashekhar P Pathak BIOCOMPATIBLE, CROSSLINKED POLYMERS
US20080114092A1 (en) 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
TW392930U (en) * 1998-12-28 2000-06-01 Hon Hai Prec Ind Co Ltd Electric connector
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
AU780397B2 (en) 1999-02-03 2005-03-17 Powderject Research Limited Hydrogel particle formulations
US6177514B1 (en) 1999-04-09 2001-01-23 Sulzer Carbomedics Inc. Blocked functional reagants for cross-linking biological tissues
ES2298135T3 (es) 1999-04-12 2008-05-16 Cornell Research Foundation, Inc. Sistema formador de hidrogel con componentes hidrofobos e hidrofilos.
US6312725B1 (en) 1999-04-16 2001-11-06 Cohesion Technologies, Inc. Rapid gelling biocompatible polymer composition
US6268405B1 (en) 1999-05-04 2001-07-31 Porex Surgical, Inc. Hydrogels and methods of making and using same
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
US6428785B1 (en) 1999-10-28 2002-08-06 Immunolytics Inc. Method and composition for treating prostate cancer
US6509031B1 (en) 1999-11-15 2003-01-21 Board Of Regents, Texas A&M University System System for polymerizing collagen and collagen composites in situ for a tissue compatible wound sealant, delivery vehicle, binding agent and/or chemically modifiable matrix
US6479079B1 (en) 1999-12-13 2002-11-12 Sulzer Carbomedics Inc. Anticalcification treatments for fixed biomaterials
JP2001192336A (ja) 2000-01-11 2001-07-17 Hironori Yamamoto 高粘性物質を用いた内視鏡的粘膜切除術
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US9314339B2 (en) 2000-03-27 2016-04-19 Formae, Inc. Implants for replacing cartilage, with negatively-charged hydrogel surfaces and flexible matrix reinforcement
EP1142535B1 (en) 2000-04-07 2012-10-03 Collagen Matrix, Inc. Embolization device
US6599448B1 (en) * 2000-05-10 2003-07-29 Hydromer, Inc. Radio-opaque polymeric compositions
US6383344B1 (en) 2000-07-19 2002-05-07 Genzyme Corporation Molecular weight reduction of polymer using irradiation treatment
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US6596471B2 (en) 2000-12-21 2003-07-22 Carbomedics Inc. Method of cross-linking tissue with a bis-maleimide compound
CA2438193A1 (en) 2001-02-26 2002-09-06 Duke University Novel dendritic polymers and their biomedical uses
JP4123856B2 (ja) 2001-07-31 2008-07-23 日油株式会社 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法
CN1277805C (zh) 2001-10-03 2006-10-04 大日本除虫菊株式会社 炔丙基苄基醇酯衍生物、其制备方法和含有其的杀虫·防虫剂
US7008626B2 (en) 2001-11-05 2006-03-07 Seikagaku Corporation Medical composition for protuberance of epithelium
US20070264227A1 (en) 2001-11-07 2007-11-15 Eidgenossische Technische Hochschule Zurich Synthetic Matrix for Controlled Cell Ingrowth and Tissue Regeneration
US20040131582A1 (en) 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
US7341716B2 (en) * 2002-04-12 2008-03-11 Boston Scientific Scimed, Inc. Occlusive composition
WO2004000103A2 (en) 2002-06-24 2003-12-31 Noyes William R Fillers and methods for displacing tissues to improve radiological outcomes
US7351430B2 (en) 2002-11-06 2008-04-01 Uluru Inc. Shape-retentive hydrogel particle aggregates and their uses
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
US20050033157A1 (en) * 2003-07-25 2005-02-10 Klein Dean A. Multi-modality marking material and method
US7790141B2 (en) * 2003-08-11 2010-09-07 Pathak Holdings, Llc Radio-opaque compounds, compositions containing same and methods of their synthesis and use
RU2373958C2 (ru) 2003-09-25 2009-11-27 Рутгерс, Дзе Стейт Юниверсити Полимерные по существу рентгеноконтрастные продукты для эмболотерапии
US20050226936A1 (en) 2004-04-08 2005-10-13 Q-Med Ab Method of soft tissue augmentation
CA2571304A1 (en) 2004-06-23 2006-01-05 Bioprotect Ltd. Device system and method for tissue displacement or separation
FR2872262B1 (fr) 2004-06-29 2010-11-26 Air Liquide Procede et installation de fourniture de secours d'un gaz sous pression
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
RU2396289C2 (ru) 2004-08-13 2010-08-10 Рева Медикал, Инк. Саморассасывающиеся рентгеноконтрастные по своей природе полимеры для многоцелевого использования
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
WO2006026325A2 (en) 2004-08-26 2006-03-09 Pathak Chandrashekhar P Implantable tissue compositions and method
WO2006078770A2 (en) 2005-01-21 2006-07-27 Civco Medical Instruments Co., Inc. Creating temporary space between body tissues
US7963287B2 (en) * 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
WO2007005249A2 (en) 2005-06-29 2007-01-11 Hyperbranch Medical Technology, Inc. Nanoparticles and dendritic-polymer-based hydrogels comprising them
DE102005051366A1 (de) * 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
EP1996243B1 (en) 2006-01-11 2014-04-23 HyperBranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
US7597882B2 (en) 2006-04-24 2009-10-06 Incept Llc Protein crosslinkers, crosslinking methods and applications thereof
US7872068B2 (en) 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
WO2008097581A1 (en) 2007-02-06 2008-08-14 Incept, Llc Polymerization with precipitation of proteins for elution in physiological solution
WO2008101173A2 (en) 2007-02-16 2008-08-21 Cornell University Biodegradable compositions and materials
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
US9987221B2 (en) 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
CA2707649A1 (en) 2007-11-02 2009-05-07 Genzyme Corporation Methods of augmenting or repairing soft tissue
EP2247645B1 (en) 2008-02-13 2017-12-06 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
JP5788326B2 (ja) 2008-11-03 2015-09-30 コーネル ユニバーシティー ジヒドロキシアセトンのポリマー組成物およびその使用
CN101724144A (zh) 2008-11-03 2010-06-09 北京键凯科技有限公司 新型的多臂聚乙二醇及其制备方法和应用
EP3960215B1 (en) * 2009-12-15 2024-10-16 Incept, LLC Implants and biodegradable fiducial markers
US8734930B2 (en) 2010-05-27 2014-05-27 Covidien Lp Hydrogel implants with varying degrees of crosslinking
US9789231B2 (en) 2013-02-08 2017-10-17 Endoshape, Inc. Radiopaque polymers for medical devices
US9789073B2 (en) 2013-03-14 2017-10-17 Pathak Holdings, Llc Compositions, methods and devices for local drug delivery
CN104448296B (zh) 2013-12-02 2018-01-05 北京键凯科技股份有限公司 炔基多臂聚乙二醇衍生物
CN106146325B (zh) 2015-04-24 2019-01-29 北京键凯科技股份有限公司 一种y型多缩乙二醇衍生物及其制备方法
EP3681934A1 (en) * 2017-09-15 2020-07-22 Université de Strasbourg Injectable hybrid alginate hydrogels and uses thereof

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