JP5820815B2 - インプラントおよび生体分解性基準マーカー - Google Patents

インプラントおよび生体分解性基準マーカー Download PDF

Info

Publication number
JP5820815B2
JP5820815B2 JP2012544750A JP2012544750A JP5820815B2 JP 5820815 B2 JP5820815 B2 JP 5820815B2 JP 2012544750 A JP2012544750 A JP 2012544750A JP 2012544750 A JP2012544750 A JP 2012544750A JP 5820815 B2 JP5820815 B2 JP 5820815B2
Authority
JP
Japan
Prior art keywords
hydrogel
particles
precursor
agent
tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2012544750A
Other languages
English (en)
Japanese (ja)
Other versions
JP2013514152A (ja
JP2013514152A5 (enExample
Inventor
パトリック・キャンベル
アマルプリート・エス・ソーニー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incept LLC
Original Assignee
Incept LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incept LLC filed Critical Incept LLC
Publication of JP2013514152A publication Critical patent/JP2013514152A/ja
Publication of JP2013514152A5 publication Critical patent/JP2013514152A5/ja
Application granted granted Critical
Publication of JP5820815B2 publication Critical patent/JP5820815B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0442Polymeric X-ray contrast-enhancing agent comprising a halogenated group
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0409Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414Particles, beads, capsules or spheres
    • A61K49/0419Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/12Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules
    • A61K51/1241Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins
    • A61K51/1244Preparations containing radioactive substances for use in therapy or testing in vivo characterised by a special physical form, e.g. emulsion, microcapsules, liposomes, characterized by a special physical form, e.g. emulsions, dispersions, microcapsules particles, powders, lyophilizates, adsorbates, e.g. polymers or resins for adsorption or ion-exchange resins microparticles or nanoparticles, e.g. polymeric nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58Materials at least partially resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145Hydrogels or hydrocolloids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/148Materials at least partially resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/18Materials at least partially X-ray or laser opaque
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Prostheses (AREA)
JP2012544750A 2009-12-15 2010-12-15 インプラントおよび生体分解性基準マーカー Active JP5820815B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28645009P 2009-12-15 2009-12-15
US61/286,450 2009-12-15
PCT/US2010/060474 WO2011084465A2 (en) 2009-12-15 2010-12-15 Implants and biodegradable fiducial markers

Publications (3)

Publication Number Publication Date
JP2013514152A JP2013514152A (ja) 2013-04-25
JP2013514152A5 JP2013514152A5 (enExample) 2014-02-06
JP5820815B2 true JP5820815B2 (ja) 2015-11-24

Family

ID=44143217

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2012544750A Active JP5820815B2 (ja) 2009-12-15 2010-12-15 インプラントおよび生体分解性基準マーカー

Country Status (8)

Country Link
US (12) US8383161B2 (enExample)
EP (3) EP3583960A1 (enExample)
JP (1) JP5820815B2 (enExample)
CN (1) CN102844054B (enExample)
AU (1) AU2010340067B2 (enExample)
CA (3) CA3042067C (enExample)
IN (1) IN2012DN05177A (enExample)
WO (1) WO2011084465A2 (enExample)

Families Citing this family (90)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10675298B2 (en) * 2006-07-27 2020-06-09 Boston Scientific Scimed Inc. Particles
CA3042067C (en) 2009-12-15 2022-10-18 Incept, Llc Implants and biodegradable fiducial markers
US10226417B2 (en) 2011-09-16 2019-03-12 Peter Jarrett Drug delivery systems and applications
CN109200013A (zh) 2011-12-05 2019-01-15 因赛普特有限责任公司 医用有机凝胶方法和组合物
AU2013212592B2 (en) * 2012-01-24 2016-06-30 Lifecell Corporation Elongated tissue matrices
US9798856B2 (en) * 2012-03-21 2017-10-24 Koninklijke Philips N.V. Clinical workstation integrating medical imaging and biopsy data and methods using same
WO2014169301A1 (en) * 2013-04-12 2014-10-16 Bui The Duy Systems and methods for delivering cross-linked halyuronic acid into a patient
US9226797B2 (en) * 2012-11-04 2016-01-05 Miba Medical Inc. Computer aided implantation of body implants
WO2014145397A1 (en) * 2013-03-15 2014-09-18 Herskovic Arnold M Device and method for delivering medicaments
WO2014152488A2 (en) * 2013-03-15 2014-09-25 Dreher Matthew R Imageable embolic microsphere
RU2703303C2 (ru) 2013-05-24 2019-10-16 Данмаркс Текниске Университет Состав геля для лучевой терапии под визуальным контролем
JP6560665B2 (ja) * 2013-06-20 2019-08-14 ナノビオティックスNanobiotix 医療診断に使用するための組成物および方法
US20160136304A1 (en) * 2013-06-20 2016-05-19 Nanobiotix Compositions and methods for use in oncology
US10842969B2 (en) 2013-10-25 2020-11-24 Mercator Medsystems, Inc. Systems and methods of treating malacia by local delivery of hydrogel to augment tissue
US12144519B2 (en) * 2014-04-03 2024-11-19 Corbin Clinical Resources, Llc Transperineal prostate biopsy and treatment methods
US10743909B2 (en) 2014-04-03 2020-08-18 Corbin Clinical Resources, Llc Transperineal prostate biopsy device, systems, and methods of use
US9561095B1 (en) * 2015-10-12 2017-02-07 Phi Nguyen Body augmentation device
US10022475B2 (en) * 2014-05-01 2018-07-17 Bao Tran Body augmentation device
US9636210B2 (en) 2014-05-19 2017-05-02 Mentor Worldwide Llc Injection zone markers for biomedical implants
US9678022B2 (en) * 2014-09-05 2017-06-13 The Boeing Company Nonaqueous radiopaque fluid and associated imaging system and method
KR101555358B1 (ko) * 2014-10-21 2015-09-24 사회복지법인 삼성생명공익재단 생분해성 다중블록 공중합체를 이용한 표적 표지자
US10550187B2 (en) 2014-10-24 2020-02-04 Incept, Llc Extra luminal scaffold
EP3229779B1 (en) 2014-12-10 2021-02-03 Incept, LLC Hydrogel drug delivery implants
BR112017012706A2 (pt) 2014-12-15 2018-03-13 The Johns Hopkins University formulações de sunitinibe e métodos para uso destas no tratamento de transtornos oculares
GB201505527D0 (en) 2015-03-31 2015-05-13 Jmedtech Pte Ltd Composition
EP3288626B8 (en) 2015-04-27 2025-12-10 Tulavi Therapeutics, Inc. Substances and compositions for use in blocking nerve regeneration
AU2016261925B2 (en) 2015-05-12 2020-10-01 Incept, Llc Drug delivery from hydrogels
EA201792560A1 (ru) 2015-05-28 2018-06-29 Нанобиотикс Наночастицы для применения в качестве терапевтической вакцины
US20170103184A1 (en) * 2015-10-12 2017-04-13 Phi Nguyen Injectable filler
CN114469872A (zh) 2015-11-12 2022-05-13 灰色视觉公司 用于治疗的聚集性微粒
US20170136144A1 (en) 2015-11-12 2017-05-18 John C. Herr Compositions and methods for vas-occlusive contraception
CN108601725B (zh) 2015-11-25 2024-03-08 因赛普特有限责任公司 形状改变的药物递送装置和方法
WO2017139487A1 (en) 2016-02-09 2017-08-17 Northwind Medical, Inc. Methods, agents, and devices for local neuromodulation of autonomic nerves
CN110035754A (zh) 2016-06-29 2019-07-19 图拉维治疗股份有限公司 通过自主神经系统的局部神经调节治疗败血症及相关炎性病况
EP3481373A4 (en) * 2016-07-07 2020-04-01 University of Virginia Patent Foundation THIOL-MICHAEL-ADDED HYDROGEL-BASED CURIETHERAPY SYSTEM AND METHODS COMPRISING SAME
US20220249366A1 (en) * 2016-07-07 2022-08-11 University Of Virginia Patent Foundation Thiol-michael addition hydrogel-based brachytherapy system and methods comprising the same
CN106334213B (zh) * 2016-08-31 2019-07-26 安疗生命科学(武汉)有限公司 一种血管栓塞材料、其制备方法及在药物制备中的用途
EP4197527A1 (en) 2016-09-23 2023-06-21 Incept, LLC Intracameral drug delivery depots
CN110022789B (zh) * 2016-11-23 2022-07-12 霍罗吉克公司 活检部位标记物
US12383421B2 (en) 2017-01-05 2025-08-12 Contraline, Inc. Contraceptive devices
EP3565484B1 (en) 2017-01-05 2024-04-03 Contraline, Inc. Compositions for implanting and reversing stimuli-responsive implants
US20180289467A1 (en) * 2017-04-05 2018-10-11 Ernesto Andrade Dispensing device, kit, and method for tissue augmentation
JP2020519585A (ja) 2017-05-10 2020-07-02 グレイバグ ビジョン インコーポレイテッド 医学療法のための延長放出マイクロ粒子及びその懸濁液
CN107307922A (zh) * 2017-07-06 2017-11-03 刘志光 一种人体植入填充颗粒的制作方法
CA3063913A1 (en) * 2017-07-07 2019-01-10 Shadwell Endoscopic, Inc. System and method for marking and subsequently locating sites of biopsies using rfid technology
KR102673196B1 (ko) 2017-09-05 2024-06-10 삼성전자주식회사 유기금속 화합물, 이를 포함한 유기 발광 소자 및 이를 포함한 진단용 조성물
JP2020536955A (ja) 2017-10-06 2020-12-17 ファウンドリー セラピューティクス, インコーポレイテッド 治療剤の制御放出のための埋込み可能なデポー
US10426424B2 (en) 2017-11-21 2019-10-01 General Electric Company System and method for generating and performing imaging protocol simulations
US12364792B2 (en) 2018-01-08 2025-07-22 Foundry Therapeutics, Inc. Devices, systems, and methods for treating intraluminal cancer via controlled delivery of therapeutic agents
CN117731963A (zh) * 2018-03-07 2024-03-22 马金-克利尔私人有限公司 局部近距放射治疗装置和治疗恶性癌细胞的方法
WO2019221853A1 (en) 2018-05-12 2019-11-21 Foundry Therapeutics, Inc. Implantable depots for the controlled release of therapeutic agents
KR20210009364A (ko) 2018-05-15 2021-01-26 인셉트, 엘엘씨 색전 조성물 및 방법
CA3105343A1 (en) 2018-07-02 2020-01-09 Corinne Bright Methods and devices for in situ formed nerve cap
US20210315587A1 (en) 2018-07-02 2021-10-14 Tulavi Therapeutics, Inc. Methods and devices for in situ formed nerve cap with rapid release
WO2020047013A1 (en) 2018-08-28 2020-03-05 Foundry Therapeutics, Inc. Polymer implants
US11160630B2 (en) 2018-09-13 2021-11-02 Allergan, Inc. Tissue expansion device
USD896383S1 (en) 2018-09-13 2020-09-15 Allergan, Inc. Tissue expansion device
JP7582939B2 (ja) 2018-11-13 2024-11-13 コントラライン,インコーポレイテッド 生体材料を送達するためのシステムおよび方法
CA3138695A1 (en) * 2019-05-03 2020-11-12 Palette Life Sciences, Inc. Improved tissue spacers
EP3983368B1 (en) 2019-06-12 2023-08-02 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
US12215074B2 (en) 2019-06-12 2025-02-04 Nouryon Chemicals International B.V. Process for the production of peroxyesters
EP3983370B1 (en) 2019-06-12 2023-08-02 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
ES2961184T3 (es) 2019-06-12 2024-03-08 Nouryon Chemicals Int Bv Proceso para la producción de peróxidos de diacilo
EP3983340B1 (en) * 2019-06-12 2023-08-02 Nouryon Chemicals International B.V. Method for isolating carboxylic acid from an aqueous side stream
US11807720B2 (en) 2019-08-28 2023-11-07 Boston Scientific Scimed, Inc. Multi-armed polyoxazolines and compositions, systems and methods pertaining to the same
CN116789979A (zh) 2019-08-28 2023-09-22 波士顿科学国际有限公司 包含自由基可聚合单体的多臂聚合物
US12297335B2 (en) 2019-08-28 2025-05-13 Boston Scientific Scimed, Inc. Radiopaque multi-armed polymers and compositions, systems and methods pertaining to the same
CN114269393A (zh) 2019-08-28 2022-04-01 波士顿科学医学有限公司 具有支化端基的反应性多臂聚合物
WO2021041227A1 (en) 2019-08-28 2021-03-04 Boston Scientific Scimed, Inc. Multifunctional nitroxide-mediated polymerization initiators and products formed therefrom
US11878092B2 (en) 2019-08-28 2024-01-23 Boston Scientific Scimed, Inc. Medical compositions based on crosslinkable hydrophilic polymers
AU2021206966A1 (en) * 2020-01-14 2022-08-04 Mochida Pharmaceutical Co., Ltd. Combination and method for treating subject using alginic acid salt
US12016969B2 (en) 2020-02-04 2024-06-25 Boston Scientific Scimed, Inc. Injectable in vivo crosslinking materials for use as soft tissue fillers
CN111905155B (zh) * 2020-07-23 2021-10-15 北京诺康达医药科技股份有限公司 一种封闭水凝胶及其制备方法和应用
US12343454B2 (en) 2020-11-12 2025-07-01 Pramand LLC Hydrogels formed in situ and composition design for intrauterine use
AU2022375618B2 (en) 2021-10-25 2025-04-10 Boston Scientific Scimed Inc. Iodine labeled hydrogels and precursors thereof with improved radiopacity
JP2025502233A (ja) * 2022-01-13 2025-01-24 ナショナル キャンサー センター 生体親和性目的病変標識用組成物およびその製造方法
JP7744528B2 (ja) 2022-02-02 2025-09-25 ボストン サイエンティフィック サイムド,インコーポレイテッド ヨウ素化化合物及びこれから形成されるヒドロゲル
CN114344554A (zh) * 2022-02-11 2022-04-15 上海益思妙医疗器械有限公司 一种peg化合物作为制备栓塞剂的应用
US11701451B1 (en) 2022-03-11 2023-07-18 Carbon Medical Technologies, Inc. Soft tissue filler and methods
US12251466B2 (en) 2022-04-20 2025-03-18 Pramand LLC Single solution hydrogels with covalent bonding formed in situ, composition design and medical procedures using the hydrogels
US12440599B2 (en) 2022-05-06 2025-10-14 Pramand LLC Water activated hydrogel-based medical patches, and methods of making and using such patches
WO2023230267A1 (en) * 2022-05-25 2023-11-30 Cedars-Sinai Medical Center Microgel-encapsulated ipsc-derived notochordal cells for treatment of intervertebral disc degeneration and discogenic pain
EP4573145A1 (en) 2022-08-17 2025-06-25 Boston Scientific Scimed Inc. Iodine labeled hydrogels and precursors thereof with improved properties
CN120265683A (zh) 2022-11-21 2025-07-04 波士顿科学医学有限公司 碘标记水凝胶及用于形成其的交联剂
WO2024182598A1 (en) 2023-03-02 2024-09-06 Boston Scientific Scimed, Inc. Polyamino iodinated compounds and radiopaque hydrogels formed therefrom
WO2024182523A1 (en) 2023-03-02 2024-09-06 Boston Scientific Scimed, Inc. Therapeutic-agent-releasing hydrogels and precursors thereof
DE102023108039A1 (de) 2023-03-29 2024-10-02 Dwi - Leibniz-Institut Für Interaktive Materialien E.V. Ein System zur Herstellung eines degradierbaren Hydrogels
WO2024227165A1 (en) * 2023-04-28 2024-10-31 Boston Scientific Scimed, Inc. Suspensions of radiopaque crosslinked hydrogel particles in carrier fluids containing biocompatible hydrophilic polymers
WO2025096930A1 (en) 2023-11-01 2025-05-08 Boston Scientific Scimed, Inc. Amino-acid- and amino-alcohol-based polyamine compounds and medical hydrogels formed therefrom
US20250228774A1 (en) * 2024-01-11 2025-07-17 Boston Scientific Scimed, Inc. Systems and methods for accelerated hydrolysis of polysaccharide-based hydrogels

Family Cites Families (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3640741A (en) 1970-02-24 1972-02-08 Hollister Inc Composition containing gel
US3865108A (en) 1971-05-17 1975-02-11 Ortho Pharma Corp Expandable drug delivery device
US3872856A (en) 1971-06-09 1975-03-25 Ralph S Clayton Apparatus for treating the walls and floor of the pelvic cavity with radiation
US4002173A (en) 1974-07-23 1977-01-11 International Paper Company Diester crosslinked polyglucan hydrogels and reticulated sponges thereof
DE2437629C3 (de) 1974-08-05 1978-09-21 Basf Ag, 6700 Ludwigshafen Verfahren zur Herstellung von unlöslichen in Wasser nur wenig quellbaren Polymerisaten von N-Vinyllactamen
US4014335A (en) 1975-04-21 1977-03-29 Alza Corporation Ocular drug delivery device
US4193813A (en) 1976-09-07 1980-03-18 Medi-Coll, Inc. Method for making collagen sponge
US4207893A (en) 1977-08-29 1980-06-17 Alza Corporation Device using hydrophilic polymer for delivering drug to biological environment
MX163953B (es) 1984-03-27 1992-07-03 Univ New Jersey Med Procedimiento para preparar una matriz biodegradable a base de colageno
US4697575A (en) 1984-11-21 1987-10-06 Henry Ford Hospital Delivery system for interstitial radiation therapy including substantially non-deflecting elongated member
US4714074A (en) 1985-06-28 1987-12-22 Centre National De La Recherche Scientifique Method for protecting human or animal organs against radiation
US4741872A (en) 1986-05-16 1988-05-03 The University Of Kentucky Research Foundation Preparation of biodegradable microspheres useful as carriers for macromolecules
US5160745A (en) 1986-05-16 1992-11-03 The University Of Kentucky Research Foundation Biodegradable microspheres as a carrier for macromolecules
IL82834A (en) 1987-06-09 1990-11-05 Yissum Res Dev Co Biodegradable polymeric materials based on polyether glycols,processes for the preparation thereof and surgical artiicles made therefrom
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5550187A (en) 1988-11-21 1996-08-27 Collagen Corporation Method of preparing crosslinked biomaterial compositions for use in tissue augmentation
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5306500A (en) 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
IL90193A (en) 1989-05-04 1993-02-21 Biomedical Polymers Int Polurethane-based polymeric materials and biomedical articles and pharmaceutical compositions utilizing the same
US5324519A (en) 1989-07-24 1994-06-28 Atrix Laboratories, Inc. Biodegradable polymer composition
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5410016A (en) 1990-10-15 1995-04-25 Board Of Regents, The University Of Texas System Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers
WO1992010218A1 (en) 1990-12-06 1992-06-25 W.L. Gore & Associates, Inc. Implantable bioabsorbable article
FR2672713A1 (fr) * 1991-02-13 1992-08-14 Inst Nat Polytech Grenoble Composant d'alimentation du type carte de credit.
US5629008A (en) 1992-06-02 1997-05-13 C.R. Bard, Inc. Method and device for long-term delivery of drugs
US5514379A (en) * 1992-08-07 1996-05-07 The General Hospital Corporation Hydrogel compositions and methods of use
US6592859B1 (en) 1992-08-20 2003-07-15 Ethicon, Inc. Controlled expansion sphincter augmentation media
DE69331387T2 (de) 1992-09-10 2002-08-22 Childrens Medical Center Biodegradierbare polymeren matrizen mit verzoegerter freisetzung von lokalanaesthetika
EP0696185B1 (en) 1993-04-28 1998-08-12 Focal, Inc. Apparatus, product and use related to intraluminal photothermoforming
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
US5499994A (en) 1993-07-30 1996-03-19 American Medical Systems, Inc. Dilation device for the urethra
DE4414755C2 (de) 1994-04-27 2000-11-16 Lohmann Therapie Syst Lts Kollagenzubereitung zur gesteuerten Abgabe von Wirkstoffen, Verfahren und Verwendung
CA2188464C (en) 1994-04-27 2006-08-08 Michael Roreger Collagen preparation for the controlled release of active substances
CA2215309C (en) 1995-03-23 2008-11-25 Focal, Inc. Redox and photoinitiator systems for priming for improved adherence of gels to substrates
US5900245A (en) 1996-03-22 1999-05-04 Focal, Inc. Compliant tissue sealants
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US6129761A (en) 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
AU6403196A (en) 1995-06-30 1997-02-05 Baylor University Polyester/carboxylic acid composite materials
CA2228118A1 (en) 1995-07-28 1997-02-13 Focal, Inc. Multiblock biodegradable hydrogels for use as controlled release agents for drugs delivery and tissue treatments agents
US5759583A (en) 1995-08-30 1998-06-02 Syntex (U.S.A.) Inc. Sustained release poly (lactic/glycolic) matrices
US5733316A (en) 1995-10-27 1998-03-31 Dornier Medical Systems, Inc. Organ separation for thermal therapy
CA2164262A1 (en) 1995-12-01 1997-06-02 Charles J. Doillon Biostable porous material comprising composite biopolymers
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
PT1704878E (pt) 1995-12-18 2013-07-17 Angiodevice Internat Gmbh Composições de polímeros reticulados e métodos para a sua utilização
US6060534A (en) 1996-07-11 2000-05-09 Scimed Life Systems, Inc. Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties
US7049346B1 (en) 1996-08-20 2006-05-23 Menlo Care Div Of Ethicon, Inc. Swollen hydrogel for sphincter augmentation
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US20020064546A1 (en) * 1996-09-13 2002-05-30 J. Milton Harris Degradable poly(ethylene glycol) hydrogels with controlled half-life and precursors therefor
US7009034B2 (en) 1996-09-23 2006-03-07 Incept, Llc Biocompatible crosslinked polymers
WO1998012274A1 (en) 1996-09-23 1998-03-26 Chandrashekar Pathak Methods and devices for preparing protein concentrates
ZA978537B (en) 1996-09-23 1998-05-12 Focal Inc Polymerizable biodegradable polymers including carbonate or dioxanone linkages.
US6214966B1 (en) 1996-09-26 2001-04-10 Shearwater Corporation Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution
US5932539A (en) 1996-10-15 1999-08-03 The Board Of Trustees Of The University Of Illinois Biodegradable polymer matrix for tissue repair
JP3092531B2 (ja) 1996-11-05 2000-09-25 日本油脂株式会社 コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法
JP3092530B2 (ja) 1996-11-05 2000-09-25 日本油脂株式会社 コハク酸イミジル基置換ポリオキシアルキレン誘導体の製造方法
US6371975B2 (en) 1998-11-06 2002-04-16 Neomend, Inc. Compositions, systems, and methods for creating in situ, chemically cross-linked, mechanical barriers
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6271278B1 (en) 1997-05-13 2001-08-07 Purdue Research Foundation Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties
IL121861A (en) 1997-09-29 2003-07-31 Moshe Ein Gal Prostate radiotherapy apparatus
US8288745B2 (en) 1997-10-10 2012-10-16 Senorx, Inc. Method of utilizing an implant for targeting external beam radiation
JP2001519203A (ja) 1997-10-10 2001-10-23 ジョン・ディ・コービット・ジュニア 胸部インプラント
AU743819B2 (en) 1997-10-27 2002-02-07 California Institute Of Technology Methods and pharmaceutical compositions for the closure of retinal breaks
DE69842217D1 (de) * 1997-11-07 2011-05-19 State University Röntgendichte polymerische Biomateriale
US6375634B1 (en) 1997-11-19 2002-04-23 Oncology Innovations, Inc. Apparatus and method to encapsulate, kill and remove malignancies, including selectively increasing absorption of x-rays and increasing free-radical damage to residual tumors targeted by ionizing and non-ionizing radiation therapy
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
US6428978B1 (en) 1998-05-08 2002-08-06 Cohesion Technologies, Inc. Methods for the production of gelatin and full-length triple helical collagen in recombinant cells
US6066856A (en) 1998-05-18 2000-05-23 Children's Medical Center Corporation Radiation protective device
US6280742B1 (en) * 1998-06-17 2001-08-28 Zonagen, Inc. Methods and materials for the treatment of prostatic carcinoma
US6206930B1 (en) 1998-08-10 2001-03-27 Charlotte-Mecklenburg Hospital Authority Absorbable tissue expander
US6605294B2 (en) 1998-08-14 2003-08-12 Incept Llc Methods of using in situ hydration of hydrogel articles for sealing or augmentation of tissue or vessels
US6632457B1 (en) 1998-08-14 2003-10-14 Incept Llc Composite hydrogel drug delivery systems
US6179862B1 (en) 1998-08-14 2001-01-30 Incept Llc Methods and apparatus for in situ formation of hydrogels
WO2000009199A1 (en) 1998-08-14 2000-02-24 Incept Llc Methods and apparatus for in situ formation of hydrogels
US6703047B2 (en) 2001-02-02 2004-03-09 Incept Llc Dehydrated hydrogel precursor-based, tissue adherent compositions and methods of use
US6152943A (en) 1998-08-14 2000-11-28 Incept Llc Methods and apparatus for intraluminal deposition of hydrogels
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
US6818018B1 (en) 1998-08-14 2004-11-16 Incept Llc In situ polymerizable hydrogels
AU761158B2 (en) 1998-10-22 2003-05-29 Bioniche Teoranta A method for preventing, reducing, and treating radiation cystitis using hyaluronic acid
US6899889B1 (en) 1998-11-06 2005-05-31 Neomend, Inc. Biocompatible material composition adaptable to diverse therapeutic indications
US8802146B2 (en) 1998-11-06 2014-08-12 Neomend, Inc. Systems, methods, and compositions for prevention of tissue adhesion
WO2000028919A1 (en) 1998-11-12 2000-05-25 Canadian Prostate Centre, Inc. Apparatus and method of separating organs to enable aggressive thermal therapy
US6110484A (en) 1998-11-24 2000-08-29 Cohesion Technologies, Inc. Collagen-polymer matrices with differential biodegradability
US20080114092A1 (en) 1998-12-04 2008-05-15 Incept Llc Adhesion barriers applicable by minimally invasive surgery and methods of use thereof
JP2002531217A (ja) 1998-12-04 2002-09-24 チャンドラシェカー ピー. パサック, 生体適合性架橋ポリマー
TW392930U (en) * 1998-12-28 2000-06-01 Hon Hai Prec Ind Co Ltd Electric connector
US6958212B1 (en) 1999-02-01 2005-10-25 Eidgenossische Technische Hochschule Zurich Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds
US6862470B2 (en) 1999-02-02 2005-03-01 Senorx, Inc. Cavity-filling biopsy site markers
KR100845769B1 (ko) * 1999-02-03 2008-07-11 파우더젝트 리서치 리미티드 하이드로겔 입자 제제
US6177514B1 (en) 1999-04-09 2001-01-23 Sulzer Carbomedics Inc. Blocked functional reagants for cross-linking biological tissues
JP4558213B2 (ja) 1999-04-12 2010-10-06 コーネル・リサーチ・ファンデーション・インコーポレイテッド 疎水性および親水性の成分を有する水性ゲル形成システム
US6268405B1 (en) 1999-05-04 2001-07-31 Porex Surgical, Inc. Hydrogels and methods of making and using same
US6426145B1 (en) 1999-05-20 2002-07-30 Scimed Life Systems, Inc. Radiopaque compositions for visualization of medical devices
US6428785B1 (en) 1999-10-28 2002-08-06 Immunolytics Inc. Method and composition for treating prostate cancer
US6509031B1 (en) 1999-11-15 2003-01-21 Board Of Regents, Texas A&M University System System for polymerizing collagen and collagen composites in situ for a tissue compatible wound sealant, delivery vehicle, binding agent and/or chemically modifiable matrix
US6479079B1 (en) 1999-12-13 2002-11-12 Sulzer Carbomedics Inc. Anticalcification treatments for fixed biomaterials
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
US9314339B2 (en) * 2000-03-27 2016-04-19 Formae, Inc. Implants for replacing cartilage, with negatively-charged hydrogel surfaces and flexible matrix reinforcement
ES2391763T3 (es) 2000-04-07 2012-11-29 Collagen Matrix, Inc. Dispositivo de embolización
US6599448B1 (en) 2000-05-10 2003-07-29 Hydromer, Inc. Radio-opaque polymeric compositions
US6383344B1 (en) 2000-07-19 2002-05-07 Genzyme Corporation Molecular weight reduction of polymer using irradiation treatment
US6545097B2 (en) 2000-12-12 2003-04-08 Scimed Life Systems, Inc. Drug delivery compositions and medical devices containing block copolymer
US6596471B2 (en) 2000-12-21 2003-07-22 Carbomedics Inc. Method of cross-linking tissue with a bis-maleimide compound
JP2004523624A (ja) 2001-02-26 2004-08-05 デューク ユニバーシティ 新規なデンドリティックポリマー、およびその生物医学的使用
JP4123856B2 (ja) 2001-07-31 2008-07-23 日油株式会社 生体関連物質の修飾剤およびポリオキシアルキレン誘導体の製造方法
CN1277805C (zh) 2001-10-03 2006-10-04 大日本除虫菊株式会社 炔丙基苄基醇酯衍生物、其制备方法和含有其的杀虫·防虫剂
US20070264227A1 (en) 2001-11-07 2007-11-15 Eidgenossische Technische Hochschule Zurich Synthetic Matrix for Controlled Cell Ingrowth and Tissue Regeneration
US20040131582A1 (en) 2002-02-26 2004-07-08 Grinstaff Mark W. Novel dendritic polymers and their biomedical uses
US7341716B2 (en) * 2002-04-12 2008-03-11 Boston Scientific Scimed, Inc. Occlusive composition
US7744913B2 (en) 2002-06-24 2010-06-29 Incept, Llc Fillers and methods for displacing tissues to improve radiological outcomes
US7351430B2 (en) 2002-11-06 2008-04-01 Uluru Inc. Shape-retentive hydrogel particle aggregates and their uses
US7129210B2 (en) 2003-07-23 2006-10-31 Covalent Medical, Inc. Tissue adhesive sealant
US20050033157A1 (en) * 2003-07-25 2005-02-10 Klein Dean A. Multi-modality marking material and method
US7790141B2 (en) 2003-08-11 2010-09-07 Pathak Holdings, Llc Radio-opaque compounds, compositions containing same and methods of their synthesis and use
RU2373958C2 (ru) 2003-09-25 2009-11-27 Рутгерс, Дзе Стейт Юниверсити Полимерные по существу рентгеноконтрастные продукты для эмболотерапии
AU2005257050A1 (en) 2004-06-23 2006-01-05 Bioprotect Ltd. Device system and method for tissue displacement or separation
FR2872262B1 (fr) 2004-06-29 2010-11-26 Air Liquide Procede et installation de fourniture de secours d'un gaz sous pression
WO2006031358A2 (en) 2004-08-13 2006-03-23 Hyperbranch Medical Technology, Inc. Dendritic polymers, crosslinked gels, and their uses as ophthalmic sealants and lenses
CA2577018C (en) 2004-08-13 2012-03-27 Reva Medical, Inc. Inherently radiopaque bioresorbable polymers for multiple uses
WO2006031388A2 (en) 2004-08-20 2006-03-23 Hyperbranch Medical Technology, Inc. Dentritic polymers, crosslinked gels, and their uses in orthopedic applications
US7919112B2 (en) 2004-08-26 2011-04-05 Pathak Holdings, Llc Implantable tissue compositions and method
WO2006078770A2 (en) 2005-01-21 2006-07-27 Civco Medical Instruments Co., Inc. Creating temporary space between body tissues
US7963287B2 (en) * 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
WO2007001926A2 (en) 2005-06-24 2007-01-04 Hyperbranch Medical Technology, Inc. Low-swelling hydrogel sealants for wound repair
WO2007005249A2 (en) 2005-06-29 2007-01-11 Hyperbranch Medical Technology, Inc. Nanoparticles and dendritic-polymer-based hydrogels comprising them
DE102005051366A1 (de) * 2005-10-25 2007-04-26 Degussa Gmbh Drug Delivery Systeme
EP1996243B1 (en) 2006-01-11 2014-04-23 HyperBranch Medical Technology, Inc. Crosslinked gels comprising polyalkyleneimines, and their uses as medical devices
US8795709B2 (en) 2006-03-29 2014-08-05 Incept Llc Superabsorbent, freeze dried hydrogels for medical applications
EP2023941B1 (en) 2006-04-24 2016-12-21 Incept, LLC Protein crosslinkers, crosslinking methods and applications thereof
US7872068B2 (en) 2006-05-30 2011-01-18 Incept Llc Materials formable in situ within a medical device
CA2677532A1 (en) 2007-02-06 2008-08-14 Incept, Llc Polymerization with precipitation of proteins for elution in physiological solution
WO2008101173A2 (en) 2007-02-16 2008-08-21 Cornell University Biodegradable compositions and materials
US20080220047A1 (en) 2007-03-05 2008-09-11 Sawhney Amarpreet S Low-swelling biocompatible hydrogels
US9987221B2 (en) 2007-08-23 2018-06-05 Boston Scientific Scimed, Inc. Injectable hydrogel compositions
WO2009059121A1 (en) 2007-11-02 2009-05-07 Genzyme Corporation Methods of augmenting or repairing soft tissue
EP2247645B1 (en) 2008-02-13 2017-12-06 Hyperbranch Medical Technology, Inc. Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
CN101724144A (zh) 2008-11-03 2010-06-09 北京键凯科技有限公司 新型的多臂聚乙二醇及其制备方法和应用
US8916143B2 (en) 2008-11-03 2014-12-23 Cornell University Polymer compositions of dihydroxyacetone and uses thereof
CA3042067C (en) 2009-12-15 2022-10-18 Incept, Llc Implants and biodegradable fiducial markers
US8734930B2 (en) 2010-05-27 2014-05-27 Covidien Lp Hydrogel implants with varying degrees of crosslinking
EP2953650B1 (en) 2013-02-08 2020-09-30 Endoshape, Inc. Radiopaque polymers for medical devices
US9789073B2 (en) 2013-03-14 2017-10-17 Pathak Holdings, Llc Compositions, methods and devices for local drug delivery
CN107759783A (zh) 2013-12-02 2018-03-06 北京键凯科技股份有限公司 炔基多臂聚乙二醇衍生物
CN106146325B (zh) 2015-04-24 2019-01-29 北京键凯科技股份有限公司 一种y型多缩乙二醇衍生物及其制备方法
EP3681934A1 (en) * 2017-09-15 2020-07-22 Université de Strasbourg Injectable hybrid alginate hydrogels and uses thereof

Also Published As

Publication number Publication date
US20110142936A1 (en) 2011-06-16
WO2011084465A2 (en) 2011-07-14
US9669117B2 (en) 2017-06-06
EP3960215A1 (en) 2022-03-02
EP3583960A1 (en) 2019-12-25
CA3042067C (en) 2022-10-18
EP3960215B1 (en) 2024-10-16
AU2010340067A1 (en) 2012-07-12
US20200206366A1 (en) 2020-07-02
CA3042067A1 (en) 2011-07-14
US11160883B2 (en) 2021-11-02
US20220125954A1 (en) 2022-04-28
US20200206367A1 (en) 2020-07-02
US20160193368A1 (en) 2016-07-07
CA2782899A1 (en) 2011-07-14
WO2011084465A3 (en) 2011-11-17
AU2010340067B2 (en) 2015-03-19
CN102844054B (zh) 2016-04-20
US20190201558A1 (en) 2019-07-04
US11083802B2 (en) 2021-08-10
US11786612B2 (en) 2023-10-17
US20210069353A1 (en) 2021-03-11
CA2782899C (en) 2019-06-11
US20200206365A1 (en) 2020-07-02
JP2013514152A (ja) 2013-04-25
EP2512540A4 (en) 2013-08-14
US8852646B2 (en) 2014-10-07
CA3149284A1 (en) 2011-07-14
US20170266324A1 (en) 2017-09-21
IN2012DN05177A (enExample) 2015-10-23
US10272164B2 (en) 2019-04-30
US8383161B2 (en) 2013-02-26
EP2512540B1 (en) 2019-08-07
EP2512540A2 (en) 2012-10-24
US20140363382A1 (en) 2014-12-11
US11154624B2 (en) 2021-10-26
US9308283B2 (en) 2016-04-12
CN102844054A (zh) 2012-12-26
US20140056816A1 (en) 2014-02-27
US20250161497A1 (en) 2025-05-22
US10786581B2 (en) 2020-09-29

Similar Documents

Publication Publication Date Title
US20250161497A1 (en) Implants and biodegradable tissue markers
WO2016065245A1 (en) Extra luminal scaffold
JP2026012700A (ja) 改善された組織スペーサー
US20240091141A1 (en) Methods and compositions for the ablation of nerves
KR20240155241A (ko) 시각화 첨가제가 포함된 개선된 조직 스페이서

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20131213

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20131213

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20150106

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20150403

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20150908

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20151005

R150 Certificate of patent or registration of utility model

Ref document number: 5820815

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250