CA3120971A1 - Substituted furanopyrimidine compounds as pde1 inhibitors - Google Patents

Substituted furanopyrimidine compounds as pde1 inhibitors Download PDF

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Publication number
CA3120971A1
CA3120971A1 CA3120971A CA3120971A CA3120971A1 CA 3120971 A1 CA3120971 A1 CA 3120971A1 CA 3120971 A CA3120971 A CA 3120971A CA 3120971 A CA3120971 A CA 3120971A CA 3120971 A1 CA3120971 A1 CA 3120971A1
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CA
Canada
Prior art keywords
furo
pyrimidine
methylcyclopropyl
methyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3120971A
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English (en)
French (fr)
Inventor
Brett Bookser
Iriny Botrous
Aaron Burns
DeMichael CHUNG
Brian Dyck
Andrew KLEINKE
Dange Vijay Kumar
Margaret MCCARRICK
Nicholas Raffaele
Joe Tran
Michael Weinhouse
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dart Neuroscience LLC
Original Assignee
Dart Neuroscience LLC
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Filing date
Publication date
Application filed by Dart Neuroscience LLC filed Critical Dart Neuroscience LLC
Publication of CA3120971A1 publication Critical patent/CA3120971A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA3120971A 2017-11-27 2018-11-26 Substituted furanopyrimidine compounds as pde1 inhibitors Pending CA3120971A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762591105P 2017-11-27 2017-11-27
US62/591,105 2017-11-27
PCT/US2018/062493 WO2019104285A1 (en) 2017-11-27 2018-11-26 Substituted furanopyrimidine compounds as pde1 inhibitors

Publications (1)

Publication Number Publication Date
CA3120971A1 true CA3120971A1 (en) 2019-05-31

Family

ID=64665119

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3120971A Pending CA3120971A1 (en) 2017-11-27 2018-11-26 Substituted furanopyrimidine compounds as pde1 inhibitors

Country Status (11)

Country Link
US (3) US11434247B1 (https=)
EP (1) EP3717488B1 (https=)
JP (1) JP7254078B2 (https=)
KR (1) KR102794907B1 (https=)
CN (1) CN111655695B (https=)
AU (1) AU2018373258B2 (https=)
CA (1) CA3120971A1 (https=)
DK (1) DK3717488T3 (https=)
ES (1) ES2902365T3 (https=)
MX (2) MX2020005447A (https=)
WO (1) WO2019104285A1 (https=)

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TWI901650B (zh) 2020-03-26 2025-10-21 匈牙利商羅特格登公司 啶及吡啶并〔３，４－ｃ〕嗒衍生物
CA3198635A1 (en) * 2020-12-03 2022-06-09 UCB Biopharma SRL Octahydroisoquinolinyl derivatives
JP2024529020A (ja) * 2021-08-06 2024-08-01 レイゼビオ，インク． 細胞内ｋｒａｓ ｇ１２ｃタンパク質を標的とするための共有結合剤を含むコンジュゲート
US20250049748A1 (en) * 2021-12-16 2025-02-13 Terran Biosciences Inc. Analogs of 4-bromo-2,5-dimethoxyphenethylamine
CN117263843A (zh) * 2023-06-16 2023-12-22 常州大学 一种多巴胺d2样受体双位配体化合物及其应用
CN121909191A (zh) * 2023-08-16 2026-04-21 智擎生技制药股份有限公司 Mta协同性的prmt5抑制剂
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Publication number Publication date
MX2020005447A (es) 2020-12-03
ES2902365T3 (es) 2022-03-28
CN111655695A (zh) 2020-09-11
US11434247B1 (en) 2022-09-06
US20250145633A1 (en) 2025-05-08
US12006325B2 (en) 2024-06-11
AU2018373258B2 (en) 2023-03-02
JP2021504380A (ja) 2021-02-15
EP3717488B1 (en) 2021-09-29
JP7254078B2 (ja) 2023-04-07
US20230295178A1 (en) 2023-09-21
WO2019104285A1 (en) 2019-05-31
DK3717488T3 (da) 2021-12-13
CN111655695B (zh) 2025-05-27
AU2018373258A1 (en) 2020-07-16
EP3717488A1 (en) 2020-10-07
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KR102794907B1 (ko) 2025-04-14
KR20200108419A (ko) 2020-09-18

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