CA3111076A1 - Cardiac cell reprogramming with myocardin and ascl1 - Google Patents

Cardiac cell reprogramming with myocardin and ascl1 Download PDF

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Publication number
CA3111076A1
CA3111076A1 CA3111076A CA3111076A CA3111076A1 CA 3111076 A1 CA3111076 A1 CA 3111076A1 CA 3111076 A CA3111076 A CA 3111076A CA 3111076 A CA3111076 A CA 3111076A CA 3111076 A1 CA3111076 A1 CA 3111076A1
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Prior art keywords
polynucleotide
vector
seq
cells
ascl1
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CA3111076A
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English (en)
French (fr)
Inventor
Huanyu Zhou
Laura LOMBARDI
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Tenaya Therapeutics Inc
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Tenaya Therapeutics Inc
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
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    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1719Muscle proteins, e.g. myosin or actin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4716Muscle proteins, e.g. myosin, actin
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    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657Cardiomyocytes; Heart cells
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    • C12N2740/10011Retroviridae
    • C12N2740/16011Human Immunodeficiency Virus, HIV
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
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    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14171Demonstrated in vivo effect
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    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/20Vector systems having a special element relevant for transcription transcription of more than one cistron

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  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Cell Biology (AREA)
  • Urology & Nephrology (AREA)
CA3111076A 2018-08-30 2019-08-30 Cardiac cell reprogramming with myocardin and ascl1 Pending CA3111076A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201862725168P 2018-08-30 2018-08-30
US62/725,168 2018-08-30
US201962788479P 2019-01-04 2019-01-04
US62/788,479 2019-01-04
US201962852746P 2019-05-24 2019-05-24
US62/852,746 2019-05-24
PCT/US2019/049150 WO2020047467A2 (en) 2018-08-30 2019-08-30 Cardiac cell reprogramming with myocardin and ascl1

Publications (1)

Publication Number Publication Date
CA3111076A1 true CA3111076A1 (en) 2020-03-05

Family

ID=69643073

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3111076A Pending CA3111076A1 (en) 2018-08-30 2019-08-30 Cardiac cell reprogramming with myocardin and ascl1

Country Status (11)

Country Link
US (3) US11015211B2 (pt)
EP (1) EP3843774A4 (pt)
JP (2) JP7450945B2 (pt)
KR (1) KR20210102870A (pt)
CN (1) CN113164556A (pt)
AU (2) AU2019333315B2 (pt)
BR (1) BR112021003897A2 (pt)
CA (1) CA3111076A1 (pt)
IL (1) IL281145A (pt)
SG (1) SG11202102058UA (pt)
WO (1) WO2020047467A2 (pt)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2571704A (en) * 2018-02-22 2019-09-11 Georg August Univ Gottingen Stiftung Offentlichen Rechts Univer Sitatsmedzin Goettingen Prevention or treatment of cardiac arrhytmia and sudden cardiac death
CA3111076A1 (en) 2018-08-30 2020-03-05 Tenaya Therapeutics, Inc. Cardiac cell reprogramming with myocardin and ascl1
US20230137971A1 (en) * 2019-07-11 2023-05-04 Tenaya Therapeutics Inc. Cardiac cell reprogramming with micrornas and other factors
CN116249768A (zh) * 2020-07-29 2023-06-09 南京昕瑞再生医药科技有限公司 通过重编程产生心肌细胞的方法
WO2022182880A1 (en) * 2021-02-25 2022-09-01 Tenaya Therapeutics, Inc. Enhancer sequences specific for cardiac fibroblasts and methods of use thereof
IL309742A (en) * 2021-07-08 2024-02-01 Tenaya Therapeutics Inc Optimal expression cassettes for gene therapy
WO2024112118A1 (ko) * 2022-11-25 2024-05-30 고려대학교 산학협력단 방사선 치료에 의하여 손상된 근육 재생을 위한 고기능성 세포 치료제 조성물

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