CA3101304A1 - Monospecific and multispecific anti-tmeff2 antibodies and their uses - Google Patents

Monospecific and multispecific anti-tmeff2 antibodies and their uses Download PDF

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Publication number
CA3101304A1
CA3101304A1 CA3101304A CA3101304A CA3101304A1 CA 3101304 A1 CA3101304 A1 CA 3101304A1 CA 3101304 A CA3101304 A CA 3101304A CA 3101304 A CA3101304 A CA 3101304A CA 3101304 A1 CA3101304 A1 CA 3101304A1
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CA
Canada
Prior art keywords
seq
antibody
tmeff2
binding fragment
antigen binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3101304A
Other languages
English (en)
French (fr)
Inventor
Philip Cooper
Robin Ernst
Rajkumar Ganesan
Colleen Kane
Michael Russell
Sanjaya Singh
Sathyadevi VENKATARAMANI
Sheng-Jiun Wu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Biotech Inc
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of CA3101304A1 publication Critical patent/CA3101304A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3101304A 2018-05-24 2019-05-21 Monospecific and multispecific anti-tmeff2 antibodies and their uses Pending CA3101304A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862675957P 2018-05-24 2018-05-24
US62/675,957 2018-05-24
PCT/IB2019/054184 WO2019224713A2 (en) 2018-05-24 2019-05-21 Monospecific and multispecific anti-tmeff2 antibodies and there uses

Publications (1)

Publication Number Publication Date
CA3101304A1 true CA3101304A1 (en) 2019-11-28

Family

ID=67211771

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3101304A Pending CA3101304A1 (en) 2018-05-24 2019-05-21 Monospecific and multispecific anti-tmeff2 antibodies and their uses

Country Status (25)

Country Link
US (1) US11866499B2 (enExample)
EP (1) EP3802607A2 (enExample)
JP (2) JP2021524255A (enExample)
KR (1) KR20210011999A (enExample)
CN (1) CN112703203B (enExample)
AR (1) AR115419A1 (enExample)
AU (1) AU2019274652B2 (enExample)
BR (1) BR112020023416A2 (enExample)
CA (1) CA3101304A1 (enExample)
CL (1) CL2020003032A1 (enExample)
CO (1) CO2020014515A2 (enExample)
CR (1) CR20200564A (enExample)
EA (1) EA202092849A1 (enExample)
EC (1) ECSP20075234A (enExample)
IL (1) IL278862A (enExample)
JO (1) JOP20200295A1 (enExample)
MA (1) MA52772A (enExample)
MX (1) MX2020012589A (enExample)
NI (1) NI202000087A (enExample)
PE (1) PE20210634A1 (enExample)
PH (1) PH12020551948A1 (enExample)
SG (1) SG11202011268VA (enExample)
TW (1) TWI865451B (enExample)
UY (1) UY38243A (enExample)
WO (1) WO2019224713A2 (enExample)

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CN116249714A (zh) 2020-05-27 2023-06-09 詹森生物科技公司 包含cd3抗原结合结构域的蛋白质及其用途
US20230374140A1 (en) * 2020-10-09 2023-11-23 Memorial Sloan Kettering Cancer Center Compositions targeting ndc80/mhc complexes and uses thereof
TW202231292A (zh) 2020-10-13 2022-08-16 美商健生生物科技公司 用於調節分化簇ｉｖ及／或ｖｉｉｉ的經生物工程改造之ｔ細胞介導之免疫力、材料、及其他方法
US12365743B2 (en) 2022-02-23 2025-07-22 Xencor, Inc. Anti-CD28 x anti-PSMA antibodies
WO2024052831A1 (en) * 2022-09-09 2024-03-14 Janssen Biotech, Inc. Method of treating cancer with an anti tmeff2xcd3 bispecific antibody

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Also Published As

Publication number Publication date
CO2020014515A2 (es) 2020-12-10
CN112703203A (zh) 2021-04-23
EP3802607A2 (en) 2021-04-14
IL278862A (en) 2021-01-31
UY38243A (es) 2019-11-29
WO2019224713A3 (en) 2020-01-02
EA202092849A1 (ru) 2021-03-16
KR20210011999A (ko) 2021-02-02
WO2019224713A2 (en) 2019-11-28
SG11202011268VA (en) 2020-12-30
US20190359711A1 (en) 2019-11-28
AU2019274652B2 (en) 2026-03-26
PH12020551948A1 (en) 2021-08-16
JP2021524255A (ja) 2021-09-13
TW202003584A (zh) 2020-01-16
TWI865451B (zh) 2024-12-11
NI202000087A (es) 2021-03-23
MA52772A (fr) 2021-04-14
PE20210634A1 (es) 2021-03-23
BR112020023416A2 (pt) 2021-02-17
MX2020012589A (es) 2021-01-29
CR20200564A (es) 2021-06-21
JP2024105476A (ja) 2024-08-06
AU2019274652A1 (en) 2020-11-26
ECSP20075234A (es) 2020-12-31
CL2020003032A1 (es) 2021-04-16
AR115419A1 (es) 2021-01-13
US11866499B2 (en) 2024-01-09
JOP20200295A1 (ar) 2020-11-22
CN112703203B (zh) 2025-02-25

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