TWI865451B - 單特異性及多特異性抗ｔｍｅｆｆ２抗體及其用途 - Google Patents

單特異性及多特異性抗ｔｍｅｆｆ２抗體及其用途 Download PDF

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TWI865451B
TWI865451B TW108117613A TW108117613A TWI865451B TW I865451 B TWI865451 B TW I865451B TW 108117613 A TW108117613 A TW 108117613A TW 108117613 A TW108117613 A TW 108117613A TW I865451 B TWI865451 B TW I865451B
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Taiwan
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seq
antibody
tmeff2
antigen
binding fragment
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TW108117613A
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English (en)
Chinese (zh)
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TW202003584A (zh
Inventor
飛利浦 古柏
羅賓 恩斯特
拉庫瑪 甘尼申
柯林 凱恩
麥可 羅素
桑加亞 辛格
莎菲亞迪維 維加塔拉瑪尼
勝君 吳
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美商健生生物科技公司
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW108117613A 2018-05-24 2019-05-22 單特異性及多特異性抗ｔｍｅｆｆ２抗體及其用途 TWI865451B (zh)

Applications Claiming Priority (2)

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US201862675957P 2018-05-24 2018-05-24
US62/675,957 2018-05-24

Publications (2)

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TW202003584A TW202003584A (zh) 2020-01-16
TWI865451B true TWI865451B (zh) 2024-12-11

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US (1) US11866499B2 (enExample)
EP (1) EP3802607A2 (enExample)
JP (2) JP2021524255A (enExample)
KR (1) KR20210011999A (enExample)
CN (1) CN112703203B (enExample)
AR (1) AR115419A1 (enExample)
AU (1) AU2019274652B2 (enExample)
BR (1) BR112020023416A2 (enExample)
CA (1) CA3101304A1 (enExample)
CL (1) CL2020003032A1 (enExample)
CO (1) CO2020014515A2 (enExample)
CR (1) CR20200564A (enExample)
EA (1) EA202092849A1 (enExample)
EC (1) ECSP20075234A (enExample)
IL (1) IL278862A (enExample)
JO (1) JOP20200295A1 (enExample)
MA (1) MA52772A (enExample)
MX (1) MX2020012589A (enExample)
NI (1) NI202000087A (enExample)
PE (1) PE20210634A1 (enExample)
PH (1) PH12020551948A1 (enExample)
SG (1) SG11202011268VA (enExample)
TW (1) TWI865451B (enExample)
UY (1) UY38243A (enExample)
WO (1) WO2019224713A2 (enExample)

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PE20230389A1 (es) 2020-05-27 2023-03-06 Janssen Biotech Inc Proteinas que comprenden dominios de union al antigeno de cd3 y usos de estas
US20230374140A1 (en) * 2020-10-09 2023-11-23 Memorial Sloan Kettering Cancer Center Compositions targeting ndc80/mhc complexes and uses thereof
KR20230086765A (ko) 2020-10-13 2023-06-15 얀센 바이오테크 인코포레이티드 분화 클러스터 iv 및/또는 viii을 조절하기 위한 바이오-조작된 t 세포 매개 면역, 물질 및 기타 방법
WO2022175255A2 (en) 2021-02-16 2022-08-25 Janssen Pharmaceutica Nv Trispecific antibody targeting bcma, gprc5d, and cd3
IL314993A (en) 2022-02-23 2024-10-01 Xencor Inc Anti-cd28 x anti-psma antibodies
EP4583980A1 (en) * 2022-09-09 2025-07-16 Janssen Biotech, Inc. Method of treating cancer with an anti tmeff2xcd3 bispecific antibody

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Publication number Publication date
IL278862A (en) 2021-01-31
AU2019274652B2 (en) 2026-03-26
SG11202011268VA (en) 2020-12-30
UY38243A (es) 2019-11-29
AU2019274652A1 (en) 2020-11-26
NI202000087A (es) 2021-03-23
JP2021524255A (ja) 2021-09-13
MX2020012589A (es) 2021-01-29
CR20200564A (es) 2021-06-21
PE20210634A1 (es) 2021-03-23
JOP20200295A1 (ar) 2020-11-22
US11866499B2 (en) 2024-01-09
JP2024105476A (ja) 2024-08-06
US20190359711A1 (en) 2019-11-28
CO2020014515A2 (es) 2020-12-10
WO2019224713A2 (en) 2019-11-28
PH12020551948A1 (en) 2021-08-16
CN112703203B (zh) 2025-02-25
ECSP20075234A (es) 2020-12-31
CL2020003032A1 (es) 2021-04-16
CA3101304A1 (en) 2019-11-28
EA202092849A1 (ru) 2021-03-16
TW202003584A (zh) 2020-01-16
EP3802607A2 (en) 2021-04-14
KR20210011999A (ko) 2021-02-02
CN112703203A (zh) 2021-04-23
BR112020023416A2 (pt) 2021-02-17
MA52772A (fr) 2021-04-14
WO2019224713A3 (en) 2020-01-02
AR115419A1 (es) 2021-01-13

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