JOP20200295A1 - أجسام أحادية النوعية ومتعددة النوعية مضادة لـ tmeff2 المضاد واستخداماتها - Google Patents
أجسام أحادية النوعية ومتعددة النوعية مضادة لـ tmeff2 المضاد واستخداماتهاInfo
- Publication number
- JOP20200295A1 JOP20200295A1 JOP/2020/0295A JOP20200295A JOP20200295A1 JO P20200295 A1 JOP20200295 A1 JO P20200295A1 JO P20200295 A JOP20200295 A JO P20200295A JO P20200295 A1 JOP20200295 A1 JO P20200295A1
- Authority
- JO
- Jordan
- Prior art keywords
- mono
- specific
- tmeff2
- antagonist
- multispecific antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862675957P | 2018-05-24 | 2018-05-24 | |
| PCT/IB2019/054184 WO2019224713A2 (en) | 2018-05-24 | 2019-05-21 | Monospecific and multispecific anti-tmeff2 antibodies and there uses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JOP20200295A1 true JOP20200295A1 (ar) | 2020-11-22 |
Family
ID=67211771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2020/0295A JOP20200295A1 (ar) | 2018-05-24 | 2019-05-21 | أجسام أحادية النوعية ومتعددة النوعية مضادة لـ tmeff2 المضاد واستخداماتها |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US11866499B2 (enExample) |
| EP (1) | EP3802607A2 (enExample) |
| JP (2) | JP2021524255A (enExample) |
| KR (1) | KR20210011999A (enExample) |
| CN (1) | CN112703203B (enExample) |
| AR (1) | AR115419A1 (enExample) |
| AU (1) | AU2019274652B2 (enExample) |
| BR (1) | BR112020023416A2 (enExample) |
| CA (1) | CA3101304A1 (enExample) |
| CL (1) | CL2020003032A1 (enExample) |
| CO (1) | CO2020014515A2 (enExample) |
| CR (1) | CR20200564A (enExample) |
| EA (1) | EA202092849A1 (enExample) |
| EC (1) | ECSP20075234A (enExample) |
| IL (1) | IL278862A (enExample) |
| JO (1) | JOP20200295A1 (enExample) |
| MA (1) | MA52772A (enExample) |
| MX (1) | MX2020012589A (enExample) |
| NI (1) | NI202000087A (enExample) |
| PE (1) | PE20210634A1 (enExample) |
| PH (1) | PH12020551948A1 (enExample) |
| SG (1) | SG11202011268VA (enExample) |
| TW (1) | TWI865451B (enExample) |
| UY (1) | UY38243A (enExample) |
| WO (1) | WO2019224713A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3101271A1 (en) | 2018-05-24 | 2019-11-28 | Janssen Biotech, Inc. | Anti-cd3 antibodies and uses thereof |
| EP4076523A1 (en) * | 2019-12-18 | 2022-10-26 | Janssen Biotech, Inc. | Materials and methods for in vivo biological targeting |
| CN116249714A (zh) | 2020-05-27 | 2023-06-09 | 詹森生物科技公司 | 包含cd3抗原结合结构域的蛋白质及其用途 |
| US20230374140A1 (en) * | 2020-10-09 | 2023-11-23 | Memorial Sloan Kettering Cancer Center | Compositions targeting ndc80/mhc complexes and uses thereof |
| TW202231292A (zh) | 2020-10-13 | 2022-08-16 | 美商健生生物科技公司 | 用於調節分化簇ｉｖ及／或ｖｉｉｉ的經生物工程改造之ｔ細胞介導之免疫力、材料、及其他方法 |
| US12365743B2 (en) | 2022-02-23 | 2025-07-22 | Xencor, Inc. | Anti-CD28 x anti-PSMA antibodies |
| WO2024052831A1 (en) * | 2022-09-09 | 2024-03-14 | Janssen Biotech, Inc. | Method of treating cancer with an anti tmeff2xcd3 bispecific antibody |
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| US226A (en) | 1837-06-03 | Samuel goss | ||
| US7709A (en) | 1850-10-08 | Chas S Gaylord | Improved spring-grapple | |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| EP0281604B1 (en) | 1986-09-02 | 1993-03-31 | Enzon Labs Inc. | Single polypeptide chain binding molecules |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
| EP1400536A1 (en) | 1991-06-14 | 2004-03-24 | Genentech Inc. | Method for making humanized antibodies |
| PT1024191E (pt) | 1991-12-02 | 2008-12-22 | Medical Res Council | Produção de auto-anticorpos a partir de reportórios de segmentos de anticorpo e exibidos em fagos |
| ES2156149T3 (es) | 1992-12-04 | 2001-06-16 | Medical Res Council | Proteinas de union multivalente y multiespecificas, su fabricacion y su uso. |
| AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
| EP0983303B1 (en) | 1997-05-21 | 2006-03-08 | Biovation Limited | Method for the production of non-immunogenic proteins |
| US6818749B1 (en) | 1998-10-31 | 2004-11-16 | The United States Of America As Represented By The Department Of Health And Human Services | Variants of humanized anti carcinoma monoclonal antibody cc49 |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| CA2430013C (en) | 2000-11-30 | 2011-11-22 | Medarex, Inc. | Transgenic transchromosomal rodents for making human antibodies |
| MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| CA2478683C (en) * | 2002-03-08 | 2016-01-26 | Protein Design Labs, Inc. | Antibodies against cancer antigen tmeff2 and uses thereof |
| WO2006028936A2 (en) | 2004-09-02 | 2006-03-16 | Genentech, Inc. | Heteromultimeric molecules |
| AU2006232287B2 (en) | 2005-03-31 | 2011-10-06 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing polypeptides by regulating polypeptide association |
| DE102005028778A1 (de) | 2005-06-22 | 2006-12-28 | SUNJÜT Deutschland GmbH | Mehrlagige Folie mit einer Barriere- und einer antistatischen Lage |
| PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
| PT1999154E (pt) | 2006-03-24 | 2013-01-24 | Merck Patent Gmbh | Domínios proteicos heterodiméricos modificados |
| JP2009541275A (ja) | 2006-06-22 | 2009-11-26 | ノボ・ノルデイスク・エー／エス | 二重特異性抗体の生産 |
| KR20100058509A (ko) | 2007-07-31 | 2010-06-03 | 메디뮨 엘엘씨 | 다중특이적 에피토프 결합 단백질 및 이의 용도 |
| NZ584514A (en) * | 2007-10-19 | 2012-07-27 | Genentech Inc | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates |
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| AU2008343589A1 (en) | 2007-12-19 | 2009-07-09 | Centocor Ortho Biotech Inc. | Design and generation of human de novo pIX phage display libraries via fusion to pIX or pVII, vectors, antibodies and methods |
| US9266967B2 (en) | 2007-12-21 | 2016-02-23 | Hoffmann-La Roche, Inc. | Bivalent, bispecific antibodies |
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| HRP20241208T1 (hr) | 2010-04-20 | 2024-11-22 | Genmab A/S | Heterodimerni proteini koji sadrže fc fragment protutijela i postupci za njihovu proizvodnju |
| ES2758994T3 (es) | 2010-11-05 | 2020-05-07 | Zymeworks Inc | Diseño anticuerpo heterodimérico estable con mutaciones en el dominio Fc |
| BR112014010580B1 (pt) | 2011-11-04 | 2021-01-12 | Zymeworks, Inc. | constructo de fc heteromultimérico isolado, composição, uso de um constructo de fc heteromultimérico isolado, composição de ácido nucléico e método para expressar o constructo de fc heteromultimérico isolado |
| WO2013093122A2 (en) * | 2011-12-23 | 2013-06-27 | Phenoquest Ag | Antibodies for the treatment and diagnosis of affective and anxiety disorders |
| PT2931030T (pt) | 2012-12-14 | 2020-08-03 | Open Monoclonal Tech Inc | Polinucleótidos que codificam anticorpos de roedores com idiótipos humanos e animais que os compreendem |
| MX366910B (es) | 2013-03-15 | 2019-07-30 | Janssen Biotech Inc | Metodos de fabricacion para controlar el contenido de lisina c-terminal, galactosa y acido sialico en proteinas recombinantes. |
| TWI680138B (zh) * | 2014-01-23 | 2019-12-21 | 美商再生元醫藥公司 | 抗ｐｄ-ｌ１之人類抗體 |
| MA40609B1 (fr) | 2014-09-05 | 2020-05-29 | Janssen Pharmaceutica Nv | Agents de liaison cd123 et leurs utilisations |
| EP3288981A1 (en) * | 2015-05-01 | 2018-03-07 | Genentech, Inc. | Masked anti-cd3 antibodies and methods of use |
| EP3916018A1 (en) | 2015-06-16 | 2021-12-01 | Genentech, Inc. | Anti-cd3 antibodies and methods of use |
| PE20181326A1 (es) * | 2015-11-03 | 2018-08-20 | Janssen Biotech Inc | Anticuerpos que se unen especificamente a pd-1 y sus usos |
| UA130542C2 (uk) * | 2018-05-16 | 2026-03-18 | Янссен Байотек, Інк. | Антитіло до cd38 та терапевтичний засіб, який перенаправляє т-клітини, для лікування множинної мієломи у суб'єкта |
| CA3101271A1 (en) | 2018-05-24 | 2019-11-28 | Janssen Biotech, Inc. | Anti-cd3 antibodies and uses thereof |
-
2019
- 2019-05-21 MA MA052772A patent/MA52772A/fr unknown
- 2019-05-21 SG SG11202011268VA patent/SG11202011268VA/en unknown
- 2019-05-21 JO JOP/2020/0295A patent/JOP20200295A1/ar unknown
- 2019-05-21 AU AU2019274652A patent/AU2019274652B2/en active Active
- 2019-05-21 MX MX2020012589A patent/MX2020012589A/es unknown
- 2019-05-21 EP EP19737217.0A patent/EP3802607A2/en active Pending
- 2019-05-21 EA EA202092849A patent/EA202092849A1/ru unknown
- 2019-05-21 CA CA3101304A patent/CA3101304A1/en active Pending
- 2019-05-21 BR BR112020023416-8A patent/BR112020023416A2/pt unknown
- 2019-05-21 KR KR1020207036922A patent/KR20210011999A/ko not_active Ceased
- 2019-05-21 CN CN201980034951.1A patent/CN112703203B/zh active Active
- 2019-05-21 PE PE2020001881A patent/PE20210634A1/es unknown
- 2019-05-21 CR CR20200564A patent/CR20200564A/es unknown
- 2019-05-21 US US16/417,889 patent/US11866499B2/en active Active
- 2019-05-21 JP JP2020565399A patent/JP2021524255A/ja active Pending
- 2019-05-21 WO PCT/IB2019/054184 patent/WO2019224713A2/en not_active Ceased
- 2019-05-22 TW TW108117613A patent/TWI865451B/zh active
- 2019-05-24 AR ARP190101399A patent/AR115419A1/es not_active Application Discontinuation
- 2019-05-24 UY UY0001038243A patent/UY38243A/es unknown
-
2020
- 2020-11-13 PH PH12020551948A patent/PH12020551948A1/en unknown
- 2020-11-19 IL IL278862A patent/IL278862A/en unknown
- 2020-11-23 CO CONC2020/0014515A patent/CO2020014515A2/es unknown
- 2020-11-23 EC ECSENADI202075234A patent/ECSP20075234A/es unknown
- 2020-11-23 NI NI202000087A patent/NI202000087A/es unknown
- 2020-11-23 CL CL2020003032A patent/CL2020003032A1/es unknown
-
2024
- 2024-05-09 JP JP2024076617A patent/JP2024105476A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CO2020014515A2 (es) | 2020-12-10 |
| CN112703203A (zh) | 2021-04-23 |
| EP3802607A2 (en) | 2021-04-14 |
| IL278862A (en) | 2021-01-31 |
| UY38243A (es) | 2019-11-29 |
| WO2019224713A3 (en) | 2020-01-02 |
| EA202092849A1 (ru) | 2021-03-16 |
| KR20210011999A (ko) | 2021-02-02 |
| WO2019224713A2 (en) | 2019-11-28 |
| SG11202011268VA (en) | 2020-12-30 |
| US20190359711A1 (en) | 2019-11-28 |
| AU2019274652B2 (en) | 2026-03-26 |
| PH12020551948A1 (en) | 2021-08-16 |
| JP2021524255A (ja) | 2021-09-13 |
| TW202003584A (zh) | 2020-01-16 |
| TWI865451B (zh) | 2024-12-11 |
| NI202000087A (es) | 2021-03-23 |
| MA52772A (fr) | 2021-04-14 |
| PE20210634A1 (es) | 2021-03-23 |
| BR112020023416A2 (pt) | 2021-02-17 |
| MX2020012589A (es) | 2021-01-29 |
| CR20200564A (es) | 2021-06-21 |
| JP2024105476A (ja) | 2024-08-06 |
| CA3101304A1 (en) | 2019-11-28 |
| AU2019274652A1 (en) | 2020-11-26 |
| ECSP20075234A (es) | 2020-12-31 |
| CL2020003032A1 (es) | 2021-04-16 |
| AR115419A1 (es) | 2021-01-13 |
| US11866499B2 (en) | 2024-01-09 |
| CN112703203B (zh) | 2025-02-25 |
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