CA3100817C - USE OF ALTERNATING ELECTRIC FIELDS TO INCREASE THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER - Google Patents

USE OF ALTERNATING ELECTRIC FIELDS TO INCREASE THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER

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Publication number
CA3100817C
CA3100817C CA3100817A CA3100817A CA3100817C CA 3100817 C CA3100817 C CA 3100817C CA 3100817 A CA3100817 A CA 3100817A CA 3100817 A CA3100817 A CA 3100817A CA 3100817 C CA3100817 C CA 3100817C
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Prior art keywords
frequency
subject
alternating electric
brain
khz
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CA3100817A
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English (en)
French (fr)
Other versions
CA3100817A1 (en
Inventor
Carsten Hagemann
Mario LOHR
Almuth F. KESSLER
Malgorzata BUREK
Carola FORSTER
Catherine BRAMI
Hadas Sara HERSHKOVICH
Tali VOLOSHIN-SELA
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Novocure GmbH
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Priority to CA3242209A priority Critical patent/CA3242209A1/en
Publication of CA3100817A1 publication Critical patent/CA3100817A1/en
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Publication of CA3100817C publication Critical patent/CA3100817C/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0092—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin using ultrasonic, sonic or infrasonic vibrations, e.g. phonophoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36002—Cancer treatment, e.g. tumour
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36025—External stimulators, e.g. with patch electrodes for treating a mental or cerebral condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37217—Means for communicating with stimulators characterised by the communication link, e.g. acoustic or tactile
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/40—Applying electric fields by inductive or capacitive coupling ; Applying radio-frequency signals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N13/00—Treatment of microorganisms or enzymes with electrical or wave energy, e.g. magnetism, sonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0085—Brain, e.g. brain implants; Spinal cord
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/0007—Special media to be introduced, removed or treated introduced into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/05—General characteristics of the apparatus combined with other kinds of therapy
    • A61M2205/054—General characteristics of the apparatus combined with other kinds of therapy with electrotherapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/06—Head
    • A61M2210/0693—Brain, cerebrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2250/00—Specially adapted for animals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medical Informatics (AREA)
  • Anesthesiology (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Acoustics & Sound (AREA)
  • Physics & Mathematics (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Developmental Disabilities (AREA)
  • Child & Adolescent Psychology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
CA3100817A 2018-08-23 2019-08-22 USE OF ALTERNATING ELECTRIC FIELDS TO INCREASE THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER Active CA3100817C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA3242209A CA3242209A1 (en) 2018-08-23 2019-08-22 Using alternating electric fields to increase permeability of the blood brain barrier

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862722100P 2018-08-23 2018-08-23
US62/722,100 2018-08-23
PCT/IB2019/057091 WO2020039390A1 (en) 2018-08-23 2019-08-22 Using alternating electric fields to increase permeability of the blood brain barrier

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA3242209A Division CA3242209A1 (en) 2018-08-23 2019-08-22 Using alternating electric fields to increase permeability of the blood brain barrier

Publications (2)

Publication Number Publication Date
CA3100817A1 CA3100817A1 (en) 2020-02-27
CA3100817C true CA3100817C (en) 2025-04-01

Family

ID=68104708

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3100817A Active CA3100817C (en) 2018-08-23 2019-08-22 USE OF ALTERNATING ELECTRIC FIELDS TO INCREASE THE PERMEABILITY OF THE BLOOD-BRAIN BARRIER
CA3242209A Pending CA3242209A1 (en) 2018-08-23 2019-08-22 Using alternating electric fields to increase permeability of the blood brain barrier

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA3242209A Pending CA3242209A1 (en) 2018-08-23 2019-08-22 Using alternating electric fields to increase permeability of the blood brain barrier

Country Status (17)

Country Link
US (5) US11400269B2 (enExample)
EP (6) EP3804648B1 (enExample)
JP (4) JP6974671B2 (enExample)
KR (3) KR102805022B1 (enExample)
CN (6) CN113908431A (enExample)
AU (2) AU2019324585C1 (enExample)
BR (1) BR112020025422A2 (enExample)
CA (2) CA3100817C (enExample)
DK (4) DK3773291T3 (enExample)
ES (4) ES2922576T3 (enExample)
FI (1) FI3878389T3 (enExample)
HU (3) HUE059062T2 (enExample)
IL (2) IL319986A (enExample)
MX (5) MX2020013519A (enExample)
PL (3) PL3804648T3 (enExample)
SG (1) SG11202012592WA (enExample)
WO (1) WO2020039390A1 (enExample)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
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US10779875B2 (en) 2013-05-06 2020-09-22 Novocure Gmbh Optimizing treatment using TTfields by changing the frequency during the course of long term tumor treatment
US10188851B2 (en) 2015-10-28 2019-01-29 Novocure Limited TTField treatment with optimization of electrode positions on the head based on MRI-based conductivity measurements
US10821283B2 (en) 2016-04-04 2020-11-03 Novocure Gmbh Reducing motility of cancer cells using tumor treating fields (TTFields)
KR102555691B1 (ko) 2016-06-30 2023-07-13 노보큐어 리미티드 신체에 대한 종양 치료장의 길이 방향 전달을 위한 어레이들
WO2018134733A1 (en) 2017-01-19 2018-07-26 Moshe Giladi System for viewing cell cultures under a microscope whilst applying ttfields
KR102592927B1 (ko) * 2018-07-03 2023-10-20 에드윈 창 세포막 투과성을 향상시키기 위한 교류 전기장 사용
JP7366990B2 (ja) 2018-07-10 2023-10-23 ノボキュア ゲーエムベーハー 交流電場を用いたウイルス感染の抑制
HUE059062T2 (hu) * 2018-08-23 2022-10-28 Novocure Gmbh Váltakozó elektromos mezõk alkalmazása vér-agy gát permeabilitásának növelésére
US11020585B2 (en) 2018-09-07 2021-06-01 Novocure Gmbh Treating autoimmune diseases using an alternating electric field to reduce the proliferation of t-cells
US11986647B2 (en) 2018-09-07 2024-05-21 Novocure Gmbh Treating autoinflammatory and mitochondrial diseases using an alternating electric field
JP7284886B2 (ja) 2018-10-15 2023-06-01 ノボキュア ゲーエムベーハー 脳全体にわたる高均一性での腫瘍治療電場（ｔｔ電場）の発生
JP7148722B2 (ja) 2018-10-25 2022-10-05 ゼーヴ・ボンゾン 被験者の脊椎構造体に対する交番電界（例えばＴＴＦｉｅｌｄ）の送達
ES2976808T3 (es) 2018-11-19 2024-08-08 Novocure Gmbh Matrices para la administración de campos de tratamiento de tumores (TTFields) con subelementos selectivamente direccionables
KR20240149988A (ko) 2018-11-29 2024-10-15 노보큐어 게엠베하 종양처리장을 전달하는 향상된 유연성 트랜스듀서 어레이
WO2020144582A1 (en) 2019-01-08 2020-07-16 Novocure Gmbh Evaluating quality of segmentation of an image into different types of tissue for planning treatment using tumor treating fields (ttfields)
EP3974022B1 (en) 2019-02-26 2024-04-17 Novocure GmbH Determining a frequency for ttfields treatment based on a physical parameter of targeted cancer cells
EP3917423B1 (en) 2019-02-27 2024-11-13 Novocure GmbH Delivering tumor treating fields (ttfields) using implantable transducer arrays
JP7419391B2 (ja) 2019-03-29 2024-01-22 ノボキュア ゲーエムベーハー ＰＴＧＥＲ３阻害剤によりＴＴＦｉｅｌｄｓ－耐性がん細胞におけるＴＴＦｉｅｌｄｓに対する感受性を回復させるための方法
EP3960232B1 (en) 2019-04-17 2023-01-04 Novocure GmbH Uploading data from an isolated system without compromising isolation
CN114364432B (zh) 2019-07-31 2025-10-31 诺沃库勒有限责任公司 经由埋入颅骨植入物中的电极施加肿瘤治疗场（TTField）
JP2022545344A (ja) 2019-08-05 2022-10-27 ノボキュア ゲーエムベーハー Ｉｌ１１活性を阻害することによって、腫瘍治療電場（ｔｔフィールド）に対するがん細胞の感受性を高める
EP4021559B1 (en) 2019-08-30 2023-10-25 Novocure GmbH Delivering tumor treating fields (ttfields) to the neck
WO2021050093A1 (en) 2019-09-10 2021-03-18 Novocure Gmbh A method of reducing viability of cancer cells by applying alternating electric fields and administering checkpoint inhibitors to the cancer cells
BR112022012409A2 (pt) 2019-12-31 2022-08-30 Novocure Gmbh Matrizes para entregar campos de tratamento de tumor (ttfields) com elementos de eletrodo acessíveis individualmente e sensores de temperatura
BR112022012431A2 (pt) 2019-12-31 2022-08-30 Novocure Gmbh Gerador de onda senoidal de alta tensão e alta eficiência que evita picos durante ajustes de amplitude e troca de canais
US12121739B2 (en) 2019-12-31 2024-10-22 Novocure Gmbh Methods, systems, and apparatuses for managing temperatures induced by alternating fields
WO2021198864A1 (en) 2020-03-30 2021-10-07 Novocure Gmbh Intravenous / intra-spinal / intra-cavity / intraventricular delivery of ttfields (tumor treating fields) for treating cancer and metastases
CA3171313A1 (en) * 2020-04-24 2021-10-28 Novocure Gmbh Using alternating electric fields to increase permeability of the blood brain barrier
US11818943B2 (en) 2020-06-25 2023-11-14 Novocure Gmbh Fabricating organic light emitting diodes (OLEDs) using tubulin
KR20230073173A (ko) 2020-09-25 2023-05-25 노보큐어 게엠베하 과열 없이 전류를 최대화하기 위해 종양 치료 필드(ttfields) 시스템의 개별 전극 요소에 대한 금속화 영역 변경
JP2023553333A (ja) 2020-11-25 2023-12-21 ノボキュア ゲーエムベーハー ピーク強度での腫瘍治療電場（ｔｔｆｉｅｌｄ）を時間の半分未満で印加することでｔｔｆｉｅｌｄの有効性を高めること
WO2022130183A2 (en) * 2020-12-17 2022-06-23 Novocure Gmbh Pyroelectric-based temperature sensing of transducer arrays for applying tumor treating fields (ttfields)
CN113008403B (zh) * 2021-02-08 2022-08-12 清华大学 电场发生装置及测温电极装置
US12397151B2 (en) 2021-02-17 2025-08-26 Novocure Gmbh Arrays for delivering tumor treating fields (TTFields) with sets of electrode elements having individually adjustable active areas
CN116981497A (zh) 2021-03-12 2023-10-31 诺沃库勒有限责任公司 通过用交变电场使巨噬细胞表型偏向来治疗疾病的方法
WO2022208444A1 (en) 2021-03-31 2022-10-06 Novocure Gmbh Impedance tomography using electrodes of a tumor treating fields (ttfields) system
WO2022215051A1 (en) * 2021-04-08 2022-10-13 Novocure Gmbh Methods of treating neurodegenerative disorders with alternating electric fields
CN113509641A (zh) * 2021-06-29 2021-10-19 北京康源嘉成生物科技有限公司 一种非药物且非侵入性开放血脑屏障的装置和方法
US20230009366A1 (en) * 2021-06-30 2023-01-12 Novocure Gmbh Using Alternating Electric Fields at Different Frequencies to Increase Permeability of the Blood Brain Barrier and also to Provide Other Benefits
CN114099963B (zh) * 2021-12-22 2025-10-03 江苏海莱新创医疗科技有限公司 肿瘤电场治疗系统
EP4408516A1 (en) * 2021-09-30 2024-08-07 Novocure GmbH Reducing electrosensation whilst treating a subject using alternating electric fields
US20230201616A1 (en) 2021-12-29 2023-06-29 Novocure Gmbh Reducing Electrosensation Whilst Treating a Subject Using Alternating Electric Fields by Using Larger Cathodes and Smaller Anodes
EP4456971A1 (en) 2021-12-30 2024-11-06 Novocure GmbH Selecting values of parameters for treatment using tumor treating fields (ttfields)
CN114367060A (zh) * 2022-01-13 2022-04-19 深圳大学 激光交变电场联合治疗仪
MX2024010258A (es) 2022-03-30 2024-08-28 Novocure Gmbh Uso de periodos de enfriamiento intercalados para aumentar la intensidad pico de los campos de tratamiento de tumores.
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