CA3071816A1 - Systems, devices, and methods for isotachophoresis - Google Patents

Systems, devices, and methods for isotachophoresis Download PDF

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Publication number
CA3071816A1
CA3071816A1 CA3071816A CA3071816A CA3071816A1 CA 3071816 A1 CA3071816 A1 CA 3071816A1 CA 3071816 A CA3071816 A CA 3071816A CA 3071816 A CA3071816 A CA 3071816A CA 3071816 A1 CA3071816 A1 CA 3071816A1
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CA
Canada
Prior art keywords
channel
reservoir
fluidic
buffer
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3071816A
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English (en)
French (fr)
Inventor
Lewis A. Marshall
Amy L. Hiddessen
Nathan P. Hoverter
Klint A. Rose
Juan G. Santiago
Matthew S. Munson
Janine Mok
Sean ARIN
Yatian Qu
Andrew Lee
Michael Christopher Derenzi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purigen Biosystems Inc
Original Assignee
Purigen Biosystems Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purigen Biosystems Inc filed Critical Purigen Biosystems Inc
Publication of CA3071816A1 publication Critical patent/CA3071816A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
    • B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/508—Rigid containers without fluid transport within
    • B01L3/5085—Rigid containers without fluid transport within for multiple samples, e.g. microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0642—Filling fluids into wells by specific techniques
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0688—Valves, specific forms thereof surface tension valves, capillary stop, capillary break
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Electrochemistry (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Environmental & Geological Engineering (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA3071816A 2017-08-02 2018-08-01 Systems, devices, and methods for isotachophoresis Pending CA3071816A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762540515P 2017-08-02 2017-08-02
US62/540,515 2017-08-02
US201762541089P 2017-08-03 2017-08-03
US201762541086P 2017-08-03 2017-08-03
US62/541,089 2017-08-03
US62/541,086 2017-08-03
PCT/US2018/044898 WO2019028197A1 (en) 2017-08-02 2018-08-01 SYSTEMS, DEVICES AND METHODS FOR ISOTACHOPHORESIS

Publications (1)

Publication Number Publication Date
CA3071816A1 true CA3071816A1 (en) 2019-02-07

Family

ID=65234157

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3071816A Pending CA3071816A1 (en) 2017-08-02 2018-08-01 Systems, devices, and methods for isotachophoresis

Country Status (8)

Country Link
US (4) US11041150B2 (https=)
EP (1) EP3661635A4 (https=)
JP (2) JP7203106B2 (https=)
CN (2) CN115569515A (https=)
AU (2) AU2018312570B2 (https=)
CA (1) CA3071816A1 (https=)
SG (1) SG11202000871WA (https=)
WO (1) WO2019028197A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7277050B2 (ja) 2016-01-29 2023-05-18 ピューリジェン バイオシステムズ， インコーポレイテッド 核酸の精製のための等速電気泳動
SG11202000871WA (en) 2017-08-02 2020-02-27 Purigen Biosystems Inc Systems, devices, and methods for isotachophoresis
CA199220S (en) * 2018-09-28 2021-02-18 Rockwool Int Display screen with graphical interface
WO2020223342A1 (en) * 2019-04-29 2020-11-05 The Florida State University Research Foundation, Inc. Devices, systems, and methods for quantitation of insulin
WO2021191276A1 (en) * 2020-03-26 2021-09-30 F. Hoffmann-La Roche Ag Devices and methods for sample analysis
WO2022061307A1 (en) * 2020-09-21 2022-03-24 Ontera Inc. Methods for accurate and reproducible detection and quantification of target polynucleotides using a nanopore device
CN112275336B (zh) * 2020-10-20 2021-11-19 大连理工大学 一种多通道集成微流控芯片及其高通量制备单分散凝胶微球的方法
CN112080806B (zh) * 2020-10-23 2024-02-20 江苏吉诺思美精准医学科技有限公司 一种毛细管96孔板的血浆游离dna建库方法
CN112371195B (zh) * 2021-01-15 2021-04-23 京东方科技集团股份有限公司 检测芯片
EP4301839A1 (en) 2021-03-03 2024-01-10 F. Hoffmann-La Roche AG Devices and methods for electrophoretic extraction of nucleic acids from biological samples
CN112994680B (zh) * 2021-04-21 2021-08-10 成都齐碳科技有限公司 多通道切换电路、切换方法
CN116273919B (zh) * 2022-09-08 2025-07-04 南京航空航天大学 一种基于电阻抗分析的微纳机器人分选平台
WO2024070313A1 (ja) * 2022-09-30 2024-04-04 富士フイルム株式会社 電気泳動装置、電気泳動装置の制御方法、及び電気泳動装置の制御プログラム
WO2024070314A1 (ja) * 2022-09-30 2024-04-04 富士フイルム株式会社 電気泳動装置、電気泳動装置の制御方法、及び電気泳動装置の制御プログラム
US20250177968A1 (en) * 2023-07-07 2025-06-05 Abbott Laboratories Two-dimensional matrix droplet array
WO2026039392A1 (en) * 2024-08-14 2026-02-19 Inso Biosciences, Inc. Methods and apparatus for extracting or separating nucleic acids from biological samples

Family Cites Families (190)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US863583A (en) 1905-11-03 1907-08-20 Reinhold Maeser Foil-stamping press.
US3799742A (en) 1971-12-20 1974-03-26 C Coleman Miniaturized integrated analytical test container
US3811326A (en) 1972-02-10 1974-05-21 V Sokol Disposable dilution system
SE390766B (sv) 1972-12-19 1977-01-17 Lkb Produkter Ab Forfarande vid motflodesisotachofores
SE369279B (https=) 1973-01-15 1974-08-19 Lkb Produkter Ab
SE386742B (sv) 1973-11-14 1976-08-16 Lkb Produkter Ab Apparat for preparativ, isotachoforetisk separation i mikroskala
DE2422260B2 (de) 1974-05-08 1979-04-12 Compur-Electronic Gmbh, 8000 Muenchen Einrichtung zur Herstellung einer optisch zu untersuchenden Meßflüssigkeit
DE2508844C2 (de) 1975-02-28 1984-06-14 Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen Einrichtung zur trägerfreien kontinuierlichen Ablenkungselektrophorese
US4233029A (en) 1978-10-25 1980-11-11 Eastman Kodak Company Liquid transport device and method
US4426451A (en) 1981-01-28 1984-01-17 Eastman Kodak Company Multi-zoned reaction vessel having pressure-actuatable control means between zones
DE3277081D1 (en) 1981-07-31 1987-10-01 Shimadzu Corp Electrophoretic apparatus
US4454235A (en) 1982-06-01 1984-06-12 Miles Laboratories, Inc. Capillary tube holder for liquid transfer in immunoassay
US4537747A (en) 1983-03-16 1985-08-27 Chemetrics, Inc. Disposable device for sampling and diluting
US4596780A (en) 1983-03-16 1986-06-24 Chemetrics, Inc. Process for sampling and diluting
DE3328964C1 (de) 1983-08-11 1985-02-14 Bernd Dr. med. 8900 Augsburg Schottdorf Vorrichtung zur selbsttätigen diskontinuierlichen Probenentnahme einer Flüssigkeit
US4618476A (en) 1984-02-10 1986-10-21 Eastman Kodak Company Capillary transport device having speed and meniscus control means
US4790919A (en) 1984-06-28 1988-12-13 E. I. Du Pont De Nemours And Company Process for preparation of electrophoresis gel material
US4897169A (en) 1986-08-18 1990-01-30 Milan Bier Process and apparatus for recycling isoelectric focusing and isotachophoresis
US4900677A (en) 1986-09-26 1990-02-13 E. I. Du Pont De Nemours And Company Process for rapid isolation of high molecular weight DNA
ES2049254T3 (es) * 1987-08-27 1994-04-16 Biotrack Inc Aparato y procedimiento para la dilucion y mezcla de muestras liquidas.
US4868129A (en) * 1987-08-27 1989-09-19 Biotrack Inc. Apparatus and method for dilution and mixing of liquid samples
ATE139260T1 (de) 1988-03-09 1996-06-15 Univ Leland Stanford Junior Diagnostische gene zum nachweis von toxoplasmose
JPH0387648A (ja) 1989-08-31 1991-04-12 Yokogawa Electric Corp キャピラリー電気泳動装置
FR2671290B1 (fr) 1991-01-04 1993-04-16 Sebia Sa Dispositif pour l'application d'echantillons biologiques sur une plaque d'electrophorese.
AU4248593A (en) 1992-05-14 1993-12-13 Mark Holodniy Polymerase chain reaction assays for monitoring antiviral therapy
US5322608A (en) 1992-12-23 1994-06-21 Northeastern University Siloxandediol coating for capillary electrophoresis and for general surface modification
US5447612A (en) 1993-02-01 1995-09-05 Protein Technologies, Inc. Buffering system and its use in electrophoretic processes
US6783651B1 (en) 1994-03-31 2004-08-31 Invitrogen Corporation System for pH-neutral stable electrophoresis gel
US5580523A (en) * 1994-04-01 1996-12-03 Bard; Allen J. Integrated chemical synthesizers
US5827415A (en) 1994-09-26 1998-10-27 The Board Of Trustees Of Leland Stanford Jun. Univ. Oxygen sensor
US5800692A (en) 1995-04-17 1998-09-01 Mayo Foundation For Medical Education And Research Preseparation processor for use in capillary electrophoresis
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US5939291A (en) 1996-06-14 1999-08-17 Sarnoff Corporation Microfluidic method for nucleic acid amplification
US5981235A (en) 1996-07-29 1999-11-09 Promega Corporation Methods for isolating nucleic acids using alkaline protease
US6074827A (en) * 1996-07-30 2000-06-13 Aclara Biosciences, Inc. Microfluidic method for nucleic acid purification and processing
US6143248A (en) 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
US5817225A (en) 1996-08-16 1998-10-06 Exxon Research And Engineering Company Electrophoresis system for the purification, concentration and size fractionation of nucleic acids
WO1998051823A1 (en) 1997-05-16 1998-11-19 Mosaic Technologies Electrophoretic analysis of molecules using immobilized probes
US6090251A (en) 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US5992820A (en) 1997-11-19 1999-11-30 Sarnoff Corporation Flow control in microfluidics devices by controlled bubble formation
GB9802600D0 (en) 1998-02-07 1998-04-01 Eastman Kodak Co Liquid separation
US6107038A (en) * 1998-08-14 2000-08-22 Agilent Technologies Inc. Method of binding a plurality of chemicals on a substrate by electrophoretic self-assembly
US6103199A (en) 1998-09-15 2000-08-15 Aclara Biosciences, Inc. Capillary electroflow apparatus and method
EP1125129A1 (en) 1998-10-13 2001-08-22 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6601613B2 (en) 1998-10-13 2003-08-05 Biomicro Systems, Inc. Fluid circuit components based upon passive fluid dynamics
US6352838B1 (en) 1999-04-07 2002-03-05 The Regents Of The Universtiy Of California Microfluidic DNA sample preparation method and device
WO2000074850A2 (en) 1999-06-03 2000-12-14 University Of Washington Microfluidic devices for transverse electrophoresis and isoelectric focusing
US7517442B1 (en) 1999-08-09 2009-04-14 Life Technologies Corporation Facile method and apparatus for the analysis of biological macromolecules in two dimensions using common and familiar electrophoresis formats
US7223325B2 (en) 1999-10-15 2007-05-29 University Of Virginia Patent Foundation Method for orthogonal analyte stacking/injection systems in electrophoresis
US20020189946A1 (en) 2000-02-11 2002-12-19 Aclara Biosciences, Inc. Microfluidic injection and separation system and method
AU2001234997B2 (en) 2000-02-11 2006-07-27 Monogram Biosciences, Inc. Microfluid device with sample injector and method of use
US6685813B2 (en) 2000-02-11 2004-02-03 Aclara Biosciences, Inc. Tandem isotachophoresis/zone electrophoresis method and system
US20040108207A1 (en) 2000-02-11 2004-06-10 Aclara Biosciences, Inc. Injection and separation system and method employing transient isotachophoretic stacking
US6908593B1 (en) * 2000-03-31 2005-06-21 Lifescan, Inc. Capillary flow control in a fluidic diagnostic device
EP1281002A4 (en) 2000-05-11 2006-08-09 Caliper Life Sciences Inc MICROFLUIDIC EQUIPMENT AND METHODS FOR INFLUENCING FLOW RESISTANCE AND ELECTRICAL RESISTANCE WITH THE HELP OF VISCOSITY INCREASING ADDITIVES
WO2002000100A2 (en) 2000-06-23 2002-01-03 Daniel Armstrong Method for separation, identification and evaluation of microbes and cells
US20020015959A1 (en) 2000-06-23 2002-02-07 Bardell Ronald L. Fluid mixing in microfluidic structures
US7004184B2 (en) 2000-07-24 2006-02-28 The Reagents Of The University Of Michigan Compositions and methods for liquid metering in microchannels
EP1309404A2 (en) 2000-08-07 2003-05-14 Nanostream, Inc. Fluidic mixer in microfluidic system
DE10047088C2 (de) 2000-09-21 2002-10-17 Gerhard Weber Medium für analytische und präparative Elektrophorese
US6780584B1 (en) 2000-09-27 2004-08-24 Nanogen, Inc. Electronic systems and component devices for macroscopic and microscopic molecular biological reactions, analyses and diagnostics
US6934836B2 (en) 2000-10-06 2005-08-23 Protasis Corporation Fluid separation conduit cartridge with encryption capability
WO2002037091A1 (en) 2000-10-31 2002-05-10 Caliper Technologies Corp. Microfluidic methods, devices and systems for in situ material concentration
US6770182B1 (en) * 2000-11-14 2004-08-03 Sandia National Laboratories Method for producing a thin sample band in a microchannel device
CA2428372A1 (en) 2000-11-16 2002-05-23 Basf Aktiengesellschaft Method for separating and detecting proteins by means of electrophoresis
AU2002226981A1 (en) * 2000-11-28 2002-06-11 Nanogen, Inc. Microcapillary arrays for high-throughput screening and separation of differently charged molecules using an electric field
JP3628611B2 (ja) 2000-11-29 2005-03-16 独立行政法人科学技術振興機構 マイクロシステムにおける流れの制御方法
JP3738899B2 (ja) * 2000-12-07 2006-01-25 株式会社 エフェクター細胞研究所 微量試料処理装置
DE10063096C1 (de) 2000-12-18 2002-09-12 Gerhard Weber Elektrophoresevorrichtung, Elektrophoreseverfahren unter Verwendung einer Elektrophoresevorrichtung und Verwendung der Elektrophoresevorrichtung
US6626417B2 (en) 2001-02-23 2003-09-30 Becton, Dickinson And Company Microfluidic valve and microactuator for a microvalve
US7429354B2 (en) 2001-03-19 2008-09-30 Gyros Patent Ab Structural units that define fluidic functions
US6761811B2 (en) 2001-03-27 2004-07-13 The Regents Of The University Of California Multi-stage separations based on dielectrophoresis
US6730204B2 (en) 2001-03-27 2004-05-04 The Regents Of The University Of California Three dimensional separation trap based on dielectrophoresis and use thereof
US6835293B2 (en) 2001-07-09 2004-12-28 Greiner Bio-One Gmbh Analysis system
EP2196799A3 (en) 2001-07-19 2010-08-25 Applera Corporation Buffers for electrophoresis and use thereof
CA2454570C (en) 2001-07-25 2016-12-20 The Trustees Of Princeton University Nanochannel arrays and their preparation and use for high throughput macromolecular analysis
US20040058349A1 (en) 2001-10-01 2004-03-25 Jeffrey Van Ness Methods for identifying nucleotides at defined positions in target nucleic acids
US7005050B2 (en) 2001-10-24 2006-02-28 The Regents Of The University Of Michigan Electrophoresis in microfabricated devices using photopolymerized polyacrylamide gels and electrode-defined sample injection
JP2003156475A (ja) 2001-11-22 2003-05-30 Shimadzu Corp チップ型電気泳動装置
WO2003106693A2 (en) 2002-01-01 2003-12-24 Princeton University Gradient structures interfacing microfluidics and nanofluidics, methods for fabrication and uses thereof
US7169278B2 (en) 2002-01-21 2007-01-30 Tecan Trading Ag Apparatus and separation media for separating particles in free-flow electrophoresis
US6561224B1 (en) 2002-02-14 2003-05-13 Abbott Laboratories Microfluidic valve and system therefor
EP2497564B1 (en) 2002-03-05 2014-05-14 Caliper Life Sciences, Inc. Electrophoretic separation in a microfluidic channel network
TW590982B (en) 2002-09-27 2004-06-11 Agnitio Science & Technology I Micro-fluid driving device
FR2848125B1 (fr) 2002-12-04 2006-06-09 Commissariat Energie Atomique Dispositif microfluidique dans lequel l'interface liquide/fluide est stabilisee
WO2004055492A2 (en) 2002-12-13 2004-07-01 Aclara Biosciences, Inc. Closed-loop control of electrokinetic processes in microfludic devices based on optical readings
US20050014134A1 (en) 2003-03-06 2005-01-20 West Jason Andrew Appleton Viral identification by generation and detection of protein signatures
ATE412902T1 (de) 2003-04-14 2008-11-15 Caliper Life Sciences Inc Reduktion der migrations-shift-assay-interferenz
US20040241656A1 (en) 2003-05-29 2004-12-02 Ming-Shiung Jan High-performance bio-tube for purifying DNA and method thereof
US20040265172A1 (en) * 2003-06-27 2004-12-30 Pugia Michael J. Method and apparatus for entry and storage of specimens into a microfluidic device
AU2003904142A0 (en) 2003-08-06 2003-08-21 Life Therapeutics Limited Electrophoresis manifold and membrane unit
EP2541239B1 (en) 2003-09-05 2019-05-01 Caliper Life Sciences, Inc. Isotachophoresis method
US20080021674A1 (en) 2003-09-30 2008-01-24 Robert Puskas Methods for Enhancing the Analysis of Particle Detection
WO2005033283A2 (en) 2003-09-30 2005-04-14 Singulex, Inc. Methods for enhancing the analysis of particle detection
US20050115837A1 (en) 2003-12-01 2005-06-02 Dean Burgi Analyte identification in transformed electropherograms
KR20070094669A (ko) * 2003-12-23 2007-09-20 칼리퍼 라이프 사이언시즈, 인크. 분석물 주입 시스템
US20050142570A1 (en) 2003-12-24 2005-06-30 3M Innovative Properties Company Methods for nucleic acid isolation and kits using a microfluidic device and sedimenting reagent
GB2416030B (en) 2004-01-28 2008-07-23 Norchip As A diagnostic system for carrying out a nucleic acid sequence amplification and detection process
CA2552262C (en) 2004-02-02 2016-04-19 The University Of British Columbia Scodaphoresis and methods and apparatus for moving and concentrating particles
US20060065528A1 (en) 2004-02-03 2006-03-30 Gabriel Lopez Nanostructured devices for separation and analysis
US7694694B2 (en) 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
CA2566962A1 (en) 2004-05-21 2005-12-01 Atonomics A/S Surface acoustic wave sensor comprising a hydrogel
US20060002817A1 (en) 2004-06-30 2006-01-05 Sebastian Bohm Flow modulation devices
US7635563B2 (en) 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
US7655470B2 (en) 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US8105471B1 (en) 2004-07-19 2012-01-31 Han Sang M Nanofluidics for bioseparation and analysis
US20060042948A1 (en) 2004-09-02 2006-03-02 The Board Of Trustees Of The Leland Stanford Junior University Microfluidic electrophoresis chip having flow-retarding structure
AU2005290314A1 (en) 2004-09-28 2006-04-06 Singulex, Inc. System and method for spectroscopic analysis of single particles
US7371533B2 (en) 2004-10-05 2008-05-13 University Of Ottawa Methods for separation of polymeric compounds
EP1843849A2 (en) * 2005-01-12 2007-10-17 Inverness Medical Switzerland GmbH A method of producing a microfluidic device and microfluidic devices
CN101184983A (zh) * 2005-03-16 2008-05-21 雅拓晶科生物系统（私人）有限公司 用于传输、封闭和分析流体样品的方法和装置
WO2006116616A2 (en) 2005-04-26 2006-11-02 Applera Corporation Systems and methods for multiple analyte detection
DE102005020134A1 (de) 2005-04-29 2006-11-02 Becton, Dickinson And Co. Verfahren und Vorrichtung zur Durchführung eines parallelen und simultanen Mehrfachprozesses der trägerfreien isoelektrischen Fokussierung
JP2006317357A (ja) 2005-05-13 2006-11-24 Shimadzu Corp マイクロチップ電気泳動方法及び装置
WO2007006033A2 (en) 2005-07-05 2007-01-11 Massachusetts Institute Of Technology Microfluidic separators for multiphase fluid-flow based on membranes
EP1742057A1 (en) 2005-07-08 2007-01-10 Stichting Voor De Technische Wetenschappen Device and method for the separation of particles
WO2007011867A2 (en) 2005-07-15 2007-01-25 Applera Corporation Fluid processing device and method
FR2888912B1 (fr) 2005-07-25 2007-08-24 Commissariat Energie Atomique Procede de commande d'une communication entre deux zones par electromouillage, dispositif comportant des zones isolables les unes des autres et procede de realisation d'un tel dispositif
KR20080066727A (ko) 2005-11-02 2008-07-16 가부시키가이샤 시마즈세이사쿠쇼 Ｒｎａ의 추출방법 및 ｒｎａ의 검출방법
JP4682874B2 (ja) 2006-03-01 2011-05-11 コニカミノルタエムジー株式会社 マイクロリアクタ
US20070284250A1 (en) 2006-03-13 2007-12-13 Sage Science, Inc. Multifunctional Electrophoresis Cassette
US20080020386A1 (en) 2006-03-29 2008-01-24 Medigen Biotechnology Corporation Methods and apparatus for genotyping
JP4609664B2 (ja) 2006-03-31 2011-01-12 ブラザー工業株式会社 インクカートリッジの収納装置に対する保護装置
US8021531B2 (en) 2006-04-14 2011-09-20 Caliper Life Sciences, Inc. Method for modifying the concentration of reactants in a microfluidic device
US8414754B1 (en) 2006-05-31 2013-04-09 The Board Of Trustees Of The Leland Stanford Junior University Electrophoretic sample analysis and approach therefor
WO2007141692A1 (en) 2006-06-02 2007-12-13 Koninklijke Philips Electronics N. V. Separation device for isoelectric focusing
US20080233402A1 (en) 2006-06-08 2008-09-25 Sid Richardson Carbon & Gasoline Co. Carbon black with attached carbon nanotubes and method of manufacture
US7951278B2 (en) 2006-07-20 2011-05-31 The Board Of Trustees Of The Leland Standford Junior University Method of detecting directly undetectable analytes using directly detectable spacer molecules
US8562804B2 (en) 2006-07-20 2013-10-22 The Board Of Trustees Of The Leland Stanford Junior University Fluorescent finger prints for indirect detection in isotachophoresis
EP1884284A1 (en) 2006-08-04 2008-02-06 Samsung Electronics Co., Ltd. Closing valve unit and reaction apparatus having closing valve
CA2661268C (en) 2006-08-29 2016-09-13 Becton, Dickinson & Company Method and apparatus for carrier-free deflection electrophoresis
JP2008099685A (ja) 2006-09-29 2008-05-01 Ebara Corp 変性剤により核酸を増幅および合成するための方法および装置
WO2008053047A2 (en) 2006-11-01 2008-05-08 Becton, Dickinson & Company Methods and devices for isotachophoresis applications
JP4852399B2 (ja) 2006-11-22 2012-01-11 富士フイルム株式会社 二液合流装置
US20080156080A1 (en) 2007-01-02 2008-07-03 Calibrant Biosystems, Inc. Methods and systems for multidimensional concentration and separation of biomolecules using capillary isotachophoresis
WO2008105308A1 (ja) 2007-02-27 2008-09-04 Konica Minolta Holdings, Inc. 流路切換システム
US8999129B2 (en) 2011-03-07 2015-04-07 Lawrence Livermore National Security, Llc Liquid and gel electrodes for transverse free flow electrophoresis
US20080237044A1 (en) 2007-03-28 2008-10-02 The Charles Stark Draper Laboratory, Inc. Method and apparatus for concentrating molecules
WO2008124046A1 (en) 2007-04-04 2008-10-16 Micropoint Bioscience Inc.. Micromachined electrowetting microfluidic valve
CA2984820C (en) 2007-04-04 2021-12-07 Ande Corporation Plastic microfluidic separation and detection platforms
US8017408B2 (en) 2007-04-27 2011-09-13 The Regents Of The University Of California Device and methods of detection of airborne agents
CN101848757B (zh) 2007-07-13 2013-12-04 里兰斯坦福初级大学理事会 用于改进的生物测定法的使用电场的方法和设备
US20100120130A1 (en) 2007-08-08 2010-05-13 Advanced Liquid Logic, Inc. Droplet Actuator with Droplet Retention Structures
US20090095057A1 (en) * 2007-10-16 2009-04-16 Phoenix S&T, Inc. Integrated microfluidic nozzle device for chromatographic sample preparation for mass spectrometry applications
WO2009061864A1 (en) 2007-11-06 2009-05-14 3M Innovative Properties Company Processing device tablet
WO2009079028A1 (en) 2007-12-14 2009-06-25 Johns Hopkins University Purification and concentration of proteins and dna from a complex sample using isotachophoresis and a device to perform the purification
US8865401B2 (en) 2007-12-14 2014-10-21 The Johns Hopkins University Purification and concentration of proteins and DNA from a complex sample using isotachophoresis and a device to perform the purification
US9480935B2 (en) 2008-02-01 2016-11-01 Lawrence Livermore National Security, Llc Systems and methods for separating particles and/or substances from a sample fluid
US20090250345A1 (en) 2008-04-03 2009-10-08 Protea Biosciences, Inc. Microfluidic electroelution devices & processes
JP5177533B2 (ja) * 2008-09-25 2013-04-03 ローム株式会社 マイクロチップ
US8852952B2 (en) 2008-05-03 2014-10-07 Advanced Liquid Logic, Inc. Method of loading a droplet actuator
US8357672B2 (en) 2008-06-13 2013-01-22 Bio-Rad Laboratories, Inc. Cell lysis reagent for isolation of RNA
EP2163305A1 (en) 2008-09-05 2010-03-17 INSTITUT FÜR MIKROTECHNIK MAINZ GmbH Device and process for rapid isolation of a compound in a sample
US8394251B2 (en) 2008-10-07 2013-03-12 The Board Of Trustees Of The Leland Stanford Junior University Control of chemical reactions using isotachophoresis
EP2213364A1 (en) 2009-01-30 2010-08-04 Albert-Ludwigs-Universität Freiburg Phase guide patterns for liquid manipulation
US8846314B2 (en) 2009-03-03 2014-09-30 The Board Of Trustees Of The Leland Stanford Junior University Isotachophoretic focusing of nucleic acids
US8580097B2 (en) 2009-04-27 2013-11-12 Wako Pure Chemical Industries, Ltd. Isotachophoresis of blood-derived samples
US9285340B2 (en) 2009-08-17 2016-03-15 Lawrence Livermore National Security, Llc Methods for separating particles and/or nucleic acids using isotachophoresis
US9144799B2 (en) 2009-11-24 2015-09-29 Lawrence Livermore National Security, Llc Modular microfluidic system for biological sample preparation
US8721858B2 (en) 2010-03-12 2014-05-13 The Board Of Trustees Of The Leland Stanford Junior University Non-focusing tracers for indirect detection in electrophoretic displacement techniques
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
ES2592380T3 (es) * 2010-07-06 2016-11-29 Molecular Control Ag Extracción de analitos separados por isotacoforesis
US8986529B2 (en) 2010-09-13 2015-03-24 The Board Of Trustees Of The Leland Stanford Junior University Isotachophoresis having interacting anionic and cationic shock waves
US9151732B2 (en) 2010-10-01 2015-10-06 The Board Of Trustees Of The Leland Stanford Junior University Enhanced isotachophoresis assays using additives with spatial gradients
US8524061B2 (en) 2010-11-29 2013-09-03 The Board Of Trustees Of The Leland Stanford Junior University On-chip hybridization coupled with ITP based purification for fast sequence specific identification
US9910011B2 (en) 2011-01-12 2018-03-06 Lawrence Livermore National Security, Llc Isotachophoresis system having larger-diameter channels flowing into channels with reduced diameter and with selectable counter-flow
GB201103917D0 (en) 2011-03-08 2011-04-20 Univ Leiden Apparatus for and methods of processing liquids or liquid based substances
US8894946B2 (en) * 2011-10-21 2014-11-25 Integenx Inc. Sample preparation, processing and analysis systems
US8986530B2 (en) 2012-01-09 2015-03-24 Washington State University Sample analysis systems, devices, and associated methods of operation
WO2013123035A1 (en) * 2012-02-13 2013-08-22 Molecular Systems Corporation System and method for processing and detecting nucleic acids
EP2888581B1 (en) * 2012-08-21 2020-04-08 Universiteit Leiden Apparatus and process for depletion zone isotachophoresis
US9057673B2 (en) 2012-08-24 2015-06-16 The Board Of Trustees Of The Leland Stanford Junior University Method of preparing RNA from ribonuclease-rich sources
GB2505706A (en) 2012-09-10 2014-03-12 Univ Leiden Apparatus comprising meniscus alignment barriers
US9599590B2 (en) 2012-10-12 2017-03-21 Sage Science, Inc. Side-eluting molecular fractionator
DE102012219156A1 (de) 2012-10-19 2014-04-24 Albert-Ludwigs-Universität Freiburg Integriertes mikrofluidisches bauteil zur anreicherung und extraktion biologischer zellbestandteile
GB2526999B (en) 2013-03-14 2020-02-19 Univ Leland Stanford Junior Capillary barriers for staged loading of microfluidic devices
US11325123B2 (en) 2013-08-02 2022-05-10 The Board Of Trustees Of The Leland Stanford Junior University Flow regulation in fluidic systems using a phase-change material at system ports
IL228026B (en) 2013-08-19 2018-05-31 Technion Res & Dev Foundation Discovery of genetic sequences using pna sensors and isotachophoresis
US10117563B2 (en) 2014-01-09 2018-11-06 Gyrus Acmi, Inc. Polyp detection from an image
JP6189231B2 (ja) * 2014-02-26 2017-08-30 株式会社東芝 微粒子検査装置と微粒子検査システム及び微粒子検査方法
US10067088B2 (en) 2014-06-20 2018-09-04 Applied Research Associates, Inc. Gradient elution isotachophoretic apparatus for separating, purifying, concentrating, quantifying, and/or extracting charged analytes and methods thereof
JP6636686B2 (ja) * 2014-07-09 2020-01-29 株式会社エンプラス 流体取扱装置の取扱方法
JP6337295B2 (ja) 2014-07-18 2018-06-06 国立大学法人 東京大学 電気泳動分析チップおよび電気泳動分析装置
JP6619286B2 (ja) 2015-05-13 2019-12-11 アークレイ株式会社 分析用具および分析システム
US10384207B2 (en) * 2015-07-21 2019-08-20 Neuro Probe Incorporated Assay apparatus and methods
US10564121B2 (en) 2015-11-26 2020-02-18 Vladislav Dolnik Device and method for separation and analysis of trace and ultra-trace ionogenic compounds by isotachophoresis and zone electrophoresis on chip
JP7277050B2 (ja) 2016-01-29 2023-05-18 ピューリジェン バイオシステムズ， インコーポレイテッド 核酸の精製のための等速電気泳動
SG11202000871WA (en) 2017-08-02 2020-02-27 Purigen Biosystems Inc Systems, devices, and methods for isotachophoresis
CN116139665B (zh) * 2023-02-06 2025-08-15 湖北文理学院 一种沥青拌合站烟气净化处理系统

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