ES2049254T3 - Aparato y procedimiento para la dilucion y mezcla de muestras liquidas. - Google Patents
Aparato y procedimiento para la dilucion y mezcla de muestras liquidas.Info
- Publication number
- ES2049254T3 ES2049254T3 ES88307946T ES88307946T ES2049254T3 ES 2049254 T3 ES2049254 T3 ES 2049254T3 ES 88307946 T ES88307946 T ES 88307946T ES 88307946 T ES88307946 T ES 88307946T ES 2049254 T3 ES2049254 T3 ES 2049254T3
- Authority
- ES
- Spain
- Prior art keywords
- chamber
- sample
- mixing
- application
- relation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/45—Magnetic mixers; Mixers with magnetically driven stirrers
- B01F33/452—Magnetic mixers; Mixers with magnetically driven stirrers using independent floating stirring elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/80—Forming a predetermined ratio of the substances to be mixed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/02—Food
- G01N33/04—Dairy products
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Sampling And Sample Adjustment (AREA)
- Accessories For Mixers (AREA)
Abstract
APARATO PARA DILUIR UNA MUESTRA CON UN DILUYENTE, QUE CONSTA DE UNA CAMARA MEDIDORA DE VOLUMEN FIJO, UNA CAMARA RECEPTORA DE VOLUMEN FIJO EN COMUNICACION CON LA ANTERIOR, UN ORIFICIO DE AIREACION DE GAS EN LA CAMARA DE RECEPCION, UNA CONEXION DE DETENCION DEL FLUJO ENTRE LA CAMARA MEDIDORA Y LA RECEPTORA, UN PUNTO DE APLICACION DE LA MUESTRA EN RELACION CON LA CAMARA DE MEDICION, SIENDO LA DIFERENCIA DE ALTURA ENTRE EL LUGAR DE APLICACION DE LA MUESTRA Y LA CONEXION INSUFICIENTE PARA QUE APAREZCA UNA PRESION HIDROSTATICA CAPAZ DE SUPERAR LA CONTRAPRESION EN LA CONEXION CUANDO LA MUESTRA SE APLICA, ASI COMO EL DILUYENTE EN RELACION CON LA CAMARA DE MEDICION. LA MUESTRA Y EL DISOLVENTE SE AÑADEN SECUENCIALMENTE AL APARATO PARA CONSEGUIR LA DISOLUCION SIN NECESIDAD DE OTRAS OPERACIONES. EN UN SEGUNDO DISEÑO, UN CARTUCHO DE DILUCION Y MEZCLA CONSTA DE UN PUNTO DE APLICACION DE LA MUESTRA, UNA CAMARA MEZCLADORA EN RELACION CON EL ANTERIOR, UN PUNTO DE APLICACION DEL DISOLVENTE EN RELACION CONLA CAMARA DE MEZCLA, UNA CAMARA DE AISLAMIENTO DE LA MEZCLA CONECTADA HIDROSTATICAMENTE A LA DE MEZCLADO, UNA PRIMERA VALVULA QUE IMPIDE DE FORMA SELECTIVA LA CIRCULACION DESDE EL PUNTO DE APLICACION DE DISOLVENTE A LA CAMARA DE MEZCLADO Y UNA CAMARA DE AISLANTE DE LA MEZCLA CONECTADA HIDROSTATICAMENTE A LA CAMARA DE MEZCLA. EL INVENTO INCLUYE IGUALMENTE UN METODO PARA UTILIZAR ESTE CARTUCHO PARA DILUIR SECUENCIALMENTE UNA MUESTRA CON UNO O VARIOS DILUYENTES.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/090,026 US4868129A (en) | 1987-08-27 | 1987-08-27 | Apparatus and method for dilution and mixing of liquid samples |
US07/117,791 US5077017A (en) | 1987-11-05 | 1987-11-05 | Integrated serial dilution and mixing cartridge |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2049254T3 true ES2049254T3 (es) | 1994-04-16 |
Family
ID=26781444
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES88307946T Expired - Lifetime ES2049254T3 (es) | 1987-08-27 | 1988-08-26 | Aparato y procedimiento para la dilucion y mezcla de muestras liquidas. |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP0305210B1 (es) |
JP (1) | JPH0756492B2 (es) |
AU (1) | AU615208B2 (es) |
CA (1) | CA1333850C (es) |
DE (1) | DE3886140T2 (es) |
ES (1) | ES2049254T3 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5104813A (en) * | 1989-04-13 | 1992-04-14 | Biotrack, Inc. | Dilution and mixing cartridge |
US5225163A (en) * | 1989-08-18 | 1993-07-06 | Angenics, Inc. | Reaction apparatus employing gravitational flow |
WO1991002589A1 (en) * | 1989-08-18 | 1991-03-07 | Cambridge Bioscience Corporation | Reaction apparatus and method employing gravitational flow |
EP0501796A3 (en) * | 1991-03-01 | 1993-10-06 | Biotrack, Inc. | Capillary stop-flow junction having improved stability against accidental fluid flow |
US5230866A (en) * | 1991-03-01 | 1993-07-27 | Biotrack, Inc. | Capillary stop-flow junction having improved stability against accidental fluid flow |
JP2002503331A (ja) * | 1995-12-05 | 2002-01-29 | ガメラ バイオサイエンス コーポレイション | 機内に搭載された情報科学を備えた超微量液体素子工学システムにおいて液体移動を推進するために求心性加速を使用するための装置及び方法 |
EP1577010A3 (en) * | 1995-12-05 | 2005-11-16 | Tecan Trading AG | Microsystem platform and its use |
US6709869B2 (en) | 1995-12-18 | 2004-03-23 | Tecan Trading Ag | Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system |
US6143248A (en) * | 1996-08-12 | 2000-11-07 | Gamera Bioscience Corp. | Capillary microvalve |
WO1998028623A1 (en) | 1996-12-20 | 1998-07-02 | Gamera Bioscience Corporation | An affinity binding-based system for detecting particulates in a fluid |
WO1998053311A2 (en) | 1997-05-23 | 1998-11-26 | Gamera Bioscience Corporation | Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system |
US6632399B1 (en) | 1998-05-22 | 2003-10-14 | Tecan Trading Ag | Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays |
WO1999009394A1 (en) | 1997-08-15 | 1999-02-25 | Alexion Pharmaceuticals, Inc. | Apparatus for performing assays at reaction sites |
SE9803734D0 (sv) | 1998-10-30 | 1998-10-30 | Amersham Pharm Biotech Ab | Liquid handling system |
US6193471B1 (en) * | 1999-06-30 | 2001-02-27 | Perseptive Biosystems, Inc. | Pneumatic control of formation and transport of small volume liquid samples |
ES2282150T3 (es) * | 1999-11-15 | 2007-10-16 | I-Stat Corporation | Aparato y metodos para someter a ensayo la coagulacion en muestras de fluidos. |
DE10057895B4 (de) * | 2000-11-22 | 2009-06-18 | peS Gesellschaft für medizinische Diagnosesysteme mbH | Vorrichtung und Verfahren zur Probenvorbereitung flüssiger Proben |
US7429354B2 (en) | 2001-03-19 | 2008-09-30 | Gyros Patent Ab | Structural units that define fluidic functions |
EP1483052B1 (en) | 2001-08-28 | 2010-12-22 | Gyros Patent Ab | Retaining microfluidic microcavity and other microfluidic structures |
US6919058B2 (en) | 2001-08-28 | 2005-07-19 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
AU2003215340A1 (en) * | 2002-02-22 | 2003-09-09 | Nanostream, Inc. | Ratiometric dilution devices and methods |
JP4210783B2 (ja) | 2002-09-26 | 2009-01-21 | アークレイ株式会社 | 分析用具 |
DE102004022423A1 (de) * | 2004-05-06 | 2005-12-15 | Siemens Ag | Mikrofluidiksystem |
JP2007003414A (ja) * | 2005-06-24 | 2007-01-11 | Arkray Inc | 分析装置用カートリッジ |
JP4660662B2 (ja) * | 2005-09-06 | 2011-03-30 | アークレイ株式会社 | カートリッジ |
JP4797619B2 (ja) * | 2005-12-22 | 2011-10-19 | 東レ株式会社 | 分析チップおよび被検物質の分析方法 |
JP5241209B2 (ja) * | 2007-11-26 | 2013-07-17 | 株式会社日立ハイテクノロジーズ | 試料前処理用デバイス及び試料分析方法 |
CN102257378B (zh) | 2008-12-18 | 2015-07-22 | 皇家飞利浦电子股份有限公司 | 用于感测流体的感测装置 |
JP5888885B2 (ja) * | 2010-06-23 | 2016-03-22 | アークレイ株式会社 | 測定装置、測定方法、測定プログラム、および測定システム |
WO2014076521A1 (en) * | 2012-11-15 | 2014-05-22 | Agilent Technologies, Inc. | Sample dilution to specifiable dilution ratio |
JP5833716B1 (ja) * | 2014-07-24 | 2015-12-16 | 日本電信電話株式会社 | 血液凝固検査方法および血液凝固検査用流路チップ |
CN116083530A (zh) | 2016-01-29 | 2023-05-09 | 普瑞珍生物系统公司 | 用于核酸纯化的等速电泳 |
JP7289792B2 (ja) * | 2017-04-21 | 2023-06-12 | メサ バイオテック,インク. | 流体検査用カセット |
CN115569515A (zh) | 2017-08-02 | 2023-01-06 | 普瑞珍生物系统公司 | 用于等速电泳的系统、设备和方法 |
CN111868501B (zh) * | 2018-02-27 | 2023-07-04 | 芯易诊有限公司 | 使用连续稀释进行样品分析的装置及其方法 |
CN108393105B (zh) * | 2018-04-20 | 2023-08-25 | 华南师范大学 | 一种微流控芯片及其控制系统、控制方法 |
JP7343191B2 (ja) * | 2019-01-17 | 2023-09-12 | 日本分光株式会社 | 液体クロマトグラフィー用スタティックミキサー |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE330624B (es) * | 1965-09-02 | 1970-11-23 | Medicinskkemiska Lab Calab Ab | |
US3799742A (en) * | 1971-12-20 | 1974-03-26 | C Coleman | Miniaturized integrated analytical test container |
US3869068A (en) * | 1974-06-06 | 1975-03-04 | Hyperion Inc | Diluter probe assembly |
US4426451A (en) * | 1981-01-28 | 1984-01-17 | Eastman Kodak Company | Multi-zoned reaction vessel having pressure-actuatable control means between zones |
US4503012A (en) * | 1983-04-19 | 1985-03-05 | American Monitor Corporation | Reagent dispensing system |
FI834387A0 (fi) * | 1983-11-30 | 1983-11-30 | Labsystems Oy | Foerfarande foer utspaedning av vaetskeprov |
-
1988
- 1988-08-26 ES ES88307946T patent/ES2049254T3/es not_active Expired - Lifetime
- 1988-08-26 CA CA000575875A patent/CA1333850C/en not_active Expired - Fee Related
- 1988-08-26 DE DE3886140T patent/DE3886140T2/de not_active Expired - Fee Related
- 1988-08-26 EP EP88307946A patent/EP0305210B1/en not_active Expired - Lifetime
- 1988-08-27 JP JP63213515A patent/JPH0756492B2/ja not_active Expired - Lifetime
- 1988-08-29 AU AU21639/88A patent/AU615208B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
AU2163988A (en) | 1989-03-02 |
AU615208B2 (en) | 1991-09-26 |
DE3886140T2 (de) | 1994-05-19 |
EP0305210A3 (en) | 1989-10-11 |
CA1333850C (en) | 1995-01-10 |
EP0305210A2 (en) | 1989-03-01 |
JPH0756492B2 (ja) | 1995-06-14 |
DE3886140D1 (de) | 1994-01-20 |
JPH01257268A (ja) | 1989-10-13 |
EP0305210B1 (en) | 1993-12-08 |
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