CA3071337A1 - Igg fc variants for veterinary use - Google Patents

Igg fc variants for veterinary use Download PDF

Info

Publication number
CA3071337A1
CA3071337A1 CA3071337A CA3071337A CA3071337A1 CA 3071337 A1 CA3071337 A1 CA 3071337A1 CA 3071337 A CA3071337 A CA 3071337A CA 3071337 A CA3071337 A CA 3071337A CA 3071337 A1 CA3071337 A1 CA 3071337A1
Authority
CA
Canada
Prior art keywords
seq
polypeptide
amino acid
igg
acid substitution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3071337A
Other languages
English (en)
French (fr)
Inventor
Hangjun Zhan
Lam Nguyen
Yongzhong Li
Fawn Qian
Shyr Jiann Li
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elanco US Inc
Original Assignee
Kindred Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=65361820&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA3071337(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Kindred Biosciences Inc filed Critical Kindred Biosciences Inc
Publication of CA3071337A1 publication Critical patent/CA3071337A1/en
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/283Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against Fc-receptors, e.g. CD16, CD32, CD64
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • C07K2317/53Hinge
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71Decreased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CA3071337A 2017-08-15 2018-08-15 Igg fc variants for veterinary use Pending CA3071337A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762545858P 2017-08-15 2017-08-15
US62/545,858 2017-08-15
PCT/IB2018/056142 WO2019035010A1 (en) 2017-08-15 2018-08-15 IGG VARIANTS FOR VETERINARY USE

Publications (1)

Publication Number Publication Date
CA3071337A1 true CA3071337A1 (en) 2019-02-21

Family

ID=65361820

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3071337A Pending CA3071337A1 (en) 2017-08-15 2018-08-15 Igg fc variants for veterinary use

Country Status (10)

Country Link
US (1) US12297272B2 (cg-RX-API-DMAC7.html)
EP (1) EP3668536A4 (cg-RX-API-DMAC7.html)
JP (1) JP2020531002A (cg-RX-API-DMAC7.html)
KR (1) KR20200057701A (cg-RX-API-DMAC7.html)
CN (2) CN111182915A (cg-RX-API-DMAC7.html)
AU (3) AU2018318440A1 (cg-RX-API-DMAC7.html)
BR (1) BR112020002871A2 (cg-RX-API-DMAC7.html)
CA (1) CA3071337A1 (cg-RX-API-DMAC7.html)
MX (1) MX2020001707A (cg-RX-API-DMAC7.html)
WO (1) WO2019035010A1 (cg-RX-API-DMAC7.html)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3939605A1 (en) 2016-12-09 2022-01-19 Akston Biosciences Corporation Insulin-fc fusions and methods of use
US12297272B2 (en) 2017-08-15 2025-05-13 Eianco US inc. IgG Fc variants for veterinary use
US11267862B2 (en) 2018-06-29 2022-03-08 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
BR112020026777A2 (pt) 2018-06-29 2021-03-30 Akston Biosciences Corporation Proteínas de fusão, composição farmacêutica, método para reduzir o nível de glicose, célula e cdna
JP2022504868A (ja) * 2018-10-18 2022-01-13 キンドレッド バイオサイエンシズ インコーポレイテッド 獣医学的使用のための、新生仔fc受容体(fcrn)への結合性が変化したfc変異体
JP7691365B2 (ja) * 2018-12-27 2025-06-11 エランコ・ユーエス・インコーポレイテッド 動物用IgGFcバリアント
CN113544153B (zh) * 2019-01-03 2024-12-10 因外泰克斯公司 用于增加治疗剂在犬中的半衰期的组合物及使用方法
AU2020240120A1 (en) * 2019-03-20 2021-09-30 Elanco Us Inc. NGF antagonists for medical use
CA3143785A1 (en) 2019-07-30 2021-02-04 Hangjun Zhan Parvovirus antibodies for veterinary use
DK4073098T5 (da) 2019-12-19 2024-07-22 Akston Biosciences Corp Ultralangtidsvirkende insulin-Fc-fusionsproteiner og fremgangsmåder til anvendelse
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
CA3167437A1 (en) 2020-02-19 2021-08-26 Verena BRAND Modified fc regions
EP4121108A4 (en) * 2020-03-18 2024-04-03 Elanco US Inc. ANTIBODIES AGAINST THE IL4 RECEPTOR FOR VETERINARY USE
LT3972987T (lt) 2020-04-10 2023-09-25 Akston Biosciences Corporation Antigenui specifinė imunoterapija, skirta sulietiems covid-19 baltymams ir naudojimo būdai
US11192930B2 (en) 2020-04-10 2021-12-07 Askton Bioscences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
GB202005879D0 (en) * 2020-04-22 2020-06-03 Petmedix Ltd Heterodimeric proteins
KR20230005875A (ko) * 2020-04-22 2023-01-10 킨드레드 바이오사이언시스, 인코포레이티드 수의학 용도를 위한 장시간-작용성 항-il31 항체
US11198719B2 (en) 2020-04-29 2021-12-14 Akston Biosciences Corporation Ultra-long acting insulin-Fc fusion protein and methods of use
BR112022022922A2 (pt) 2020-05-11 2023-01-17 Invetx Inc Composições para aumentar a meia-vida de um agente terapêutico em caninos e métodos de uso
MX2023000500A (es) 2020-07-10 2023-04-12 Invetx Inc Composiciones para aumentar la semivida de un agente terapeutico en felinos y modos de uso.
JP2023539247A (ja) * 2020-08-24 2023-09-13 ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア Glp-1受容体アゴニスト融合物をコードするウイルスベクター及びネコの代謝性疾患の治療におけるその使用
CN112625093B (zh) * 2020-12-29 2022-12-23 清远市图微安创科技开发有限公司 用于预防和/或治疗非酒精性脂肪肝炎的多肽化合物
US11667689B2 (en) 2021-07-23 2023-06-06 Akston Biosciences Corporation Insulin-Fc fusion proteins and methods of use to treat cancer
CN117940455A (zh) * 2021-08-06 2024-04-26 佩特迈迪有限公司 抗体Fc变体
WO2024145280A2 (en) 2022-12-27 2024-07-04 Invetx, Inc. Polypeptides with altered binding to neonatal fc receptor (fcrn) and methods of use
CN121002059A (zh) 2023-01-20 2025-11-21 因外泰克斯公司 用于伴侣动物的双特异性结合剂
GB202311984D0 (en) * 2023-08-04 2023-09-20 Petmedix Ltd Optimised fc molecules
WO2025166165A1 (en) * 2024-02-01 2025-08-07 Zoetis Services, Llc Compositions and methods for modifying antibody effector functions

Family Cites Families (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194551B1 (en) * 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
US6207383B1 (en) * 1998-07-27 2001-03-27 University Of Utah Research Foundation Mutations in and genomic structure of HERG—a long QT syndrome gene
US7297482B2 (en) * 1998-10-08 2007-11-20 Rigel Pharmaceuticals, Inc. Structurally biased random peptide libraries based on different scaffolds
JP2003518929A (ja) * 1999-12-23 2003-06-17 ユニヴェルシテ・ドゥ・ジュネーブ 基底側部選別シグナル、およびその阻害物質
PT1355919E (pt) 2000-12-12 2011-03-02 Medimmune Llc Moléculas com semivida longa, composições que as contêm e suas utilizações
US7658921B2 (en) 2000-12-12 2010-02-09 Medimmune, Llc Molecules with extended half-lives, compositions and uses thereof
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
US20090010920A1 (en) 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
JP2004321100A (ja) 2003-04-25 2004-11-18 Rikogaku Shinkokai IgGのFc領域を含むタンパク質の変異体
MXPA05013565A (es) 2003-06-12 2006-03-09 Lilly Co Eli Proteinas de fusion analogas al glp-1.
US8367805B2 (en) 2004-11-12 2013-02-05 Xencor, Inc. Fc variants with altered binding to FcRn
CN101044162B (zh) 2004-12-22 2010-10-27 伊莱利利公司 Glp-1类似物融合蛋白质制剂
WO2006105062A2 (en) * 2005-03-29 2006-10-05 Verenium Corporation Altered antibody fc regions and uses thereof
WO2007012188A1 (en) 2005-07-27 2007-02-01 Qinghua Wang GLP/1/EXENDM 4 IgG Fc FUSION CONSTRUCTS FOR TREATMENT OF DIABETES
JP2008169195A (ja) 2007-01-05 2008-07-24 Hanmi Pharmaceutical Co Ltd キャリア物質を用いたインスリン分泌ペプチド薬物結合体
AU2008254951A1 (en) 2007-05-14 2008-11-27 Biogen Idec Ma Inc. Single-chain Fc (ScFc) regions, binding polypeptides comprising same, and methods related thereto
EP1997832A1 (en) 2007-05-29 2008-12-03 Ganymed Pharmaceuticals AG Monoclonal antibodies against Claudin-18 for treatment of cancer
EP2175834B8 (en) 2007-07-10 2012-08-22 Eli Lilly And Company Glp-1-fc fusion protein formulation
JP6039183B2 (ja) * 2008-12-23 2016-12-07 ジェネンテック, インコーポレイテッド プロテインaに対する結合が変化した免疫グロブリン変異体
US20120093814A1 (en) 2009-03-30 2012-04-19 Boehringer Ingelheim International Gmbh Fusion Proteins Comprising Canine FC Portions
WO2010117448A2 (en) 2009-04-05 2010-10-14 Provenance Biopharmaceuticals Corp. Chimeric immunocytokines and methods of use thereof
AU2011235569B2 (en) * 2010-03-29 2016-06-30 Zymeworks Bc Inc. Antibodies with enhanced or suppressed effector function
JP2013537416A (ja) 2010-08-13 2013-10-03 メディミューン リミテッド 変異型Fc領域を含むモノマーポリペプチド及び使用方法
ES2692268T5 (en) 2011-03-29 2025-02-26 Roche Glycart Ag Antibody fc variants
CA2835094C (en) * 2011-05-06 2020-12-22 David Gearing Anti-nerve growth factor antibodies and methods of preparing and using the same
CN103764677A (zh) 2011-05-06 2014-04-30 Nvip私人有限公司 抗神经生长因子抗体及其制备和使用方法
EP2537864B1 (en) 2011-06-24 2019-08-07 Laboratoire Français du Fractionnement et des Biotechnologies Fc variants with reduced effector functions
CA2842323A1 (en) 2011-07-18 2013-01-24 Arts Biologics A/S Long acting biologically active luteinizing hormone (lh) compound
EP2734541B1 (en) 2011-07-19 2017-09-06 The National Institute for Biotechnology in the Negev, Ltd. Novel il-17r-ecd mutants
CA2853637C (en) 2011-10-26 2023-04-04 Novartis Ag Anti-canine cd20 monoclonal antibodies and methods of use
KR102052774B1 (ko) 2011-11-04 2019-12-04 자임워크스 인코포레이티드 Fc 도메인 내의 돌연변이를 갖는 안정한 이종이합체 항체 설계
KR102041412B1 (ko) 2011-12-30 2019-11-11 한미사이언스 주식회사 면역글로불린 Fc 단편 유도체
WO2013124666A1 (en) * 2012-02-22 2013-08-29 Nvip Pty Ltd Tumour necrosis factor receptor fusion proteins and methods of using the same
US10011660B2 (en) 2012-04-30 2018-07-03 Medimmune, Llc Molecules with reduced effector function and extended half-lives, compositions, and uses thereof
ES2894852T3 (es) 2012-06-06 2022-02-16 Zoetis Services Llc Anticuerpos anti-NGF caninizados y métodos de los mismos
WO2014022592A1 (en) 2012-08-02 2014-02-06 Jn Biosciences Llc Antibodies or fusion proteins multimerized via cysteine mutation and a mu tailpiece
WO2014093387A1 (en) 2012-12-10 2014-06-19 Kindred Biosciences, Inc. Vegf receptor fusion proteins for veterinary use
US9487587B2 (en) 2013-03-05 2016-11-08 Macrogenics, Inc. Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof
WO2015017548A2 (en) 2013-07-31 2015-02-05 Amgen Inc. Stabilization of fc-containing polypeptides
HK1226084A1 (zh) 2013-08-16 2017-09-22 Medimmune Limited 用於治疗糖尿病的gip和glp-1受体双重激动剂
PT3083694T (pt) 2013-12-20 2024-02-01 Intervet Int Bv Anticorpos murinos caninizados anti-pd-1 canino
US20170182154A1 (en) 2014-01-22 2017-06-29 Beijing Advaccine Biotechnology Co. Ltd Vaccines with interleukin-17 as an adjuvant
WO2016044189A1 (en) 2014-09-15 2016-03-24 Genentech, Inc. Methods of treating cancer using pd-1 axis binding antagonist and il-17 binding antagonists
AU2015326996B2 (en) 2014-09-30 2021-05-20 Intervet International B.V. PD-L1 antibodies binding canine PD-L1
EP3842453A1 (en) * 2014-11-06 2021-06-30 F. Hoffmann-La Roche AG Fc-region variants with modified fcrn- and protein a-binding properties
KR101825048B1 (ko) * 2014-12-31 2018-02-05 주식회사 제넥신 GLP 및 면역글로불린 하이브리드 Fc 융합 폴리펩타이드 및 이의 용도
DK3273992T3 (da) 2015-03-23 2020-07-27 Jounce Therapeutics Inc Antistoffer mod ICOS
US20190330328A1 (en) 2015-10-19 2019-10-31 Christian Mann Methods of treating non-radiographic axial spondyloarthritis using interleukin-17 (il-17) antagonists
EP3390451B1 (en) 2015-12-18 2025-01-22 Intervet International B.V. Caninized human antibodies to human and canine il-4r alpha
US20190111107A1 (en) 2016-01-26 2019-04-18 Defensin Therapeutics Aps Methods for modulating intestinal microbiota
CA3014461C (en) * 2016-02-18 2023-02-28 Elanco Us Inc. Chimeric canine anti-cd20 antibody
WO2017201527A2 (en) 2016-05-20 2017-11-23 President And Fellows Of Harvard College Gene therapy methods for age-related diseases and conditions
WO2018009921A1 (en) 2016-07-08 2018-01-11 AskGene Pharma, Inc. Fusion protein comprising leptin and methods for producing and using the same
US20200181258A1 (en) 2016-10-17 2020-06-11 Vetoquinol Sa Modified antibody constant region
CN110799210A (zh) 2016-12-02 2020-02-14 得克萨斯A&M大学系统 选择性消耗抗原特异性抗体的融合蛋白
KR20250057131A (ko) * 2017-04-21 2025-04-28 엘랑코 유에스 인코포레이티드 수의학 용도를 위한 il4/il13 수용체 분자
CA3065553A1 (en) 2017-06-18 2018-12-27 Kindred Biosciences, Inc. Il17a antibodies and antagonists for veterinary use
US12297272B2 (en) 2017-08-15 2025-05-13 Eianco US inc. IgG Fc variants for veterinary use
BR112020026777A2 (pt) 2018-06-29 2021-03-30 Akston Biosciences Corporation Proteínas de fusão, composição farmacêutica, método para reduzir o nível de glicose, célula e cdna
CN113164593A (zh) 2018-09-14 2021-07-23 金德雷德生物科学股份有限公司 兽用抗il4受体抗体
JP2022504868A (ja) 2018-10-18 2022-01-13 キンドレッド バイオサイエンシズ インコーポレイテッド 獣医学的使用のための、新生仔fc受容体(fcrn)への結合性が変化したfc変異体
US12428466B2 (en) 2018-10-25 2025-09-30 Elanco Us Inc. IL4/IL13 receptor molecule for veterinary use
JP7536294B2 (ja) 2018-12-05 2024-08-20 株式会社バイカ・セラピュティクス 抗体のFc領域改変体
US20220025005A1 (en) 2018-12-12 2022-01-27 Kindred Biosciences, Inc. Erythropoietin Analogs For Veterinary Use
JP7691365B2 (ja) 2018-12-27 2025-06-11 エランコ・ユーエス・インコーポレイテッド 動物用IgGFcバリアント
CN113544153B (zh) 2019-01-03 2024-12-10 因外泰克斯公司 用于增加治疗剂在犬中的半衰期的组合物及使用方法
AU2020240120A1 (en) 2019-03-20 2021-09-30 Elanco Us Inc. NGF antagonists for medical use
JP7762645B2 (ja) 2019-08-22 2025-10-30 シダラ セラピューティクス インコーポレーテッド バリアントfcドメイン及びその使用
WO2021043127A1 (zh) 2019-09-02 2021-03-11 甘李药业股份有限公司 嵌合蛋白
US11186623B2 (en) 2019-12-24 2021-11-30 Akston Bioscience Corporation Ultra-long acting insulin-Fc fusion proteins and methods of use
CA3176434A1 (en) 2020-04-17 2021-10-21 Zoetis Services Llc Feline antibody variants
PE20230108A1 (es) 2020-04-17 2023-01-25 Zoetis Services Llc Variantes de anticuerpos caninos
KR20230005875A (ko) 2020-04-22 2023-01-10 킨드레드 바이오사이언시스, 인코포레이티드 수의학 용도를 위한 장시간-작용성 항-il31 항체
AU2021259785A1 (en) 2020-04-22 2022-11-17 Elanco Us Inc. IL4/IL13 receptor molecules for veterinary use
BR112022022922A2 (pt) 2020-05-11 2023-01-17 Invetx Inc Composições para aumentar a meia-vida de um agente terapêutico em caninos e métodos de uso
JPWO2021251438A1 (cg-RX-API-DMAC7.html) 2020-06-10 2021-12-16
WO2022005883A1 (en) 2020-06-29 2022-01-06 Zoetis Services Llc Feline antibody variants for improving stability
MX2023000500A (es) 2020-07-10 2023-04-12 Invetx Inc Composiciones para aumentar la semivida de un agente terapeutico en felinos y modos de uso.
WO2022046941A1 (en) 2020-08-26 2022-03-03 Angiex, Inc. Antimitotic tetrapeptide-antibody conjugates and methods of using same

Also Published As

Publication number Publication date
AU2025220819A1 (en) 2025-09-25
EP3668536A4 (en) 2021-05-26
RU2020110584A3 (cg-RX-API-DMAC7.html) 2021-12-15
AU2023226676A1 (en) 2023-09-28
AU2023226676B2 (en) 2025-05-22
CN111182915A (zh) 2020-05-19
RU2020110584A (ru) 2021-09-17
CN119390821A (zh) 2025-02-07
US12297272B2 (en) 2025-05-13
WO2019035010A1 (en) 2019-02-21
MX2020001707A (es) 2020-03-20
US20200362034A1 (en) 2020-11-19
EP3668536A1 (en) 2020-06-24
AU2018318440A1 (en) 2020-02-13
JP2020531002A (ja) 2020-11-05
BR112020002871A2 (pt) 2020-07-28
KR20200057701A (ko) 2020-05-26

Similar Documents

Publication Publication Date Title
US12297272B2 (en) IgG Fc variants for veterinary use
US20240270820A1 (en) Il4/il13 receptor molecule for veterinary use
US20220064263A1 (en) IGG FC Variants for Veterinary Use
US12428466B2 (en) IL4/IL13 receptor molecule for veterinary use
US20220169740A1 (en) NGF Antagonists for Medical Use
US20240270819A1 (en) Il4/il13 receptor molecules for veterinary use
TW201617366A (zh) 新穎抗人類Tie2抗體
US8454969B2 (en) Soluble tumor necrosis factor receptor mutant
CA3121586A1 (en) Erythropoietin analogs for veterinary use
CA3065540A1 (en) Erythropoietin and analogs for veterinary use
RU2814952C2 (ru) ВАРИАНТЫ IgG-FC ДЛЯ ПРИМЕНЕНИЯ В ВЕТЕРИНАРИИ
RU2829812C2 (ru) Антагонисты ngf для медицинского использования
RU2850882C2 (ru) Варианты fc igg для ветеринарного применения

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20220831

EEER Examination request

Effective date: 20220831

EEER Examination request

Effective date: 20220831

EEER Examination request

Effective date: 20220831

EEER Examination request

Effective date: 20220831

EEER Examination request

Effective date: 20220831

EEER Examination request

Effective date: 20220831