CA3070095A1 - Dosage regimens of anti-lag-3 antibodies and uses thereof - Google Patents

Dosage regimens of anti-lag-3 antibodies and uses thereof Download PDF

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Publication number
CA3070095A1
CA3070095A1 CA3070095A CA3070095A CA3070095A1 CA 3070095 A1 CA3070095 A1 CA 3070095A1 CA 3070095 A CA3070095 A CA 3070095A CA 3070095 A CA3070095 A CA 3070095A CA 3070095 A1 CA3070095 A1 CA 3070095A1
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Canada
Prior art keywords
antibody molecule
cancer
lag
seq
amino acid
Prior art date
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Pending
Application number
CA3070095A
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English (en)
French (fr)
Inventor
Andrew Marc Stein
Florian Dominik VOGL
Dalila SELLAMI
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Novartis AG
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Novartis AG
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Filing date
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Application filed by Novartis AG filed Critical Novartis AG
Publication of CA3070095A1 publication Critical patent/CA3070095A1/en
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA3070095A 2017-07-20 2018-07-20 Dosage regimens of anti-lag-3 antibodies and uses thereof Pending CA3070095A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762534798P 2017-07-20 2017-07-20
US62/534,798 2017-07-20
US201862643992P 2018-03-16 2018-03-16
US62/643,992 2018-03-16
PCT/US2018/043030 WO2019018730A1 (en) 2017-07-20 2018-07-20 DOSAGE REGIMES FOR ANTI-LAG3 ANTIBODIES AND USES THEREOF

Publications (1)

Publication Number Publication Date
CA3070095A1 true CA3070095A1 (en) 2019-01-24

Family

ID=63143376

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3070095A Pending CA3070095A1 (en) 2017-07-20 2018-07-20 Dosage regimens of anti-lag-3 antibodies and uses thereof

Country Status (9)

Country Link
US (1) US20200172617A1 (enExample)
EP (1) EP3655023A1 (enExample)
JP (2) JP2020527572A (enExample)
KR (2) KR20200031659A (enExample)
CN (1) CN111163798A (enExample)
AU (1) AU2018302283B2 (enExample)
CA (1) CA3070095A1 (enExample)
IL (2) IL319798A (enExample)
WO (1) WO2019018730A1 (enExample)

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JOP20200096A1 (ar) 2014-01-31 2017-06-16 Children’S Medical Center Corp جزيئات جسم مضاد لـ tim-3 واستخداماتها
CA2936962C (en) * 2014-03-14 2024-03-05 Novartis Ag Antibody molecules to lag-3 and uses thereof
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CA3251366A1 (en) 2022-02-25 2023-08-31 Bristol-Myers Squibb Company POLYTHERAPY AGAINST COLORECTAL CARCINOMA
JP2025518785A (ja) 2022-06-02 2025-06-19 ブリストル－マイヤーズ スクイブ カンパニー 抗体組成物及びその使用方法
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EP4470542A1 (en) * 2023-05-31 2024-12-04 Fundación Miguel Servet Oleuropein in the management of cancer
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