CA3059364A1 - Treatment of asthma with anti-tslp antibody - Google Patents

Treatment of asthma with anti-tslp antibody Download PDF

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Publication number
CA3059364A1
CA3059364A1 CA3059364A CA3059364A CA3059364A1 CA 3059364 A1 CA3059364 A1 CA 3059364A1 CA 3059364 A CA3059364 A CA 3059364A CA 3059364 A CA3059364 A CA 3059364A CA 3059364 A1 CA3059364 A1 CA 3059364A1
Authority
CA
Canada
Prior art keywords
antibody
seq
sequence
tslp
set forth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3059364A
Other languages
English (en)
French (fr)
Inventor
Jane R. Parnes
Janet GRIFFITHS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
MedImmune LLC
Original Assignee
Amgen Inc
MedImmune LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc, MedImmune LLC filed Critical Amgen Inc
Publication of CA3059364A1 publication Critical patent/CA3059364A1/en
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CA3059364A 2017-04-12 2018-04-12 Treatment of asthma with anti-tslp antibody Pending CA3059364A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762484864P 2017-04-12 2017-04-12
US62/484,864 2017-04-12
US201762553575P 2017-09-01 2017-09-01
US201762553477P 2017-09-01 2017-09-01
US62/553,575 2017-09-01
US62/553,477 2017-09-01
PCT/US2018/027271 WO2018191479A1 (en) 2017-04-12 2018-04-12 Treatment of asthma with anti-tslp antibody

Publications (1)

Publication Number Publication Date
CA3059364A1 true CA3059364A1 (en) 2018-10-18

Family

ID=62092313

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3059364A Pending CA3059364A1 (en) 2017-04-12 2018-04-12 Treatment of asthma with anti-tslp antibody

Country Status (22)

Country Link
US (3) US10828365B2 (https=)
EP (1) EP3609917A1 (https=)
JP (4) JP7330896B2 (https=)
KR (2) KR20240070727A (https=)
CN (1) CN110573525A (https=)
AU (2) AU2018253118B2 (https=)
BR (1) BR112019021482A2 (https=)
CA (1) CA3059364A1 (https=)
CL (1) CL2019002897A1 (https=)
CO (1) CO2019011462A2 (https=)
IL (1) IL269791B (https=)
JO (1) JOP20190243B1 (https=)
MX (1) MX2019012158A (https=)
MY (1) MY207509A (https=)
PE (1) PE20200484A1 (https=)
PH (1) PH12019502331A1 (https=)
SG (1) SG11201909322VA (https=)
TN (1) TN2019000289A1 (https=)
TW (2) TW202523688A (https=)
UA (1) UA130334C2 (https=)
UY (1) UY37676A (https=)
WO (1) WO2018191479A1 (https=)

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JP6516925B2 (ja) * 2015-09-09 2019-05-22 ノバルティス アーゲー 胸腺間質性リンパ球新生因子（ｔｓｌｐ）結合性抗体および抗体を使用する方法
KR20240070727A (ko) * 2017-04-12 2024-05-21 암젠 인크 항-tslp 항체를 이용한 천식의 치료
EP3981788A4 (en) * 2019-06-04 2023-03-22 Jiangsu Hengrui Medicine Co., Ltd. ANTIBODY CAPABLE OF BINDING THYMIC STROMAL LYMPHOPOIETIN AND ITS USE
JP7597784B2 (ja) * 2019-07-11 2024-12-10 タヴォテック バイオセラピューティクス （ホン コン） リミテッド 胸腺間質性リンパ球新生因子（ｔｓｌｐ）受容体シグナル伝達に干渉する薬剤
KR102809618B1 (ko) * 2019-09-04 2025-05-16 바이오션, 인코포레이티드 Tslp에 결합하는 항체 및 이의 용도
LT4051708T (lt) * 2019-10-28 2025-04-10 Medimmune Limited Užkrūčio liaukos stromos limfopoetiną (tslp) surišančių antikūnų sausų miltelių pavidalo vaisto formos ir jų panaudojimo būdai
CN114887053B (zh) * 2019-11-29 2026-04-24 康诺亚生物医药科技（成都）有限公司 一种tslp相关病症治疗剂的开发和应用
MX2022004919A (es) * 2019-12-13 2022-05-16 Sichuan Kelun Biotech Biopharmaceutical Co Ltd Anticuerpo anti-linfopoyetina estromal timica (tslp) y sus usos.
TW202140550A (zh) 2020-01-29 2021-11-01 瑞士商諾華公司 使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法
EP4103235A1 (en) * 2020-02-13 2022-12-21 Amgen Inc. Formulations of human anti-tslp antibodies and methods of treating inflammatory disease
US20230073888A1 (en) * 2020-02-13 2023-03-09 Amgen Inc. Treatment of atopic dermatitis with anti-tslp antibody
EP4106811A1 (en) * 2020-02-18 2022-12-28 Amgen Inc. Formulations of human anti-tslp antibodies and methods of using the same
CN113388035B (zh) * 2020-03-13 2026-02-27 迈威(上海)生物科技股份有限公司 特异性针对人tslp的抗体及其应用
WO2022117079A1 (zh) * 2020-12-03 2022-06-09 江苏恒瑞医药股份有限公司 结合胸腺基质淋巴细胞生成素的抗体及其应用
CN113501878B (zh) * 2021-02-03 2022-12-02 北京智仁美博生物科技有限公司 针对人tslp的多种抗体及其用途
CN114853888B (zh) * 2021-02-05 2023-11-03 上海洛启生物医药技术有限公司 抗tslp纳米抗体及其应用
KR20230152062A (ko) * 2021-03-03 2023-11-02 치아타이 티안큉 파마수티컬 그룹 주식회사 항tslp 항체를 포함하는 의약 조성물
PH12023552762A1 (en) * 2021-04-19 2024-04-15 Medimmune Ltd An anti-tslp fab with improved stability
WO2022226339A1 (en) 2021-04-23 2022-10-27 Amgen Inc. Anti-tslp antibody compositions and uses thereof
KR20230175245A (ko) 2021-04-23 2023-12-29 암젠 인크 변형된 항-tslp 항체
CN113683694B (zh) * 2021-09-03 2022-05-13 江苏荃信生物医药股份有限公司 一种抗人tslp单克隆抗体及其应用
CN117106084B (zh) * 2021-12-02 2024-03-22 北京东方百泰生物科技股份有限公司 一种抗tslp的单克隆抗体、其抗原结合片段及其应用
CN117327176A (zh) * 2022-06-24 2024-01-02 南京融捷康生物科技有限公司 一种抗tslp的单域抗体及其用途
US12110324B2 (en) 2022-07-22 2024-10-08 Flagship Pioneering Innovations Vi, Llc Antigen binding molecules targeting thymic stromal lymphopoietin (TSLP)
TW202426485A (zh) 2022-10-26 2024-07-01 美商安進公司 抗ｔｓｌｐ抗體組成物及其用途
TW202523697A (zh) * 2023-08-25 2025-06-16 美商普羅特歐拉吉克適美國公司 抗ｔｓｌｐ抗體構築體及其用途
TW202525846A (zh) 2023-08-25 2025-07-01 美商普羅特歐拉吉克適美國公司 抗ｉｌ—１３多特異性抗體構築體及其用途
CN117551195B (zh) * 2024-01-12 2024-04-09 杭州畅溪制药有限公司 靶向tslp的vhh纳米抗体及其应用
WO2025179220A1 (en) * 2024-02-22 2025-08-28 Flagship Pioneering Innovations Vi, Llc Dosing of antigen binding molecules targeting thymic stromal lymphopoietin (tslp)
WO2025264860A2 (en) 2024-06-18 2025-12-26 Yale University Methods of treating post-covid airway disease
US20260098100A1 (en) * 2024-10-04 2026-04-09 Prana Therapies, Inc. Il-4r and tslp inhibitors and methods of use thereof

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Also Published As

Publication number Publication date
UY37676A (es) 2018-10-31
TW202523688A (zh) 2025-06-16
IL269791A (en) 2019-11-28
JP2025170430A (ja) 2025-11-18
US20180296669A1 (en) 2018-10-18
JP2020516647A (ja) 2020-06-11
EP3609917A1 (en) 2020-02-19
SG11201909322VA (en) 2019-11-28
TWI856945B (zh) 2024-10-01
WO2018191479A1 (en) 2018-10-18
PH12019502331A1 (en) 2020-09-28
US20250032608A1 (en) 2025-01-30
KR102666879B1 (ko) 2024-05-23
MY207509A (en) 2025-02-28
US10828365B2 (en) 2020-11-10
AU2018253118B2 (en) 2025-04-10
MX2019012158A (es) 2019-12-16
JP7330896B2 (ja) 2023-08-22
PE20200484A1 (es) 2020-03-03
UA130334C2 (uk) 2026-01-28
US20210052726A1 (en) 2021-02-25
CO2019011462A2 (es) 2019-10-31
KR20190140956A (ko) 2019-12-20
JOP20190243B1 (ar) 2024-12-22
JOP20190243A1 (ar) 2019-10-13
BR112019021482A2 (pt) 2020-05-12
CN110573525A (zh) 2019-12-13
AU2025204735A1 (en) 2025-07-17
TN2019000289A1 (en) 2021-05-07
JP2024150751A (ja) 2024-10-23
TW201838652A (zh) 2018-11-01
CL2019002897A1 (es) 2020-03-06
KR20240070727A (ko) 2024-05-21
AU2018253118A1 (en) 2019-10-24
JP2023099233A (ja) 2023-07-11
IL269791B (en) 2022-07-01

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