CA3058966A1 - Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use - Google Patents

Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use Download PDF

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Publication number
CA3058966A1
CA3058966A1 CA3058966A CA3058966A CA3058966A1 CA 3058966 A1 CA3058966 A1 CA 3058966A1 CA 3058966 A CA3058966 A CA 3058966A CA 3058966 A CA3058966 A CA 3058966A CA 3058966 A1 CA3058966 A1 CA 3058966A1
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Canada
Prior art keywords
immunomodulating
conjugate
polynucleotide
oligonucleotide
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3058966A
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English (en)
French (fr)
Inventor
Sukumar Sakamuri
Curt W. Bradshaw
Son Lam
Joseph Stock
Edward Hyungsuk Ha
Laxman Eltepu
Dingguo Liu
Bin Liu
Giuseppe DELLO IACONO
Bryan R. Meade
Ayman Kabakibi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tallac Therapeutics Inc
Original Assignee
Tollnine Inc
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Filing date
Publication date
Application filed by Tollnine Inc filed Critical Tollnine Inc
Publication of CA3058966A1 publication Critical patent/CA3058966A1/en
Pending legal-status Critical Current

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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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