CA3042401A1 - Compositions de thiophosphate pour lubrifiants - Google Patents
Compositions de thiophosphate pour lubrifiants Download PDFInfo
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- CA3042401A1 CA3042401A1 CA3042401A CA3042401A CA3042401A1 CA 3042401 A1 CA3042401 A1 CA 3042401A1 CA 3042401 A CA3042401 A CA 3042401A CA 3042401 A CA3042401 A CA 3042401A CA 3042401 A1 CA3042401 A1 CA 3042401A1
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- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Abstract
La présente invention concerne des compositions d'acide nucléique qui incorporent une ou plusieurs molécules d'halogéno-uracile. Plus spécifiquement, la présente invention montre que le remplacement de nucléotides d'uracile dans une séquence nucléotidique de microARN avec un 5-halogéno-uracile augmente la capacité du microARN à inhiber la progression du cancer et la tumorigenèse. Par conséquent, la présente invention concerne différentes compositions d'acide nucléique (par exemple, des microARN) comportant des molécules de 5-halogéno-uracile incorporées dans leurs séquences d'acide nucléique et des procédés d'utilisation de celles-ci. La présente invention concerne en outre des compositions pharmaceutiques (par exemple, des formulations) comprenant les compositions d'acides nucléiques modifiées, et des procédés de traitement de cancers, tels que le cancer colorectal, du pacréas et du poumon.
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
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US201662415740P | 2016-11-01 | 2016-11-01 | |
US62/415,740 | 2016-11-01 | ||
US201662422298P | 2016-11-15 | 2016-11-15 | |
US62/422,298 | 2016-11-15 | ||
US201762464491P | 2017-02-28 | 2017-02-28 | |
US62/464,491 | 2017-02-28 | ||
PCT/US2017/059011 WO2018085198A1 (fr) | 2016-11-01 | 2017-10-30 | Microarn modifiés par 5-halogéno-uracile et leur utilisation dans le traitement du cancer |
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CA3042401A1 true CA3042401A1 (fr) | 2018-05-11 |
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CA3042401A Pending CA3042401A1 (fr) | 2016-11-01 | 2017-10-30 | Compositions de thiophosphate pour lubrifiants |
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US (2) | US11584932B2 (fr) |
EP (2) | EP3534912A4 (fr) |
JP (2) | JP7130639B2 (fr) |
KR (2) | KR102502248B1 (fr) |
CN (2) | CN110290794A (fr) |
AU (2) | AU2017353907B2 (fr) |
BR (1) | BR112019008810A2 (fr) |
CA (1) | CA3042401A1 (fr) |
IL (1) | IL282836A (fr) |
MX (1) | MX2019005101A (fr) |
SG (1) | SG11202104571RA (fr) |
WO (2) | WO2018085198A1 (fr) |
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- 2017-10-30 EP EP17867742.3A patent/EP3534912A4/fr active Pending
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CN110290794A (zh) | 2019-09-27 |
US20190062754A1 (en) | 2019-02-28 |
IL282836A (en) | 2021-06-30 |
EP3534912A1 (fr) | 2019-09-11 |
BR112019008810A2 (pt) | 2019-07-16 |
WO2020092466A1 (fr) | 2020-05-07 |
SG11202104571RA (en) | 2021-06-29 |
JP7498230B2 (ja) | 2024-06-11 |
JP2019533697A (ja) | 2019-11-21 |
JP7130639B2 (ja) | 2022-09-05 |
AU2017353907B2 (en) | 2023-11-30 |
EP3873613A4 (fr) | 2023-11-15 |
WO2018085198A1 (fr) | 2018-05-11 |
MX2019005101A (es) | 2019-08-22 |
KR20210088614A (ko) | 2021-07-14 |
EP3534912A4 (fr) | 2020-10-07 |
AU2017353907A1 (en) | 2019-05-23 |
CN113573781A (zh) | 2021-10-29 |
EP3873613A1 (fr) | 2021-09-08 |
AU2019371830A1 (en) | 2021-06-03 |
US20230365972A1 (en) | 2023-11-16 |
KR102502248B1 (ko) | 2023-02-21 |
JP2022173194A (ja) | 2022-11-18 |
US11584932B2 (en) | 2023-02-21 |
KR20190086688A (ko) | 2019-07-23 |
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