CA3027498A1 - Cxcr4 inhibitors and uses thereof - Google Patents

Cxcr4 inhibitors and uses thereof Download PDF

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Publication number
CA3027498A1
CA3027498A1 CA3027498A CA3027498A CA3027498A1 CA 3027498 A1 CA3027498 A1 CA 3027498A1 CA 3027498 A CA3027498 A CA 3027498A CA 3027498 A CA3027498 A CA 3027498A CA 3027498 A1 CA3027498 A1 CA 3027498A1
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CA
Canada
Prior art keywords
compound
cancer
pharmaceutically acceptable
optionally substituted
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3027498A
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English (en)
French (fr)
Inventor
Elyse Marie Josee Bourque
Renato Skerlj
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
X4 Pharmaceuticals Inc
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X4 Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by X4 Pharmaceuticals Inc filed Critical X4 Pharmaceuticals Inc
Publication of CA3027498A1 publication Critical patent/CA3027498A1/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA3027498A 2016-06-21 2017-06-21 Cxcr4 inhibitors and uses thereof Pending CA3027498A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662352820P 2016-06-21 2016-06-21
US62/352,820 2016-06-21
US201762456526P 2017-02-08 2017-02-08
US62/456,526 2017-02-08
PCT/US2017/038609 WO2017223239A1 (en) 2016-06-21 2017-06-21 Cxcr4 inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
CA3027498A1 true CA3027498A1 (en) 2017-12-28

Family

ID=60783547

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3027498A Pending CA3027498A1 (en) 2016-06-21 2017-06-21 Cxcr4 inhibitors and uses thereof

Country Status (7)

Country Link
US (4) US10759796B2 (https=)
EP (2) EP3808748A1 (https=)
JP (2) JP7054529B2 (https=)
CN (2) CN116554168B (https=)
CA (1) CA3027498A1 (https=)
ES (1) ES2870920T3 (https=)
WO (1) WO2017223239A1 (https=)

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JP2022076020A (ja) 2022-05-18
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US20200123150A1 (en) 2020-04-23
US20210047320A1 (en) 2021-02-18
US11780837B2 (en) 2023-10-10
US20220372032A1 (en) 2022-11-24
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EP3471727B1 (en) 2020-12-09
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US11306088B2 (en) 2022-04-19
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