CA3024706A1 - Heterocyclic inhibitors of ptpn11 - Google Patents
Heterocyclic inhibitors of ptpn11 Download PDFInfo
- Publication number
- CA3024706A1 CA3024706A1 CA3024706A CA3024706A CA3024706A1 CA 3024706 A1 CA3024706 A1 CA 3024706A1 CA 3024706 A CA3024706 A CA 3024706A CA 3024706 A CA3024706 A CA 3024706A CA 3024706 A1 CA3024706 A1 CA 3024706A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- recited
- mmol
- optionally substituted
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- APONNRJYWMMGTG-OAHLLOKOSA-N Cc(nccc1)c1-c1n[nH]c2c1ncc(N(CC1)CCC1(CCC1)[C@@H]1N)n2 Chemical compound Cc(nccc1)c1-c1n[nH]c2c1ncc(N(CC1)CCC1(CCC1)[C@@H]1N)n2 APONNRJYWMMGTG-OAHLLOKOSA-N 0.000 description 1
- UJAJJWWOYYKKKK-UHFFFAOYSA-N Clc(nccc1)c1-c1n[nH]c2c1ncc(N1CCC3(CCCC3)CC1)n2 Chemical compound Clc(nccc1)c1-c1n[nH]c2c1ncc(N1CCC3(CCCC3)CC1)n2 UJAJJWWOYYKKKK-UHFFFAOYSA-N 0.000 description 1
- ZRNNEEZHPVJUQT-UHFFFAOYSA-N FC(CC1)(CC1(CC1)CCN1c1nc([nH]nc2-c(cc(cc3Cl)-c(cc4)c(-c5n[nH]c6c5ncc(N5CCC7(CCCC7)CC5)n6)c(Cl)c4Cl)c3Cl)c2nc1)F Chemical compound FC(CC1)(CC1(CC1)CCN1c1nc([nH]nc2-c(cc(cc3Cl)-c(cc4)c(-c5n[nH]c6c5ncc(N5CCC7(CCCC7)CC5)n6)c(Cl)c4Cl)c3Cl)c2nc1)F ZRNNEEZHPVJUQT-UHFFFAOYSA-N 0.000 description 1
- KCRBJSWWABFQLC-UHFFFAOYSA-N NC(CF)(CC1)CCN1c1nc([nH]nc2-c3cccc(Cl)c3Cl)c2nc1 Chemical compound NC(CF)(CC1)CCN1c1nc([nH]nc2-c3cccc(Cl)c3Cl)c2nc1 KCRBJSWWABFQLC-UHFFFAOYSA-N 0.000 description 1
- FHEXWCNTNTWBTH-UHFFFAOYSA-N NC(CO)(CC1)CCN1c1cnc(c(-c2cccc(F)c2Cl)n[nH]2)c2n1 Chemical compound NC(CO)(CC1)CCN1c1cnc(c(-c2cccc(F)c2Cl)n[nH]2)c2n1 FHEXWCNTNTWBTH-UHFFFAOYSA-N 0.000 description 1
- DCZHDAUEYSJCLK-UHFFFAOYSA-N NC(CO)(CC1)CCN1c1nc([nH]nc2-c(cccc3)c3Cl)c2nc1 Chemical compound NC(CO)(CC1)CCN1c1nc([nH]nc2-c(cccc3)c3Cl)c2nc1 DCZHDAUEYSJCLK-UHFFFAOYSA-N 0.000 description 1
- XVECDRYVLBLJQU-UHFFFAOYSA-N NC(CO)(CC1)CCN1c1nc([nH]nc2-c(cccn3)c3Cl)c2nc1 Chemical compound NC(CO)(CC1)CCN1c1nc([nH]nc2-c(cccn3)c3Cl)c2nc1 XVECDRYVLBLJQU-UHFFFAOYSA-N 0.000 description 1
- YCRNZPYPOFXDCB-UHFFFAOYSA-N NC(CO)(CC1)CCN1c1nc([nH]nc2-c3cccc(Cl)c3Cl)c2nc1 Chemical compound NC(CO)(CC1)CCN1c1nc([nH]nc2-c3cccc(Cl)c3Cl)c2nc1 YCRNZPYPOFXDCB-UHFFFAOYSA-N 0.000 description 1
- OLCQKOFQXXDERP-UHFFFAOYSA-N NCC(CC1)(CCN1c1nc([nH]nc2-c(c(F)ccc3)c3Cl)c2nc1)O Chemical compound NCC(CC1)(CCN1c1nc([nH]nc2-c(c(F)ccc3)c3Cl)c2nc1)O OLCQKOFQXXDERP-UHFFFAOYSA-N 0.000 description 1
- YMDXJDQSJVLAPR-UHFFFAOYSA-N NCC(CC1)(CCN1c1nc([nH]nc2-c(cccc3)c3Cl)c2nc1)O Chemical compound NCC(CC1)(CCN1c1nc([nH]nc2-c(cccc3)c3Cl)c2nc1)O YMDXJDQSJVLAPR-UHFFFAOYSA-N 0.000 description 1
- MGKIMAOKUSXGGL-CQSZACIVSA-N N[C@H](CCC1)C1(CC1)CCN1c1cnc(c(-c(ccnc2)c2Cl)n[nH]2)c2n1 Chemical compound N[C@H](CCC1)C1(CC1)CCN1c1cnc(c(-c(ccnc2)c2Cl)n[nH]2)c2n1 MGKIMAOKUSXGGL-CQSZACIVSA-N 0.000 description 1
- HWNCRAHYJRQMMV-OAHLLOKOSA-N N[C@H](CCC1)C1(CC1)CCN1c1nc([nH]nc2-c(cccc3)c3Cl)c2nc1 Chemical compound N[C@H](CCC1)C1(CC1)CCN1c1nc([nH]nc2-c(cccc3)c3Cl)c2nc1 HWNCRAHYJRQMMV-OAHLLOKOSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662343455P | 2016-05-31 | 2016-05-31 | |
| US62/343,455 | 2016-05-31 | ||
| US201762451432P | 2017-01-27 | 2017-01-27 | |
| US62/451,432 | 2017-01-27 | ||
| PCT/US2017/034806 WO2017210134A1 (en) | 2016-05-31 | 2017-05-26 | Heterocyclic inhibitors of ptpn11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3024706A1 true CA3024706A1 (en) | 2017-12-07 |
Family
ID=60420381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3024706A Pending CA3024706A1 (en) | 2016-05-31 | 2017-05-26 | Heterocyclic inhibitors of ptpn11 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US10280171B2 (enExample) |
| EP (1) | EP3463343B1 (enExample) |
| JP (1) | JP7044375B2 (enExample) |
| CN (1) | CN109475531B (enExample) |
| AU (1) | AU2017274199B2 (enExample) |
| CA (1) | CA3024706A1 (enExample) |
| WO (1) | WO2017210134A1 (enExample) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11466017B2 (en) | 2011-03-10 | 2022-10-11 | Board Of Regents, The University Of Texas System | Heterocyclic inhibitors of PTPN11 |
| JO3517B1 (ar) | 2014-01-17 | 2020-07-05 | Novartis Ag | ان-ازاسبيرو الكان حلقي كبديل مركبات اريل-ان مغايرة وتركيبات لتثبيط نشاط shp2 |
| KR20220100719A (ko) | 2015-12-10 | 2022-07-15 | 피티씨 테라퓨틱스, 인크. | 헌팅턴병 치료 또는 개선을 위한 조성물 |
| JP7044375B2 (ja) | 2016-05-31 | 2022-03-30 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | Ｐｔｐｎ１１の複素環式阻害剤 |
| EA202092442A3 (ru) | 2016-06-07 | 2021-08-31 | Джакобио Фармасьютикалс Ко., Лтд. | Новые гетероциклические производные, применимые в качестве ингибиторов shp2 |
| AU2017283769B2 (en) | 2016-06-14 | 2019-08-15 | Novartis Ag | Compounds and compositions for inhibiting the activity of SHP2 |
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| WO2018172984A1 (en) | 2017-03-23 | 2018-09-27 | Jacobio Pharmaceuticals Co., Ltd. | Novel heterocyclic derivatives useful as shp2 inhibitors |
| US11591336B2 (en) | 2017-05-26 | 2023-02-28 | D. E. Shaw Research, Llc | Substituted pyrazolo[3,4-b]pyrazines as SHP2 phosphatase inhibitors |
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| WO2019067843A1 (en) | 2017-09-29 | 2019-04-04 | Relay Therapeutics, Inc. | PYRAZOLO [3,4-B] PYRAZINE DERIVATIVES AS INHIBITORS OF PHOSPHATASE SHP2 |
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| AU2019243048A1 (en) | 2018-03-27 | 2020-10-15 | Ptc Therapeutics, Inc. | Compounds for treating Huntington's disease |
| JP7297871B2 (ja) | 2018-05-02 | 2023-06-26 | ナビール ファーマ，インコーポレイティド | Ｐｔｐｎ１１の置換されたヘテロ環式インヒビター |
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Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| JP7044375B2 (ja) | 2022-03-30 |
| EP3463343A4 (en) | 2019-10-23 |
| CN109475531B (zh) | 2021-08-17 |
| US20170342078A1 (en) | 2017-11-30 |
| US20190270746A1 (en) | 2019-09-05 |
| CN109475531A (zh) | 2019-03-15 |
| EP3463343B1 (en) | 2022-03-23 |
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