CA3017776A1 - Multispecific fab fusion proteins and use thereof - Google Patents
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- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- C07K16/2821—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against ICAM molecules, e.g. CD50, CD54, CD102
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| KR20190087539A (ko) | 2016-11-23 | 2019-07-24 | 하푼 테라퓨틱스, 인크. | Psma 표적화 삼중특이성 단백질 및 사용 방법 |
| US11535668B2 (en) | 2017-02-28 | 2022-12-27 | Harpoon Therapeutics, Inc. | Inducible monovalent antigen binding protein |
| EP3621994A4 (en) | 2017-05-12 | 2020-12-30 | Harpoon Therapeutics, Inc. | MESOTHELIN BINDING PROTEINS |
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| CN111630070B (zh) | 2017-10-13 | 2024-07-30 | 哈普恩治疗公司 | 三特异性蛋白质及使用方法 |
| BR112020007309A2 (pt) * | 2017-10-14 | 2020-09-29 | Cytomx Therapeutics, Inc. | anticorpos, anticorpos ativáveis, anticorpos biespecíficos e anticorpos ativáveis biespecíficos e métodos de uso dos mesmos |
| CN119192397A (zh) | 2018-05-14 | 2024-12-27 | 哈普恩治疗公司 | 用于条件性激活免疫球蛋白分子的结合部分 |
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| JP7548587B2 (ja) * | 2018-09-07 | 2024-09-10 | アイタブメッド (エイチケイ) リミテッド | 二重特異性抗原結合タンパク質及びその使用 |
| WO2020061482A1 (en) | 2018-09-21 | 2020-03-26 | Harpoon Therapeutics, Inc. | Egfr binding proteins and methods of use |
| EP3856771A4 (en) | 2018-09-25 | 2022-06-29 | Harpoon Therapeutics, Inc. | Dll3 binding proteins and methods of use |
| WO2020132810A1 (en) * | 2018-12-24 | 2020-07-02 | Generon (Shanghai) Corporation Ltd. | Multispecific antigen binding proteins capable of binding cd19 and cd3, and use thereof |
| KR20210142638A (ko) * | 2019-02-22 | 2021-11-25 | 우한 이지 바이오파마 씨오., 엘티디. | Cd3 항원 결합 단편 및 이의 응용 |
| EP3969479B1 (en) * | 2019-05-14 | 2025-07-30 | Harpoon Therapeutics, Inc. | Epcam binding proteins and methods of use |
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| KR20210095781A (ko) * | 2020-01-24 | 2021-08-03 | 주식회사 에이프릴바이오 | 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물 |
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- 2017-03-15 CN CN201780029960.2A patent/CN109476756B/zh active Active
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| EP3430058A4 (en) | 2019-10-23 |
| AU2017233121A1 (en) | 2018-09-13 |
| JP7034489B2 (ja) | 2022-03-14 |
| WO2017157305A1 (en) | 2017-09-21 |
| CN109476756B (zh) | 2022-05-31 |
| US10870701B2 (en) | 2020-12-22 |
| EP3430058A1 (en) | 2019-01-23 |
| JP2019513701A (ja) | 2019-05-30 |
| CN109476756A (zh) | 2019-03-15 |
| AU2017233121B2 (en) | 2023-12-21 |
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