CA2988362C - Orodispersible tablet containing estetrol - Google Patents
Orodispersible tablet containing estetrol Download PDFInfo
- Publication number
- CA2988362C CA2988362C CA2988362A CA2988362A CA2988362C CA 2988362 C CA2988362 C CA 2988362C CA 2988362 A CA2988362 A CA 2988362A CA 2988362 A CA2988362 A CA 2988362A CA 2988362 C CA2988362 C CA 2988362C
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- Prior art keywords
- dosage unit
- estetrol
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- solid dosage
- weight
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15172755.9 | 2015-06-18 | ||
| EP15172755 | 2015-06-18 | ||
| PCT/EP2016/064181 WO2016203044A1 (en) | 2015-06-18 | 2016-06-20 | Orodispersible tablet containing estetrol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2988362A1 CA2988362A1 (en) | 2016-12-22 |
| CA2988362C true CA2988362C (en) | 2022-07-19 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2988362A Active CA2988362C (en) | 2015-06-18 | 2016-06-20 | Orodispersible tablet containing estetrol |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10888518B2 (enExample) |
| EP (1) | EP3310346B1 (enExample) |
| JP (1) | JP6813150B2 (enExample) |
| CN (1) | CN107750157B (enExample) |
| CA (1) | CA2988362C (enExample) |
| CY (1) | CY1124052T1 (enExample) |
| DK (1) | DK3310346T3 (enExample) |
| ES (1) | ES2877476T3 (enExample) |
| HR (1) | HRP20210555T1 (enExample) |
| HU (1) | HUE054551T2 (enExample) |
| LT (1) | LT3310346T (enExample) |
| MA (1) | MA44206B1 (enExample) |
| MD (1) | MD3310346T2 (enExample) |
| PL (1) | PL3310346T3 (enExample) |
| PT (1) | PT3310346T (enExample) |
| RS (1) | RS61777B1 (enExample) |
| SI (1) | SI3310346T1 (enExample) |
| SM (1) | SMT202100350T1 (enExample) |
| WO (1) | WO2016203044A1 (enExample) |
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| HRP20161369T1 (hr) | 2011-06-01 | 2016-12-02 | Estetra S.P.R.L. | Postupak za proizvodnju intermedijera estetrola |
| SG195118A1 (en) | 2011-06-01 | 2013-12-30 | Estetra S A | Process for the production of estetrol intermediates |
| EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| EP3310333B1 (en) | 2015-06-18 | 2020-04-29 | Estetra SPRL | Orodispersible dosage unit containing an estetrol component |
| PL3106148T3 (pl) | 2015-06-18 | 2018-08-31 | Mithra Pharmaceuticals S A | Jednostka dawkowania ulegająca rozpadowi w jamie ustnej zawierająca składnik estetrolowy |
| US10894014B2 (en) | 2015-06-18 | 2021-01-19 | Estetra Sprl | Orodispersible tablet containing Estetrol |
| MD3310346T2 (ro) | 2015-06-18 | 2021-06-30 | Estetra Sprl | Comprimată orodispersabilă ce conține estetrol |
| KR102712911B1 (ko) | 2016-08-05 | 2024-10-04 | 에스테트라, 소시에떼 아 레스폰서빌리떼 리미떼 | 월경통 및 생리통의 관리방법 |
| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| EP3647413A1 (en) * | 2018-10-31 | 2020-05-06 | Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas O.A., M.P. (CIEMAT) | Improvements for performing and facilitating the recovery after hematopoietic stem cell transplantation |
| HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
| GB2603868B (en) * | 2019-09-27 | 2023-10-11 | Ind Chimica Srl | Process for preparing (15ALPHA,16ALPHA,17BETA)-ESTRA-1,3,5(10)-TRIENE-3,15,16,17-tetrol monohydrate (estetrol monohydrate) and intermediates of said process |
| TWI893101B (zh) | 2020-04-16 | 2025-08-11 | 比利時商埃斯特拉有限責任公司 | 具有降低之副作用之避孕組成物 |
| EP4221693A1 (en) | 2020-09-29 | 2023-08-09 | Millicent Pharma Limited | Orodispersible formulations |
| WO2022103638A1 (en) | 2020-11-16 | 2022-05-19 | Orcosa Inc. | Cannabinoids in the treatment of autism spectrum disorder |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
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| US3138588A (en) | 1962-08-24 | 1964-06-23 | American Home Prod | 17-ketals of estrone and derivatives thereof |
| US3433785A (en) | 1966-07-11 | 1969-03-18 | Sterling Drug Inc | 15,16-disubstituted aromatic steroids,intermediates and processes |
| US5073374A (en) | 1988-11-30 | 1991-12-17 | Schering Corporation | Fast dissolving buccal tablet |
| US5340586A (en) | 1991-04-12 | 1994-08-23 | University Of Southern California | Methods and formulations for use in treating oophorectomized women |
| JPH07101977A (ja) | 1993-10-05 | 1995-04-18 | Kureha Chem Ind Co Ltd | ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤 |
| DE4344405C2 (de) | 1993-12-24 | 1995-12-07 | Marika Dr Med Ehrlich | Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption |
| WO1997004752A1 (en) | 1995-07-26 | 1997-02-13 | Duramed Pharmaceuticals, Inc. | Pharmaceutical compositions of conjugated estrogens and methods for their use |
| US6117446A (en) | 1999-01-26 | 2000-09-12 | Place; Virgil A. | Drug dosage unit for buccal administration of steroidal active agents |
| TW548277B (en) | 1999-07-16 | 2003-08-21 | Akzo Nobel Nv | Orally active androgens |
| CA2390226A1 (en) | 1999-12-02 | 2001-06-07 | Akzo Nobel N.V. | 14,15-beta-methylene substituted androgens |
| US20020132801A1 (en) | 2001-01-11 | 2002-09-19 | Schering Aktiengesellschaft | Drospirenone for hormone replacement therapy |
| EP1216713A1 (en) | 2000-12-20 | 2002-06-26 | Schering Aktiengesellschaft | Compositions of estrogen-cyclodextrin complexes |
| EP1260225A1 (en) | 2001-05-18 | 2002-11-27 | Pantarhei Bioscience B.V. | A pharmaceutical composition for use in hormone replacement therapy |
| PT1390040E (pt) | 2001-05-18 | 2007-04-30 | Pantarhei Bioscience Bv | Composição farmacêutica para ser utilizado na terapia hormonal de substituição. |
| WO2002094278A1 (en) | 2001-05-23 | 2002-11-28 | Pantarhei Bioscience B.V. | Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception |
| ES2296943T3 (es) | 2001-05-23 | 2008-05-01 | Pantarhei Bioscience B.V. | Sistema de administracion de un medicamento estrogeno tetrahidroxilado destinado a la contracepcion hormonal. |
| WO2003018026A1 (en) | 2001-08-31 | 2003-03-06 | Pantarhei Bioscience B.V. | Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy |
| DE60216630T2 (de) | 2001-11-15 | 2007-09-20 | Pantarhei Bioscience B.V. | Verwendung von östrogen in kombination mit progestogen für die hormonsubstitutiionstherapie |
| US6723348B2 (en) | 2001-11-16 | 2004-04-20 | Ethypharm | Orodispersible tablets containing fexofenadine |
| HU227198B1 (en) | 2001-11-27 | 2010-10-28 | Richter Gedeon Nyrt | Pharmaceutical composition for emergency contraception containing levonorgestrel |
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2016
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- 2016-06-20 CA CA2988362A patent/CA2988362C/en active Active
- 2016-06-20 CN CN201680035672.3A patent/CN107750157B/zh active Active
- 2016-06-20 LT LTEP16733352.5T patent/LT3310346T/lt unknown
- 2016-06-20 MA MA44206A patent/MA44206B1/fr unknown
- 2016-06-20 RS RS20210486A patent/RS61777B1/sr unknown
- 2016-06-20 SI SI201631150T patent/SI3310346T1/sl unknown
- 2016-06-20 PL PL16733352T patent/PL3310346T3/pl unknown
- 2016-06-20 HU HUE16733352A patent/HUE054551T2/hu unknown
- 2016-06-20 JP JP2017563337A patent/JP6813150B2/ja active Active
- 2016-06-20 ES ES16733352T patent/ES2877476T3/es active Active
- 2016-06-20 HR HRP20210555TT patent/HRP20210555T1/hr unknown
- 2016-06-20 US US15/737,189 patent/US10888518B2/en active Active
- 2016-06-20 DK DK16733352.5T patent/DK3310346T3/da active
- 2016-06-20 EP EP16733352.5A patent/EP3310346B1/en active Active
- 2016-06-20 PT PT167333525T patent/PT3310346T/pt unknown
- 2016-06-20 SM SM20210350T patent/SMT202100350T1/it unknown
- 2016-06-20 WO PCT/EP2016/064181 patent/WO2016203044A1/en not_active Ceased
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Also Published As
| Publication number | Publication date |
|---|---|
| RS61777B1 (sr) | 2021-06-30 |
| DK3310346T3 (da) | 2021-05-25 |
| CY1124052T1 (el) | 2022-05-27 |
| CN107750157B (zh) | 2021-07-13 |
| HUE054551T2 (hu) | 2021-09-28 |
| US20180153801A1 (en) | 2018-06-07 |
| WO2016203044A1 (en) | 2016-12-22 |
| EP3310346A1 (en) | 2018-04-25 |
| JP6813150B2 (ja) | 2021-01-13 |
| PT3310346T (pt) | 2021-04-22 |
| CA2988362A1 (en) | 2016-12-22 |
| EP3310346B1 (en) | 2021-03-24 |
| CN107750157A (zh) | 2018-03-02 |
| SI3310346T1 (sl) | 2021-07-30 |
| JP2018517715A (ja) | 2018-07-05 |
| PL3310346T3 (pl) | 2021-10-25 |
| MD3310346T2 (ro) | 2021-06-30 |
| SMT202100350T1 (it) | 2021-07-12 |
| HK1254649A1 (en) | 2019-07-26 |
| LT3310346T (lt) | 2021-06-10 |
| US10888518B2 (en) | 2021-01-12 |
| MA44206A (fr) | 2018-04-25 |
| HRP20210555T1 (hr) | 2021-05-14 |
| MA44206B1 (fr) | 2021-04-30 |
| ES2877476T3 (es) | 2021-11-16 |
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