DK3310346T3 - Orodispersibel tablet indeholdende estetrol - Google Patents

Orodispersibel tablet indeholdende estetrol Download PDF

Info

Publication number
DK3310346T3
DK3310346T3 DK16733352.5T DK16733352T DK3310346T3 DK 3310346 T3 DK3310346 T3 DK 3310346T3 DK 16733352 T DK16733352 T DK 16733352T DK 3310346 T3 DK3310346 T3 DK 3310346T3
Authority
DK
Denmark
Prior art keywords
tablet containing
orodispersible tablet
containing estetrol
estetrol
orodispersible
Prior art date
Application number
DK16733352.5T
Other languages
Danish (da)
English (en)
Inventor
Séverine Francine Isabelle Jaspart
Johannes Jan Platteeuw
Den Heuvel Denny Johan Marijn Van
Original Assignee
Estetra Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Estetra Sprl filed Critical Estetra Sprl
Application granted granted Critical
Publication of DK3310346T3 publication Critical patent/DK3310346T3/da

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK16733352.5T 2015-06-18 2016-06-20 Orodispersibel tablet indeholdende estetrol DK3310346T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15172755 2015-06-18
PCT/EP2016/064181 WO2016203044A1 (en) 2015-06-18 2016-06-20 Orodispersible tablet containing estetrol

Publications (1)

Publication Number Publication Date
DK3310346T3 true DK3310346T3 (da) 2021-05-25

Family

ID=53476702

Family Applications (1)

Application Number Title Priority Date Filing Date
DK16733352.5T DK3310346T3 (da) 2015-06-18 2016-06-20 Orodispersibel tablet indeholdende estetrol

Country Status (19)

Country Link
US (1) US10888518B2 (enExample)
EP (1) EP3310346B1 (enExample)
JP (1) JP6813150B2 (enExample)
CN (1) CN107750157B (enExample)
CA (1) CA2988362C (enExample)
CY (1) CY1124052T1 (enExample)
DK (1) DK3310346T3 (enExample)
ES (1) ES2877476T3 (enExample)
HR (1) HRP20210555T1 (enExample)
HU (1) HUE054551T2 (enExample)
LT (1) LT3310346T (enExample)
MA (1) MA44206B1 (enExample)
MD (1) MD3310346T2 (enExample)
PL (1) PL3310346T3 (enExample)
PT (1) PT3310346T (enExample)
RS (1) RS61777B1 (enExample)
SI (1) SI3310346T1 (enExample)
SM (1) SMT202100350T1 (enExample)
WO (1) WO2016203044A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107266514A (zh) 2011-06-01 2017-10-20 埃斯特拉私人有限责任公司 用于产生雌四醇中间体的方法
SI2714712T1 (sl) 2011-06-01 2016-11-30 Estetra S.P.R.L. Postopek za proizvodnjo intermediatov estetrola
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
US10894014B2 (en) 2015-06-18 2021-01-19 Estetra Sprl Orodispersible tablet containing Estetrol
JP6863547B2 (ja) 2015-06-18 2021-04-21 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロール成分を含有する口腔内崩壊性投与単位
GEP20217243B (en) 2015-06-18 2021-04-26 Sprl Estetra Orodispersible dosage unit containing an estetrol component
US10888518B2 (en) 2015-06-18 2021-01-12 Estetra Sprl Orodispersible tablet containing estetrol
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
TWI801561B (zh) 2018-04-19 2023-05-11 比利時商依思特拉私人有限責任公司 化合物及其用於緩解絕經相關症狀的用途
JOP20200260A1 (ar) 2018-04-19 2019-10-19 Estetra Sprl مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث
EP3647413A1 (en) * 2018-10-31 2020-05-06 Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas O.A., M.P. (CIEMAT) Improvements for performing and facilitating the recovery after hematopoietic stem cell transplantation
HU231240B1 (hu) 2019-09-03 2022-04-28 Richter Gedeon Nyrt. Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására
ES2915058B2 (es) * 2019-09-27 2024-06-21 Ind Chimica Srl Proceso para preparar (15alfa,16alfa,17beta)-estra-1,3,5(10)-trieno-3,15,16,17-tetrol (Estetrol) e intermedios de dicho proceso
TWI893101B (zh) 2020-04-16 2025-08-11 比利時商埃斯特拉有限責任公司 具有降低之副作用之避孕組成物
JP2023543953A (ja) 2020-09-29 2023-10-18 ミリセント・ファーマ・リミテッド 口腔内分散性配合物
EP4243602A4 (en) 2020-11-16 2024-11-13 Orcosa Inc. Improved use of cannabinoids in the treatment of alzheimer's disease
US11672761B2 (en) 2020-11-16 2023-06-13 Orcosa Inc. Rapidly infusing platform and compositions for therapeutic treatment in humans

Family Cites Families (91)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3138588A (en) 1962-08-24 1964-06-23 American Home Prod 17-ketals of estrone and derivatives thereof
US3433785A (en) 1966-07-11 1969-03-18 Sterling Drug Inc 15,16-disubstituted aromatic steroids,intermediates and processes
US5073374A (en) 1988-11-30 1991-12-17 Schering Corporation Fast dissolving buccal tablet
US5340586A (en) 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
JPH07101977A (ja) 1993-10-05 1995-04-18 Kureha Chem Ind Co Ltd ホルモン作用を軽減した新規なエストラジオール誘導体及びその増殖因子阻害剤
DE4344405C2 (de) 1993-12-24 1995-12-07 Marika Dr Med Ehrlich Ovulationshemmendes Mittel und Verfahren zur hormonalen Kontrazeption
WO1997004752A1 (en) 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions of conjugated estrogens and methods for their use
US6117446A (en) 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
TW548277B (en) 1999-07-16 2003-08-21 Akzo Nobel Nv Orally active androgens
CA2390226A1 (en) 1999-12-02 2001-06-07 Akzo Nobel N.V. 14,15-beta-methylene substituted androgens
US20020132801A1 (en) 2001-01-11 2002-09-19 Schering Aktiengesellschaft Drospirenone for hormone replacement therapy
EP1216713A1 (en) 2000-12-20 2002-06-26 Schering Aktiengesellschaft Compositions of estrogen-cyclodextrin complexes
EP1260225A1 (en) 2001-05-18 2002-11-27 Pantarhei Bioscience B.V. A pharmaceutical composition for use in hormone replacement therapy
DE60217324T2 (de) 2001-05-18 2007-04-26 Pantarhei Bioscience B.V. Pharmazeutische zusammensetzung für die hormonersatztherapie
PT1390042E (pt) 2001-05-23 2008-03-10 Pantarhei Bioscience Bv Sistema de administração de um medicamento que compreende estrogénio tetrahidroxilado destinado à contracepção hormonal
EP1390041B1 (en) 2001-05-23 2009-11-25 Pantarhei Bioscience B.V. Drug delivery system comprising a tetrahydroxylated estrogen for use in hormonal contraception
WO2003018026A1 (en) 2001-08-31 2003-03-06 Pantarhei Bioscience B.V. Use of estrogenic compounds in combination with progestogenic compounds in hormone-replacement therapy
ES2278925T3 (es) 2001-11-15 2007-08-16 Pantarhei Bioscience B.V. Uso de compuestos estrogenicos en combinacion con compuestos progestogenicos en terapias de sustitucion hormonal.
US6723348B2 (en) 2001-11-16 2004-04-20 Ethypharm Orodispersible tablets containing fexofenadine
HU227198B1 (en) 2001-11-27 2010-10-28 Richter Gedeon Nyrt Pharmaceutical composition for emergency contraception containing levonorgestrel
IL163579A0 (en) 2002-02-21 2005-12-18 Schering Ag Pharmaceutical compositions comprising one or moresteroids oneor more tetrahydrofolate components and vitamin B12
US20050147670A1 (en) 2002-05-29 2005-07-07 Impax Laboratories Inc. Oral disintegrating dosage forms
CA2489271C (en) 2002-06-11 2011-12-06 Pantarhei Bioscience B.V. Method of treating or preventing immune mediated disorders and pharmaceutical formulation for use therein
ES2399423T3 (es) 2002-06-11 2013-04-01 Pantarhei Bioscience B.V. Método para tratar la piel humana y una composición para el cuidado de la piel para su uso en tal método
SI1526856T1 (sl) * 2002-07-12 2008-04-30 Pantarhei Bioscience Bv Farmacevtski sestavek, ki obsega estetrolne derivate za uporabo pri zdravljenju raka
JP2005538150A (ja) 2002-08-28 2005-12-15 キャスパー,ロバート エストロゲン補充療法
CA2503549C (en) 2002-10-23 2012-07-10 Pantarhei Bioscience B.V. Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy
AU2003278434A1 (en) 2002-11-05 2004-06-07 Schering Aktiengesellschaft Cardiovascular protection using anti-aldosteronic progestins
PT1562976E (pt) 2002-11-08 2010-08-12 Pantarhei Bioscience Bv Síntese do estetrol via esteróides derivados da estrona
CN100431545C (zh) * 2003-05-22 2008-11-12 潘塔希生物科学股份有限公司 雌激素成分在制备用于治疗及预防肌与骨疼痛中的组合物中的应用
EP1673071A1 (en) 2003-09-29 2006-06-28 Novo Nordisk Femcare AG Improved stability of progestogen formulations
EP2295041A3 (en) 2003-09-29 2012-01-04 Novo Nordisk Femcare AG HRT formulations
EP1535618A1 (en) 2003-11-26 2005-06-01 Schering Aktiengesellschaft Pharmaceutical preparation for continuous hormonal treatment over a period of longer than 21-28 days comprising two estrogen and/or progestin compositions
CN1557291A (zh) * 2004-01-14 2004-12-29 杨喜鸿 那格列奈分散片及其制备方法
MY151322A (en) 2004-04-30 2014-05-15 Bayer Ip Gmbh Management of breakthrough bleeding in extended hormonal contraceptive regimens
GB0410616D0 (en) 2004-05-13 2004-06-16 Unilever Plc Antiperspirant or deodorant compositions
DE102004026670A1 (de) 2004-05-28 2005-12-15 Grünenthal GmbH Hormonales Kontrazeptivum enthaltend eine Kombination aus Ethinylestradiol und Chlormadinonacetat
PE20060318A1 (es) 2004-05-28 2006-06-15 Gruenenthal Chemie Forma de administracion para la contracepcion hormonal
UA89964C2 (ru) 2004-09-08 2010-03-25 Н.В. Органон 15β-ЗАМЕЩЕННЫЕ СТЕРОИДЫ, КОТОРЫЕ ИМЕЮТ СЕЛЕКТИВНУЮ ЭСТРОГЕННУЮ АКТИВНОСТЬ
JP5268635B2 (ja) 2005-05-26 2013-08-21 アボット プロダクツ ゲゼルシャフト ミット ベシュレンクテル ハフツング 17β−HSD1及びSTSインヒビター
US20070048369A1 (en) 2005-08-26 2007-03-01 National Starch And Chemical Investment Holding Corporation Mucosal delivery tablet
WO2007081206A1 (en) 2006-01-09 2007-07-19 Pantarhei Bioscience B.V. A method of treating an acute vascular disorder
MX2008011074A (es) 2006-03-02 2008-09-10 Warner Chilcott Co Inc Metodo anticonceptivo oral multifasico de ciclo prolongado.
WO2007146805A2 (en) 2006-06-08 2007-12-21 Warner Chilcott Company, Inc. Methods to administer solid dosage forms of ethinyl estradiol and prodrugs thereof with improved bioavailabilty
US20080113953A1 (en) 2006-06-08 2008-05-15 Warner Chilcott Company, Inc. Methods to administer solid dosage forms of ethinyl estradiol and prodrugs thereof with improved bioavailability
US20070286819A1 (en) 2006-06-08 2007-12-13 Warner Chilcott Company, Inc. Methods to administer ethinyl estradiol and prodrugs thereof with improved bioavailability
KR20090029824A (ko) 2006-07-06 2009-03-23 바이엘 쉐링 파마 악티엔게젤샤프트 피임용 및 선천성 기형 위험 예방용 제약 제제
CN101489563A (zh) 2006-07-06 2009-07-22 拜耳先灵医药股份有限公司 用于避孕和预防先天性畸形风险的药物制剂
EP2086550A2 (en) 2006-11-29 2009-08-12 Wyeth Estrogen/ serm and estrogen/ progestin bi-layer tablets
AU2007338843B2 (en) 2006-12-20 2013-05-09 Teva Women's Health, Inc. Orally disintegrating solid dosage forms comprising progestin and methods of making and use thereof
CN101583363B (zh) 2007-01-08 2013-08-21 潘塔希生物科学股份有限公司 治疗或预防雌性哺乳动物不育症的方法和此类方法中使用的药物试剂盒
US20080175908A1 (en) 2007-01-12 2008-07-24 Wyeth Tablet-in-tablet compositions
WO2008156365A1 (en) 2007-06-21 2008-12-24 Pantarhei Bioscience B.V. Treatment of meconium aspiration syndrome with estrogens
US8518923B2 (en) 2007-07-19 2013-08-27 Pantarhei Bioscience B.V. Treatment or prevention of hypertensive disorders of pregnancy or fetal growth retardation
JP5399749B2 (ja) 2008-03-27 2014-01-29 沢井製薬株式会社 プロトンポンプ阻害剤を含有する被覆微粒子
WO2010033832A2 (en) 2008-09-19 2010-03-25 Evestra, Inc. Estriol formulations
DE102009007771B4 (de) 2009-02-05 2012-02-16 Bayer Schering Pharma Aktiengesellschaft Bukkales Applikationssystem, 17α-Estradiol enthaltend
BRPI1011815A2 (pt) 2009-06-23 2016-03-29 Bayer Pharma AG "composição farmacêutica para a contracepção de emergência"
CN102058604A (zh) 2009-11-17 2011-05-18 北京万全阳光医学技术有限公司 一种含有地诺孕素和戊酸雌二醇的药物组合物及其制备方法
WO2011128336A1 (en) 2010-04-15 2011-10-20 Bayer Pharma Aktiengesellschaft Very low-dosed solid oral dosage forms for hrt
US10849857B2 (en) 2010-07-28 2020-12-01 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
AR081670A1 (es) 2010-06-29 2012-10-10 Leon Farma Sa Lab Composicion farmaceutica que comprende drospirenona y kit anticonceptivo
US9603860B2 (en) 2010-07-28 2017-03-28 Laboratorios Leon Farma Sa Pharmaceutical compositions comprising active drugs, contraceptive kits comprising active drugs, and methods of administering the same
WO2012055840A1 (en) 2010-10-28 2012-05-03 Bayer Pharma Aktiengesellschaft Composition and preparation for treatment of dysmenorrhea and menstrual pain and use of a hormonal agent and a zinc salt for treatment of menstrual disorders
JP2012240917A (ja) 2011-05-16 2012-12-10 Zensei Yakuhin Kogyo Kk 製剤化用微粒子とそれを含む製剤
CN107266514A (zh) 2011-06-01 2017-10-20 埃斯特拉私人有限责任公司 用于产生雌四醇中间体的方法
SI2714712T1 (sl) 2011-06-01 2016-11-30 Estetra S.P.R.L. Postopek za proizvodnjo intermediatov estetrola
EP2383279A1 (en) 2011-07-19 2011-11-02 Pantarhei Bioscience B.V. Process for the preparation of estetrol
KR102033187B1 (ko) * 2011-07-19 2019-10-16 판타레이 바이오사이언스 비.브이. 디하이드로에피안드로스테론(dhea)을 함유하는 정제
RS55974B1 (sr) * 2011-08-11 2017-09-29 Estetra Sprl Upotreba estetrola kao kontraceptivnog sredstva u hitnim slučajevima
RU2633640C2 (ru) 2011-09-16 2017-10-16 Ферринг Б.В. Быстрорастворимая фармацевтическая композиция
RS55231B1 (sr) 2011-10-07 2017-02-28 Estetra Sprl Postupak proizvodnje estetrola
EP2790688B1 (en) 2011-12-13 2019-11-20 Arstat, Inc. A multiphasic contraceptive regimen for an oral formulation of progestin and estrogen
EP2653163A1 (en) 2012-04-19 2013-10-23 Université de Liège Estrogenic components for use in the treatment of neurological disorders
US9808470B2 (en) 2012-04-19 2017-11-07 Universite De Liege Estrogenic components for use in the treatment of neurological disorders
WO2014159377A1 (en) 2013-03-14 2014-10-02 Teva Women's Health, Inc. Compositions containing tanaproget and natural estrogens
JP6126456B2 (ja) * 2013-05-17 2017-05-10 東和薬品株式会社 打錠用顆粒とその製造方法、その打錠用顆粒を用いた口腔内崩壊錠
EP2999474A4 (en) 2013-05-21 2016-12-28 Predictive Therapeutics Llc THERAPEUTIC AND METHOD FOR USE
JP6254289B2 (ja) 2013-09-18 2017-12-27 クリスタル ファルマ、エセ、ア、ウCrystal Pharma,S.A.U. エステトロールの製造プロセス
SI3079671T1 (en) 2013-12-12 2018-04-30 Donesta Bioscience B.V. Oral disintegration solid dosage form containing an esterol component
WO2016023009A1 (en) 2014-08-07 2016-02-11 Wake Forest University Health Sciences Compositions and methods for clearing a biological sample
US9962395B2 (en) 2014-09-29 2018-05-08 The Regents Of The University Of California Compositions and methods for maintaining cognitive function
WO2016187269A1 (en) 2015-05-18 2016-11-24 Agile Therapeutics, Inc. Contraceptive compositions and methods for improved efficacy and modulation of side effects
GEP20217243B (en) 2015-06-18 2021-04-26 Sprl Estetra Orodispersible dosage unit containing an estetrol component
JP6863547B2 (ja) 2015-06-18 2021-04-21 エステトラ ソシエテ プリーヴ ア レスポンサビリテ リミテ エステトロール成分を含有する口腔内崩壊性投与単位
US10894014B2 (en) 2015-06-18 2021-01-19 Estetra Sprl Orodispersible tablet containing Estetrol
US10888518B2 (en) 2015-06-18 2021-01-12 Estetra Sprl Orodispersible tablet containing estetrol
CN113750108B (zh) 2015-06-23 2025-08-19 莱昂实验室制药股份有限公司 用于过重女性患者的基于屈螺酮的避孕药
CA3178291A1 (en) 2016-08-05 2018-04-12 Estetra Srl Method for the management of dysmenorrhea and menstrual pain
US20200046729A1 (en) 2016-08-05 2020-02-13 Estetra Sprl Methods using combined oral contraceptive compositions with reduced cardiovascular effects
EP4140489A1 (en) 2018-02-07 2023-03-01 Estetra SRL Contraceptive composition with reduced cardiovascular effects

Also Published As

Publication number Publication date
ES2877476T3 (es) 2021-11-16
CN107750157A (zh) 2018-03-02
JP2018517715A (ja) 2018-07-05
CA2988362A1 (en) 2016-12-22
PT3310346T (pt) 2021-04-22
CN107750157B (zh) 2021-07-13
EP3310346A1 (en) 2018-04-25
HRP20210555T1 (hr) 2021-05-14
MA44206A (fr) 2018-04-25
CY1124052T1 (el) 2022-05-27
WO2016203044A1 (en) 2016-12-22
MD3310346T2 (ro) 2021-06-30
PL3310346T3 (pl) 2021-10-25
CA2988362C (en) 2022-07-19
US10888518B2 (en) 2021-01-12
EP3310346B1 (en) 2021-03-24
SI3310346T1 (sl) 2021-07-30
SMT202100350T1 (it) 2021-07-12
RS61777B1 (sr) 2021-06-30
HK1254649A1 (en) 2019-07-26
MA44206B1 (fr) 2021-04-30
HUE054551T2 (hu) 2021-09-28
JP6813150B2 (ja) 2021-01-13
US20180153801A1 (en) 2018-06-07
LT3310346T (lt) 2021-06-10

Similar Documents

Publication Publication Date Title
DK3310346T3 (da) Orodispersibel tablet indeholdende estetrol
DK3310345T3 (da) Orodispersibel tablet indeholdende estetrol
DK3265421T3 (da) Doseringssystem
DK3368108T3 (da) Medikamenttilførselsanordning
EP3754089C0 (de) Dosiereinrichtung
HUE054344T2 (hu) Gyógyászati készítmények AZD9291 tartalommal
LT3298027T (lt) Antihelmintiniai depsipeptido junginiai
SI4070787T1 (sl) Farmacevtske formulacije
ME03728B (me) Orodisperzibilna dozna jedinica koja sadrži komponentu estetrola
DK3310414T3 (da) Lægemiddeladministrationsanordning
HUE043290T2 (hu) Adagoló kapszula
DK3283058T3 (da) Ribociclib-tablet
EP3424940A4 (en) Radiolabeled drug
HUE037383T2 (hu) Egy esztetrol komponenst tartalmazó, szájban diszpergálódó dózisegység
DK3380146T3 (da) Medikamentadministrationsanordning
EP3449912A4 (en) MELTING TABLET
EP3246047C0 (en) COMBINATION MEDICATION
ES1162584Y (es) Aparato dosificador
EP3446684A4 (en) MELTING TABLET
KR20180084810A (ko) 정제 세트
EP3383371C0 (en) PHARMACEUTICAL FORMULATION
DK3280447T3 (da) Farmaceutiske formuleringer
EP3373871C0 (de) Uterotubar-implantat-vorrichtung
DK3215118T3 (da) Lægemiddelanordningsenhed indeholdende quinagolid
DK3163094T3 (da) Fastgørelsesanordning