CA2966634C - Engineered gamma delta t-cells - Google Patents

Engineered gamma delta t-cells Download PDF

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Publication number
CA2966634C
CA2966634C CA2966634A CA2966634A CA2966634C CA 2966634 C CA2966634 C CA 2966634C CA 2966634 A CA2966634 A CA 2966634A CA 2966634 A CA2966634 A CA 2966634A CA 2966634 C CA2966634 C CA 2966634C
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Prior art keywords
cells
cell
engineered
antigen
tumor
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CA2966634A
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English (en)
French (fr)
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CA2966634A1 (en
Inventor
Aya Jakobovits
Orit Foord
Andy An-Deh Lin
Marianne Theresa Santaguida
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Adicet Therapeutics Inc
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Adicet Therapeutics Inc
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    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
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    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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CA2966634A 2014-11-17 2015-11-17 Engineered gamma delta t-cells Active CA2966634C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462080500P 2014-11-17 2014-11-17
US62/080,500 2014-11-17
PCT/US2015/061189 WO2016081518A2 (en) 2014-11-17 2015-11-17 Engineered gamma delta t-cells

Publications (2)

Publication Number Publication Date
CA2966634A1 CA2966634A1 (en) 2016-05-26
CA2966634C true CA2966634C (en) 2024-04-23

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CA2966634A Active CA2966634C (en) 2014-11-17 2015-11-17 Engineered gamma delta t-cells

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US (2) US11135245B2 (https=)
EP (2) EP3220926B1 (https=)
JP (2) JP7146397B2 (https=)
KR (1) KR102660362B1 (https=)
CN (2) CN107249605A (https=)
AU (2) AU2015350103A1 (https=)
CA (1) CA2966634C (https=)
DK (1) DK3220926T3 (https=)
ES (1) ES3023783T3 (https=)
IL (2) IL297773B2 (https=)
MX (1) MX2017006408A (https=)
RU (1) RU2756247C2 (https=)
WO (1) WO2016081518A2 (https=)
ZA (1) ZA201703505B (https=)

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EP1814580B1 (en) 2004-11-24 2016-08-10 Fred Hutchinson Cancer Research Center Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens
GB201506423D0 (en) 2015-04-15 2015-05-27 Tc Biopharm Ltd Gamma delta T cells and uses thereof
IL297773B2 (en) 2014-11-17 2024-07-01 Adicet Bio Inc Engineered gamma delta t-cells
US10501541B2 (en) 2015-01-27 2019-12-10 Lava Therapeutics B.V. Single domain antibodies targeting CD1d
GB201507368D0 (en) 2015-04-30 2015-06-17 Ucl Business Plc Cell
DK3307875T3 (da) * 2015-06-09 2022-03-21 Lymphact Lymphocyte Activation Tech S A Fremgangsmåder til fremstilling af tcr-gamma-delta+-t-celler
ES2965437T3 (es) 2015-09-03 2024-04-15 Uab Res Found Células T modificadas genéticamente resistentes a fármacos y procedimientos de utilización de las mismas
US11299708B2 (en) 2016-05-12 2022-04-12 Adicet Bio, Inc. Methods for selective expansion of γδ T-cell populations and compositions thereof
US10426796B2 (en) * 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
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