PT2710123T - Linha celular de linfócitos compreendendo células t gama-delta, método de composição e produção resultante dos mesmos - Google Patents
Linha celular de linfócitos compreendendo células t gama-delta, método de composição e produção resultante dos mesmosInfo
- Publication number
- PT2710123T PT2710123T PT127279438T PT12727943T PT2710123T PT 2710123 T PT2710123 T PT 2710123T PT 127279438 T PT127279438 T PT 127279438T PT 12727943 T PT12727943 T PT 12727943T PT 2710123 T PT2710123 T PT 2710123T
- Authority
- PT
- Portugal
- Prior art keywords
- lymphocytes
- delta
- gamma
- cells
- composition
- Prior art date
Links
- 210000004027 cell Anatomy 0.000 title 1
- 210000004475 gamma-delta t lymphocyte Anatomy 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/463—Cellular immunotherapy characterised by recombinant expression
- A61K39/4632—T-cell receptors [TCR]; antibody T-cell receptor constructs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/998—Proteins not provided for elsewhere
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT10571411 | 2011-05-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2710123T true PT2710123T (pt) | 2017-10-13 |
Family
ID=46317465
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127279438T PT2710123T (pt) | 2011-05-19 | 2012-05-21 | Linha celular de linfócitos compreendendo células t gama-delta, método de composição e produção resultante dos mesmos |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9499788B2 (pt) |
| EP (1) | EP2710123B1 (pt) |
| JP (1) | JP6086904B2 (pt) |
| CN (1) | CN103635573B (pt) |
| ES (1) | ES2643387T3 (pt) |
| PT (1) | PT2710123T (pt) |
| WO (1) | WO2012156958A2 (pt) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2976579B1 (fr) * | 2011-06-14 | 2013-07-05 | Coatex Sas | Epaississants non ioniques associatifs contenant des alkyls cyclohexylols, formulations les contenant et leurs utilisations |
| WO2013147606A1 (en) | 2012-03-28 | 2013-10-03 | Umc Utrecht Holding B.V. | Combinatorial gamma 9 delta 2 t cell receptor chain exchange |
| GB201304626D0 (en) * | 2013-03-14 | 2013-05-01 | Univ Cardiff | Method of identifying a bacterial infection |
| AU2014339926B2 (en) * | 2013-10-25 | 2018-02-08 | Board Of Regents, The University Of Texas System | Polyclonal gamma delta T cells for immunotherapy |
| MX2017006408A (es) | 2014-11-17 | 2018-03-23 | Adicet Bio Inc | Linfocitos t gamma delta modificados geneticamente. |
| EA201890013A1 (ru) * | 2015-06-09 | 2018-07-31 | Лимфакт - Лимфоцит Активэйшн Текнолоджис, С.А. | Способы получения tcr гамма дельтат-клеток |
| CN115137752A (zh) * | 2015-08-25 | 2022-10-04 | Uab研究基金会 | 用于干细胞移植的方法 |
| CN108473958A (zh) | 2015-10-30 | 2018-08-31 | 癌症研究技术有限公司 | 非造血组织驻留γδT细胞的扩增及这些细胞的用途 |
| WO2017197347A1 (en) * | 2016-05-12 | 2017-11-16 | Adicet Bio, Inc. | METHODS FOR SELECTIVE EXPANSION OF γδ T-CELL POPULATIONS AND COMPOSITIONS THEREOF |
| CN109997041B (zh) | 2016-06-10 | 2022-10-28 | 歌德塔有限公司 | 人白细胞抗原限制的γδT细胞受体及其使用方法 |
| GB201707048D0 (en) * | 2017-05-03 | 2017-06-14 | King S College London | Expansion of gamma delta cells, compositions, and methods of use thereof |
| WO2018229163A1 (en) | 2017-06-14 | 2018-12-20 | King's College London | Methods of activating v delta 2 negative gamma delta t cells |
| GB201804701D0 (en) | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| AU2019311290A1 (en) * | 2018-07-26 | 2021-01-28 | Ospedale Pediatrico Bambino Gesù (Opbg) | Therapeutic preparations of gamma-delta T cells and Natural Killer cells and methods for manufacture and use |
| EP3860645A1 (en) | 2018-10-01 | 2021-08-11 | Adicet Bio Inc. | Compositions and methods regarding engineered and non- engineered gamma-delta t cells for treatment of hematological tumors |
| CN113272016A (zh) | 2018-10-01 | 2021-08-17 | 阿迪塞特生物股份有限公司 | 关于治疗实体肿瘤的工程化和非工程化γδ-T细胞的组合物和方法 |
| AU2019374488A1 (en) * | 2018-11-08 | 2021-05-27 | GammaDelta Therapeutics Limited | Methods for isolating and expanding cells |
| BR112022001416A2 (pt) | 2019-08-16 | 2022-06-21 | Gammadelta Therapeutics Ltd | Populações de células t gama delta ex vivo |
| CN110488012B (zh) * | 2019-08-30 | 2023-02-03 | 广东普锐生物科技有限公司 | 一种新生儿肺炎的辅助诊断试剂盒及应用 |
| EP4051710A1 (en) | 2019-10-31 | 2022-09-07 | MorphoSys AG | Anti-tumor combination therapy comprising anti-cd19 antibody and gamma delta t-cells |
| US20230055186A1 (en) * | 2019-12-27 | 2023-02-23 | Zhaotai Immugene Biomedicine (Hong Kong) Limited | Engineered immune killer cell, preparation method therefor and use thereof |
| AU2022258567A1 (en) * | 2021-04-16 | 2023-11-02 | Acepodia Biotechnologies Ltd. | Novel compositions enriched in gamma delta t cells, methods of preparation, and uses thereof |
| CA3228168A1 (en) | 2021-08-03 | 2023-02-09 | Gammadelta Therapeutics Ltd | Engineering of gamma delta t cells and compositions thereof |
| EP4183871A1 (en) | 2021-11-23 | 2023-05-24 | Université d'Aix-Marseille | Process for preparing a composition comprising a combined cell population |
| WO2023156506A1 (en) | 2022-02-16 | 2023-08-24 | Priothera Sas | Methods of treatment with car cells in combination with s1p receptor modulators |
| WO2023194915A1 (en) | 2022-04-04 | 2023-10-12 | Gammadelta Therapeutics Ltd | Novel gene armoring |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU771710B2 (en) | 1999-01-28 | 2004-04-01 | Palmetto Health Alliance D/B/A Palmetto Richland Memorial Hospital | In vitro activated gamma delta lymphocytes |
| EP3970736A1 (en) | 2009-11-02 | 2022-03-23 | Emory University | Drug resistant immunotherapy for treatment of a cancer |
-
2012
- 2012-05-21 WO PCT/IB2012/052545 patent/WO2012156958A2/en active Application Filing
- 2012-05-21 CN CN201280024189.7A patent/CN103635573B/zh active Active
- 2012-05-21 JP JP2014510941A patent/JP6086904B2/ja active Active
- 2012-05-21 EP EP12727943.8A patent/EP2710123B1/en active Active
- 2012-05-21 PT PT127279438T patent/PT2710123T/pt unknown
- 2012-05-21 ES ES12727943.8T patent/ES2643387T3/es active Active
- 2012-05-21 US US14/118,863 patent/US9499788B2/en active Active - Reinstated
Also Published As
| Publication number | Publication date |
|---|---|
| US20140141513A1 (en) | 2014-05-22 |
| US9499788B2 (en) | 2016-11-22 |
| WO2012156958A3 (en) | 2013-01-17 |
| EP2710123A2 (en) | 2014-03-26 |
| CN103635573A (zh) | 2014-03-12 |
| EP2710123B1 (en) | 2017-07-12 |
| JP6086904B2 (ja) | 2017-03-01 |
| WO2012156958A4 (en) | 2013-04-04 |
| CN103635573B (zh) | 2016-05-11 |
| ES2643387T3 (es) | 2017-11-22 |
| JP2014515259A (ja) | 2014-06-30 |
| WO2012156958A2 (en) | 2012-11-22 |
| WO2012156958A8 (en) | 2013-08-01 |
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