CA2960101C - Substituted carboline derivative and compositions thereof useful as camkii inhibitors - Google Patents

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Publication number

CA2960101C

CA2960101C CA2960101A CA2960101A CA2960101C CA 2960101 C CA2960101 C CA 2960101C CA 2960101 A CA2960101 A CA 2960101A CA 2960101 A CA2960101 A CA 2960101A CA 2960101 C CA2960101 C CA 2960101C

Authority

CA

Canada

Prior art keywords

compound

disorder

condition

disease

group

Prior art date

2014-09-05

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

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• 229940043709 CaM kinase II inhibitor Drugs 0.000 title claims description 10
• 150000001875 compounds Chemical class 0.000 claims abstract description 462
• 238000000034 method Methods 0.000 claims abstract description 84
• 150000003839 salts Chemical class 0.000 claims abstract description 50
• 102000004657 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Human genes 0.000 claims abstract description 10
• 108010003721 Calcium-Calmodulin-Dependent Protein Kinase Type 2 Proteins 0.000 claims abstract description 10
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 156
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 120
• 229910052757 nitrogen Inorganic materials 0.000 claims description 107
• 229910052739 hydrogen Inorganic materials 0.000 claims description 93
• 239000001257 hydrogen Substances 0.000 claims description 93
• -1 piperazino Chemical group 0.000 claims description 92
• 125000005842 heteroatom Chemical group 0.000 claims description 79
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 78
• 229910052717 sulfur Chemical group 0.000 claims description 78
• 239000011593 sulfur Chemical group 0.000 claims description 78
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 76
• 229910052760 oxygen Inorganic materials 0.000 claims description 76
• 239000001301 oxygen Chemical group 0.000 claims description 76
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• 125000001931 aliphatic group Chemical group 0.000 claims description 56
• 125000000623 heterocyclic group Chemical group 0.000 claims description 51
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• 125000001072 heteroaryl group Chemical group 0.000 claims description 49
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• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 15
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