CA2946593A1 - Vecteurs aav pour therapie genique de la retine et du snc - Google Patents
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- CA2946593A1 CA2946593A1 CA2946593A CA2946593A CA2946593A1 CA 2946593 A1 CA2946593 A1 CA 2946593A1 CA 2946593 A CA2946593 A CA 2946593A CA 2946593 A CA2946593 A CA 2946593A CA 2946593 A1 CA2946593 A1 CA 2946593A1
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Abstract
La présente invention concerne des rAAV améliorés (par exemple, rAAV2 rAAVrh8R, etc) pour une thérapie génique améliorée de troubles oculaires ou de troubles du SNC, lesquels rAAV comprennent une ou plusieurs substitutions d'acides aminés qui interagissent avec un protéoglycane à sulfate d'héparane. L'invention concerne la transduction améliorée de cellules rétiniennes et des procédés de traitement de maladies oculaires avec des compositions améliorées de particules de rAAV. En outre l'invention concerne des virus adéno-associés recombinés (rAAV) (par exemple, rAAV2 rAAVrh8R, etc) pour une thérapie génique améliorée de troubles du SNC. L'invention concerne des procédés d'administration de rAAV au SNC, des procédés de traitement de troubles du SNC avec les compositions améliorées de particules de rAAV, et des kits pour administrer le rAAV au SNC et/ou traiter un trouble du SNC.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461988131P | 2014-05-02 | 2014-05-02 | |
US61/988,131 | 2014-05-02 | ||
US201562114575P | 2015-02-10 | 2015-02-10 | |
US62/114,575 | 2015-02-10 | ||
PCT/US2015/028966 WO2015168666A2 (fr) | 2014-05-02 | 2015-05-02 | Vecteurs aav pour thérapie génique de la rétine et du snc |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2946593A1 true CA2946593A1 (fr) | 2015-11-05 |
Family
ID=53189202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2946593A Pending CA2946593A1 (fr) | 2014-05-02 | 2015-05-02 | Vecteurs aav pour therapie genique de la retine et du snc |
Country Status (32)
Country | Link |
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US (2) | US10982228B2 (fr) |
EP (2) | EP3137497B1 (fr) |
JP (3) | JP6741591B2 (fr) |
KR (2) | KR20160147974A (fr) |
CN (2) | CN106661591B (fr) |
AU (3) | AU2015252797C1 (fr) |
BR (1) | BR112016025263A2 (fr) |
CA (1) | CA2946593A1 (fr) |
CL (2) | CL2016002713A1 (fr) |
CR (1) | CR20160555A (fr) |
DK (1) | DK3137497T3 (fr) |
DO (1) | DOP2016000280A (fr) |
EA (1) | EA034355B1 (fr) |
ES (1) | ES2879636T3 (fr) |
GT (1) | GT201600227A (fr) |
HR (1) | HRP20211024T1 (fr) |
HU (1) | HUE054768T2 (fr) |
IL (2) | IL248102B (fr) |
LT (1) | LT3137497T (fr) |
MX (2) | MX2016014220A (fr) |
MY (1) | MY188987A (fr) |
PE (1) | PE20170260A1 (fr) |
PH (1) | PH12016502046A1 (fr) |
PL (1) | PL3137497T4 (fr) |
PT (1) | PT3137497T (fr) |
RS (1) | RS62078B1 (fr) |
SG (3) | SG10201912977RA (fr) |
SI (1) | SI3137497T1 (fr) |
TW (1) | TWI686476B (fr) |
UY (1) | UY36106A (fr) |
WO (1) | WO2015168666A2 (fr) |
ZA (1) | ZA201606763B (fr) |
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