CA2922821C - Device and methods of using device for detection of hyperammonemia - Google Patents

Device and methods of using device for detection of hyperammonemia Download PDF

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Publication number
CA2922821C
CA2922821C CA2922821A CA2922821A CA2922821C CA 2922821 C CA2922821 C CA 2922821C CA 2922821 A CA2922821 A CA 2922821A CA 2922821 A CA2922821 A CA 2922821A CA 2922821 C CA2922821 C CA 2922821C
Authority
CA
Canada
Prior art keywords
sample
biosensor
ammonia
vessel
indophenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2922821A
Other languages
English (en)
French (fr)
Other versions
CA2922821A1 (en
Inventor
Omar Bilal AYYUB
Adam Michael BEHRENS
Peter Kofinas
Marshall Lynn SUMMAR
Juan Manuel CABRERA-LUQUE
Gary Cunningham
Anton Simeonov
Juan MARUGAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Childrens National Medical Center Inc
University of Maryland College Park
Office of Technology Transfer
Original Assignee
Childrens National Medical Center Inc
University of Maryland College Park
Office of Technology Transfer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Childrens National Medical Center Inc, University of Maryland College Park, Office of Technology Transfer filed Critical Childrens National Medical Center Inc
Publication of CA2922821A1 publication Critical patent/CA2922821A1/en
Application granted granted Critical
Publication of CA2922821C publication Critical patent/CA2922821C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4925—Blood measuring blood gas content, e.g. O2, CO2, HCO3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plasma & Fusion (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
CA2922821A 2013-08-30 2014-09-02 Device and methods of using device for detection of hyperammonemia Active CA2922821C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361872149P 2013-08-30 2013-08-30
US61/872,149 2013-08-30
PCT/US2014/053756 WO2015031911A1 (en) 2013-08-30 2014-09-02 Device and methods of using device for detection of hyperammonemia

Publications (2)

Publication Number Publication Date
CA2922821A1 CA2922821A1 (en) 2015-03-05
CA2922821C true CA2922821C (en) 2023-01-03

Family

ID=52587421

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2922821A Active CA2922821C (en) 2013-08-30 2014-09-02 Device and methods of using device for detection of hyperammonemia

Country Status (15)

Country Link
US (2) US9952199B2 (enExample)
EP (2) EP3039422B1 (enExample)
JP (1) JP6646579B2 (enExample)
KR (1) KR102278346B1 (enExample)
CN (1) CN105940300B (enExample)
AU (1) AU2014311977B2 (enExample)
BR (1) BR112016004320B1 (enExample)
CA (1) CA2922821C (enExample)
CL (1) CL2016000467A1 (enExample)
DK (2) DK3039422T3 (enExample)
IL (1) IL244274B (enExample)
MX (1) MX2016002632A (enExample)
SA (1) SA516370640B1 (enExample)
TR (1) TR201903528T4 (enExample)
WO (1) WO2015031911A1 (enExample)

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EP3289353B1 (en) * 2015-04-27 2024-09-25 University of Maryland, College Park Device and methods of using device for detection of hyperammonemia
US10792339B2 (en) 2015-07-17 2020-10-06 Children's National Medical Center Methods and compositions for treating phenylketonuria
CN109803685B (zh) 2016-08-16 2023-02-17 瑞士苏黎世联邦理工学院 跨膜pH-梯度聚合物囊泡及其制备方法
KR101920272B1 (ko) * 2016-11-22 2018-11-20 (주)인트인 조명이 개선된 체액 검사장치
CN110945076B (zh) * 2017-09-12 2023-10-17 苏黎士联邦理工大学 用于定量体液中的氨的跨膜pH梯度聚合物囊泡
US11793431B2 (en) 2018-01-12 2023-10-24 Mayo Foundation For Medical Education And Research Systems and methods for the detection and quantification of ammonia and ammonium in fluids
EP3942285B1 (en) * 2019-03-20 2025-05-14 McMaster University Differential signal biosensing for detecting an analyte
US11156991B2 (en) 2019-06-24 2021-10-26 Nanotronics Imaging, Inc. Predictive process control for a manufacturing process
US20220364076A1 (en) * 2019-07-02 2022-11-17 The Texas A&M University System Microfluidic platform for selective exosome isolation
US12596114B2 (en) 2019-09-20 2026-04-07 The Board Of Trustees Of The Leland Stanford Junior University Electrochemical pre-concentration for improved detection of gaseous species in water
US20220361776A1 (en) * 2019-10-23 2022-11-17 The Regents Of The University Of California Sensing devices based on microneedle arrays for sensing applications including ketone bodies monitoring
CN110806448B (zh) * 2019-11-21 2022-03-22 北京市药品检验所 测定复方氨基酸注射液中游离氨的方法
KR102369697B1 (ko) * 2020-05-18 2022-03-03 국민대학교산학협력단 바이오 센싱 모듈, 바이오 센싱 장치, 및 이를 포함하는 바이오 센싱 시스템
JP7558379B2 (ja) * 2020-07-10 2024-09-30 ラジオメーター・メディカル・アー・ペー・エス 血液ガス分析装置、および血液ガス分析装置を備えるシステム、ならびにその使用
EP3968009B1 (en) * 2020-09-10 2024-11-06 Hach Lange GmbH Method for determining ammonium
US20250000957A1 (en) * 2021-09-16 2025-01-02 Arcturus Therapeutics, Inc. Compositions and methods for treating phenylketonuria
EP4449118A4 (en) 2021-12-14 2025-04-02 Gazi Universitesi Rektorlugu Biosensor system for quantitative measurement of phenylalanine from blood
CN114088026B (zh) * 2022-01-20 2022-04-05 江苏奥琳斯邦装备科技股份有限公司 一种应变测量的热压固化装置以及固化方法
US12030045B1 (en) 2023-01-05 2024-07-09 Sequitur Health Corp. Devices, methods, and systems for deriving ammonia gas from whole blood
US12140534B2 (en) 2023-01-05 2024-11-12 Sequitur Health Corp. Devices, methods, and systems for deriving a permeate from a feed solution
GB2633752B (en) * 2023-09-14 2026-03-11 Palintest Ltd Electrochemical detection of monochloramine and/or ammonia
CN121359911B (zh) * 2025-12-17 2026-02-17 华东师范大学 无创体液采样的同型半胱氨酸检测系统

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Also Published As

Publication number Publication date
EP3540429B1 (en) 2020-11-11
US9952199B2 (en) 2018-04-24
CN105940300A (zh) 2016-09-14
IL244274A0 (en) 2016-04-21
US20180284099A1 (en) 2018-10-04
JP2016529515A (ja) 2016-09-23
AU2014311977A1 (en) 2016-03-17
EP3540429A1 (en) 2019-09-18
DK3039422T3 (en) 2019-03-25
US20160231310A1 (en) 2016-08-11
EP3039422A1 (en) 2016-07-06
BR112016004320B1 (pt) 2022-03-03
WO2015031911A1 (en) 2015-03-05
CA2922821A1 (en) 2015-03-05
JP6646579B2 (ja) 2020-02-14
BR112016004320A2 (pt) 2017-10-24
AU2014311977B2 (en) 2019-02-21
TR201903528T4 (tr) 2019-04-22
EP3039422A4 (en) 2017-04-19
KR102278346B1 (ko) 2021-07-19
DK3540429T3 (da) 2021-02-15
KR20160048204A (ko) 2016-05-03
CL2016000467A1 (es) 2016-10-28
CN105940300B (zh) 2019-01-22
US10620187B2 (en) 2020-04-14
IL244274B (en) 2020-09-30
MX2016002632A (es) 2016-10-04
EP3039422B1 (en) 2019-01-09
SA516370640B1 (ar) 2019-02-24

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