DK3039422T3 - DEVICE AND METHODS FOR USING THE DEVICE FOR THE DETECTION OF HYPERAMMONIA - Google Patents

DEVICE AND METHODS FOR USING THE DEVICE FOR THE DETECTION OF HYPERAMMONIA Download PDF

Info

Publication number
DK3039422T3
DK3039422T3 DK14841207.5T DK14841207T DK3039422T3 DK 3039422 T3 DK3039422 T3 DK 3039422T3 DK 14841207 T DK14841207 T DK 14841207T DK 3039422 T3 DK3039422 T3 DK 3039422T3
Authority
DK
Denmark
Prior art keywords
ammonia
sample
biosensor
disclosure
liter
Prior art date
Application number
DK14841207.5T
Other languages
Danish (da)
English (en)
Inventor
Omar Bilal Ayyub
Adam Michael Behrens
Peter Kofinas
Marshall Lynn Summar
Juan Manuel Cabrera-Luque
Gary Cunningham
Anton Simeonov
Juan MARUGAN
Original Assignee
Univ Maryland
Childrens Nat Medical Ct
Us Health
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland, Childrens Nat Medical Ct, Us Health filed Critical Univ Maryland
Application granted granted Critical
Publication of DK3039422T3 publication Critical patent/DK3039422T3/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4925Blood measuring blood gas content, e.g. O2, CO2, HCO3
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01JMEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28Investigating the spectrum
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28Electrolytic cell components
    • G01N27/30Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/04Endocrine or metabolic disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plasma & Fusion (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
DK14841207.5T 2013-08-30 2014-09-02 DEVICE AND METHODS FOR USING THE DEVICE FOR THE DETECTION OF HYPERAMMONIA DK3039422T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361872149P 2013-08-30 2013-08-30
PCT/US2014/053756 WO2015031911A1 (en) 2013-08-30 2014-09-02 Device and methods of using device for detection of hyperammonemia

Publications (1)

Publication Number Publication Date
DK3039422T3 true DK3039422T3 (en) 2019-03-25

Family

ID=52587421

Family Applications (2)

Application Number Title Priority Date Filing Date
DK19150428.1T DK3540429T3 (da) 2013-08-30 2014-09-02 Indretning og fremgangsmåder til anvendelse af indretning til detektion af hyperammoniæmi
DK14841207.5T DK3039422T3 (en) 2013-08-30 2014-09-02 DEVICE AND METHODS FOR USING THE DEVICE FOR THE DETECTION OF HYPERAMMONIA

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK19150428.1T DK3540429T3 (da) 2013-08-30 2014-09-02 Indretning og fremgangsmåder til anvendelse af indretning til detektion af hyperammoniæmi

Country Status (15)

Country Link
US (2) US9952199B2 (enExample)
EP (2) EP3039422B1 (enExample)
JP (1) JP6646579B2 (enExample)
KR (1) KR102278346B1 (enExample)
CN (1) CN105940300B (enExample)
AU (1) AU2014311977B2 (enExample)
BR (1) BR112016004320B1 (enExample)
CA (1) CA2922821C (enExample)
CL (1) CL2016000467A1 (enExample)
DK (2) DK3540429T3 (enExample)
IL (1) IL244274B (enExample)
MX (1) MX2016002632A (enExample)
SA (1) SA516370640B1 (enExample)
TR (1) TR201903528T4 (enExample)
WO (1) WO2015031911A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160092653A1 (en) * 2014-09-30 2016-03-31 Koninklijke Philips N.V. NUTRITIONAL INTAKE VIEWER (NutriWeb)
EP3289353B1 (en) 2015-04-27 2024-09-25 University of Maryland, College Park Device and methods of using device for detection of hyperammonemia
US10792339B2 (en) 2015-07-17 2020-10-06 Children's National Medical Center Methods and compositions for treating phenylketonuria
DK3500311T3 (da) 2016-08-16 2020-08-17 Eth Zuerich Trans-membran ph-gradient polymersomer og deres anvendelse i rensningen af ammoniak og dens denaturerede analoge
KR101920272B1 (ko) * 2016-11-22 2018-11-20 (주)인트인 조명이 개선된 체액 검사장치
PL3668927T3 (pl) * 2017-09-12 2024-06-24 Eth Zurich Przezbłonowe polimerosomy z gradientem pH do ilościowego oznaczania amoniaku w płynach ustrojowych
CN112292595B (zh) * 2018-01-12 2024-03-08 梅约医学教育与研究基金会 用于检测和定量流体中氨和铵的系统和方法
US20220317082A1 (en) * 2019-03-20 2022-10-06 Mcmaster University Differential signal biosensing for detecting an analyte
US11156991B2 (en) 2019-06-24 2021-10-26 Nanotronics Imaging, Inc. Predictive process control for a manufacturing process
WO2021003392A1 (en) * 2019-07-02 2021-01-07 The Texas A&M University System Microfluidic platform for selective exosome isolation
US20220365059A1 (en) * 2019-09-20 2022-11-17 The Board Trustees Of The Leland Stanford Junior University Electrochemical pre-concentration for improved detection of gaseous species in water
US20220361776A1 (en) * 2019-10-23 2022-11-17 The Regents Of The University Of California Sensing devices based on microneedle arrays for sensing applications including ketone bodies monitoring
CN110806448B (zh) * 2019-11-21 2022-03-22 北京市药品检验所 测定复方氨基酸注射液中游离氨的方法
KR102369697B1 (ko) * 2020-05-18 2022-03-03 국민대학교산학협력단 바이오 센싱 모듈, 바이오 센싱 장치, 및 이를 포함하는 바이오 센싱 시스템
JP7558379B2 (ja) * 2020-07-10 2024-09-30 ラジオメーター・メディカル・アー・ペー・エス 血液ガス分析装置、および血液ガス分析装置を備えるシステム、ならびにその使用
EP3968009B1 (en) * 2020-09-10 2024-11-06 Hach Lange GmbH Method for determining ammonium
US20250000957A1 (en) * 2021-09-16 2025-01-02 Arcturus Therapeutics, Inc. Compositions and methods for treating phenylketonuria
EP4449118A4 (en) 2021-12-14 2025-04-02 Gazi Universitesi Rektorlugu Biosensor system for quantitative measurement of phenylalanine from blood
CN114088026B (zh) * 2022-01-20 2022-04-05 江苏奥琳斯邦装备科技股份有限公司 一种应变测量的热压固化装置以及固化方法
US12030045B1 (en) 2023-01-05 2024-07-09 Sequitur Health Corp. Devices, methods, and systems for deriving ammonia gas from whole blood
US12140534B2 (en) 2023-01-05 2024-11-12 Sequitur Health Corp. Devices, methods, and systems for deriving a permeate from a feed solution
GB2633752A (en) * 2023-09-14 2025-03-26 Palintest Ltd Electrochemical detection of monochloramine and/or ammonia

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5786053A (en) * 1980-11-18 1982-05-28 Yokogawa Hokushin Electric Corp Method and device for measuring amino compound
JPS59187249A (ja) * 1983-04-07 1984-10-24 Fuji Electric Corp Res & Dev Ltd 尿素窒素分析装置
JPS63218860A (ja) * 1987-03-07 1988-09-12 Aoki Hiroko 溶液中のアンモニアの定量方法
US5128015A (en) 1988-03-15 1992-07-07 Tall Oak Ventures Method and apparatus for amperometric diagnostic analysis
JP2739484B2 (ja) * 1988-09-29 1998-04-15 株式会社ヤトロン 自動分析装置用尿素窒素測定試薬
JPH02104272A (ja) * 1988-10-12 1990-04-17 Ricoh Co Ltd 液体検出装置
US4963814A (en) 1989-12-15 1990-10-16 Boehringer Mannheim Corporation Regulated bifurcated power supply
US4999632A (en) 1989-12-15 1991-03-12 Boehringer Mannheim Corporation Analog to digital conversion with noise reduction
US5243516A (en) 1989-12-15 1993-09-07 Boehringer Mannheim Corporation Biosensing instrument and method
US4999582A (en) 1989-12-15 1991-03-12 Boehringer Mannheim Corp. Biosensor electrode excitation circuit
DE4318519C2 (de) 1993-06-03 1996-11-28 Fraunhofer Ges Forschung Elektrochemischer Sensor
US5366609A (en) 1993-06-08 1994-11-22 Boehringer Mannheim Corporation Biosensing meter with pluggable memory key
US5405511A (en) 1993-06-08 1995-04-11 Boehringer Mannheim Corporation Biosensing meter with ambient temperature estimation method and system
CA2153883C (en) 1993-06-08 1999-02-09 Bradley E. White Biosensing meter which detects proper electrode engagement and distinguishes sample and check strips
US5352351A (en) 1993-06-08 1994-10-04 Boehringer Mannheim Corporation Biosensing meter with fail/safe procedures to prevent erroneous indications
US5762770A (en) 1994-02-21 1998-06-09 Boehringer Mannheim Corporation Electrochemical biosensor test strip
AU2365895A (en) 1994-04-26 1995-11-16 Regents Of The University Of Michigan, The Unitary sandwich enzyme immunoassay cassette, device and method of use
US5624537A (en) 1994-09-20 1997-04-29 The University Of British Columbia - University-Industry Liaison Office Biosensor and interface membrane
US5698083A (en) 1995-08-18 1997-12-16 Regents Of The University Of California Chemiresistor urea sensor
JPH09271398A (ja) * 1996-02-09 1997-10-21 Asahi Chem Ind Co Ltd アンモニア測定法および測定用組成物
JP2000146899A (ja) 1998-11-06 2000-05-26 Horiba Ltd アンモニウムイオン測定装置
WO2000057166A1 (en) 1999-03-19 2000-09-28 Sapporo Immuno Diagnostic Laboratory Method of determining substrate, and biosensor
US6662439B1 (en) 1999-10-04 2003-12-16 Roche Diagnostics Corporation Laser defined features for patterned laminates and electrodes
US6645359B1 (en) 2000-10-06 2003-11-11 Roche Diagnostics Corporation Biosensor
US20040186359A1 (en) 2001-07-09 2004-09-23 Beaudoin Stephen P. Afinity biosensor for monitoring biological process
US7150975B2 (en) * 2002-08-19 2006-12-19 Animas Technologies, Llc Hydrogel composition for measuring glucose flux
US9101302B2 (en) 2004-05-03 2015-08-11 Abbott Diabetes Care Inc. Analyte test device
JP2006126092A (ja) * 2004-10-29 2006-05-18 Ntt Advanced Technology Corp 薄層流路および透析膜を有する微小バイオセンサ
US8409864B2 (en) * 2006-01-06 2013-04-02 Renal Solutions, Inc. Ammonia sensor and system for use
US20090294302A1 (en) * 2008-05-28 2009-12-03 John Pasqua Use of Alginate to Reduce Hematocrit Bias in Biosensors
JP2010160134A (ja) * 2008-12-11 2010-07-22 Unitika Ltd 検知材および定量方法
JP2014010145A (ja) 2012-07-02 2014-01-20 Aquatech Co Ltd 液中アンモニアを検知し、反応を制御する装置

Also Published As

Publication number Publication date
CA2922821A1 (en) 2015-03-05
EP3039422A1 (en) 2016-07-06
EP3039422A4 (en) 2017-04-19
DK3540429T3 (da) 2021-02-15
US20160231310A1 (en) 2016-08-11
TR201903528T4 (tr) 2019-04-22
CL2016000467A1 (es) 2016-10-28
US9952199B2 (en) 2018-04-24
US10620187B2 (en) 2020-04-14
KR20160048204A (ko) 2016-05-03
EP3039422B1 (en) 2019-01-09
CA2922821C (en) 2023-01-03
BR112016004320B1 (pt) 2022-03-03
US20180284099A1 (en) 2018-10-04
JP2016529515A (ja) 2016-09-23
SA516370640B1 (ar) 2019-02-24
CN105940300B (zh) 2019-01-22
EP3540429B1 (en) 2020-11-11
IL244274A0 (en) 2016-04-21
AU2014311977A1 (en) 2016-03-17
IL244274B (en) 2020-09-30
WO2015031911A1 (en) 2015-03-05
AU2014311977B2 (en) 2019-02-21
MX2016002632A (es) 2016-10-04
EP3540429A1 (en) 2019-09-18
KR102278346B1 (ko) 2021-07-19
BR112016004320A2 (pt) 2017-10-24
CN105940300A (zh) 2016-09-14
JP6646579B2 (ja) 2020-02-14

Similar Documents

Publication Publication Date Title
DK3039422T3 (en) DEVICE AND METHODS FOR USING THE DEVICE FOR THE DETECTION OF HYPERAMMONIA
EP3289353B1 (en) Device and methods of using device for detection of hyperammonemia
Kong et al. A paper disk equipped with graphene/polyaniline/Au nanoparticles/glucose oxidase biocomposite modified screen-printed electrode: Toward whole blood glucose determination
EP3132049B1 (en) Device and methods of using device for detection of aminoacidopathies
US20250076316A1 (en) Detection of creatine levels using enzyme compositions
US11733197B2 (en) Biosensors produced from enzymes with reduced solubility and methods of production and use thereof
Huang et al. Enzyme-based color bar-style lateral flow strip for equipment-free and semi-quantitative determination of urinary oxalate
JP4600787B2 (ja) クロマトデバイス
CA3057963A1 (en) Methods and devices for the separation, detection and measurement of molecules in liquid samples
EP3264081B1 (en) Dry chemical test strip with multiple layers of membranes based on concentration gradient
Sheeraz et al. Additive-manufactured paper–PMMA hybrid microfluidic chip for simultaneous monitoring of creatinine and pH in artificial urine
Razumiene et al. Development of multi-parameter analyser based on electrochemical urea biosensors and electrolyte electrodes for monitoring of hemodialysis patients
Hinson The rate-based paper detection of vanillin and m-cresol using a colorimetric tyrosinase mediated chitosan-quinone reaction