CN105940300B - 检测高氨血症的装置和使用此类装置的方法 - Google Patents

检测高氨血症的装置和使用此类装置的方法 Download PDF

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Publication number
CN105940300B
CN105940300B CN201480057514.9A CN201480057514A CN105940300B CN 105940300 B CN105940300 B CN 105940300B CN 201480057514 A CN201480057514 A CN 201480057514A CN 105940300 B CN105940300 B CN 105940300B
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sample
biosensor
ammonia
container
concentration
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Chinese (zh)
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CN105940300A (zh
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O·B·阿雅布
A·M·伯赫恩斯
P·科菲纳斯
M·L·萨默
J·M·卡布里拉-卢克
G·坎宁安
A·萨米欧诺夫
J·马鲁甘
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Childrens National Medical Center Inc
University of Maryland College Park
Office of Technology Transfer
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Childrens National Medical Center Inc
University of Maryland College Park
Office of Technology Transfer
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4925—Blood measuring blood gas content, e.g. O2, CO2, HCO3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Ecology (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plasma & Fusion (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
CN201480057514.9A 2013-08-30 2014-09-02 检测高氨血症的装置和使用此类装置的方法 Active CN105940300B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361872149P 2013-08-30 2013-08-30
US61/872,149 2013-08-30
PCT/US2014/053756 WO2015031911A1 (en) 2013-08-30 2014-09-02 Device and methods of using device for detection of hyperammonemia

Publications (2)

Publication Number Publication Date
CN105940300A CN105940300A (zh) 2016-09-14
CN105940300B true CN105940300B (zh) 2019-01-22

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US (2) US9952199B2 (enExample)
EP (2) EP3039422B1 (enExample)
JP (1) JP6646579B2 (enExample)
KR (1) KR102278346B1 (enExample)
CN (1) CN105940300B (enExample)
AU (1) AU2014311977B2 (enExample)
BR (1) BR112016004320B1 (enExample)
CA (1) CA2922821C (enExample)
CL (1) CL2016000467A1 (enExample)
DK (2) DK3540429T3 (enExample)
IL (1) IL244274B (enExample)
MX (1) MX2016002632A (enExample)
SA (1) SA516370640B1 (enExample)
TR (1) TR201903528T4 (enExample)
WO (1) WO2015031911A1 (enExample)

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WO2016176366A1 (en) * 2015-04-27 2016-11-03 University Of Maryland, College Park Device and methods of using device for detection of hyperammonemia
US10792339B2 (en) 2015-07-17 2020-10-06 Children's National Medical Center Methods and compositions for treating phenylketonuria
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KR101920272B1 (ko) * 2016-11-22 2018-11-20 (주)인트인 조명이 개선된 체액 검사장치
PL3668927T3 (pl) * 2017-09-12 2024-06-24 Eth Zurich Przezbłonowe polimerosomy z gradientem pH do ilościowego oznaczania amoniaku w płynach ustrojowych
KR20250103785A (ko) * 2018-01-12 2025-07-07 아리조나 보드 오브 리젠츠 온 비하프 오브 아리조나 스테이트 유니버시티 체액 중의 암모니아 및 암모늄의 검출 및 정량화를 위한 시스템 및 방법
WO2020186362A1 (en) * 2019-03-20 2020-09-24 Mcmaster University Differential signal biosensing for detecting an analyte
US11156991B2 (en) 2019-06-24 2021-10-26 Nanotronics Imaging, Inc. Predictive process control for a manufacturing process
US20220364076A1 (en) * 2019-07-02 2022-11-17 The Texas A&M University System Microfluidic platform for selective exosome isolation
WO2021055792A1 (en) * 2019-09-20 2021-03-25 The Board Of Trustees Of The Leland Stanford Junior University Electrochemical pre-concentration for improved detection of gaseous species in water
AU2020370511A1 (en) * 2019-10-23 2022-06-09 President And Fellows Of Harvard College Sensing devices based on microneedle arrays for sensing applications including ketone bodies monitoring
CN110806448B (zh) * 2019-11-21 2022-03-22 北京市药品检验所 测定复方氨基酸注射液中游离氨的方法
KR102369697B1 (ko) * 2020-05-18 2022-03-03 국민대학교산학협력단 바이오 센싱 모듈, 바이오 센싱 장치, 및 이를 포함하는 바이오 센싱 시스템
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US20250000957A1 (en) * 2021-09-16 2025-01-02 Arcturus Therapeutics, Inc. Compositions and methods for treating phenylketonuria
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CN114088026B (zh) * 2022-01-20 2022-04-05 江苏奥琳斯邦装备科技股份有限公司 一种应变测量的热压固化装置以及固化方法
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CL2016000467A1 (es) 2016-10-28
US20180284099A1 (en) 2018-10-04
EP3039422B1 (en) 2019-01-09
JP6646579B2 (ja) 2020-02-14
DK3540429T3 (da) 2021-02-15
US9952199B2 (en) 2018-04-24
EP3540429A1 (en) 2019-09-18
IL244274A0 (en) 2016-04-21
IL244274B (en) 2020-09-30
KR20160048204A (ko) 2016-05-03
EP3540429B1 (en) 2020-11-11
US10620187B2 (en) 2020-04-14
BR112016004320A2 (pt) 2017-10-24
JP2016529515A (ja) 2016-09-23
EP3039422A4 (en) 2017-04-19
BR112016004320B1 (pt) 2022-03-03
TR201903528T4 (tr) 2019-04-22
AU2014311977B2 (en) 2019-02-21
KR102278346B1 (ko) 2021-07-19
AU2014311977A1 (en) 2016-03-17
CN105940300A (zh) 2016-09-14
SA516370640B1 (ar) 2019-02-24
CA2922821C (en) 2023-01-03
CA2922821A1 (en) 2015-03-05
WO2015031911A1 (en) 2015-03-05
US20160231310A1 (en) 2016-08-11
MX2016002632A (es) 2016-10-04
DK3039422T3 (en) 2019-03-25
EP3039422A1 (en) 2016-07-06

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