BR112016004320B1 - Biossensor, sistema, kit, métodos de determinação ou de identificação e de quantificação de uma concentração de amônia ou íon amônio, de diagnóstico de uma doença metabólica em um sujeito, de determinação da resposta do paciente a uma terapia, de fabricação de um biossensor, de um sistema ou de qualquer tira de teste e de detecção da presença, ausência, ou quantidade de aminoácidos em uma amostra, e, tira de teste - Google Patents

Biossensor, sistema, kit, métodos de determinação ou de identificação e de quantificação de uma concentração de amônia ou íon amônio, de diagnóstico de uma doença metabólica em um sujeito, de determinação da resposta do paciente a uma terapia, de fabricação de um biossensor, de um sistema ou de qualquer tira de teste e de detecção da presença, ausência, ou quantidade de aminoácidos em uma amostra, e, tira de teste Download PDF

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Publication number
BR112016004320B1
BR112016004320B1 BR112016004320-0A BR112016004320A BR112016004320B1 BR 112016004320 B1 BR112016004320 B1 BR 112016004320B1 BR 112016004320 A BR112016004320 A BR 112016004320A BR 112016004320 B1 BR112016004320 B1 BR 112016004320B1
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BR
Brazil
Prior art keywords
ammonia
sample
biosensor
indophenol
concentration
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BR112016004320-0A
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English (en)
Portuguese (pt)
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BR112016004320A2 (pt
Inventor
Omar Bilal Ayyub
Adam Michael Behrens
Peter Kofinas
Marshall Lynn Summar
Juan Manuel Carbrera-Luque
Gary Cunningham
Anton Simeonov
Juan Marugan
Original Assignee
University Of Maryland, College Park
Children's National Medical Center
THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH
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Application filed by University Of Maryland, College Park, Children's National Medical Center, THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OFFICE OF TECHNOLOGY TRANSFER, NATIONAL INSTITUTES OF HEALTH filed Critical University Of Maryland, College Park
Publication of BR112016004320A2 publication Critical patent/BR112016004320A2/pt
Publication of BR112016004320B1 publication Critical patent/BR112016004320B1/pt

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4925—Blood measuring blood gas content, e.g. O2, CO2, HCO3
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/78—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator producing a change of colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Ecology (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Plasma & Fusion (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
BR112016004320-0A 2013-08-30 2014-09-02 Biossensor, sistema, kit, métodos de determinação ou de identificação e de quantificação de uma concentração de amônia ou íon amônio, de diagnóstico de uma doença metabólica em um sujeito, de determinação da resposta do paciente a uma terapia, de fabricação de um biossensor, de um sistema ou de qualquer tira de teste e de detecção da presença, ausência, ou quantidade de aminoácidos em uma amostra, e, tira de teste BR112016004320B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361872149P 2013-08-30 2013-08-30
US61/872,149 2013-08-30
PCT/US2014/053756 WO2015031911A1 (en) 2013-08-30 2014-09-02 Device and methods of using device for detection of hyperammonemia

Publications (2)

Publication Number Publication Date
BR112016004320A2 BR112016004320A2 (pt) 2017-10-24
BR112016004320B1 true BR112016004320B1 (pt) 2022-03-03

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BR112016004320-0A BR112016004320B1 (pt) 2013-08-30 2014-09-02 Biossensor, sistema, kit, métodos de determinação ou de identificação e de quantificação de uma concentração de amônia ou íon amônio, de diagnóstico de uma doença metabólica em um sujeito, de determinação da resposta do paciente a uma terapia, de fabricação de um biossensor, de um sistema ou de qualquer tira de teste e de detecção da presença, ausência, ou quantidade de aminoácidos em uma amostra, e, tira de teste

Country Status (15)

Country Link
US (2) US9952199B2 (enExample)
EP (2) EP3540429B1 (enExample)
JP (1) JP6646579B2 (enExample)
KR (1) KR102278346B1 (enExample)
CN (1) CN105940300B (enExample)
AU (1) AU2014311977B2 (enExample)
BR (1) BR112016004320B1 (enExample)
CA (1) CA2922821C (enExample)
CL (1) CL2016000467A1 (enExample)
DK (2) DK3039422T3 (enExample)
IL (1) IL244274B (enExample)
MX (1) MX2016002632A (enExample)
SA (1) SA516370640B1 (enExample)
TR (1) TR201903528T4 (enExample)
WO (1) WO2015031911A1 (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160092653A1 (en) * 2014-09-30 2016-03-31 Koninklijke Philips N.V. NUTRITIONAL INTAKE VIEWER (NutriWeb)
US10591495B2 (en) 2015-04-27 2020-03-17 University Of Maryland, College Park Device and methods of using device for detection of hyperammonemia
WO2017015154A1 (en) * 2015-07-17 2017-01-26 Children's National Medical Center Methods and compositions for treating phenyltonuria
CN109803685B (zh) 2016-08-16 2023-02-17 瑞士苏黎世联邦理工学院 跨膜pH-梯度聚合物囊泡及其制备方法
KR101920272B1 (ko) * 2016-11-22 2018-11-20 (주)인트인 조명이 개선된 체액 검사장치
PT3668927T (pt) 2017-09-12 2024-04-05 Eth Zuerich Polimersomas transmembranares de gradiente ph para a quantificação de amoníaco em fluidos corporais
WO2019140224A2 (en) 2018-01-12 2019-07-18 Thomas Marylaura Systems and methods for the detection and quantification of ammonia and ammonium in fluids
EP3942285B1 (en) * 2019-03-20 2025-05-14 McMaster University Differential signal biosensing for detecting an analyte
US11156991B2 (en) 2019-06-24 2021-10-26 Nanotronics Imaging, Inc. Predictive process control for a manufacturing process
WO2021003392A1 (en) * 2019-07-02 2021-01-07 The Texas A&M University System Microfluidic platform for selective exosome isolation
US20220365059A1 (en) * 2019-09-20 2022-11-17 The Board Trustees Of The Leland Stanford Junior University Electrochemical pre-concentration for improved detection of gaseous species in water
AU2020370511A1 (en) * 2019-10-23 2022-06-09 President And Fellows Of Harvard College Sensing devices based on microneedle arrays for sensing applications including ketone bodies monitoring
CN110806448B (zh) * 2019-11-21 2022-03-22 北京市药品检验所 测定复方氨基酸注射液中游离氨的方法
KR102369697B1 (ko) * 2020-05-18 2022-03-03 국민대학교산학협력단 바이오 센싱 모듈, 바이오 센싱 장치, 및 이를 포함하는 바이오 센싱 시스템
EP4179317A1 (en) * 2020-07-10 2023-05-17 Radiometer Medical ApS A blood gas analyzer and a system comprising a blood gas analyzer, and use thereof
EP3968009B1 (en) * 2020-09-10 2024-11-06 Hach Lange GmbH Method for determining ammonium
WO2023044381A1 (en) * 2021-09-16 2023-03-23 Arcturus Therapeutics, Inc. Compositions and methods for treating phenylketonuria
EP4449118A4 (en) 2021-12-14 2025-04-02 Gazi Universitesi Rektorlugu Biosensor system for quantitative measurement of phenylalanine from blood
CN114088026B (zh) * 2022-01-20 2022-04-05 江苏奥琳斯邦装备科技股份有限公司 一种应变测量的热压固化装置以及固化方法
US12140534B2 (en) 2023-01-05 2024-11-12 Sequitur Health Corp. Devices, methods, and systems for deriving a permeate from a feed solution
US12030045B1 (en) 2023-01-05 2024-07-09 Sequitur Health Corp. Devices, methods, and systems for deriving ammonia gas from whole blood
GB2633752A (en) * 2023-09-14 2025-03-26 Palintest Ltd Electrochemical detection of monochloramine and/or ammonia

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5786053A (en) * 1980-11-18 1982-05-28 Yokogawa Hokushin Electric Corp Method and device for measuring amino compound
JPS59187249A (ja) * 1983-04-07 1984-10-24 Fuji Electric Corp Res & Dev Ltd 尿素窒素分析装置
JPS63218860A (ja) * 1987-03-07 1988-09-12 Aoki Hiroko 溶液中のアンモニアの定量方法
US5128015A (en) 1988-03-15 1992-07-07 Tall Oak Ventures Method and apparatus for amperometric diagnostic analysis
JP2739484B2 (ja) * 1988-09-29 1998-04-15 株式会社ヤトロン 自動分析装置用尿素窒素測定試薬
JPH02104272A (ja) * 1988-10-12 1990-04-17 Ricoh Co Ltd 液体検出装置
US5243516A (en) 1989-12-15 1993-09-07 Boehringer Mannheim Corporation Biosensing instrument and method
US4999632A (en) 1989-12-15 1991-03-12 Boehringer Mannheim Corporation Analog to digital conversion with noise reduction
US4963814A (en) 1989-12-15 1990-10-16 Boehringer Mannheim Corporation Regulated bifurcated power supply
US4999582A (en) 1989-12-15 1991-03-12 Boehringer Mannheim Corp. Biosensor electrode excitation circuit
DE4318519C2 (de) 1993-06-03 1996-11-28 Fraunhofer Ges Forschung Elektrochemischer Sensor
CA2153883C (en) 1993-06-08 1999-02-09 Bradley E. White Biosensing meter which detects proper electrode engagement and distinguishes sample and check strips
US5405511A (en) 1993-06-08 1995-04-11 Boehringer Mannheim Corporation Biosensing meter with ambient temperature estimation method and system
US5366609A (en) 1993-06-08 1994-11-22 Boehringer Mannheim Corporation Biosensing meter with pluggable memory key
US5352351A (en) 1993-06-08 1994-10-04 Boehringer Mannheim Corporation Biosensing meter with fail/safe procedures to prevent erroneous indications
US5762770A (en) 1994-02-21 1998-06-09 Boehringer Mannheim Corporation Electrochemical biosensor test strip
US5981203A (en) * 1994-04-26 1999-11-09 The Regents Of The University Of Michigan Unitary sandwich enzyme immunoassay cassette, device and method of use
US5624537A (en) * 1994-09-20 1997-04-29 The University Of British Columbia - University-Industry Liaison Office Biosensor and interface membrane
US5698083A (en) 1995-08-18 1997-12-16 Regents Of The University Of California Chemiresistor urea sensor
JPH09271398A (ja) * 1996-02-09 1997-10-21 Asahi Chem Ind Co Ltd アンモニア測定法および測定用組成物
JP2000146899A (ja) * 1998-11-06 2000-05-26 Horiba Ltd アンモニウムイオン測定装置
KR100490762B1 (ko) * 1999-03-19 2005-05-19 가부시키가이샤 삿뽀로 이무노 다이아그노스틱 라보라토리 기질의 정량방법 및 바이오센서
US6662439B1 (en) 1999-10-04 2003-12-16 Roche Diagnostics Corporation Laser defined features for patterned laminates and electrodes
US6645359B1 (en) 2000-10-06 2003-11-11 Roche Diagnostics Corporation Biosensor
AU2002317557A1 (en) 2001-07-09 2003-01-29 Arizona Board Of Regents A Body Corporate Acting On Behalf Of Arizona State University Afinity biosensor for monitoring of biological process
US7150975B2 (en) * 2002-08-19 2006-12-19 Animas Technologies, Llc Hydrogel composition for measuring glucose flux
US9101302B2 (en) 2004-05-03 2015-08-11 Abbott Diabetes Care Inc. Analyte test device
JP2006126092A (ja) * 2004-10-29 2006-05-18 Ntt Advanced Technology Corp 薄層流路および透析膜を有する微小バイオセンサ
US8409864B2 (en) * 2006-01-06 2013-04-02 Renal Solutions, Inc. Ammonia sensor and system for use
US20090294302A1 (en) * 2008-05-28 2009-12-03 John Pasqua Use of Alginate to Reduce Hematocrit Bias in Biosensors
JP2010160134A (ja) * 2008-12-11 2010-07-22 Unitika Ltd 検知材および定量方法
JP2014010145A (ja) * 2012-07-02 2014-01-20 Aquatech Co Ltd 液中アンモニアを検知し、反応を制御する装置

Also Published As

Publication number Publication date
DK3540429T3 (da) 2021-02-15
IL244274A0 (en) 2016-04-21
US20180284099A1 (en) 2018-10-04
DK3039422T3 (en) 2019-03-25
CL2016000467A1 (es) 2016-10-28
BR112016004320A2 (pt) 2017-10-24
TR201903528T4 (tr) 2019-04-22
EP3039422B1 (en) 2019-01-09
IL244274B (en) 2020-09-30
MX2016002632A (es) 2016-10-04
AU2014311977B2 (en) 2019-02-21
KR20160048204A (ko) 2016-05-03
JP6646579B2 (ja) 2020-02-14
EP3039422A1 (en) 2016-07-06
EP3540429A1 (en) 2019-09-18
KR102278346B1 (ko) 2021-07-19
AU2014311977A1 (en) 2016-03-17
US10620187B2 (en) 2020-04-14
CA2922821C (en) 2023-01-03
EP3540429B1 (en) 2020-11-11
SA516370640B1 (ar) 2019-02-24
US20160231310A1 (en) 2016-08-11
CA2922821A1 (en) 2015-03-05
EP3039422A4 (en) 2017-04-19
JP2016529515A (ja) 2016-09-23
CN105940300B (zh) 2019-01-22
US9952199B2 (en) 2018-04-24
CN105940300A (zh) 2016-09-14
WO2015031911A1 (en) 2015-03-05

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/09/2014, OBSERVADAS AS CONDICOES LEGAIS.