CA2913849A1 - Dihydroetorphine for the provision of pain relief and anaesthesia - Google Patents
Dihydroetorphine for the provision of pain relief and anaesthesia Download PDFInfo
- Publication number
- CA2913849A1 CA2913849A1 CA2913849A CA2913849A CA2913849A1 CA 2913849 A1 CA2913849 A1 CA 2913849A1 CA 2913849 A CA2913849 A CA 2913849A CA 2913849 A CA2913849 A CA 2913849A CA 2913849 A1 CA2913849 A1 CA 2913849A1
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- Prior art keywords
- dihydroetorphine
- administration
- dose
- subject
- level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
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- LOXCOAXRHYDLOW-UHFFFAOYSA-N phenadoxone Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)CC)CC(C)N1CCOCC1 LOXCOAXRHYDLOW-UHFFFAOYSA-N 0.000 description 1
- 229950004540 phenadoxone Drugs 0.000 description 1
- ZQHYKVKNPWDQSL-KNXBSLHKSA-N phenazocine Chemical compound C([C@@]1(C)C2=CC(O)=CC=C2C[C@@H]2[C@@H]1C)CN2CCC1=CC=CC=C1 ZQHYKVKNPWDQSL-KNXBSLHKSA-N 0.000 description 1
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- 229960000436 phendimetrazine Drugs 0.000 description 1
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- 229950011496 phenomorphan Drugs 0.000 description 1
- IPOPQVVNCFQFRK-UHFFFAOYSA-N phenoperidine Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCC(O)C1=CC=CC=C1 IPOPQVVNCFQFRK-UHFFFAOYSA-N 0.000 description 1
- 229960004315 phenoperidine Drugs 0.000 description 1
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- PXXKIYPSXYFATG-UHFFFAOYSA-N piminodine Chemical compound C1CC(C(=O)OCC)(C=2C=CC=CC=2)CCN1CCCNC1=CC=CC=C1 PXXKIYPSXYFATG-UHFFFAOYSA-N 0.000 description 1
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- ZXWAUWBYASJEOE-UHFFFAOYSA-N proheptazine Chemical compound C=1C=CC=CC=1C1(OC(=O)CC)CCCN(C)CC1C ZXWAUWBYASJEOE-UHFFFAOYSA-N 0.000 description 1
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- XJKQCILVUHXVIQ-UHFFFAOYSA-N properidine Chemical compound C=1C=CC=CC=1C1(C(=O)OC(C)C)CCN(C)CC1 XJKQCILVUHXVIQ-UHFFFAOYSA-N 0.000 description 1
- 229950004345 properidine Drugs 0.000 description 1
- JCRIVQIOJSSCQD-UHFFFAOYSA-N propylhexedrine Chemical compound CNC(C)CC1CCCCC1 JCRIVQIOJSSCQD-UHFFFAOYSA-N 0.000 description 1
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- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P23/00—Anaesthetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/09—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems
- C07D489/10—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14
- C07D489/12—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: containing 4aH-8, 9 c-Iminoethano- phenanthro [4, 5-b, c, d] furan ring systems condensed with carbocyclic rings or ring systems with a bridge between positions 6 and 14 the bridge containing only two carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Anesthesiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Dermatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1309654.0 | 2013-05-30 | ||
| GBGB1309654.0A GB201309654D0 (en) | 2013-05-30 | 2013-05-30 | Method |
| PCT/GB2014/000206 WO2014191710A1 (en) | 2013-05-30 | 2014-05-30 | Dihydroetorphine for the provision of pain relief and anaesthesia |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2913849A1 true CA2913849A1 (en) | 2014-12-04 |
Family
ID=48805475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2913849A Abandoned CA2913849A1 (en) | 2013-05-30 | 2014-05-30 | Dihydroetorphine for the provision of pain relief and anaesthesia |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10898479B2 (OSRAM) |
| EP (1) | EP3003310A1 (OSRAM) |
| JP (3) | JP2016520114A (OSRAM) |
| KR (1) | KR20160013977A (OSRAM) |
| CN (1) | CN105555274A (OSRAM) |
| AU (1) | AU2014272924B2 (OSRAM) |
| BR (1) | BR112015029709A2 (OSRAM) |
| CA (1) | CA2913849A1 (OSRAM) |
| GB (1) | GB201309654D0 (OSRAM) |
| HK (1) | HK1222585A1 (OSRAM) |
| MX (1) | MX2015016418A (OSRAM) |
| PH (1) | PH12015502655A1 (OSRAM) |
| WO (1) | WO2014191710A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI3287123T1 (sl) | 2011-03-04 | 2020-07-31 | Gruenenthal Gmbh | Vodna farmacevtska formulacija tapentadola za peroralno uporabo |
| PT3479823T (pt) | 2015-03-27 | 2020-09-29 | Gruenenthal Gmbh | Formulação estável para administração parentérica de tapentadol |
| GB201513442D0 (en) * | 2015-07-30 | 2015-09-16 | Euro Celtique Sa | Transdermal patch |
| EP3515412B1 (en) | 2016-09-23 | 2025-04-23 | Grünenthal GmbH | Stable formulation for parenteral administration of tapentadol |
| WO2018153947A1 (en) | 2017-02-23 | 2018-08-30 | Grünenthal GmbH | Tapentadol as local anesthetic |
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| GB937214A (en) | 1961-06-02 | 1963-09-18 | J F Macfarlan & Company Ltd | Oripavine derivatives |
| GB925723A (en) | 1960-09-05 | 1963-05-08 | J F Macfarlan & Company Ltd | Novel thebaine derivatives |
| JPS59184182A (ja) | 1983-04-02 | 1984-10-19 | Res Inst For Prod Dev | ３−ベンゾイルチオ−４、５α−エポキシ−７α−〔１（Ｒ）−ヒドロキシ−１−メチルベンチル〕−６−メトキシ−１７−メチル−６、１４−エンド−エタノモルヒナン |
| JPS62153214A (ja) | 1985-12-26 | 1987-07-08 | Nitto Electric Ind Co Ltd | 医薬製剤 |
| JPS62281815A (ja) | 1986-05-27 | 1987-12-07 | Teisan Seiyaku Kk | 貼付剤及びその製造法 |
| JPS63201119A (ja) | 1987-02-17 | 1988-08-19 | Kao Corp | 貼付剤組成物 |
| US4891377A (en) | 1988-12-02 | 1990-01-02 | Board Of Regents Acting For And On Behalf Of University Of Michigan | Transdermal delivery of the narcotic analgesics etorphine and analogs |
| PT95069B (pt) | 1989-08-24 | 1997-10-31 | Searle & Co | Processo para a preparacao de (+)-isomeros de derivados de endoetano/endoetanoepoximofinano, uteis como agentes anti-tussicos |
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2013
- 2013-05-30 GB GBGB1309654.0A patent/GB201309654D0/en not_active Ceased
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2014
- 2014-05-30 JP JP2016516232A patent/JP2016520114A/ja active Pending
- 2014-05-30 EP EP14731983.4A patent/EP3003310A1/en not_active Ceased
- 2014-05-30 US US14/894,775 patent/US10898479B2/en not_active Expired - Fee Related
- 2014-05-30 BR BR112015029709A patent/BR112015029709A2/pt not_active IP Right Cessation
- 2014-05-30 MX MX2015016418A patent/MX2015016418A/es unknown
- 2014-05-30 HK HK16110921.5A patent/HK1222585A1/zh unknown
- 2014-05-30 AU AU2014272924A patent/AU2014272924B2/en not_active Ceased
- 2014-05-30 WO PCT/GB2014/000206 patent/WO2014191710A1/en not_active Ceased
- 2014-05-30 CN CN201480042250.XA patent/CN105555274A/zh active Pending
- 2014-05-30 KR KR1020157036442A patent/KR20160013977A/ko not_active Ceased
- 2014-05-30 CA CA2913849A patent/CA2913849A1/en not_active Abandoned
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2015
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2019
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2020
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- 2020-09-30 US US17/038,651 patent/US20210085673A1/en not_active Abandoned
Also Published As
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|---|---|
| EP3003310A1 (en) | 2016-04-13 |
| PH12015502655A1 (en) | 2016-03-07 |
| JP2016520114A (ja) | 2016-07-11 |
| GB201309654D0 (en) | 2013-07-17 |
| AU2014272924A1 (en) | 2016-01-28 |
| AU2014272924B2 (en) | 2019-05-02 |
| JP2020200345A (ja) | 2020-12-17 |
| WO2014191710A1 (en) | 2014-12-04 |
| HK1222585A1 (zh) | 2017-07-07 |
| US10898479B2 (en) | 2021-01-26 |
| BR112015029709A2 (pt) | 2017-07-25 |
| KR20160013977A (ko) | 2016-02-05 |
| US20210085673A1 (en) | 2021-03-25 |
| US20160106736A1 (en) | 2016-04-21 |
| JP2019123730A (ja) | 2019-07-25 |
| CN105555274A (zh) | 2016-05-04 |
| MX2015016418A (es) | 2016-11-08 |
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