CA2887203A1 - 2,3-(hetero)aryl substituted pyridinyl compounds and their use as gdf-8 inhibitors - Google Patents

2,3-(hetero)aryl substituted pyridinyl compounds and their use as gdf-8 inhibitors Download PDF

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Publication number
CA2887203A1
CA2887203A1 CA2887203A CA2887203A CA2887203A1 CA 2887203 A1 CA2887203 A1 CA 2887203A1 CA 2887203 A CA2887203 A CA 2887203A CA 2887203 A CA2887203 A CA 2887203A CA 2887203 A1 CA2887203 A1 CA 2887203A1
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Prior art keywords
pyridin
fluoro
methylphenyl
pyridine
imidazo
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Pending
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CA2887203A
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English (en)
French (fr)
Inventor
Somasekhar Bhamidipati
Marina Gelman
Pingyu Ding
Rajinder Singh
Jeffrey Clough
Todd Kinsella
Donald Payan
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Rigel Pharmaceuticals Inc
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Rigel Pharmaceuticals Inc
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Application filed by Rigel Pharmaceuticals Inc filed Critical Rigel Pharmaceuticals Inc
Publication of CA2887203A1 publication Critical patent/CA2887203A1/en
Pending legal-status Critical Current

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C07F9/65038—Five-membered rings having the nitrogen atoms in the positions 1 and 2 condensed with carbocyclic rings or carbocyclic ring systems

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  • Chemical & Material Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Epidemiology (AREA)
CA2887203A 2012-10-05 2013-10-04 2,3-(hetero)aryl substituted pyridinyl compounds and their use as gdf-8 inhibitors Pending CA2887203A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261710449P 2012-10-05 2012-10-05
US61/710,449 2012-10-05
PCT/US2013/063585 WO2014055955A1 (en) 2012-10-05 2013-10-04 Gdf-8 inhibitors

Publications (1)

Publication Number Publication Date
CA2887203A1 true CA2887203A1 (en) 2014-04-10

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CA2887203A Pending CA2887203A1 (en) 2012-10-05 2013-10-04 2,3-(hetero)aryl substituted pyridinyl compounds and their use as gdf-8 inhibitors

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US (3) US9145433B2 (cg-RX-API-DMAC7.html)
EP (1) EP2903978B1 (cg-RX-API-DMAC7.html)
JP (2) JP6457942B2 (cg-RX-API-DMAC7.html)
KR (1) KR20150072412A (cg-RX-API-DMAC7.html)
CN (1) CN104837832B (cg-RX-API-DMAC7.html)
AU (1) AU2013326867B2 (cg-RX-API-DMAC7.html)
BR (1) BR112015007182A2 (cg-RX-API-DMAC7.html)
CA (1) CA2887203A1 (cg-RX-API-DMAC7.html)
CL (1) CL2015000851A1 (cg-RX-API-DMAC7.html)
EA (1) EA201590693A1 (cg-RX-API-DMAC7.html)
IL (1) IL238031A0 (cg-RX-API-DMAC7.html)
MA (1) MA38050B1 (cg-RX-API-DMAC7.html)
MX (1) MX2015004151A (cg-RX-API-DMAC7.html)
PE (1) PE20150767A1 (cg-RX-API-DMAC7.html)
PH (1) PH12015500719A1 (cg-RX-API-DMAC7.html)
SA (1) SA515360229B1 (cg-RX-API-DMAC7.html)
SG (1) SG11201502527UA (cg-RX-API-DMAC7.html)
TN (1) TN2015000121A1 (cg-RX-API-DMAC7.html)
WO (1) WO2014055955A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201503041B (cg-RX-API-DMAC7.html)

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ME03654B (me) 2014-02-13 2020-07-20 Incyte Corp Ciklopropilamini kao lsd1 inhibitori
PE20161384A1 (es) 2014-02-13 2016-12-28 Incyte Corp Ciclopropilaminas como inhibidores de lsd 1
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
ES2759240T3 (es) * 2014-04-08 2020-05-08 Rigel Pharmaceuticals Inc Compuestos de piridina 2,3-disustituidos como inhibidores de TGF-beta
JP6513105B2 (ja) 2014-04-22 2019-05-15 ウニヴェルズィテート バーゼル トリアジン、ピリミジン及びピリジン誘導体の新規製造方法
CN103965192B (zh) * 2014-05-20 2016-01-13 定陶县友帮化工有限公司 一种6-氯咪唑并[1,2-a]吡啶-3-甲酸的合成方法
CN103965191A (zh) * 2014-05-20 2014-08-06 定陶县友帮化工有限公司 一种6-溴咪唑并[1,2-a]吡啶-3-甲酸的合成方法
CN103965190A (zh) * 2014-05-20 2014-08-06 定陶县友帮化工有限公司 一种咪唑并[1,2-a]吡啶-3-甲酸的合成方法
US9394305B2 (en) * 2014-06-23 2016-07-19 Dr. Reddy's Laboratories Ltd. Substituted imidazo[1,2-a]pyridine compounds as tropomyosin receptor kinase a (TrkA) inhibitors
US9695168B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
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