CA2878481A1 - Method for preparing substituted triazolopyridines - Google Patents

Method for preparing substituted triazolopyridines Download PDF

Info

Publication number
CA2878481A1
CA2878481A1 CA2878481A CA2878481A CA2878481A1 CA 2878481 A1 CA2878481 A1 CA 2878481A1 CA 2878481 A CA2878481 A CA 2878481A CA 2878481 A CA2878481 A CA 2878481A CA 2878481 A1 CA2878481 A1 CA 2878481A1
Authority
CA
Canada
Prior art keywords
amino
phenyl
pyridin
triazolo
fluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2878481A
Other languages
English (en)
French (fr)
Inventor
Volker Schulze
Franz-Josef Mais
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CA2878481A1 publication Critical patent/CA2878481A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2878481A 2012-07-10 2013-07-03 Method for preparing substituted triazolopyridines Abandoned CA2878481A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
EP12175640 2012-07-10
EP12175640.7 2012-07-10
EP12185590.2 2012-09-24
EP12185590 2012-09-24
EP13170585 2013-06-05
EP13170585.7 2013-06-05
PCT/EP2013/064017 WO2014009219A1 (en) 2012-07-10 2013-07-03 Method for preparing substituted triazolopyridines

Publications (1)

Publication Number Publication Date
CA2878481A1 true CA2878481A1 (en) 2014-01-16

Family

ID=48793197

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2878481A Abandoned CA2878481A1 (en) 2012-07-10 2013-07-03 Method for preparing substituted triazolopyridines

Country Status (24)

Country Link
US (1) US9388177B2 (en:Method)
EP (1) EP2872506A1 (en:Method)
JP (1) JP6238979B2 (en:Method)
KR (1) KR20150040845A (en:Method)
CN (1) CN104603136B (en:Method)
AP (1) AP3778A (en:Method)
AU (1) AU2013289381A1 (en:Method)
BR (1) BR112015000308A2 (en:Method)
CA (1) CA2878481A1 (en:Method)
CL (1) CL2015000038A1 (en:Method)
CO (1) CO7160002A2 (en:Method)
CR (1) CR20150006A (en:Method)
DO (1) DOP2015000007A (en:Method)
EA (1) EA027544B1 (en:Method)
HK (1) HK1206731A1 (en:Method)
IL (1) IL236265A (en:Method)
IN (1) IN2015DN00085A (en:Method)
MX (1) MX2015000348A (en:Method)
NZ (1) NZ703020A (en:Method)
PE (1) PE20150354A1 (en:Method)
PH (1) PH12015500061A1 (en:Method)
SG (1) SG11201408419QA (en:Method)
TN (1) TN2015000008A1 (en:Method)
WO (1) WO2014009219A1 (en:Method)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016527193A (ja) * 2013-06-07 2016-09-08 バイエル・ファルマ・アクティエンゲゼルシャフト 置換トリアゾロピリジン
HUE033131T2 (en) * 2013-06-11 2017-11-28 Bayer Pharma AG Derivatives of substituted triazolopyridines
HK1219879A1 (zh) 2013-06-11 2017-04-21 Bayer Pharma Aktiengesellschaft 用於治疗癌症的包含mps-1激酶抑制剂和有丝分裂抑制剂的组合
CN114592061A (zh) 2015-04-17 2022-06-07 荷兰转化研究中心有限责任公司 用于ttk抑制剂化疗的预后生物标记
TW201800408A (zh) 2016-06-15 2018-01-01 拜耳製藥公司 Mps-1抑制劑

Family Cites Families (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003030937A1 (en) * 2001-10-05 2003-04-17 Ono Pharmaceutical Co., Ltd. Remedies for stress diseases comprising mitochondrial benzodiazepine receptor antagonists
US20060074102A1 (en) * 2004-05-14 2006-04-06 Kevin Cusack Kinase inhibitors as therapeutic agents
UA89503C2 (uk) * 2004-09-13 2010-02-10 Х. Луннбек А/С Заміщені похідні аніліну
WO2006038116A2 (en) * 2004-10-07 2006-04-13 Warner-Lambert Company Llc Triazolopyridine derivatives as antibacterial agents
US20060194823A1 (en) * 2004-12-22 2006-08-31 Georg Kettschau Sulfonamido-macrocycles as Tie2 inhibitors and the salts thereof, a pharmaceutical composition comprising these compounds, the method of preparing and the use thereof
CN101516883A (zh) * 2006-06-06 2009-08-26 先灵公司 作为蛋白激酶抑制剂的咪唑并吡嗪化合物
EP1870416A1 (en) * 2006-06-21 2007-12-26 Bayer Schering Pharma Aktiengesellschaft Sulphonamido-macrocycles as tie2 inhibitors
MX2009002171A (es) 2006-08-30 2009-05-28 Cellzome Ltd Derivados de triazol como inhibidores de cinasas.
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
CA2693232A1 (en) 2007-07-18 2009-01-22 Novartis Ag Bicyclic heteroaryl compounds and their use as kinase inhibitors
EA201000341A1 (ru) 2007-08-23 2010-10-29 Астразенека Аб 2-анилинопурин-8-оны в качестве ингибиторов ttk/mps1 для лечения пролиферативных нарушений
MX2010002312A (es) 2007-08-31 2010-03-18 Merck Serono Sa Compuestos de triazolopiridina y su uso como inhibidores de cinasa reguladora de señal de apoptosis.
GB0719803D0 (en) 2007-10-10 2007-11-21 Cancer Rec Tech Ltd Therapeutic compounds and their use
GB0724342D0 (en) * 2007-12-13 2008-01-30 Prolysis Ltd Anitbacterial compositions
US8530689B2 (en) * 2008-05-05 2013-09-10 The Trustees Of The University Of Pennsylvania Processes for the preparation of biphenyl compounds
US20110212053A1 (en) * 2008-06-19 2011-09-01 Dapeng Qian Phosphatidylinositol 3 kinase inhibitors
SG173610A1 (en) 2009-02-13 2011-09-29 Fovea Pharmaceuticals Sa [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors
EP2424537B1 (en) 2009-04-29 2015-07-08 Bayer Intellectual Property GmbH Substituted imidazoquinoxalines
WO2010141360A1 (en) * 2009-06-05 2010-12-09 Merck Sharp & Dohme Corp. Biaryl benzotriazole derivatives
BRPI1009637A2 (pt) * 2009-06-05 2019-04-30 Cephalon, Inc composto, composição e uso de um composto
EP2473498A1 (en) 2009-09-04 2012-07-11 Bayer Pharma Aktiengesellschaft Substituted aminoquinoxalines as tyrosine threonine kinase inhibitors
EP2343297A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridines
EP2343294A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Substituted triazolopyridines
EP2343295A1 (en) * 2009-11-30 2011-07-13 Bayer Schering Pharma AG Triazolopyridine derivates
UY33452A (es) * 2010-06-16 2012-01-31 Bayer Schering Pharma Ag Triazolopiridinas sustituidas
WO2012044567A2 (en) * 2010-09-30 2012-04-05 Merck Sharp & Dohme Corp. Imidazole derivatives
JP5989091B2 (ja) * 2011-04-21 2016-09-07 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ トリアゾロピリジン類
WO2012160029A1 (en) * 2011-05-23 2012-11-29 Bayer Intellectual Property Gmbh Substituted triazolopyridines
UA112096C2 (uk) * 2011-12-12 2016-07-25 Байєр Інтеллектуал Проперті Гмбх Заміщені триазолопіридини та їх застосування як інгібіторів ttk

Also Published As

Publication number Publication date
KR20150040845A (ko) 2015-04-15
CO7160002A2 (es) 2015-01-15
PH12015500061A1 (en) 2015-03-02
CN104603136A (zh) 2015-05-06
US20150148542A1 (en) 2015-05-28
HK1206731A1 (en) 2016-01-15
CN104603136B (zh) 2017-06-27
JP2015523372A (ja) 2015-08-13
AP2014008177A0 (en) 2014-12-31
IL236265A (en) 2017-07-31
IL236265A0 (en) 2015-02-26
PE20150354A1 (es) 2015-03-21
EA027544B1 (ru) 2017-08-31
JP6238979B2 (ja) 2017-11-29
MX2015000348A (es) 2015-04-14
IN2015DN00085A (en:Method) 2015-05-29
AP3778A (en) 2016-08-31
TN2015000008A1 (en) 2016-06-29
EA201590116A1 (ru) 2015-07-30
CL2015000038A1 (es) 2015-03-13
AU2013289381A1 (en) 2015-01-22
US9388177B2 (en) 2016-07-12
EP2872506A1 (en) 2015-05-20
NZ703020A (en) 2017-08-25
CR20150006A (es) 2015-02-16
WO2014009219A1 (en) 2014-01-16
DOP2015000007A (es) 2015-02-15
BR112015000308A2 (pt) 2017-06-27
SG11201408419QA (en) 2015-01-29

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Legal Events

Date Code Title Description
FZDE Discontinued

Effective date: 20190703