CA2869058C - Pharmaceutical formulations comprising ccr3 antagonists - Google Patents

Pharmaceutical formulations comprising ccr3 antagonists Download PDF

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Publication number
CA2869058C
CA2869058C CA2869058A CA2869058A CA2869058C CA 2869058 C CA2869058 C CA 2869058C CA 2869058 A CA2869058 A CA 2869058A CA 2869058 A CA2869058 A CA 2869058A CA 2869058 C CA2869058 C CA 2869058C
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CA
Canada
Prior art keywords
pharmaceutical composition
diluent
composition according
disintegrant
lubricant
Prior art date
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Active
Application number
CA2869058A
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English (en)
French (fr)
Other versions
CA2869058A1 (en
Inventor
Alfred FETSCHER
Jochen Matthias SCHER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alkahest Inc
Original Assignee
Alkahest Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49292482&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2869058(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Alkahest Inc filed Critical Alkahest Inc
Publication of CA2869058A1 publication Critical patent/CA2869058A1/en
Application granted granted Critical
Publication of CA2869058C publication Critical patent/CA2869058C/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
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    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1617Organic compounds, e.g. phospholipids, fats
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    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
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    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/2022Organic macromolecular compounds
    • A61K9/2031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
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    • A61K9/2853Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers, poly(lactide-co-glycolide)
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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2869058A 2012-04-04 2013-04-02 Pharmaceutical formulations comprising ccr3 antagonists Active CA2869058C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12163078.4 2012-04-04
EP12163078 2012-04-04
PCT/EP2013/056867 WO2013149987A1 (en) 2012-04-04 2013-04-02 Pharmaceutical formulations comprising ccr3 antagonists

Publications (2)

Publication Number Publication Date
CA2869058A1 CA2869058A1 (en) 2013-10-10
CA2869058C true CA2869058C (en) 2020-07-07

Family

ID=49292482

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2869058A Active CA2869058C (en) 2012-04-04 2013-04-02 Pharmaceutical formulations comprising ccr3 antagonists

Country Status (31)

Country Link
US (3) US10213421B2 (enEXAMPLES)
EP (3) EP2833864B1 (enEXAMPLES)
JP (4) JP6320990B2 (enEXAMPLES)
KR (2) KR102138709B1 (enEXAMPLES)
CN (1) CN104203213A (enEXAMPLES)
AR (1) AR090596A1 (enEXAMPLES)
AU (1) AU2013245028B2 (enEXAMPLES)
BR (1) BR112014024479A8 (enEXAMPLES)
CA (1) CA2869058C (enEXAMPLES)
CL (1) CL2014002524A1 (enEXAMPLES)
CY (1) CY1121137T1 (enEXAMPLES)
DK (2) DK3524230T3 (enEXAMPLES)
EA (1) EA027627B1 (enEXAMPLES)
ES (2) ES2898179T3 (enEXAMPLES)
HR (1) HRP20190069T1 (enEXAMPLES)
HU (2) HUE041519T2 (enEXAMPLES)
IL (1) IL234299A (enEXAMPLES)
IN (1) IN2014DN07082A (enEXAMPLES)
LT (1) LT2833864T (enEXAMPLES)
MX (1) MX358307B (enEXAMPLES)
NZ (1) NZ628993A (enEXAMPLES)
PH (1) PH12014502241A1 (enEXAMPLES)
PL (2) PL2833864T3 (enEXAMPLES)
PT (2) PT2833864T (enEXAMPLES)
RS (1) RS58360B1 (enEXAMPLES)
SI (1) SI2833864T1 (enEXAMPLES)
SM (1) SMT201900121T1 (enEXAMPLES)
TR (1) TR201821285T4 (enEXAMPLES)
TW (1) TW201400115A (enEXAMPLES)
UY (1) UY34730A (enEXAMPLES)
WO (1) WO2013149987A1 (enEXAMPLES)

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US8278302B2 (en) 2009-04-08 2012-10-02 Boehringer Ingelheim International Gmbh Substituted piperidines as CCR3 antagonists
UA109290C2 (uk) 2010-10-07 2015-08-10 Спільні кристали і солі інгібіторів ccr3
AR090566A1 (es) 2012-04-02 2014-11-19 Boehringer Ingelheim Int Proceso para la produccion de inhibidores de crr
US20130261153A1 (en) * 2012-04-03 2013-10-03 Boehringer Ingelheim International Gmbh Use of ccr3-inhibitors
US10213421B2 (en) 2012-04-04 2019-02-26 Alkahest, Inc. Pharmaceutical formulations comprising CCR3 antagonists
EP3606521B1 (en) * 2017-04-05 2023-04-19 Alkahest, Inc. Compounds and pharmaceutical compositions for use in treating retina-associated disease using ccr3-inhibitors
MX394341B (es) 2017-04-05 2025-03-24 Alkahest Inc Metodos y composiciones para tratar deterioros asociados con el envejecimiento usando inhibidores de ccr3
SG11202002437VA (en) * 2017-10-13 2020-04-29 Alkahest Inc Methods and compositions for treating pruritus, xerosis, and associated disease using ccr3-inhibitors
MY198220A (en) 2018-05-15 2023-08-14 Alkahest Inc Treatment Of Aging-Associated Disease With Modulators Of Leukotriene A4 Hydrolase
KR20210065950A (ko) * 2018-09-26 2021-06-04 알카헤스트 인코포레이티드 Ccr3-억제제를 사용한 노화 관련 장애 치료를 위한 방법 및 조성물
JPWO2022045226A1 (enEXAMPLES) 2020-08-27 2022-03-03
AU2022376563A1 (en) 2021-11-01 2023-12-07 Alkahest, Inc. Benzodioxane modulators of leukotriene a4 hydrolase (lta4h) for prevention and treatment of aging-associated diseases

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