CA2849040C - Antimicrobial peptides from tilapia (oreochromis niloticus) - Google Patents
Antimicrobial peptides from tilapia (oreochromis niloticus) Download PDFInfo
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- CA2849040C CA2849040C CA2849040A CA2849040A CA2849040C CA 2849040 C CA2849040 C CA 2849040C CA 2849040 A CA2849040 A CA 2849040A CA 2849040 A CA2849040 A CA 2849040A CA 2849040 C CA2849040 C CA 2849040C
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- 238000007865 diluting Methods 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 238000004520 electroporation Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- ZMMJGEGLRURXTF-UHFFFAOYSA-N ethidium bromide Chemical compound [Br-].C12=CC(N)=CC=C2C2=CC=C(N)C=C2[N+](CC)=C1C1=CC=CC=C1 ZMMJGEGLRURXTF-UHFFFAOYSA-N 0.000 description 1
- 229960005542 ethidium bromide Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 210000003918 fraction a Anatomy 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
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- 238000001502 gel electrophoresis Methods 0.000 description 1
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- 210000004943 gill filament Anatomy 0.000 description 1
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 1
- 230000009036 growth inhibition Effects 0.000 description 1
- 230000002008 hemorrhagic effect Effects 0.000 description 1
- 102000018511 hepcidin Human genes 0.000 description 1
- 108060003558 hepcidin Proteins 0.000 description 1
- 229940066919 hepcidin Drugs 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 230000005965 immune activity Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
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- 230000002458 infectious effect Effects 0.000 description 1
- 230000001524 infective effect Effects 0.000 description 1
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- 230000005764 inhibitory process Effects 0.000 description 1
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- 239000002054 inoculum Substances 0.000 description 1
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- 238000001990 intravenous administration Methods 0.000 description 1
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- 125000003473 lipid group Chemical group 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
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- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
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- 125000003729 nucleotide group Chemical group 0.000 description 1
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- 229940049954 penicillin Drugs 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
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- 235000011007 phosphoric acid Nutrition 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 238000007747 plating Methods 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000000164 protein isolation Methods 0.000 description 1
- 229940116540 protein supplement Drugs 0.000 description 1
- 235000005974 protein supplement Nutrition 0.000 description 1
- 238000003259 recombinant expression Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 108091008146 restriction endonucleases Proteins 0.000 description 1
- 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
- 238000003757 reverse transcription PCR Methods 0.000 description 1
- 239000003161 ribonuclease inhibitor Substances 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
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- 238000000926 separation method Methods 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
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- 210000004989 spleen cell Anatomy 0.000 description 1
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- 230000001131 transforming effect Effects 0.000 description 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1706—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/461—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from fish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Marine Sciences & Fisheries (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Fodder In General (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CU2011-0181 | 2011-09-30 | ||
| CU20110181A CU24076B1 (es) | 2011-09-30 | 2011-09-30 | Composición para el control de patógenos |
| PCT/CU2012/000005 WO2013044890A1 (es) | 2011-09-30 | 2012-10-01 | Secuencias de aminoácidos para el control de patógenos |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2849040A1 CA2849040A1 (en) | 2013-04-04 |
| CA2849040C true CA2849040C (en) | 2019-11-26 |
Family
ID=47143463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2849040A Active CA2849040C (en) | 2011-09-30 | 2012-10-01 | Antimicrobial peptides from tilapia (oreochromis niloticus) |
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| Country | Link |
|---|---|
| US (1) | US9549978B2 (enExample) |
| EP (1) | EP2767290B1 (enExample) |
| JP (1) | JP6034385B2 (enExample) |
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| AU (1) | AU2012315083B2 (enExample) |
| BR (1) | BR112014007491B1 (enExample) |
| CA (1) | CA2849040C (enExample) |
| CL (1) | CL2014000760A1 (enExample) |
| CU (1) | CU24076B1 (enExample) |
| ES (1) | ES2600903T3 (enExample) |
| MX (1) | MX348934B (enExample) |
| RU (1) | RU2636001C2 (enExample) |
| WO (1) | WO2013044890A1 (enExample) |
| ZA (1) | ZA201402171B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104262485B (zh) * | 2014-04-15 | 2017-01-18 | 四川农业大学 | 罗非鱼sIgM截短重链恒定区蛋白多克隆抗体及其制备方法 |
| CN105061575B (zh) * | 2015-02-03 | 2020-08-04 | 浙江海洋学院 | 一种金枪鱼肝脏抗菌肽及其制备方法和用途 |
| CN109350731A (zh) * | 2018-12-18 | 2019-02-19 | 汕尾市维明生物科技股份有限公司 | 一种罗非鱼蛋白肽在制备免疫制剂中的应用 |
| CN112979763A (zh) * | 2021-03-03 | 2021-06-18 | 山东大学 | 一种基于可溶性疏水载体抗菌肽Oreoch-2的液相合成方法 |
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| US20030056244A1 (en) * | 2000-05-02 | 2003-03-20 | Ning Huang | Feed additive compositions and methods |
| US6753407B2 (en) * | 2000-08-15 | 2004-06-22 | North Carolina State University | Antimicrobial peptides isolated from fish |
| AU2001287178A1 (en) * | 2000-08-15 | 2002-02-25 | North Carolina State University | Antimicrobial peptides isolated from mast cells |
| WO2004018706A2 (en) * | 2002-08-22 | 2004-03-04 | National Research Council Of Canada | A genomic approach to identification of novel broad-spectrum antimicrobial peptides from bony fish |
| EP1838331A4 (en) * | 2004-12-15 | 2012-12-26 | Univ Colorado | ANTIMICROBIAL PEPTIDES AND METHOD OF USE |
| RU2302467C1 (ru) * | 2005-12-01 | 2007-07-10 | Институт биоорганической химии им. академиков М.М. Шемякина и Ю.А. Овчинникова Российской академии наук | Пептиды латарцины, проявляющие антимикробную активность |
| US20090186047A1 (en) * | 2006-04-25 | 2009-07-23 | Intercell Ag | HCV Vaccinations |
| TWI299335B (en) * | 2006-12-05 | 2008-08-01 | Academia Sinica | Anti-microbal peptides and uses thereof |
| WO2009149554A1 (en) * | 2008-06-11 | 2009-12-17 | National Research Council Of Canada | Antimicrobial components of the mucus and extruded slime of hagfish (myxine glutinosa) |
| CN103665170A (zh) * | 2008-12-05 | 2014-03-26 | 安吉奥开米公司 | 肽治疗剂轭合物及其应用 |
| US20100184684A1 (en) * | 2009-01-06 | 2010-07-22 | C3 Jian, Inc. | Antibacterial and antifungal peptides |
| US8389679B2 (en) * | 2009-02-05 | 2013-03-05 | The Regents Of The University Of California | Targeted antimicrobial moieties |
| CN101559214A (zh) * | 2009-05-27 | 2009-10-21 | 珍奥集团股份有限公司 | 具有增强免疫功能作用的组合物及其用途 |
| CN102021172A (zh) * | 2010-06-23 | 2011-04-20 | 广西壮族自治区水产研究所 | 罗非鱼白细胞 cAMP 诱导早期抑制因子基因序列及用途 |
| EP2661451B1 (en) * | 2011-01-07 | 2019-10-09 | Valiant Biopharma SDN BHD | Antimicrobial fusion compounds and uses thereof |
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2011
- 2011-09-30 CU CU20110181A patent/CU24076B1/es active IP Right Grant
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2012
- 2012-09-27 AR ARP120103606A patent/AR088176A1/es unknown
- 2012-10-01 CN CN201280050943.4A patent/CN103874502B/zh active Active
- 2012-10-01 EP EP12783080.0A patent/EP2767290B1/en not_active Not-in-force
- 2012-10-01 JP JP2014532244A patent/JP6034385B2/ja active Active
- 2012-10-01 CA CA2849040A patent/CA2849040C/en active Active
- 2012-10-01 WO PCT/CU2012/000005 patent/WO2013044890A1/es not_active Ceased
- 2012-10-01 RU RU2014117659A patent/RU2636001C2/ru active
- 2012-10-01 AU AU2012315083A patent/AU2012315083B2/en active Active
- 2012-10-01 MX MX2014003892A patent/MX348934B/es active IP Right Grant
- 2012-10-01 KR KR1020147009805A patent/KR101986358B1/ko active Active
- 2012-10-01 BR BR112014007491-7A patent/BR112014007491B1/pt active IP Right Grant
- 2012-10-01 ES ES12783080.0T patent/ES2600903T3/es active Active
- 2012-10-01 US US14/346,562 patent/US9549978B2/en active Active
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2014
- 2014-03-24 ZA ZA2014/02171A patent/ZA201402171B/en unknown
- 2014-03-27 CL CL2014000760A patent/CL2014000760A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201402171B (en) | 2015-12-23 |
| CU24076B1 (es) | 2015-01-29 |
| KR101986358B1 (ko) | 2019-06-05 |
| ES2600903T3 (es) | 2017-02-13 |
| KR20140070597A (ko) | 2014-06-10 |
| AR088176A1 (es) | 2014-05-14 |
| RU2014117659A (ru) | 2015-11-10 |
| CA2849040A1 (en) | 2013-04-04 |
| CL2014000760A1 (es) | 2014-08-22 |
| CU20110181A7 (es) | 2013-05-31 |
| US9549978B2 (en) | 2017-01-24 |
| US20140294871A1 (en) | 2014-10-02 |
| MX348934B (es) | 2017-07-03 |
| EP2767290A1 (en) | 2014-08-20 |
| WO2013044890A1 (es) | 2013-04-04 |
| AU2012315083A1 (en) | 2014-05-08 |
| AU2012315083B2 (en) | 2016-02-25 |
| BR112014007491A2 (pt) | 2017-04-04 |
| CN103874502B (zh) | 2015-11-25 |
| CN103874502A (zh) | 2014-06-18 |
| EP2767290B1 (en) | 2016-09-14 |
| BR112014007491B1 (pt) | 2022-03-03 |
| JP6034385B2 (ja) | 2016-11-30 |
| RU2636001C2 (ru) | 2017-11-17 |
| MX2014003892A (es) | 2014-07-09 |
| JP2014533931A (ja) | 2014-12-18 |
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Legal Events
| Date | Code | Title | Description |
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| EEER | Examination request |
Effective date: 20170718 |