CA2830616C - Pharmaceutical composition for treating hepatic disease - Google Patents

Pharmaceutical composition for treating hepatic disease Download PDF

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Publication number
CA2830616C
CA2830616C CA2830616A CA2830616A CA2830616C CA 2830616 C CA2830616 C CA 2830616C CA 2830616 A CA2830616 A CA 2830616A CA 2830616 A CA2830616 A CA 2830616A CA 2830616 C CA2830616 C CA 2830616C
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CA
Canada
Prior art keywords
liver
proanthocyanidin
pharmaceutical composition
bel
group
Prior art date
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Application number
CA2830616A
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English (en)
French (fr)
Other versions
CA2830616A1 (en
Inventor
Shau-Feng Chang
Chun-Hsien Ma
Kuo-Yi Yang
Shyh-Horng Lin
Chien-Tung Lin
Kai-wen HUANG
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Belx Bio Pharmaceutical Taiwan Corp
Original Assignee
Industrial Technology Research Institute ITRI
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Publication of CA2830616A1 publication Critical patent/CA2830616A1/en
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/45—Ericaceae or Vacciniaceae (Heath or Blueberry family), e.g. blueberry, cranberry or bilberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Botany (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
CA2830616A 2011-03-22 2011-03-22 Pharmaceutical composition for treating hepatic disease Active CA2830616C (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2011/072045 WO2012126178A2 (zh) 2011-03-22 2011-03-22 减缓肝癌恶化、改善肝功能、改善肝纤维化、改善肝硬化、改善肝发炎及促进受损肝脏再生之药物组合物

Publications (2)

Publication Number Publication Date
CA2830616A1 CA2830616A1 (en) 2012-09-27
CA2830616C true CA2830616C (en) 2017-02-21

Family

ID=46879777

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2830616A Active CA2830616C (en) 2011-03-22 2011-03-22 Pharmaceutical composition for treating hepatic disease

Country Status (13)

Country Link
EP (1) EP2689777B1 (enExample)
JP (1) JP6166251B2 (enExample)
KR (2) KR101981378B1 (enExample)
CN (1) CN103442709B (enExample)
AU (1) AU2011362905B2 (enExample)
CA (1) CA2830616C (enExample)
DK (1) DK2689777T3 (enExample)
ES (1) ES2668785T3 (enExample)
NO (1) NO2689777T3 (enExample)
PL (1) PL2689777T3 (enExample)
RU (1) RU2561688C2 (enExample)
SG (1) SG193486A1 (enExample)
WO (1) WO2012126178A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2838528B1 (en) * 2012-12-26 2025-08-06 Belx Bio-Pharmaceutical (Taiwan) Corporation Methods for inhibition of shc-1/p66 to combat aging-related diseases

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104774909A (zh) * 2014-10-17 2015-07-15 江苏大学 一种原花青素诱导肝癌细胞自噬性死亡的分析方法及应用
GB201909709D0 (en) * 2019-07-05 2019-08-21 Univ Liverpool Biomarkers for irritable bowel syndrome
WO2022080846A1 (ko) * 2020-10-13 2022-04-21 서울대학교병원 플라본을 포함하는 섬유증의 예방 또는 치료용 조성물
WO2022205137A1 (zh) * 2021-03-31 2022-10-06 贝尔克斯生技股份有限公司 高聚原花青素组合物及其应用
CN115010720B (zh) * 2022-06-02 2023-08-11 中国科学院昆明植物研究所 中甸艾中倍半萜二聚体及其药物组合物与其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713506B2 (en) * 2000-10-11 2004-03-30 University Of South Florida Tea polyphenol esters and analogs thereof for cancer prevention and treatment
CN1443533A (zh) * 2002-03-07 2003-09-24 程彦杰 原花青素类化合物在用于制备解酒保肝产品方面的用途
TW200505468A (en) * 2003-08-11 2005-02-16 Suntory Ltd Agent for improving hepato-bililary dysfunction
WO2005074632A2 (en) * 2004-01-30 2005-08-18 Mars, Incorporated Methods and compositions for treating cancer
US20070054868A1 (en) * 2005-06-20 2007-03-08 The Trustees Of Columbia University In The City Of New York Synergistic polyphenol compounds, compositions thereof, and uses thereof
JP2008156265A (ja) * 2006-12-22 2008-07-10 Yamagata Prefecture Ａ型プロアントシアニジンオリゴマー画分及びその製造方法
JP2008195672A (ja) * 2007-02-14 2008-08-28 Okayama Univ 経口摂取用組成物及び経口摂取用組成物の製造方法
JP4822291B2 (ja) * 2008-03-14 2011-11-24 財団法人宮崎県産業支援財団 肝線維化抑制剤
TWI370736B (en) * 2008-12-31 2012-08-21 Ind Tech Res Inst Pharmaceutical composition for treating hepatitis b and heath food for inhibiting hepatitis b virus
CN101822372A (zh) * 2009-03-05 2010-09-08 财团法人工业技术研究院 用以治疗b型肝炎的药学组合物与抑制b型肝炎病毒的保健食品
CN101507730B (zh) * 2009-03-26 2011-01-26 复旦大学 表没食子儿茶素没食子酸酯与柔红霉素的组合物及其应用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2838528B1 (en) * 2012-12-26 2025-08-06 Belx Bio-Pharmaceutical (Taiwan) Corporation Methods for inhibition of shc-1/p66 to combat aging-related diseases

Also Published As

Publication number Publication date
PL2689777T3 (pl) 2018-08-31
CN103442709A (zh) 2013-12-11
JP2014508785A (ja) 2014-04-10
WO2012126178A3 (zh) 2012-11-22
RU2013146602A (ru) 2015-04-27
KR101981378B1 (ko) 2019-05-22
ES2668785T3 (es) 2018-05-22
AU2011362905B2 (en) 2015-11-12
KR20140020966A (ko) 2014-02-19
KR20160143868A (ko) 2016-12-14
CA2830616A1 (en) 2012-09-27
DK2689777T3 (en) 2018-05-22
CN103442709B (zh) 2018-10-19
EP2689777A4 (en) 2014-09-17
EP2689777A2 (en) 2014-01-29
NO2689777T3 (enExample) 2018-08-25
AU2011362905A1 (en) 2013-10-31
WO2012126178A2 (zh) 2012-09-27
RU2561688C2 (ru) 2015-08-27
JP6166251B2 (ja) 2017-07-19
SG193486A1 (en) 2013-10-30
EP2689777B1 (en) 2018-03-28

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