CN103442709A - 用于治疗肝脏疾病的药物组合物 - Google Patents
用于治疗肝脏疾病的药物组合物 Download PDFInfo
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- CN103442709A CN103442709A CN2011800694765A CN201180069476A CN103442709A CN 103442709 A CN103442709 A CN 103442709A CN 2011800694765 A CN2011800694765 A CN 2011800694765A CN 201180069476 A CN201180069476 A CN 201180069476A CN 103442709 A CN103442709 A CN 103442709A
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Abstract
本发明提供一种减缓肝癌恶化、改善肝功能、改善肝纤维化、改善肝硬化、改善肝发炎及促进受损肝脏再生之药物组合物，包括：一有效量之原花青素；以及一药学上可接受之载体或盐类，其中该原花青素之单体具有下列化学式。
上述化学式中，当R1为OCH3时，R2为OH，R3为H，当R1为OH时，R2为H，R3为H，当R1为OH时，R2为OH，R3为H或当R1为OH时，R2为OH，R3为OH，R4为3-(α)-OH、3-(β)-OH、3-(α)-O-sugar或3-(β)-O-sugar。
Description
PCT国内申请，说明书已公开。
Claims (1)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/CN2011/072045 WO2012126178A2 (zh) | 2011-03-22 | 2011-03-22 | 减缓肝癌恶化、改善肝功能、改善肝纤维化、改善肝硬化、改善肝发炎及促进受损肝脏再生之药物组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103442709A true CN103442709A (zh) | 2013-12-11 |
| CN103442709B CN103442709B (zh) | 2018-10-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201180069476.5A Active CN103442709B (zh) | 2011-03-22 | 2011-03-22 | 减缓肝癌恶化、改善肝功能、改善肝纤维化、改善肝硬化、改善肝发炎及促进受损肝脏再生之药物组合物 |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2689777B1 (zh) |
| JP (1) | JP6166251B2 (zh) |
| KR (2) | KR20140020966A (zh) |
| CN (1) | CN103442709B (zh) |
| AU (1) | AU2011362905B2 (zh) |
| CA (1) | CA2830616C (zh) |
| DK (1) | DK2689777T3 (zh) |
| ES (1) | ES2668785T3 (zh) |
| NO (1) | NO2689777T3 (zh) |
| PL (1) | PL2689777T3 (zh) |
| RU (1) | RU2561688C2 (zh) |
| SG (1) | SG193486A1 (zh) |
| WO (1) | WO2012126178A2 (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI807738B (zh) * | 2021-03-31 | 2023-07-01 | 貝爾克斯生技股份有限公司 | 高聚原花青素組合物及其應用 |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140179774A1 (en) * | 2012-12-26 | 2014-06-26 | Industrial Technology Research Institute | Methods for inhibition of shc-1/p66 to combat aging-related diseases |
| CN104774909A (zh) * | 2014-10-17 | 2015-07-15 | 江苏大学 | 一种原花青素诱导肝癌细胞自噬性死亡的分析方法及应用 |
| WO2022080846A1 (ko) * | 2020-10-13 | 2022-04-21 | 서울대학교병원 | 플라본을 포함하는 섬유증의 예방 또는 치료용 조성물 |
| CN115010720B (zh) * | 2022-06-02 | 2023-08-11 | 中国科学院昆明植物研究所 | 中甸艾中倍半萜二聚体及其药物组合物与其制备方法和应用 |
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| US6713506B2 (en) * | 2000-10-11 | 2004-03-30 | University Of South Florida | Tea polyphenol esters and analogs thereof for cancer prevention and treatment |
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| US20070054868A1 (en) * | 2005-06-20 | 2007-03-08 | The Trustees Of Columbia University In The City Of New York | Synergistic polyphenol compounds, compositions thereof, and uses thereof |
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-
2011
- 2011-03-22 SG SG2013069604A patent/SG193486A1/en unknown
- 2011-03-22 JP JP2014500226A patent/JP6166251B2/ja active Active
- 2011-03-22 AU AU2011362905A patent/AU2011362905B2/en active Active
- 2011-03-22 DK DK11861553.3T patent/DK2689777T3/en active
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- 2011-03-22 PL PL11861553T patent/PL2689777T3/pl unknown
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| CN1933818A (zh) * | 2004-01-30 | 2007-03-21 | 马尔斯公司 | 用于治疗癌症的方法和组合物 |
| JP2009242374A (ja) * | 2008-03-14 | 2009-10-22 | Miyazakiken Sangyo Shien Zaidan | 肝線維化抑制剤 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI807738B (zh) * | 2021-03-31 | 2023-07-01 | 貝爾克斯生技股份有限公司 | 高聚原花青素組合物及其應用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2689777A4 (en) | 2014-09-17 |
| SG193486A1 (en) | 2013-10-30 |
| CN103442709B (zh) | 2018-10-19 |
| PL2689777T3 (pl) | 2018-08-31 |
| JP6166251B2 (ja) | 2017-07-19 |
| WO2012126178A3 (zh) | 2012-11-22 |
| KR20140020966A (ko) | 2014-02-19 |
| EP2689777B1 (en) | 2018-03-28 |
| ES2668785T3 (es) | 2018-05-22 |
| RU2561688C2 (ru) | 2015-08-27 |
| WO2012126178A2 (zh) | 2012-09-27 |
| CA2830616A1 (en) | 2012-09-27 |
| EP2689777A2 (en) | 2014-01-29 |
| JP2014508785A (ja) | 2014-04-10 |
| KR101981378B1 (ko) | 2019-05-22 |
| AU2011362905B2 (en) | 2015-11-12 |
| KR20160143868A (ko) | 2016-12-14 |
| NO2689777T3 (zh) | 2018-08-25 |
| DK2689777T3 (en) | 2018-05-22 |
| AU2011362905A1 (en) | 2013-10-31 |
| CA2830616C (en) | 2017-02-21 |
| RU2013146602A (ru) | 2015-04-27 |
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