CA2828890A1 - Anti-fgfr4 antibodies and methods of use - Google Patents
Anti-fgfr4 antibodies and methods of use Download PDFInfo
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- CA2828890A1 CA2828890A1 CA2828890A CA2828890A CA2828890A1 CA 2828890 A1 CA2828890 A1 CA 2828890A1 CA 2828890 A CA2828890 A CA 2828890A CA 2828890 A CA2828890 A CA 2828890A CA 2828890 A1 CA2828890 A1 CA 2828890A1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/734—Complement-dependent cytotoxicity [CDC]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161473106P | 2011-04-07 | 2011-04-07 | |
| US61/473,106 | 2011-04-07 | ||
| PCT/US2012/032491 WO2012138975A1 (en) | 2011-04-07 | 2012-04-06 | Anti-fgfr4 antibodies and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2828890A1 true CA2828890A1 (en) | 2012-10-11 |
Family
ID=45952667
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2828890A Abandoned CA2828890A1 (en) | 2011-04-07 | 2012-04-06 | Anti-fgfr4 antibodies and methods of use |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9266955B2 (enExample) |
| EP (1) | EP2694551A1 (enExample) |
| JP (1) | JP2014516511A (enExample) |
| KR (1) | KR20140021589A (enExample) |
| CN (1) | CN103596983B (enExample) |
| BR (1) | BR112013024717A2 (enExample) |
| CA (1) | CA2828890A1 (enExample) |
| MX (1) | MX342240B (enExample) |
| RU (1) | RU2013143358A (enExample) |
| WO (1) | WO2012138975A1 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012088266A2 (en) | 2010-12-22 | 2012-06-28 | Incyte Corporation | Substituted imidazopyridazines and benzimidazoles as inhibitors of fgfr3 |
| ES2984771T3 (es) | 2012-06-13 | 2024-10-31 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
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| CN102224170A (zh) * | 2008-09-03 | 2011-10-19 | 利琴蒂亚有限公司 | 抑制与fgfr4相关的癌细胞侵袭的材料和方法 |
-
2012
- 2012-04-06 MX MX2013011479A patent/MX342240B/es active IP Right Grant
- 2012-04-06 CN CN201280028220.4A patent/CN103596983B/zh not_active Expired - Fee Related
- 2012-04-06 JP JP2014504018A patent/JP2014516511A/ja active Pending
- 2012-04-06 CA CA2828890A patent/CA2828890A1/en not_active Abandoned
- 2012-04-06 RU RU2013143358/10A patent/RU2013143358A/ru not_active Application Discontinuation
- 2012-04-06 KR KR1020137025948A patent/KR20140021589A/ko not_active Withdrawn
- 2012-04-06 WO PCT/US2012/032491 patent/WO2012138975A1/en not_active Ceased
- 2012-04-06 BR BR112013024717A patent/BR112013024717A2/pt not_active IP Right Cessation
- 2012-04-06 EP EP12713846.9A patent/EP2694551A1/en not_active Withdrawn
-
2013
- 2013-10-04 US US14/046,659 patent/US9266955B2/en not_active Expired - Fee Related
-
2016
- 2016-01-13 US US14/995,111 patent/US20160237157A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20140037624A1 (en) | 2014-02-06 |
| KR20140021589A (ko) | 2014-02-20 |
| WO2012138975A1 (en) | 2012-10-11 |
| US20160237157A1 (en) | 2016-08-18 |
| EP2694551A1 (en) | 2014-02-12 |
| US9266955B2 (en) | 2016-02-23 |
| CN103596983A (zh) | 2014-02-19 |
| MX342240B (es) | 2016-09-21 |
| BR112013024717A2 (pt) | 2017-08-08 |
| JP2014516511A (ja) | 2014-07-17 |
| MX2013011479A (es) | 2013-11-04 |
| CN103596983B (zh) | 2016-10-26 |
| RU2013143358A (ru) | 2015-05-20 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20180406 |