CA2822432C - Bicyclic pkm2 activators - Google Patents
Bicyclic pkm2 activators Download PDFInfo
- Publication number
- CA2822432C CA2822432C CA2822432A CA2822432A CA2822432C CA 2822432 C CA2822432 C CA 2822432C CA 2822432 A CA2822432 A CA 2822432A CA 2822432 A CA2822432 A CA 2822432A CA 2822432 C CA2822432 C CA 2822432C
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- Prior art keywords
- alkyl
- compound
- halo
- independently selected
- formulas
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
- C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (9)
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| US201061425557P | 2010-12-21 | 2010-12-21 | |
| US201061425528P | 2010-12-21 | 2010-12-21 | |
| US201061425513P | 2010-12-21 | 2010-12-21 | |
| US201061425499P | 2010-12-21 | 2010-12-21 | |
| US61/425,513 | 2010-12-21 | ||
| US61/425,499 | 2010-12-21 | ||
| US61/425,557 | 2010-12-21 | ||
| US61/425,528 | 2010-12-21 | ||
| PCT/US2011/066595 WO2012088314A1 (en) | 2010-12-21 | 2011-12-21 | Bicyclic pkm2 activators |
Publications (2)
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| CA2822432A1 CA2822432A1 (en) | 2012-06-28 |
| CA2822432C true CA2822432C (en) | 2019-09-24 |
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| CA2822432A Expired - Fee Related CA2822432C (en) | 2010-12-21 | 2011-12-21 | Bicyclic pkm2 activators |
Country Status (7)
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|---|---|
| US (3) | US9328077B2 (https=) |
| EP (1) | EP2655350B1 (https=) |
| JP (2) | JP6092118B2 (https=) |
| CA (1) | CA2822432C (https=) |
| ES (1) | ES2569712T3 (https=) |
| MX (1) | MX336022B (https=) |
| WO (1) | WO2012088314A1 (https=) |
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| RU2561132C2 (ru) | 2009-06-29 | 2015-08-20 | Аджиос Фармасьютикалз, Инк. | Производные хинолинсульфонамидов и их применение для модулирования пкм2 активности |
| WO2012088314A1 (en) * | 2010-12-21 | 2012-06-28 | Agios Pharmaceuticals, Inc. | Bicyclic pkm2 activators |
| DK2909181T3 (da) | 2012-10-16 | 2017-11-20 | Tolero Pharmaceuticals Inc | PKM2-modulatorer og fremgangsmåder til anvendelse deraf |
| CN105272904B (zh) * | 2014-07-18 | 2019-04-09 | 中国科学院广州生物医药与健康研究院 | N-苯基酰胺类化合物及其应用 |
| DE102017005089A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substitulerte 3,4-Dihydrochinoxalin-2(1H)-one |
| DE102017005091A1 (de) | 2016-05-30 | 2017-11-30 | Bayer Pharma Aktiengesellschaft | Substituierte 3,4-Dihydropyrido[2,3-b]pyrazin-2(1H)-one |
| ES2747768T3 (es) | 2017-03-20 | 2020-03-11 | Forma Therapeutics Inc | Composiciones de pirrolopirrol como activadores de quinasa de piruvato (PKR) |
| US20200237766A1 (en) | 2017-10-13 | 2020-07-30 | Tolero Pharmaceuticals, Inc. | Pkm2 activators in combination with reactive oxygen species for treatment of cancer |
| US20200247815A1 (en) | 2017-10-19 | 2020-08-06 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | Pyrazolyl-containing tricyclic derivative, preparation method therefor and use thereof |
| US12053458B2 (en) | 2018-09-19 | 2024-08-06 | Novo Nordisk Health Care Ag | Treating sickle cell disease with a pyruvate kinase R activating compound |
| ES2989438T3 (es) * | 2018-09-19 | 2024-11-26 | Novo Nordisk Healthcare Ag | Activación de la piruvato cinasa R |
| CA3133460A1 (en) | 2019-03-22 | 2020-10-01 | Sumitomo Dainippon Pharma Oncology, Inc. | Compositions comprising pkm2 modulators and methods of treatment using the same |
| US20220378756A1 (en) | 2019-09-19 | 2022-12-01 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
| US11566030B2 (en) | 2021-02-08 | 2023-01-31 | Global Blood Therapeutics, Inc. | Substituted 2,6-dihydropyrrolo[3,4-c]pyrazoles as pyruvate kinase activators |
| US12128035B2 (en) | 2021-03-19 | 2024-10-29 | Novo Nordisk Health Care Ag | Activating pyruvate kinase R |
| WO2026080713A1 (en) * | 2024-10-09 | 2026-04-16 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Autophagy inhibitor that targets the atg14l-beclin1 protein-protein interaction |
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2011
- 2011-12-21 WO PCT/US2011/066595 patent/WO2012088314A1/en not_active Ceased
- 2011-12-21 CA CA2822432A patent/CA2822432C/en not_active Expired - Fee Related
- 2011-12-21 EP EP11811257.2A patent/EP2655350B1/en not_active Not-in-force
- 2011-12-21 JP JP2013546384A patent/JP6092118B2/ja not_active Expired - Fee Related
- 2011-12-21 MX MX2013007268A patent/MX336022B/es unknown
- 2011-12-21 US US13/996,286 patent/US9328077B2/en not_active Expired - Fee Related
- 2011-12-21 ES ES11811257.2T patent/ES2569712T3/es active Active
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2016
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2017
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Also Published As
| Publication number | Publication date |
|---|---|
| JP6092118B2 (ja) | 2017-03-08 |
| US20160280697A1 (en) | 2016-09-29 |
| JP2016153418A (ja) | 2016-08-25 |
| MX336022B (es) | 2016-01-06 |
| JP2014500330A (ja) | 2014-01-09 |
| US9328077B2 (en) | 2016-05-03 |
| US10087169B2 (en) | 2018-10-02 |
| CA2822432A1 (en) | 2012-06-28 |
| EP2655350A1 (en) | 2013-10-30 |
| US20170369481A1 (en) | 2017-12-28 |
| EP2655350B1 (en) | 2016-03-09 |
| MX2013007268A (es) | 2013-12-06 |
| ES2569712T3 (es) | 2016-05-12 |
| HK1190406A1 (zh) | 2014-07-04 |
| US20140011804A1 (en) | 2014-01-09 |
| WO2012088314A1 (en) | 2012-06-28 |
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