CA2820362C - Substituted pyrazolopyrimidines as glucocerebrosidase activators - Google Patents

Substituted pyrazolopyrimidines as glucocerebrosidase activators Download PDF

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Publication number
CA2820362C
CA2820362C CA2820362A CA2820362A CA2820362C CA 2820362 C CA2820362 C CA 2820362C CA 2820362 A CA2820362 A CA 2820362A CA 2820362 A CA2820362 A CA 2820362A CA 2820362 C CA2820362 C CA 2820362C
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Prior art keywords
carboxamide
pyrimidine
difluoromethyl
dihydropyrazolo
methyl
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CA2820362A
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English (en)
French (fr)
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CA2820362A1 (en
Inventor
Juan Jose Marugan
Noel Southall
Ehud Goldin
Samarjit Patnaik
Ellen Sidransky
Omid Motabar
Wendy Westbrook
Wei Zheng
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US Department of Health and Human Services
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US Department of Health and Human Services
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2820362A 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators Active CA2820362C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US42094610P 2010-12-08 2010-12-08
US61/420,946 2010-12-08
PCT/US2011/063928 WO2012078855A1 (en) 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators

Publications (2)

Publication Number Publication Date
CA2820362A1 CA2820362A1 (en) 2012-06-14
CA2820362C true CA2820362C (en) 2020-03-24

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CA2820362A Active CA2820362C (en) 2010-12-08 2011-12-08 Substituted pyrazolopyrimidines as glucocerebrosidase activators

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US (3) US9353117B2 (https=)
EP (2) EP3366688B1 (https=)
JP (1) JP6154746B2 (https=)
KR (1) KR101931224B1 (https=)
CN (1) CN103534255B (https=)
AU (1) AU2011338377B2 (https=)
BR (1) BR112013014242B1 (https=)
CA (1) CA2820362C (https=)
CY (1) CY1125186T1 (https=)
DK (2) DK2649075T3 (https=)
ES (2) ES2681218T3 (https=)
HR (1) HRP20220512T1 (https=)
HU (1) HUE038635T2 (https=)
IL (2) IL226767B (https=)
LT (1) LT3366688T (https=)
MX (2) MX354506B (https=)
PL (2) PL3366688T3 (https=)
PT (2) PT3366688T (https=)
RS (1) RS63320B1 (https=)
RU (1) RU2603637C2 (https=)
SI (2) SI3366688T1 (https=)
TR (1) TR201810523T4 (https=)
WO (1) WO2012078855A1 (https=)
ZA (1) ZA201304215B (https=)

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Publication number Publication date
EP3366688A1 (en) 2018-08-29
SI2649075T1 (sl) 2018-10-30
CN103534255A (zh) 2014-01-22
DK2649075T3 (en) 2018-07-30
JP2013544893A (ja) 2013-12-19
IL226767B (en) 2018-06-28
PT3366688T (pt) 2022-05-11
MX354506B (es) 2018-01-16
BR112013014242A2 (pt) 2018-06-26
ES2912284T3 (es) 2022-05-25
US10925874B2 (en) 2021-02-23
RS63320B1 (sr) 2022-07-29
KR101931224B1 (ko) 2018-12-20
US9974789B2 (en) 2018-05-22
CY1125186T1 (el) 2024-12-13
ES2681218T3 (es) 2018-09-12
EP2649075A1 (en) 2013-10-16
TR201810523T4 (tr) 2018-08-27
PT2649075T (pt) 2018-07-30
EP2649075B1 (en) 2018-04-25
LT3366688T (lt) 2022-05-25
MX2013006462A (es) 2013-10-01
SI3366688T1 (sl) 2022-07-29
JP6154746B2 (ja) 2017-06-28
US9353117B2 (en) 2016-05-31
CA2820362A1 (en) 2012-06-14
BR112013014242B1 (pt) 2022-02-22
AU2011338377A1 (en) 2013-07-04
ZA201304215B (en) 2014-03-26
HRP20220512T1 (hr) 2022-05-27
RU2603637C2 (ru) 2016-11-27
CN103534255B (zh) 2016-12-21
EP3366688B1 (en) 2022-02-09
US20160346284A1 (en) 2016-12-01
WO2012078855A1 (en) 2012-06-14
IL259648B (en) 2021-03-25
US20180263988A1 (en) 2018-09-20
US20140249145A1 (en) 2014-09-04
RU2013126094A (ru) 2015-01-20
IL259648A (en) 2018-07-31
PL2649075T3 (pl) 2018-09-28
DK3366688T3 (da) 2022-05-02
KR20140010012A (ko) 2014-01-23
AU2011338377B2 (en) 2016-08-04
PL3366688T3 (pl) 2022-05-23
AU2011338377A8 (en) 2015-10-29
MX385600B (es) 2025-03-18
HUE038635T2 (hu) 2018-11-28

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