CA2811493C - Method for separating target molecules or particles from fibrinogen-containing samples including blood components - Google Patents

Method for separating target molecules or particles from fibrinogen-containing samples including blood components Download PDF

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Publication number
CA2811493C
CA2811493C CA2811493A CA2811493A CA2811493C CA 2811493 C CA2811493 C CA 2811493C CA 2811493 A CA2811493 A CA 2811493A CA 2811493 A CA2811493 A CA 2811493A CA 2811493 C CA2811493 C CA 2811493C
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CA
Canada
Prior art keywords
fibrinogen
sample
fibrin
particles
thrombin
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Active
Application number
CA2811493A
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English (en)
French (fr)
Other versions
CA2811493A1 (en
Inventor
Amar Rida
Nicolas Mermod
Patrice Francois
Vladimir Lazarevic
Jacques Schrenzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Debiopharm International SA
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Debiopharm International SA
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Publication date
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Publication of CA2811493A1 publication Critical patent/CA2811493A1/en
Application granted granted Critical
Publication of CA2811493C publication Critical patent/CA2811493C/en
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/14Streptococcus; Staphylococcus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911Bacteria
    • G01N33/56938Staphylococcus
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745Assays involving non-enzymic blood coagulation factors
    • G01N2333/75Fibrin; Fibrinogen
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/974Thrombin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)
CA2811493A 2010-09-15 2011-09-15 Method for separating target molecules or particles from fibrinogen-containing samples including blood components Active CA2811493C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CH01478/10 2010-09-15
CH14782010 2010-09-15
CH20412010 2010-12-07
CH02041/10 2010-12-07
CH01207/11 2011-07-20
CH12072011 2011-07-20
PCT/IB2011/054035 WO2012035508A2 (en) 2010-09-15 2011-09-15 Method for separating target molecules or particles from fibrinogen-containing samples including blood components

Publications (2)

Publication Number Publication Date
CA2811493A1 CA2811493A1 (en) 2012-03-22
CA2811493C true CA2811493C (en) 2020-06-16

Family

ID=45044632

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2811493A Active CA2811493C (en) 2010-09-15 2011-09-15 Method for separating target molecules or particles from fibrinogen-containing samples including blood components

Country Status (17)

Country Link
US (4) US9689881B2 (enExample)
EP (2) EP2616550B1 (enExample)
JP (1) JP5999776B2 (enExample)
KR (1) KR101948944B1 (enExample)
CN (2) CN107389932B (enExample)
AU (2) AU2011303467C1 (enExample)
CA (1) CA2811493C (enExample)
CY (1) CY1122166T1 (enExample)
DK (2) DK2616550T3 (enExample)
ES (2) ES2751660T3 (enExample)
HR (1) HRP20191785T1 (enExample)
HU (2) HUE028915T2 (enExample)
LT (1) LT3067431T (enExample)
PL (2) PL2616550T3 (enExample)
PT (1) PT3067431T (enExample)
SI (1) SI3067431T1 (enExample)
WO (1) WO2012035508A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12398176B2 (en) 2018-08-27 2025-08-26 Regeneron Pharmaceuticals, Inc. Use of Raman spectroscopy in downstream purification

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9689881B2 (en) 2010-09-15 2017-06-27 Spinomix S.A. Method for separating target molecules or particles from fibrinogen-containing samples including blood components
CN103702674B (zh) 2011-06-27 2018-05-29 爱默蕾大学 血小板裂解物的组合物、用途和制备
EP2979093B1 (en) * 2013-03-29 2019-10-23 Siemens Healthcare Diagnostics Inc. Rare cell concentration
ES2740838T3 (es) * 2014-06-01 2020-02-06 Debiopharm Int Sa Dispositivo de recolección y procesamiento de muestras
US12397302B2 (en) 2015-11-30 2025-08-26 Dh Technologies Development Pte. Ltd. Electromagnetic assemblies for processing fluids
WO2017156375A1 (en) 2016-03-10 2017-09-14 Arthrex, Inc. Systems and methods for preparing a thrombin serum
WO2017156379A2 (en) 2016-03-10 2017-09-14 Arthrex, Inc. Systems and methods for preparing protein enhanced serums
JP7298449B2 (ja) * 2019-11-14 2023-06-27 株式会社島津製作所 血液凝固分析装置、及び分注ノズルの洗浄方法

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FR2625321B1 (fr) * 1987-12-24 1992-10-02 Pasteur Institut Reactif pour le diagnostic de staphylococcus aureus par agglutination
DE58902472D1 (de) * 1988-01-05 1992-11-26 Linhart Axel Verfahren und test-kit zur semiquantitativen bestimmung des kalziumgehaltes im blut.
DE3803463A1 (de) * 1988-02-05 1989-08-17 Linhart Axel Semiquantitativer kalzium-schnelltest
US5691160A (en) * 1992-08-14 1997-11-25 Biogen, Inc. Effects of actin filaments of fibrin clot structure and lysis
EP0587398B1 (en) * 1992-09-09 1998-01-14 Tokuyama Corporation Method of assaying fibrinogen, dry reagent therefor, and process for the preparation thereof
JP3292760B2 (ja) * 1993-04-22 2002-06-17 テルモ株式会社 採血管およびその製造方法
US5670329A (en) * 1993-05-28 1997-09-23 Cardiovascular Diagnostics, Inc. Method and analytical system for performing fibrinogen assays accurately, rapidly and simply using a rotating magnetic field
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DE19602673A1 (de) * 1996-01-25 1997-08-07 Pereg Gmbh Synthetische Testanschmutzung
US6121232A (en) * 1997-01-31 2000-09-19 Omrix Biopharmaceuticals Sa Stabilized mixture comprising fibrinogen
US6680195B1 (en) * 1997-11-26 2004-01-20 Inhibitex, Inc. Extracellular matrix-binding proteins from staphylococcus aureus
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WO2003028743A1 (en) * 2001-10-03 2003-04-10 Woolverton Christopher J Storage-stable fibrinogen solutions
JP4718833B2 (ja) * 2002-05-01 2011-07-06 シナプス ベスローテン フェンノートシャップ 複合生物媒体における、一時的なタンパク質分解活性の濃度を決定するための診断試験
EP1400589B1 (de) 2002-09-18 2006-08-09 SIRS-Lab GmbH Verfahren zum Nachweis prokaryontischer DNA
SI1654387T1 (sl) * 2003-08-15 2009-10-31 Univ South Florida Materiali in postopki za ujetje patogenov in odstranitev avrintrikarboksilne kisline iz vzorca
US20050065454A1 (en) * 2003-09-22 2005-03-24 Becton, Dickinson And Company Non-evacuated blood collection tube
US7399609B2 (en) * 2003-12-30 2008-07-15 3M Innovative Properties Company Staphylococcus detection
US8419722B2 (en) * 2004-10-29 2013-04-16 Spinal Restoration, Inc. Apparatus and method for injection of fibrin sealant in spinal applications
DE102005009479A1 (de) 2005-03-02 2006-09-07 Molzym Gmbh & Co. Kg Verwendung von Nukleasen zum Abbau von Nukleinsäure in Gegenwart von chaotropen Agenzien und/oder Tensiden
US20100009409A1 (en) * 2005-07-29 2010-01-14 Ecole Polytechnique Federale De Lausanne Molecular variant fibrinogen fusion proteins
US20080299587A1 (en) * 2007-05-03 2008-12-04 Dennis Durbin Methods of measuring inhibition of platelet aggregation by thrombin receptor antagonists
CA2693565C (en) 2007-08-02 2015-05-26 Universite Laval Concentration and enrichment of microbial cells and microbial nucleic acids from bodily fluids
JP5029217B2 (ja) * 2007-08-27 2012-09-19 東レ株式会社 シート状物の製造方法
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CA2768485C (en) 2009-07-16 2018-12-04 Timothy Foster Treatment of staphylococci infections using recombinant fibrinogen binding protein clumping factor a
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12398176B2 (en) 2018-08-27 2025-08-26 Regeneron Pharmaceuticals, Inc. Use of Raman spectroscopy in downstream purification

Also Published As

Publication number Publication date
KR20130107300A (ko) 2013-10-01
KR101948944B1 (ko) 2019-02-15
US20210148940A1 (en) 2021-05-20
AU2011303467B2 (en) 2016-09-15
US20130164737A1 (en) 2013-06-27
CA2811493A1 (en) 2012-03-22
JP5999776B2 (ja) 2016-09-28
AU2011303467C1 (en) 2017-03-09
EP3067431A1 (en) 2016-09-14
EP2616550A2 (en) 2013-07-24
WO2012035508A3 (en) 2012-05-18
PT3067431T (pt) 2019-10-29
ES2571127T3 (es) 2016-05-24
WO2012035508A2 (en) 2012-03-22
EP2616550B1 (en) 2016-02-10
CN103108959A (zh) 2013-05-15
HRP20191785T1 (hr) 2019-12-27
HUE028915T2 (en) 2017-01-30
JP2013538355A (ja) 2013-10-10
AU2016266066A1 (en) 2016-12-22
PL2616550T3 (pl) 2016-08-31
SI3067431T1 (sl) 2019-11-29
HK1247280A1 (zh) 2018-09-21
DK3067431T3 (da) 2019-10-14
CN107389932B (zh) 2019-11-22
WO2012035508A4 (en) 2012-07-19
AU2016266066B2 (en) 2017-12-21
EP3067431B1 (en) 2019-07-24
HUE045771T2 (hu) 2020-01-28
US20170336424A1 (en) 2017-11-23
US9689881B2 (en) 2017-06-27
CY1122166T1 (el) 2020-11-25
PL3067431T3 (pl) 2019-12-31
DK2616550T3 (en) 2016-05-23
ES2751660T3 (es) 2020-04-01
AU2011303467A1 (en) 2013-04-04
US20240280593A1 (en) 2024-08-22
CN107389932A (zh) 2017-11-24
CN103108959B (zh) 2017-06-09
LT3067431T (lt) 2019-11-11

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Effective date: 20160829