CA2783001C - Sustained-release nucleic acid matrix compositions - Google Patents
Sustained-release nucleic acid matrix compositions Download PDFInfo
- Publication number
- CA2783001C CA2783001C CA2783001A CA2783001A CA2783001C CA 2783001 C CA2783001 C CA 2783001C CA 2783001 A CA2783001 A CA 2783001A CA 2783001 A CA2783001 A CA 2783001A CA 2783001 C CA2783001 C CA 2783001C
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- Prior art keywords
- another embodiment
- matrix composition
- matrix
- lipid
- nucleic acid
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- 239000011159 matrix material Substances 0.000 title claims abstract description 215
- 150000007523 nucleic acids Chemical class 0.000 title claims abstract description 152
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- 108020004707 nucleic acids Proteins 0.000 title claims abstract description 140
- 238000013268 sustained release Methods 0.000 title claims description 18
- 239000012730 sustained-release form Substances 0.000 title claims description 12
- 238000000034 method Methods 0.000 claims abstract description 80
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- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 12
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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| US20140335165A1 (en) | 2014-11-13 |
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| US20120294944A1 (en) | 2012-11-22 |
| EP2525778A2 (en) | 2012-11-28 |
| CA2783001A1 (en) | 2011-07-28 |
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| JP5860409B2 (ja) | 2016-02-16 |
| AU2011208374B2 (en) | 2016-09-08 |
| US9616032B2 (en) | 2017-04-11 |
| WO2011089595A2 (en) | 2011-07-28 |
| CN102892406A (zh) | 2013-01-23 |
| WO2011089595A3 (en) | 2011-10-20 |
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