AU2011208374B2 - Sustained-release nucleic acid matrix compositions - Google Patents

Sustained-release nucleic acid matrix compositions Download PDF

Info

Publication number
AU2011208374B2
AU2011208374B2 AU2011208374A AU2011208374A AU2011208374B2 AU 2011208374 B2 AU2011208374 B2 AU 2011208374B2 AU 2011208374 A AU2011208374 A AU 2011208374A AU 2011208374 A AU2011208374 A AU 2011208374A AU 2011208374 B2 AU2011208374 B2 AU 2011208374B2
Authority
AU
Australia
Prior art keywords
another embodiment
coated substrate
peg
nucleic acid
fatty acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
AU2011208374A
Other languages
English (en)
Other versions
AU2011208374A1 (en
Inventor
Noam Emanuel
Yosef Rosenfeld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Polypid Ltd
Original Assignee
Polypid Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polypid Ltd filed Critical Polypid Ltd
Publication of AU2011208374A1 publication Critical patent/AU2011208374A1/en
Application granted granted Critical
Publication of AU2011208374B2 publication Critical patent/AU2011208374B2/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Materials For Medical Uses (AREA)
AU2011208374A 2010-01-19 2011-01-18 Sustained-release nucleic acid matrix compositions Active AU2011208374B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29604010P 2010-01-19 2010-01-19
US61/296,040 2010-01-19
PCT/IL2011/000054 WO2011089595A2 (en) 2010-01-19 2011-01-18 Sustained-release nucleic acid matrix compositions

Publications (2)

Publication Number Publication Date
AU2011208374A1 AU2011208374A1 (en) 2012-06-21
AU2011208374B2 true AU2011208374B2 (en) 2016-09-08

Family

ID=44307336

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2011208374A Active AU2011208374B2 (en) 2010-01-19 2011-01-18 Sustained-release nucleic acid matrix compositions

Country Status (7)

Country Link
US (2) US8795726B2 (OSRAM)
EP (1) EP2525778B1 (OSRAM)
JP (1) JP5860409B2 (OSRAM)
CN (1) CN102892406B (OSRAM)
AU (1) AU2011208374B2 (OSRAM)
CA (1) CA2783001C (OSRAM)
WO (1) WO2011089595A2 (OSRAM)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2630805T3 (es) 2008-07-14 2017-08-24 Polypid Ltd. Composición de vehículo de fármaco de liberación sostenida
IN2012DN00570A (OSRAM) 2009-07-14 2015-06-12 Polypid Ltd
CN103500847B (zh) * 2013-10-02 2016-08-17 中国地质大学（武汉） 锂硫电池添加剂、含有该添加剂的正极材料及其制备方法
WO2015069870A1 (en) * 2013-11-07 2015-05-14 The University Of North Carolina At Chapel Hill Particles containing phospholipids or bioactive fatty acid
US20160340659A1 (en) 2014-01-30 2016-11-24 Yissum Research And Development Company Of The Hebrew University Of Jerusalem Ltd. Actin binding peptides and compositions comprising same for inhibiting angiogenesis and treating medical conditions associated with same
JP2016023148A (ja) * 2014-07-17 2016-02-08 富士フイルム株式会社 脂質粒子の製造法および脂質粒子を有する核酸送達キャリア
SG10202012452UA (en) * 2014-10-02 2021-01-28 Polypid Ltd Compositions and methods for the treatment and prophylaxis of surgical site infections
AU2018341389A1 (en) * 2017-09-26 2020-04-23 Nanomi B.V. Method for preparing micro-particles by double emulsion technique
CN107823725B (zh) * 2017-10-11 2020-10-09 上海君联医疗设备有限公司 一种可延期回收的血栓滤器及其制作方法
JP6388700B2 (ja) * 2017-10-20 2018-09-12 富士フイルム株式会社 脂質粒子の製造法および脂質粒子を有する核酸送達キャリア
EP3700965A1 (en) 2017-10-27 2020-09-02 Massachusetts Institute of Technology Poly (beta-amino esters) and uses thereof
CN113166783B (zh) 2018-10-09 2024-10-11 不列颠哥伦比亚大学 包含无有机溶剂和去污剂的转染活性囊泡的组合物和系统以及与之相关的方法
AU2019366996A1 (en) * 2018-10-26 2021-05-27 Massachusetts Institute Of Technology Polymer-lipids and compositions
US12433847B2 (en) 2021-03-09 2025-10-07 Massachusetts Institute Of Technology Branched poly(-amino esters) for the delivery of nucleic acids

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999056731A1 (en) * 1998-04-30 1999-11-11 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
US6793938B2 (en) * 1998-07-17 2004-09-21 Skye Pharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances
US20050181928A1 (en) * 2004-02-12 2005-08-18 Hayward Peter J. Reaction-bonded porous magnesia body
WO2008105773A2 (en) * 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
WO2009110939A2 (en) * 2007-12-10 2009-09-11 Massachusetts Institute Of Technology Drug delivery system for pharmaceuticals and radiation

Family Cites Families (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4882167A (en) 1983-05-31 1989-11-21 Jang Choong Gook Dry direct compression compositions for controlled release dosage forms
US4578384A (en) 1984-02-15 1986-03-25 The United States Of America As Represented By The Secretary Of The Army Polylactic-polyglycolic acids combined with an acidic phospholipid-lysozyme complex for healing osseous tissue
JPS6163613A (ja) 1984-09-04 1986-04-01 Mitsui Toatsu Chem Inc 顆粒状に調整された徐放性製剤
US5043166A (en) 1987-01-09 1991-08-27 Hadasit Medical Research, Inc. Liposome/anthraquinone drug composition and method
IL91664A (en) 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
CA2068216C (en) 1989-11-13 1999-04-13 Abraham J. Domb Lipospheres for controlled delivery of substances
US6120805A (en) 1990-04-06 2000-09-19 Rhone-Poulenc Rorer Sa Microspheres, process for their preparation and their use
JPH046115A (ja) 1990-04-25 1992-01-10 Olympus Optical Co Ltd 光学素子成形用型
JPH0418035A (ja) 1990-05-10 1992-01-22 Nkk Corp 徐放性製剤および製造法
JPH0446115A (ja) 1990-06-13 1992-02-17 Eisai Co Ltd マイクロスフィアの製造法
US5922340A (en) 1992-09-10 1999-07-13 Children's Medical Center Corporation High load formulations and methods for providing prolonged local anesthesia
US6180134B1 (en) 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
EP0804249A2 (en) 1994-03-15 1997-11-05 Brown University Research Foundation Polymeric gene delivery system
US6156337A (en) 1994-07-08 2000-12-05 Opperbas Holding B.V. Method for high loading of vesicles with biopolymeric substances
US6333021B1 (en) 1994-11-22 2001-12-25 Bracco Research S.A. Microcapsules, method of making and their use
US6040295A (en) 1995-01-13 2000-03-21 Genemedicine, Inc. Formulated nucleic acid compositions and methods of administering the same for gene therapy
US5919480A (en) 1996-06-24 1999-07-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Liposomal influenza vaccine composition and method
US5837221A (en) 1996-07-29 1998-11-17 Acusphere, Inc. Polymer-lipid microencapsulated gases for use as imaging agents
WO1998007412A1 (en) 1996-08-21 1998-02-26 Alkermes Controlled Therapeutics, Inc. Controlled release microparticles with a hydrophobic material
ES2189974T3 (es) 1996-09-11 2003-07-16 Imarx Pharmaceutical Corp Procedimientos mejorados para la obtencion de imagenes de diagnostico usando un agente de contraste y un vasodilatador.
US6048551A (en) 1997-03-27 2000-04-11 Hilfinger; John M. Microsphere encapsulation of gene transfer vectors
US6248345B1 (en) 1997-07-02 2001-06-19 Euro-Celtique, S.A. Prolonged anesthesia in joints and body spaces
US6287587B2 (en) 1997-07-15 2001-09-11 Takeda Chemical Industries, Ltd. Process for producing sustained-release preparation by in-water drying
US6787132B1 (en) 1997-12-04 2004-09-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Combined chemo-immunotherapy with liposomal drugs and cytokines
AU747391B2 (en) 1998-04-27 2002-05-16 Cantab Biopharmaceuticals Patents Limited Pharmaceutical composition comprising factor VIII and neutral liposomes
WO2000003683A2 (en) * 1998-07-20 2000-01-27 Inex Pharmaceuticals Corporation Liposomal encapsulated nucleic acid-complexes
DE69935435T2 (de) 1998-08-12 2007-12-06 Yissum Research Development Company Of The Hebrew University Of Jerusalem Mittels Ammoniumsulfatgradient hergestellte liposomale analgetische Zusammensetzungen
US6153217A (en) 1999-01-22 2000-11-28 Biodelivery Sciences, Inc. Nanocochleate formulations, process of preparation and method of delivery of pharmaceutical agents
US6083482A (en) 1999-05-11 2000-07-04 Icn Pharmaceuticals, Inc. Conformationally locked nucleosides and oligonucleotides
WO2000078358A2 (en) 1999-06-18 2000-12-28 The Collaborative Group, Ltd. Hyaluronic acid microspheres for sustained gene transfer
DE10001172A1 (de) 2000-01-13 2001-07-26 Max Planck Gesellschaft Templatieren von Feststoffpartikeln mit Polymermultischichten
US6967028B2 (en) 2000-07-31 2005-11-22 Mainelab Prolonged release microspheres for injectable administration
IL155204A0 (en) 2000-10-02 2003-11-23 Arizeke Pharmaceuticals Inc Compositions and methods for the transport of biologically active agents across cellular barriers
FI20010540A0 (fi) 2001-03-16 2001-03-16 Yli Urpo Antti Komposiitti pehmyt- ja kovakudosvammojen korjaamiseksi ja mainitun komposiitin käyttö
US20020137433A1 (en) * 2001-03-26 2002-09-26 Lee Lawrence K. Abrasive drill bit
EP1429745A2 (en) 2001-09-28 2004-06-23 McNEIL-PPC, INC. Composite dosage forms having an inlaid portion
TWI226249B (en) 2001-12-19 2005-01-11 Ind Tech Res Inst Biodegradable composite matrix for enhancing angiogenesis
AU2003237864B2 (en) 2002-05-15 2008-12-18 California Pacific Medical Center Delivery of nucleic acid-like compounds
WO2004071452A2 (en) 2003-02-12 2004-08-26 Ceremed, Inc. Random and non-random alkylene oxide polymer alloy compositions
EP1622540A4 (en) * 2003-03-11 2009-12-30 Qlt Usa Inc PREPARATIONS OF ANTI-CANCER AGENTS DEPENDENT ON THE CELLULAR PROGRAM
GB0305941D0 (en) 2003-03-14 2003-04-23 Camurus Ab Composition
KR101293002B1 (ko) 2003-04-10 2013-08-02 데이진 가부시키가이샤 허니콤 구조를 갖는 생분해성 필름
US20040247624A1 (en) 2003-06-05 2004-12-09 Unger Evan Charles Methods of making pharmaceutical formulations for the delivery of drugs having low aqueous solubility
US20060188573A1 (en) 2003-06-10 2006-08-24 Anna Imberg Composite materials and particles
US20050249697A1 (en) 2003-09-24 2005-11-10 Uhrich Kathryn E Compositions and methods for the inhibition of bone growth and resorption
US7915028B2 (en) 2003-11-21 2011-03-29 Teijin Limited Tissue regeneration substrate, complex thereof with cells, and method for its production
WO2005070466A2 (en) * 2004-01-15 2005-08-04 Alza Corporation Liposome composition for delivery of therapeutic agents
US8277831B2 (en) 2004-02-17 2012-10-02 Advanced Technologies And Regenerative Medicine, Llc. Drug-enhanced adhesion prevention
US7744644B2 (en) 2004-03-19 2010-06-29 Boston Scientific Scimed, Inc. Medical articles having regions with polyelectrolyte multilayer coatings for regulating drug release
PL1768650T3 (pl) 2004-06-04 2009-01-30 Camurus Ab Ciekłe formulacje depot
US20050287180A1 (en) 2004-06-15 2005-12-29 Chen Andrew X Phospholipid compositions and methods for their preparation and use
US20060147520A1 (en) 2004-07-26 2006-07-06 Curtis Ruegg Treatment of pulmonary hypertension by inhaled iloprost with a microparticle formulation
CA2605000A1 (en) 2005-04-25 2006-11-02 Amgen Inc. Biodegradable peptide sustained release compositions containing porogens
GB2430929A (en) * 2005-10-04 2007-04-11 Acco Uk Ltd Apparatus for dividing a bundle of sheet material from a larger bundle
US20070141134A1 (en) 2005-12-16 2007-06-21 Kosak Matthew K Shielded micelles for polynucleotide delivery
US20090318355A1 (en) 2006-02-15 2009-12-24 Chen Thomas T Compositions and methods for promoting tissue repair and wound healing
US8703167B2 (en) 2006-06-05 2014-04-22 Advanced Cardiovascular Systems, Inc. Coatings for implantable medical devices for controlled release of a hydrophilic drug and a hydrophobic drug
US20080181928A1 (en) * 2006-12-22 2008-07-31 Miv Therapeutics, Inc. Coatings for implantable medical devices for liposome delivery
WO2008108286A1 (ja) 2007-03-02 2008-09-12 Teika Pharmaceutical Co., Ltd. 経皮吸収医薬組成物、医薬組成物貯蔵ユニットおよびこれを利用する経皮吸収製剤
WO2008124634A1 (en) 2007-04-04 2008-10-16 Massachusetts Institute Of Technology Polymer-encapsulated reverse micelles
US20100210575A1 (en) 2007-06-29 2010-08-19 Wisconsin Alumni Research Foundation Structuring effect of cholesterol in peg-phospholipid micelles, drug delivery of amphotericin b, and combination antifungals
US20090110713A1 (en) 2007-10-31 2009-04-30 Florencia Lim Biodegradable polymeric materials providing controlled release of hydrophobic drugs from implantable devices
US20100285111A1 (en) 2007-11-09 2010-11-11 Northeastern University Self-assembling micelle-like nanoparticles for systemic gene delivery
US8128983B2 (en) * 2008-04-11 2012-03-06 Abbott Cardiovascular Systems Inc. Coating comprising poly(ethylene glycol)-poly(lactide-glycolide-caprolactone) interpenetrating network
CA2721333C (en) 2008-04-15 2020-12-01 Protiva Biotherapeutics, Inc. Novel lipid formulations for nucleic acid delivery
WO2010001325A2 (en) * 2008-06-30 2010-01-07 Silenseed Ltd Methods, compositions and systems for local delivery of drugs
ES2630805T3 (es) 2008-07-14 2017-08-24 Polypid Ltd. Composición de vehículo de fármaco de liberación sostenida
WO2010078517A2 (en) 2008-12-31 2010-07-08 Sirnaomics, Inc. Compositions and methods using sirna molecules and sirna cocktails for the treatment of breast cancer
WO2010135207A1 (en) 2009-05-16 2010-11-25 Agave Pharma, Incorporated Compositions comprising cationic amphiphiles and colipids for delivering therapeutics molecules
IN2012DN00570A (OSRAM) 2009-07-14 2015-06-12 Polypid Ltd

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
WO1999056731A1 (en) * 1998-04-30 1999-11-11 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US20070104656A1 (en) * 1998-04-30 2007-05-10 Acusphere, Inc. Matrices Formed of Polymer and Hydrophobic Compounds For Use in Drug Delivery
US6793938B2 (en) * 1998-07-17 2004-09-21 Skye Pharma, Inc. Biodegradable compositions for the controlled release of encapsulated substances
US20050181928A1 (en) * 2004-02-12 2005-08-18 Hayward Peter J. Reaction-bonded porous magnesia body
WO2008105773A2 (en) * 2006-03-31 2008-09-04 Massachusetts Institute Of Technology System for targeted delivery of therapeutic agents
WO2009110939A2 (en) * 2007-12-10 2009-09-11 Massachusetts Institute Of Technology Drug delivery system for pharmaceuticals and radiation

Also Published As

Publication number Publication date
CN102892406B (zh) 2015-04-08
CA2783001C (en) 2017-12-12
US8795726B2 (en) 2014-08-05
JP5860409B2 (ja) 2016-02-16
EP2525778B1 (en) 2018-08-01
CN102892406A (zh) 2013-01-23
AU2011208374A1 (en) 2012-06-21
CA2783001A1 (en) 2011-07-28
JP2013517265A (ja) 2013-05-16
EP2525778A2 (en) 2012-11-28
WO2011089595A3 (en) 2011-10-20
US20140335165A1 (en) 2014-11-13
US20120294944A1 (en) 2012-11-22
US9616032B2 (en) 2017-04-11
WO2011089595A2 (en) 2011-07-28
EP2525778A4 (en) 2013-07-03

Similar Documents

Publication Publication Date Title
AU2011208374B2 (en) Sustained-release nucleic acid matrix compositions
Sato et al. Understanding structure-activity relationships of pH-sensitive cationic lipids facilitates the rational identification of promising lipid nanoparticles for delivering siRNAs in vivo
JP7256824B2 (ja) 粒子状製剤用の凍結保護剤
Chirila et al. The use of synthetic polymers for delivery of therapeutic antisense oligodeoxynucleotides
KR102641298B1 (ko) 지질양이온성 덴드리머 및 이의 용도
EP2591770B1 (en) Compositions for siRNA delivery and methods of manufacturing and using same
KR101198354B1 (ko) 핵산 전달용 저밀도 지단백질 유사(ＬＤＬ-ｌｉｋｅ) 양이온성 나노입자, 그의 제조방법 및 이를 이용한 핵산의 전달 방법
CN105131067B (zh) 皮肤与纤维化症候中的rna干扰
US20220259597A1 (en) Oligonucleotide antagonists for rna guided genome editing
JP2008520600A (ja) 局所投与のための医薬組成物におけるまたはそれに関する改善
JP2017500865A (ja) レプチンｍＲＮＡの組成物および製剤
TW202329986A (zh) 脂質化合物及脂質奈米顆粒組合物
CN120129532A (zh) 稳定的脂质或类脂质纳米颗粒悬浮液
CN104388427B (zh) miRNA‑200b在制备β‑catenin抑制剂的新用途
TWI428135B (zh) And a carrier composition for quick-acting nucleic acid delivery
CN114306367A (zh) 一种含有C/EBPα-saRNA的组合物
CA2753703A1 (en) Nucleic acid complex and nucleic acid-delivering composition
RU2820713C2 (ru) Криопротективные агенты для содержащих частицы составов
CN120112275A (zh) 用于递送包括核酸的活性剂的组合物和方法
WO2024167924A2 (en) Multi-functional lipid nanoparticles and uses thereof
KR20250092049A (ko) mRNA/LNP 백신의 면역원성 향상용 지질
WO2025171319A1 (en) Photoreactive compositions and methods for producing circular polyribonucleotides
JP2006158314A (ja) 化合物の細胞内導入用キャリア剤およびそれを用いた化合物の細胞内導入方法

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)