CA2778895C - Anti-fractalkine antibody, composition and method for treating inflammatory disorders - Google Patents

Anti-fractalkine antibody, composition and method for treating inflammatory disorders Download PDF

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Publication number
CA2778895C
CA2778895C CA2778895A CA2778895A CA2778895C CA 2778895 C CA2778895 C CA 2778895C CA 2778895 A CA2778895 A CA 2778895A CA 2778895 A CA2778895 A CA 2778895A CA 2778895 C CA2778895 C CA 2778895C
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Prior art keywords
antibody
fkn
binding fragment
seq
amino acid
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CA2778895A
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English (en)
French (fr)
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CA2778895A1 (en
Inventor
Miyuki Nishimura
Yoshimasa Sakamoto
Tetsu Kawano
Toshio Imai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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Application filed by Eisai R&D Management Co Ltd filed Critical Eisai R&D Management Co Ltd
Publication of CA2778895A1 publication Critical patent/CA2778895A1/en
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46Hybrid immunoglobulins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Transplantation (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2778895A 2009-10-30 2010-10-28 Anti-fractalkine antibody, composition and method for treating inflammatory disorders Active CA2778895C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US25652109P 2009-10-30 2009-10-30
US61/256,521 2009-10-30
PCT/JP2010/069653 WO2011052799A1 (en) 2009-10-30 2010-10-28 Compositions and methods for treating inflammatory disorders

Publications (2)

Publication Number Publication Date
CA2778895A1 CA2778895A1 (en) 2011-05-05
CA2778895C true CA2778895C (en) 2018-08-07

Family

ID=43922220

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2778895A Active CA2778895C (en) 2009-10-30 2010-10-28 Anti-fractalkine antibody, composition and method for treating inflammatory disorders

Country Status (33)

Country Link
US (1) US8932592B2 (enExample)
EP (1) EP2493930B1 (enExample)
JP (2) JP5631991B2 (enExample)
KR (2) KR102099596B1 (enExample)
CN (1) CN102597003B (enExample)
AR (2) AR078796A1 (enExample)
AU (1) AU2010312408B2 (enExample)
BR (1) BR112012010266A2 (enExample)
CA (1) CA2778895C (enExample)
CL (2) CL2012001143A1 (enExample)
CY (1) CY1121167T1 (enExample)
DK (1) DK2493930T3 (enExample)
ES (1) ES2698389T3 (enExample)
HR (1) HRP20181973T1 (enExample)
HU (1) HUE041952T2 (enExample)
IL (1) IL219470A (enExample)
JO (1) JO3437B1 (enExample)
LT (1) LT2493930T (enExample)
MX (1) MX2012005052A (enExample)
MY (1) MY158481A (enExample)
NZ (1) NZ599779A (enExample)
PE (1) PE20121645A1 (enExample)
PH (1) PH12012500828A1 (enExample)
PL (1) PL2493930T3 (enExample)
PT (1) PT2493930T (enExample)
RS (1) RS58142B1 (enExample)
RU (1) RU2569109C2 (enExample)
SI (1) SI2493930T1 (enExample)
SM (1) SMT201800637T1 (enExample)
TW (1) TWI414308B (enExample)
UA (1) UA105073C2 (enExample)
WO (1) WO2011052799A1 (enExample)
ZA (1) ZA201203002B (enExample)

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US9415118B2 (en) * 2013-03-13 2016-08-16 Novartis Ag Antibody drug conjugates
EP3789399A1 (en) 2014-11-21 2021-03-10 Bristol-Myers Squibb Company Antibodies comprising modified heavy constant regions
LT3221363T (lt) 2014-11-21 2020-08-10 Bristol-Myers Squibb Company Antikūnai prieš cd73 ir jų panaudojimas
EP3159007A1 (en) 2015-10-19 2017-04-26 Eisai R&D Management Co., Ltd. Pharmaceutical composition for treating rheumatoid arthritis
JP2017154975A (ja) * 2016-02-29 2017-09-07 エーザイ・アール・アンド・ディー・マネジメント株式会社 クローン病を治療するための医薬組成物
JP2018070473A (ja) * 2016-10-26 2018-05-10 エーザイ・アール・アンド・ディー・マネジメント株式会社 関節リウマチを治療するための医薬組成物
JP2018177701A (ja) * 2017-04-14 2018-11-15 エーザイ・アール・アンド・ディー・マネジメント株式会社 クローン病を治療するための医薬組成物
US20220196674A1 (en) * 2019-04-17 2022-06-23 Abdolamir Landi Treatment of autoimmune liver disease
EP3960198A4 (en) 2019-04-23 2023-01-11 Eisai R&D Management Co., Ltd. BIOMARKERS FOR TREATMENT OF RHEUMATOID ARTHRITIS
CA3161271A1 (en) * 2019-12-09 2021-06-17 Alexion Pharmaceuticals, Inc. Anti-c5 antibody for the treatment of neuromyelitis optica spectrum disorder
CN113087795B (zh) * 2019-12-23 2025-06-10 上海普铭生物科技有限公司 针对趋化因子cx3cl1的抗体及其应用
JPWO2022092183A1 (enExample) 2020-10-30 2022-05-05

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Also Published As

Publication number Publication date
PT2493930T (pt) 2018-11-29
MY158481A (en) 2016-10-14
CN102597003B (zh) 2016-03-23
TWI414308B (zh) 2013-11-11
CL2012001143A1 (es) 2012-10-05
UA105073C2 (uk) 2014-04-10
RU2012122203A (ru) 2013-12-10
KR20160066055A (ko) 2016-06-09
PE20121645A1 (es) 2012-12-06
IL219470A0 (en) 2012-06-28
TW201127401A (en) 2011-08-16
CN102597003A (zh) 2012-07-18
BR112012010266A2 (pt) 2016-12-06
KR20120104560A (ko) 2012-09-21
AU2010312408A1 (en) 2012-06-21
IL219470A (en) 2017-10-31
CY1121167T1 (el) 2020-05-29
RU2569109C2 (ru) 2015-11-20
EP2493930B1 (en) 2018-09-19
EP2493930A1 (en) 2012-09-05
ZA201203002B (en) 2013-06-26
LT2493930T (lt) 2019-01-10
MX2012005052A (es) 2012-05-29
CL2015000114A1 (es) 2015-04-10
JO3437B1 (ar) 2019-10-20
EP2493930A4 (en) 2013-12-04
PL2493930T3 (pl) 2019-03-29
AR109533A2 (es) 2018-12-19
NZ599779A (en) 2014-03-28
ES2698389T3 (es) 2019-02-04
KR101627605B1 (ko) 2016-06-07
US20120213799A1 (en) 2012-08-23
DK2493930T3 (en) 2018-12-17
SI2493930T1 (sl) 2018-12-31
SMT201800637T1 (it) 2019-01-11
HUE041952T2 (hu) 2019-06-28
WO2011052799A1 (en) 2011-05-05
CA2778895A1 (en) 2011-05-05
AU2010312408B2 (en) 2015-07-09
JP2013509158A (ja) 2013-03-14
AR078796A1 (es) 2011-12-07
HRP20181973T1 (hr) 2019-01-25
US8932592B2 (en) 2015-01-13
RS58142B1 (sr) 2019-02-28
KR102099596B1 (ko) 2020-04-10
JP5631991B2 (ja) 2014-11-26
JP2015027304A (ja) 2015-02-12
PH12012500828A1 (en) 2013-01-07

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