CA2769251C - 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives - Google Patents

5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives Download PDF

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Publication number
CA2769251C
CA2769251C CA2769251A CA2769251A CA2769251C CA 2769251 C CA2769251 C CA 2769251C CA 2769251 A CA2769251 A CA 2769251A CA 2769251 A CA2769251 A CA 2769251A CA 2769251 C CA2769251 C CA 2769251C
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CA
Canada
Prior art keywords
optionally substituted
compound
ring system
benzyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2769251A
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English (en)
French (fr)
Other versions
CA2769251A1 (en
Inventor
Timothy A. Boebel
Kristy Bryan
Beth Lorsbach
Timothy P. Martin
W. John Owen
Mark A. Pobanz
Scott Thornburgh
Jeffery D. Webster
Chenglin Yao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Adama Makhteshim Ltd
Original Assignee
Adama Makhteshim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43535293&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2769251(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Adama Makhteshim Ltd filed Critical Adama Makhteshim Ltd
Publication of CA2769251A1 publication Critical patent/CA2769251A1/en
Application granted granted Critical
Publication of CA2769251C publication Critical patent/CA2769251C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/16—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof the nitrogen atom being part of a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/20—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D239/22—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to ring carbon atoms

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  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2769251A 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives Expired - Fee Related CA2769251C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23223209P 2009-08-07 2009-08-07
US61/232,232 2009-08-07
PCT/US2010/044585 WO2011017544A1 (en) 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives

Publications (2)

Publication Number Publication Date
CA2769251A1 CA2769251A1 (en) 2011-02-10
CA2769251C true CA2769251C (en) 2018-05-15

Family

ID=43535293

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2769251A Expired - Fee Related CA2769251C (en) 2009-08-07 2010-08-05 5-fluoro-2-oxopyrimidine- 1(2h)-carboxylate derivatives

Country Status (28)

Country Link
US (1) US8318758B2 (enExample)
EP (1) EP2462133B1 (enExample)
JP (1) JP5818791B2 (enExample)
KR (1) KR101792286B1 (enExample)
CN (1) CN102548979B (enExample)
AU (1) AU2010279408B2 (enExample)
BR (1) BR112012002807B1 (enExample)
CA (1) CA2769251C (enExample)
CL (1) CL2012000314A1 (enExample)
CO (1) CO6491089A2 (enExample)
CR (1) CR20120033A (enExample)
DK (1) DK2462133T3 (enExample)
EA (1) EA022930B1 (enExample)
EC (1) ECSP12011651A (enExample)
ES (1) ES2506169T3 (enExample)
HN (1) HN2012000261A (enExample)
IL (1) IL217954A (enExample)
IN (1) IN2012DN00695A (enExample)
MX (1) MX2012001623A (enExample)
NI (1) NI201200019A (enExample)
NZ (1) NZ597638A (enExample)
PE (1) PE20120689A1 (enExample)
PL (1) PL2462133T3 (enExample)
PT (1) PT2462133E (enExample)
RS (1) RS53658B1 (enExample)
UA (1) UA106086C2 (enExample)
WO (1) WO2011017544A1 (enExample)
ZA (1) ZA201305992B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20120691A1 (es) * 2009-08-07 2012-06-08 Dow Agrosciences Llc Derivados de n1-sulfonil-5-fluoropirimidinona
CN104884062B (zh) 2012-12-28 2018-11-06 阿达玛马克西姆股份有限公司 N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-甲酰胺衍生物
CN104902757B (zh) * 2012-12-28 2019-01-08 阿达玛马克西姆股份有限公司 N-(取代的)-5-氟-4-亚氨基-3-甲基-2-氧代-3,4-二氢嘧啶-1(2h)-羧酸酯衍生物
CN104994859B (zh) * 2012-12-28 2018-10-26 阿达玛马克西姆股份有限公司 1-(取代的苯甲酰基)-5-氟-4-亚氨基-3-甲基-3,4-二氢嘧啶-2(1h)-酮衍生物
JP2016503816A (ja) 2012-12-31 2016-02-08 ダウ アグロサイエンシィズ エルエルシー 殺真菌剤としての３−アルキル−５−フルオロ−４置換イミノ−３，４−ジヒドロピリミジン−２（１ｈ）−オン誘導体
JP6585057B2 (ja) 2013-12-31 2019-10-02 アダマ・マクテシム・リミテッド ５−フルオロ−４−イミノ−３−（アルキル／置換アルキル）−１−（アリールスルホニル）−３，４−ジヒドロピリミジン−２（１ｈ）−オンおよびそれらの調製方法
CR20160345A (es) 2013-12-31 2017-02-21 Adama Makhteshim Ltd Mezclas fungicidas sinérgicas y composiciones que comprenden 5-fluoro-4-imino-3-metil-1-tosil-3,4-dihidropirimidin-2(1h)-ona e inhibidor(es) de la biosíntesis de esteroles para el control fúngico
WO2016040193A1 (en) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine and therapeutic uses thereof
CN108473491A (zh) 2015-11-06 2018-08-31 萨穆梅德有限公司 2-(1h-吲唑-3-基)-3h-咪唑并[4,5-c]吡啶以及其抗炎用途
SMT202200486T1 (it) 2016-06-01 2023-01-13 Biosplice Therapeutics Inc Processo per la preparazione di n-(5-(3-(7-(3- fluorofen il)-3h-imidaz0[4,5-c]piridin-2-il)-1h-indazol-5- il)piridin-3-il)-3-metilbutanammide
AU2018320492C1 (en) 2017-07-17 2023-07-13 Adama Makhteshim Ltd. Polymorphs of 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2-one
WO2020095181A1 (en) 2018-11-05 2020-05-14 Adama Makhteshim Ltd. Mixtures and compositions comprising 5-fluoro-4-imino-3- methyl-1-tosyl-3,4-dihydropyrimidin-2-one, and methods of use thereof
UY38890A (es) 2019-09-23 2021-04-30 Adama Makhteshim Ltd Procedimiento para preparar 5-(fluoro-4-imino-3-metil)-1-tosil-3,4-dihidropirimidin-(1h)-ona y derivados del compuesto

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3368938A (en) * 1966-01-13 1968-02-13 Hoffmann La Roche Controlling fungi with 5-fluorocytosine
PL328777A1 (en) * 1996-03-11 1999-02-15 Novartis Ag Pesticides
WO2004037159A2 (en) * 2002-10-23 2004-05-06 Obetherapy Biotechnology Compounds, compositions and methods for modulating fat metabolism
SI2151439T1 (sl) * 2007-04-27 2014-05-30 Daiichi Sankyo Company, Limited Nitrogeniran aromatski derivat s 6-členskim obročem in farmacevtsko sredstvo, ki obsega ta derivat
EP2317851B1 (en) * 2008-08-01 2014-01-15 Dow AgroSciences LLC Use of 5-fluorocytosine as a fungicide

Also Published As

Publication number Publication date
PE20120689A1 (es) 2012-06-06
NI201200019A (es) 2012-05-22
ECSP12011651A (es) 2012-03-30
US8318758B2 (en) 2012-11-27
JP2013501726A (ja) 2013-01-17
IL217954A (en) 2016-02-29
US20110034491A1 (en) 2011-02-10
RS53658B1 (sr) 2015-04-30
KR101792286B1 (ko) 2017-10-31
CA2769251A1 (en) 2011-02-10
IN2012DN00695A (enExample) 2015-06-19
BR112012002807A2 (pt) 2015-10-13
PL2462133T3 (pl) 2015-03-31
HK1172892A1 (en) 2013-05-03
UA106086C2 (uk) 2014-07-25
BR112012002807A8 (pt) 2017-07-11
CR20120033A (es) 2012-03-22
MX2012001623A (es) 2012-04-11
NZ597638A (en) 2014-06-27
EP2462133A1 (en) 2012-06-13
EP2462133B1 (en) 2014-09-24
KR20120043069A (ko) 2012-05-03
CL2012000314A1 (es) 2012-10-05
AU2010279408A1 (en) 2012-02-09
JP5818791B2 (ja) 2015-11-18
BR112012002807B1 (pt) 2018-07-10
CN102548979B (zh) 2015-05-13
AU2010279408B2 (en) 2015-09-10
ZA201305992B (en) 2014-10-29
DK2462133T3 (en) 2015-01-05
IL217954A0 (en) 2012-03-29
CO6491089A2 (es) 2012-07-31
CN102548979A (zh) 2012-07-04
PT2462133E (pt) 2014-12-26
EA022930B1 (ru) 2016-03-31
HN2012000261A (es) 2015-01-05
EP2462133A4 (en) 2013-01-16
ES2506169T3 (es) 2014-10-13
WO2011017544A1 (en) 2011-02-10
EA201270255A1 (ru) 2012-07-30

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