MX2022011088A - Procedimiento para preparar 5-fluoro-4-imino-3-metil-1-(tolueno-4- sulfonil)-3,4-dihidro-1h-pirimidin-2-ona. - Google Patents

Procedimiento para preparar 5-fluoro-4-imino-3-metil-1-(tolueno-4- sulfonil)-3,4-dihidro-1h-pirimidin-2-ona.

Info

Publication number
MX2022011088A
MX2022011088A MX2022011088A MX2022011088A MX2022011088A MX 2022011088 A MX2022011088 A MX 2022011088A MX 2022011088 A MX2022011088 A MX 2022011088A MX 2022011088 A MX2022011088 A MX 2022011088A MX 2022011088 A MX2022011088 A MX 2022011088A
Authority
MX
Mexico
Prior art keywords
sub
formula
pyrimidin
imino
dihydro
Prior art date
Application number
MX2022011088A
Other languages
English (en)
Inventor
Samaa Alasibi
Gal Suez
Eynat Matzner
Original Assignee
Adama Makhteshim Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Adama Makhteshim Ltd filed Critical Adama Makhteshim Ltd
Publication of MX2022011088A publication Critical patent/MX2022011088A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención proporciona un procedimiento para preparar el compuesto 5-fluoro-4-imino-3-metil-1-(fenil-4-sulfonil)-3,4-dih idro-1H-pirimidin-2-ona que tiene la fórmula (I): (ver Fórmula) (I), que comprende (a)hacer reaccionar 5-fluorocitosina con un compuesto que tiene la fórmula (III): (ver Fórmula) (III) en presencia de al menos un disolvente polar y al menos una base para obtener el compuesto que tiene la fórmula (II) (ver Fórmula) (II) y (b) hacer reaccionar el compuesto que tiene la fórmula (II) con sulfato de dimetilo (DMS), en la que R es hidrógeno, alquilo, alquenilo, alquinilo, alcoxilo, haloalquilo, haloalcoxilo, alquiltio, haloalquiltio, amino, alquilamino, dialquilamino, alcoxicarbonilo, alquilcarbonilo, hidroxialquilo, éster, halógeno ácido, -SH, -OH, -NH2, -NO2, -CN o CF3, y X es un halógeno o -OSO2PhR.
MX2022011088A 2020-03-09 2021-03-09 Procedimiento para preparar 5-fluoro-4-imino-3-metil-1-(tolueno-4- sulfonil)-3,4-dihidro-1h-pirimidin-2-ona. MX2022011088A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062986883P 2020-03-09 2020-03-09
US202063082053P 2020-09-23 2020-09-23
PCT/IB2021/051957 WO2021181274A1 (en) 2020-03-09 2021-03-09 Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1h-pyrimidin-2-one

Publications (1)

Publication Number Publication Date
MX2022011088A true MX2022011088A (es) 2022-09-29

Family

ID=75426643

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2022011088A MX2022011088A (es) 2020-03-09 2021-03-09 Procedimiento para preparar 5-fluoro-4-imino-3-metil-1-(tolueno-4- sulfonil)-3,4-dihidro-1h-pirimidin-2-ona.

Country Status (6)

Country Link
US (1) US20230104954A1 (es)
EP (1) EP4118073A1 (es)
CN (1) CN115776980A (es)
IL (1) IL296178A (es)
MX (1) MX2022011088A (es)
WO (1) WO2021181274A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR127068A1 (es) 2021-09-15 2023-12-13 Adama Makhteshim Ltd Procedimiento para preparar 5-fluoro-4-imino-3-metil-1(tolueno-4-sulfonil)-3,4-dihidro-1h-pirimidin-2-ona
AR128692A1 (es) 2022-03-03 2024-06-05 Adama Makhteshim Ltd Combinaciones, mezclas y composiciones fungicidas y usos de las mismas
WO2023228148A1 (en) 2022-05-26 2023-11-30 Adama Makhteshim Ltd. Fungicidal combinations, mixtures and compositions and uses thereof
WO2024028812A1 (en) 2022-08-03 2024-02-08 Adama Makhteshim Ltd. 5-fluoro-4-imino-3-methyl-1-tosyl-3,4-dihydropyrimidin-2(1h)-one for fungicide-resistant fungus
WO2024184859A1 (en) 2023-03-09 2024-09-12 Conese Salvatore Fungicidal combinations, mixtures and compositions and uses thereof
WO2024189563A1 (en) 2023-03-14 2024-09-19 Adama Makhteshim Ltd. Liquid compositions containing 5-(fluoro-4-imino-3-methyl)-1-tosyl-3,4 dihydropyrimidine-(1h)-one and derivatives thereof and a uv absorber
WO2024194833A1 (en) 2023-03-23 2024-09-26 Adama Makhteshim Ltd. Process for preparing 5-fluoro-4-imino-3-methyl-1-(toluene-4-sulfonyl)-3,4-dihydro-1h-pyrimidin-2-one

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2563129B1 (en) * 2010-04-26 2016-06-01 Dow AgroSciences, LLC N3-substituted-n1-sulfonyl-5-fluoropyrimidinone derivatives
ME02924B (me) * 2011-08-17 2018-04-20 Adama Makhteshim Ltd 1-supstituisani derivati 5-fluor-3,6-dihidro-6-imino-2(1h)-pirimidinona kao fungicidna sredstva za upotrebu u proizvodnji bilja
CR20160343A (es) * 2013-12-31 2016-12-14 Adama Makhteshim Ltd 5-fluor-4-imino-3-(alquil/alquilo sustituido)-1-(arilsulfonil)-3,4-dihidropirimidin-2 (1h)-ona y los procesos para su preparación

Also Published As

Publication number Publication date
IL296178A (en) 2022-11-01
EP4118073A1 (en) 2023-01-18
US20230104954A1 (en) 2023-04-06
WO2021181274A1 (en) 2021-09-16
CN115776980A (zh) 2023-03-10

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