CA2762022A1 - Redox drug derivatives - Google Patents

Redox drug derivatives Download PDF

Info

Publication number
CA2762022A1
CA2762022A1 CA2762022A CA2762022A CA2762022A1 CA 2762022 A1 CA2762022 A1 CA 2762022A1 CA 2762022 A CA2762022 A CA 2762022A CA 2762022 A CA2762022 A CA 2762022A CA 2762022 A1 CA2762022 A1 CA 2762022A1
Authority
CA
Canada
Prior art keywords
group
compound
alkyl
substituted
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2762022A
Other languages
English (en)
French (fr)
Inventor
Derek Lindsay
Peter Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Redx Pharma Ltd
Original Assignee
Redx Pharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0908338A external-priority patent/GB0908338D0/en
Priority claimed from GBGB1006112.5A external-priority patent/GB201006112D0/en
Application filed by Redx Pharma Ltd filed Critical Redx Pharma Ltd
Publication of CA2762022A1 publication Critical patent/CA2762022A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/52—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CA2762022A 2009-05-15 2010-05-17 Redox drug derivatives Abandoned CA2762022A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0908338A GB0908338D0 (en) 2009-05-15 2009-05-15 Redox drug derivatives
GB0908338.7 2009-05-15
GB1006112.5 2010-04-13
GBGB1006112.5A GB201006112D0 (en) 2010-04-13 2010-04-13 Redox drug derivatives
PCT/GB2010/050797 WO2010131054A1 (en) 2009-05-15 2010-05-17 Redox drug derivatives

Publications (1)

Publication Number Publication Date
CA2762022A1 true CA2762022A1 (en) 2010-11-18

Family

ID=42304532

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2762022A Abandoned CA2762022A1 (en) 2009-05-15 2010-05-17 Redox drug derivatives

Country Status (15)

Country Link
US (1) US8877945B2 (enExample)
EP (1) EP2429991B1 (enExample)
JP (1) JP2012526793A (enExample)
KR (1) KR20120025519A (enExample)
CN (1) CN102459169B (enExample)
AU (1) AU2010247141A1 (enExample)
BR (1) BRPI1010981A2 (enExample)
CA (1) CA2762022A1 (enExample)
EA (1) EA201101564A1 (enExample)
IL (1) IL216214A (enExample)
MX (1) MX2011012134A (enExample)
NZ (2) NZ596492A (enExample)
SG (1) SG176056A1 (enExample)
WO (1) WO2010131054A1 (enExample)
ZA (1) ZA201108276B (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013072703A1 (en) * 2011-11-18 2013-05-23 Redx Pharma Limited Antibacterial drug derivatives
WO2013093458A2 (en) * 2011-12-21 2013-06-27 Redx Pharma Limited Antiviral drug derivatives
CN102827187B (zh) * 2012-07-18 2014-05-14 河南大学 氟喹诺酮醛缩异烟腙及其制备方法和应用
WO2014186465A1 (en) * 2013-05-14 2014-11-20 Biocryst Pharmaceuticals, Inc. Anti-influenza compositions and methods

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292317A (en) 1977-09-20 1981-09-29 Laboratorie Roger Bellon 1,4-Dihydro-quinoline-3-carboxylic acid derivatives, process for their preparation and compositions containing them
SE444566B (sv) 1977-09-20 1986-04-21 Bellon Labor Sa Roger 7-dialkylamin-6-halogen-4-oxo-1,4-dihydrokinolin-3-karboxylsyra, forfarande for framstellning derav och farmaceutiskt preparat derav
JPS5746986A (en) 1980-09-02 1982-03-17 Dai Ichi Seiyaku Co Ltd Pyrido(1,2,3-de)(1,4)benzoxazine derivative
DE3333719A1 (de) 1983-09-17 1985-04-04 Bayer Ag Loesungen milchsaurer salze von piperazinylchinolon- und piperazinyl-azachinoloncarbonsaeuren
JPH0635458B2 (ja) 1985-02-15 1994-05-11 大日本製薬株式会社 ピリドンカルボン酸誘導体、そのエステルおよびその塩
DK170473B1 (da) 1985-06-20 1995-09-11 Daiichi Seiyaku Co S(-)-pyridobenzoxazinforbindelser
DE3881939T2 (de) 1987-02-26 1993-09-30 Daiichi Seiyaku Co Verwendung von Ofloxacin zur lokalen Behandlung oder Prophylaxe von Beschwerden der Wurzelhaut der Zähne.
JPH07113026B2 (ja) * 1988-06-01 1995-12-06 ダイセル化学工業株式会社 オフロキサシンのエステル類の光学分割方法
DE3906365A1 (de) 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
JP2777661B2 (ja) 1988-10-20 1998-07-23 大塚製薬株式会社 ベンゾヘテロ環化合物
GB8906166D0 (en) 1989-03-17 1989-05-04 Pfizer Ltd Therapeutic agents
CZ288492B6 (en) 1990-04-24 2001-06-13 Biota Scient Management Derivatives of alpha-D-neuraminic acid, process of their preparation, their use and pharmaceutical preparations based thereon
US6197819B1 (en) 1990-11-27 2001-03-06 Northwestern University Gamma amino butyric acid analogs and optical isomers
NO179912C (no) 1990-11-28 1997-01-08 Daiichi Seiyaku Co Analogifremgangsmåte for fremstilling av et terapeutisk virksomt optisk aktivt pyridobenzoksazinderivat
AU659501B2 (en) 1991-10-23 1995-05-18 Biota Scientific Management Pty Ltd Antiviral 4-substituted-2-deoxy-2,3-didehydro-derivatives of alpha-D-neuraminic acid
DE4200414A1 (de) 1992-01-10 1993-07-15 Bayer Ag Chinolon- und naphthyridon-carbonsaeure-derivate
NO304832B1 (no) 1992-05-27 1999-02-22 Ube Industries Aminokinolonderivater samt middel mot HIV
AU673824B2 (en) 1992-05-29 1996-11-28 Bayer Aktiengesellschaft Cyclopentane- and -pentene-beta-amino acids
US5235054A (en) 1992-07-15 1993-08-10 Pfizer Inc. 3-carboxaldehyde substituted quinolines and naphthyridines
DE4234078A1 (de) 1992-10-09 1994-04-14 Bayer Ag Chinoloncarbonsäuren
CA2112165C (en) 1992-12-25 2003-04-08 Makoto Takemura Bicyclic amine derivatives
US5527910A (en) 1992-12-30 1996-06-18 Cheil Foods & Chemicals, Inc. Pyridone carboxylic acid compounds and their uses for treating infectious diseases caused by bacteria
KR0148277B1 (ko) * 1993-01-18 1998-11-02 채영복 신규한 플루오르퀴놀론계 유도체 및 그의 제조방법
DE4301246A1 (de) 1993-01-19 1994-07-21 Bayer Ag Chinolon- und Naphthyridoncarbonsäurederivate
TW301607B (enExample) 1993-03-09 1997-04-01 Takeda Pharm Industry Co Ltd
US5665754A (en) 1993-09-20 1997-09-09 Glaxo Wellcome Inc. Substituted pyrrolidines
ATE191711T1 (de) 1995-02-27 2000-04-15 Gilead Sciences Inc Neue selektive inhibitoren viraler oder bakterieller neuraminidasen
DE19546249A1 (de) 1995-12-12 1997-06-19 Bayer Ag Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
US5763483A (en) 1995-12-29 1998-06-09 Gilead Sciences, Inc. Carbocyclic compounds
PL186737B1 (pl) 1996-02-23 2004-02-27 Bayer Ag Kwasy 8-cyjano-1-cyklopropylo-7-/2, 8-diazabicyklo [ 4.3.0 ] nonan-8-ylo/-6-fluoro-1,4-dihydro-4-okso-3-chinolinokarboksylowe i ich pochodne, sposób ich wytwarzania, środki medyczne je zawierające i ich zastosowanie do wytwarzania środków medycznychi antybakteryjnych
PT823428E (pt) 1996-07-22 2002-04-29 Sankyo Co Derivados do acido neuraminico sua preparacao e sua utilizacao em medicina
US6340702B1 (en) 1996-07-22 2002-01-22 Sankyo Company, Limited Neuraminic acid derivatives, their preparation and their medical use
AU714980B2 (en) * 1996-07-24 2000-01-13 Warner-Lambert Company Llc Isobutylgaba and its derivatives for the treatment of pain
TR199901081T2 (xx) 1996-11-14 1999-08-23 Biota Scientific Management Pty.Ltd. Y�ntem ve bu y�ntemde kullan�lan yeni bile�imler.
US6127418A (en) 1997-08-20 2000-10-03 Warner-Lambert Company GABA analogs to prevent and treat gastrointestinal damage
TW477783B (en) 1997-12-12 2002-03-01 Gilead Sciences Inc Novel compounds useful as neuraminidase inhibitors and pharmaceutical compositions containing same
CN1282316A (zh) 1997-12-17 2001-01-31 生物晶体药品股份有限公司 用作神经氨酸酶抑制剂的取代环戊烷和环戊烯化合物
HN1999000174A (es) 1998-10-30 1999-10-13 Bayer Ag Formulacion medicamentosa acuisa para administracion oral.
DE19941217A1 (de) 1999-08-30 2001-03-15 Asta Medica Ag Behandlung der Migräne durch Verabreichung von alpha-Liponsäure oder Derivaten derselben
EP1262477B1 (en) 2000-02-09 2008-09-03 Daiichi Sankyo Company, Limited Anti-acid-fast bacterial agents containing pyridonecarboxylic acids as the active ingredient
JP2004099494A (ja) 2002-09-09 2004-04-02 Shiono Chemical Co Ltd 光学活性三環式化合物の製造方法
PT1675852E (pt) 2003-09-22 2009-03-25 Janssen Pharmaceutica Nv Quinolonas e naftiridonas heterocíclicas de 7-aminoalquilidenilo
WO2006002302A1 (en) 2004-06-23 2006-01-05 Hofmann Robert F Use of targeted oxidative therapeutic formulation in treatment of burns
EP1986636B1 (en) 2006-02-22 2013-04-24 Edison Pharmaceuticals, Inc. Phenol and 1,4-benzoquinone derivatives for use in the treatment of mitochondrial diseases
EP2017273A1 (en) 2007-07-18 2009-01-21 Laboratorios del Dr. Esteve S.A. Process for the enantioselective preparation of pregabalin
EP2190439B1 (en) 2007-08-31 2016-03-09 Academia Sinica Oseltamivir phosphonate derivatives with anti-influenza activity and synthesis thereof
EP2053040A1 (en) 2007-10-26 2009-04-29 Chemo Ibérica, S.A. Pregabalin intermediates and process for preparing them and Pregabalin

Also Published As

Publication number Publication date
WO2010131054A1 (en) 2010-11-18
IL216214A (en) 2015-01-29
JP2012526793A (ja) 2012-11-01
US8877945B2 (en) 2014-11-04
CN102459169A (zh) 2012-05-16
AU2010247141A1 (en) 2011-12-15
SG176056A1 (en) 2011-12-29
CN102459169B (zh) 2014-12-31
EA201101564A1 (ru) 2012-07-30
WO2010131054A9 (en) 2011-05-12
US20120077974A1 (en) 2012-03-29
BRPI1010981A2 (pt) 2018-12-04
MX2011012134A (es) 2012-02-08
EP2429991B1 (en) 2014-09-10
EP2429991A1 (en) 2012-03-21
IL216214A0 (en) 2012-01-31
NZ610978A (en) 2014-11-28
ZA201108276B (en) 2015-08-26
KR20120025519A (ko) 2012-03-15
NZ596492A (en) 2013-08-30

Similar Documents

Publication Publication Date Title
DE60118241T2 (de) Verfahren zur herstellung von oxazolidinonverbindungen
WO2013049605A1 (en) Processes for the preparation of an intermediate in the synthesis of eltrombopag
JP5531097B2 (ja) アンブリセンタンを調製するための改善された方法およびその新規な中間体
WO2018029711A2 (en) Process for the preparation of venetoclax
EP3307711A1 (en) Process for preparation of apremilast and its intermediates
CA2762022A1 (en) Redox drug derivatives
WO2022018625A1 (en) Process for the preparation of an intermediate used in the synthesis of letermovir
US20170267633A1 (en) Novel crystalline arylalkylamine compound and process for producing the same
JPH02178287A (ja) 光学活性ベンゾオキサジン及びベンゾチアジン及びそれらの立体選択的製造方法
CA2573129C (en) Process for preparing levofloxacin or its hydrate
US9988389B2 (en) Processes for making ponatinib and intermediates thereof
JPWO2009142194A1 (ja) 光学活性アミノアルコール誘導体の製造方法
CN111471041B (zh) 一种噁唑烷酮类抗菌药物中间体的合成方法
CN105330590A (zh) 西他沙星五元环侧链中间体的制备方法
CN113754643A (zh) 苯并吡喃衍生物的精制方法、其晶型及所述晶型的制备方法
CN107428761B (zh) 制备二肽基肽酶-4(dpp-4)抑制剂的方法
WO2019023479A1 (en) METHOD AND INTERMEDIATES FOR THE SYNTHESIS OF PEPTIDE COMPOUNDS
JPWO2012157504A1 (ja) β−ラクタム化合物およびその製造方法
CN103339124A (zh) 二(芳氨基)芳基化合物的制备方法及其合成中间体
KR100232541B1 (ko) 4-아미노메틸피롤리딘-3-온-0-알킬 혹은 아릴 옥심 유도체 및 이의 제조방법
CN121194977A (zh) 用于制备芦可替尼及其新晶型的改良方法
KR20250092192A (ko) 알로가바트 제조 방법
EP2516448B1 (en) Amine salts of cefdinir
JPH04270272A (ja) アミノアルキルモルホリン誘導体の製造法
JP2016132660A (ja) 新規イミダゾピリミジンおよびその医薬用途

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20150515

FZDE Discontinued

Effective date: 20170517