CA2756347A1 - Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use - Google Patents
Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use Download PDFInfo
- Publication number
- CA2756347A1 CA2756347A1 CA2756347A CA2756347A CA2756347A1 CA 2756347 A1 CA2756347 A1 CA 2756347A1 CA 2756347 A CA2756347 A CA 2756347A CA 2756347 A CA2756347 A CA 2756347A CA 2756347 A1 CA2756347 A1 CA 2756347A1
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- Prior art keywords
- compound
- atropisomer
- formula
- optically active
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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| EA201270184A1 (ru) * | 2009-07-21 | 2012-08-30 | ГИЛИЭД КАЛИСТОГА ЭлЭлСи | Лечение расстройств печени ингибиторами pi3k |
| GB0918249D0 (en) | 2009-10-19 | 2009-12-02 | Respivert Ltd | Compounds |
| UY33337A (es) | 2010-10-18 | 2011-10-31 | Respivert Ltd | DERIVADOS SUSTITUIDOS DE 1H-PIRAZOL[ 3,4-d]PIRIMIDINA COMO INHIBIDORES DE LAS FOSFOINOSITIDA 3-QUINASAS |
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| EP2518070A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
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| UA115544C2 (uk) | 2012-03-13 | 2017-11-27 | Респіверт Лімітед | Спосіб підвищення стабільності до хімічного розкладання фармацевтичної композиції та застосування стабілізуючого агента у фармацевтичній коипозиції |
| KR101988079B1 (ko) * | 2012-07-04 | 2019-06-11 | 리젠 파마슈티컬스 소시에떼 아노님 | 선택적 pi3k 델타 억제제 |
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| WO2014060431A1 (en) * | 2012-10-16 | 2014-04-24 | Almirall, S.A. | Pyrrolotriazinone derivatives as pi3k inhibitors |
| EA027277B1 (ru) | 2012-10-16 | 2017-07-31 | Альмираль, С.А. | Производные пирроллотриазинона в качестве ингибиторов pi3k |
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| TW201522341A (zh) * | 2013-03-15 | 2015-06-16 | Respivert Ltd | 化合物 |
| US9227977B2 (en) | 2013-03-15 | 2016-01-05 | Respivert Ltd. | Phosphoinositide 3-kinase inhibitors |
| UY35675A (es) | 2013-07-24 | 2015-02-27 | Novartis Ag | Derivados sustituidos de quinazolin-4-ona |
| CN104418849B (zh) * | 2013-09-02 | 2020-04-21 | 广东东阳光药业有限公司 | 取代的氨基嘧啶类化合物及其使用方法和用途 |
| SG11201600707QA (en) | 2013-09-22 | 2016-02-26 | Calitor Sciences Llc | Substituted aminopyrimidine compounds and methods of use |
| CA2934534A1 (en) | 2013-12-20 | 2015-06-25 | Gilead Calistoga Llc | Polymorphic forms of a hydrochloride salt of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one |
| JP2017502021A (ja) | 2013-12-20 | 2017-01-19 | ギリアード カリストガ エルエルシー | ホスファチジルイノシトール３−キナーゼ阻害剤のためのプロセス方法 |
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| CN111635406A (zh) | 2014-05-27 | 2020-09-08 | 理森制药股份公司 | 用于药物制剂中的PI3Kδ选择性抑制剂的改良形式 |
| SG11201609877XA (en) | 2014-06-13 | 2016-12-29 | Gilead Sciences Inc | Phosphatidylinositol 3-kinase inhibitors |
| JP6291601B2 (ja) | 2014-07-04 | 2018-03-14 | ルピン・リミテッド | Ｐｉ３ｋ阻害剤としてのキノリジノン誘導体 |
| WO2017027883A1 (en) | 2015-08-13 | 2017-02-16 | San Diego State University Research Foundation | Atropisomerism for increased kinase inhibitor selectivity |
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| US10016425B2 (en) | 2016-11-03 | 2018-07-10 | King Saud University | Anti-ulcerative colitis compound |
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| WO2005016348A1 (en) | 2003-08-14 | 2005-02-24 | Icos Corporation | Method of inhibiting immune responses stimulated by an endogenous factor |
| CA2552664A1 (en) | 2004-01-08 | 2005-07-28 | Michigan State University | Methods for treating and preventing hypertension and hypertension-related disorders |
| WO2005112935A1 (en) | 2004-05-13 | 2005-12-01 | Vanderbilt University | Phosphoinositide 3-kinase delta selective inhibitors for inhibiting angiogenesis |
| EP1761540B1 (en) | 2004-05-13 | 2016-09-28 | Icos Corporation | Quinazolinones as inhibitors of human phosphatidylinositol 3-kinase delta |
| EP1755609A1 (en) | 2004-05-25 | 2007-02-28 | Icos Corporation | Methods for treating and/or preventing aberrant proliferation of hematopoietic cells |
| JP2008501707A (ja) * | 2004-06-04 | 2008-01-24 | アイコス、コーポレーション | マスト細胞障害を処置するための方法 |
| WO2006089106A2 (en) | 2005-02-17 | 2006-08-24 | Icos Corporation | Phosphoinositide 3-kinase inhibitors for inhibiting leukocyte accumulation |
| US20090170834A1 (en) | 2005-12-22 | 2009-07-02 | Prolexys Pharmaceuticals, Inc. | Fused Pyrimidones and Thiopyrimidones, and Uses Thereof |
| EP2097422A4 (en) | 2006-11-13 | 2010-04-14 | Lilly Co Eli | THIENOPYRIMIDINONE FOR THE TREATMENT OF INFLAMMATORY DISEASES AND CARCINOMAS |
| US20110160232A1 (en) | 2007-10-04 | 2011-06-30 | Pingda Ren | Certain chemical entities and therapeutic uses thereof |
| US20090131512A1 (en) | 2007-10-31 | 2009-05-21 | Dynavax Technologies Corp. | Inhibition of type I in IFN production |
| SG187426A1 (en) | 2008-01-04 | 2013-02-28 | Intellikine Llc | Certain chemical entities, compositions and methods |
| EP2355828B1 (en) | 2008-11-13 | 2018-05-30 | Gilead Calistoga LLC | Therapies for hematologic malignancies |
| AU2009322187B2 (en) | 2008-12-04 | 2015-02-19 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Phosphatidylinositol-3-kinase p110 delta-targeted drugs in the treatment of CNS disorders |
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| CN102458410A (zh) | 2009-04-20 | 2012-05-16 | 吉联亚·卡利斯托加有限责任公司 | 治疗实体瘤的方法 |
| EA201270184A1 (ru) * | 2009-07-21 | 2012-08-30 | ГИЛИЭД КАЛИСТОГА ЭлЭлСи | Лечение расстройств печени ингибиторами pi3k |
| CA3113343C (en) | 2010-06-03 | 2024-10-08 | Pharmacyclics Llc | USE OF BRUTON'S TYROSINE KINASE INHIBITORS IN THE TREATMENT OF FOLLICULAR LYMPHOMA |
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2010
- 2010-03-24 JP JP2012502219A patent/JP2012521994A/ja active Pending
- 2010-03-24 CA CA2756347A patent/CA2756347A1/en not_active Abandoned
- 2010-03-24 BR BRPI1012333A patent/BRPI1012333A2/pt not_active IP Right Cessation
- 2010-03-24 WO PCT/US2010/028554 patent/WO2010111432A1/en not_active Ceased
- 2010-03-24 SG SG2011068822A patent/SG174529A1/en unknown
- 2010-03-24 NZ NZ595307A patent/NZ595307A/xx not_active IP Right Cessation
- 2010-03-24 CN CN2010800226099A patent/CN102439012A/zh active Pending
- 2010-03-24 KR KR1020117024913A patent/KR20120002995A/ko not_active Withdrawn
- 2010-03-24 MX MX2011009955A patent/MX2011009955A/es active IP Right Grant
- 2010-03-24 AU AU2010229968A patent/AU2010229968A1/en not_active Abandoned
- 2010-03-24 EP EP10722454A patent/EP2411391A1/en not_active Withdrawn
- 2010-03-24 US US12/731,089 patent/US8440677B2/en not_active Expired - Fee Related
- 2010-03-24 PE PE2011001710A patent/PE20120602A1/es not_active Application Discontinuation
- 2010-03-24 AP AP2011005943A patent/AP2011005943A0/xx unknown
- 2010-03-24 EA EA201171160A patent/EA019499B1/ru not_active IP Right Cessation
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2011
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- 2011-09-23 CL CL2011002359A patent/CL2011002359A1/es unknown
- 2011-10-20 CO CO11140750A patent/CO6450655A2/es not_active Application Discontinuation
- 2011-10-21 EC ECSP11011412 patent/ECSP11011412A/es unknown
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|---|---|
| EP2411391A1 (en) | 2012-02-01 |
| BRPI1012333A2 (pt) | 2016-03-29 |
| PE20120602A1 (es) | 2012-05-21 |
| US8440677B2 (en) | 2013-05-14 |
| SG174529A1 (en) | 2011-10-28 |
| US20100249155A1 (en) | 2010-09-30 |
| CO6450655A2 (es) | 2012-05-31 |
| AU2010229968A1 (en) | 2011-10-13 |
| WO2010111432A1 (en) | 2010-09-30 |
| MX2011009955A (es) | 2011-11-18 |
| CN102439012A (zh) | 2012-05-02 |
| IL215251A0 (en) | 2011-12-29 |
| EA201171160A1 (ru) | 2012-04-30 |
| JP2012521994A (ja) | 2012-09-20 |
| ECSP11011412A (es) | 2012-03-30 |
| EA019499B1 (ru) | 2014-04-30 |
| AP2011005943A0 (en) | 2011-10-31 |
| KR20120002995A (ko) | 2012-01-09 |
| CL2011002359A1 (es) | 2012-04-09 |
| NZ595307A (en) | 2013-11-29 |
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