CA2756347A1 - Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use - Google Patents
Atropisomers of 2-purinyl-3-tolyl-quinazolinone derivatives and methods of use Download PDFInfo
- Publication number
- CA2756347A1 CA2756347A1 CA2756347A CA2756347A CA2756347A1 CA 2756347 A1 CA2756347 A1 CA 2756347A1 CA 2756347 A CA2756347 A CA 2756347A CA 2756347 A CA2756347 A CA 2756347A CA 2756347 A1 CA2756347 A1 CA 2756347A1
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- Prior art keywords
- compound
- atropisomer
- formula
- optically active
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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| NZ631024A (en) | 2008-11-13 | 2016-04-29 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
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| PT2421536E (pt) * | 2009-04-20 | 2015-10-20 | Gilead Calistoga Llc | Métodos de tratamento para tumores sólidos |
| EP2435048B1 (en) * | 2009-05-29 | 2019-07-03 | Merck Sharp & Dohme Corp. | Radiolabeled pde10 inhibitors |
| EP2456443A1 (en) * | 2009-07-21 | 2012-05-30 | Gilead Calistoga LLC | Treatment of liver disorders with pi3k inhibitors |
| GB0918249D0 (en) | 2009-10-19 | 2009-12-02 | Respivert Ltd | Compounds |
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| EP2518070A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
| EP2518071A1 (en) * | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Imidazopyridine derivatives as PI3K inhibitors |
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| KR101988079B1 (ko) | 2012-07-04 | 2019-06-11 | 리젠 파마슈티컬스 소시에떼 아노님 | 선택적 pi3k 델타 억제제 |
| WO2014015523A1 (en) * | 2012-07-27 | 2014-01-30 | Hutchison Medipharma Limited | Novel heteroaryl and heterocycle compounds, compositions and methods |
| EA027277B1 (ru) * | 2012-10-16 | 2017-07-31 | Альмираль, С.А. | Производные пирроллотриазинона в качестве ингибиторов pi3k |
| WO2014060431A1 (en) * | 2012-10-16 | 2014-04-24 | Almirall, S.A. | Pyrrolotriazinone derivatives as pi3k inhibitors |
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| JO3279B1 (ar) | 2013-03-15 | 2018-09-16 | Respivert Ltd | مشتقات 2-((4- امينو -3- (3- فلورو-5- هيدروكسي فينيل)-h1- بيرازولو [d-3,4] بيرمدين-1-يل )ميثيل )- 3- (2- تراي فلورو ميثيل ) بينزيل ) كوينازولين -4 (h3)- واحد واستخدامها كمثبطات فوسفواينوسيتايد 3- كاينيز |
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| CN104447727B (zh) * | 2013-09-02 | 2018-04-27 | 广东东阳光药业有限公司 | 取代的氨基嘧啶类化合物及其使用方法和用途 |
| KR20160060100A (ko) | 2013-09-22 | 2016-05-27 | 칼리토르 사이언시즈, 엘엘씨 | 치환된 아미노피리미딘 화합물 및 이용 방법 |
| EP3083623A1 (en) | 2013-12-20 | 2016-10-26 | Gilead Calistoga LLC | Polymorphic forms of a hydrochloride salt of (s) -2-(9h-purin-6-ylamino) propyl) -5-fluoro-3-phenylquinazolin-4 (3h) -one |
| PT3083630T (pt) | 2013-12-20 | 2019-11-15 | Gilead Calistoga Llc | Procedimentos para inibidores da fosfatidilinositol 3-quinase |
| CA2949932C (en) | 2014-05-27 | 2021-08-10 | Rhizen Pharmaceuticals Sa | Improved forms of a pi3k delta selective inhibitor for use in pharmaceutical formulations |
| CA2944611A1 (en) * | 2014-05-27 | 2015-12-03 | Almirall, S.A. | Addition salts of (s)-2-(1-(6-amino-5-cyanopyrimidin-4-ylamino)ethyl)-4-oxo-3-phenyl-3,4-dihydropyrrolo[1,2-f][1,2,4]triazine-5-carbonitrile |
| JP6455995B2 (ja) | 2014-06-13 | 2019-01-23 | ギリアード サイエンシーズ， インコーポレイテッド | ホスファチジルイノシトール３−キナーゼ阻害剤 |
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| US10550124B2 (en) * | 2015-08-13 | 2020-02-04 | San Diego State University Foundation | Atropisomerism for increased kinase inhibitor selectivity |
| US11351209B2 (en) | 2016-01-11 | 2022-06-07 | Queen Mary University Of London | Inhibitors of PI3K p-delta 110 for use in delivery of viruses in the treatment of cancer |
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- 2010-03-24 SG SG2011068822A patent/SG174529A1/en unknown
- 2010-03-24 EA EA201171160A patent/EA019499B1/ru not_active IP Right Cessation
- 2010-03-24 BR BRPI1012333A patent/BRPI1012333A2/pt not_active IP Right Cessation
- 2010-03-24 AU AU2010229968A patent/AU2010229968A1/en not_active Abandoned
- 2010-03-24 CA CA2756347A patent/CA2756347A1/en not_active Abandoned
- 2010-03-24 AP AP2011005943A patent/AP2011005943A0/xx unknown
- 2010-03-24 KR KR1020117024913A patent/KR20120002995A/ko not_active Withdrawn
- 2010-03-24 MX MX2011009955A patent/MX2011009955A/es active IP Right Grant
- 2010-03-24 EP EP10722454A patent/EP2411391A1/en not_active Withdrawn
- 2010-03-24 US US12/731,089 patent/US8440677B2/en not_active Expired - Fee Related
- 2010-03-24 WO PCT/US2010/028554 patent/WO2010111432A1/en not_active Ceased
- 2010-03-24 NZ NZ595307A patent/NZ595307A/xx not_active IP Right Cessation
- 2010-03-24 PE PE2011001710A patent/PE20120602A1/es not_active Application Discontinuation
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- 2010-03-24 JP JP2012502219A patent/JP2012521994A/ja active Pending
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- 2011-09-23 CL CL2011002359A patent/CL2011002359A1/es unknown
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Also Published As
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|---|---|
| AU2010229968A1 (en) | 2011-10-13 |
| KR20120002995A (ko) | 2012-01-09 |
| AP2011005943A0 (en) | 2011-10-31 |
| US8440677B2 (en) | 2013-05-14 |
| WO2010111432A1 (en) | 2010-09-30 |
| MX2011009955A (es) | 2011-11-18 |
| CN102439012A (zh) | 2012-05-02 |
| US20100249155A1 (en) | 2010-09-30 |
| CO6450655A2 (es) | 2012-05-31 |
| EA201171160A1 (ru) | 2012-04-30 |
| EA019499B1 (ru) | 2014-04-30 |
| JP2012521994A (ja) | 2012-09-20 |
| IL215251A0 (en) | 2011-12-29 |
| SG174529A1 (en) | 2011-10-28 |
| EP2411391A1 (en) | 2012-02-01 |
| NZ595307A (en) | 2013-11-29 |
| ECSP11011412A (es) | 2012-03-30 |
| BRPI1012333A2 (pt) | 2016-03-29 |
| CL2011002359A1 (es) | 2012-04-09 |
| PE20120602A1 (es) | 2012-05-21 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |
Effective date: 20160324 |