CA2750701C - Method for production of lactoferrin - Google Patents

Method for production of lactoferrin Download PDF

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Publication number
CA2750701C
CA2750701C CA2750701A CA2750701A CA2750701C CA 2750701 C CA2750701 C CA 2750701C CA 2750701 A CA2750701 A CA 2750701A CA 2750701 A CA2750701 A CA 2750701A CA 2750701 C CA2750701 C CA 2750701C
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CA
Canada
Prior art keywords
lactoferrin
lps
iron
milk
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CA2750701A
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English (en)
French (fr)
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CA2750701A1 (en
Inventor
Jean-Paul Perraudin
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Individual
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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/79Transferrins, e.g. lactoferrins, ovotransferrins
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17Amino acids, peptides or proteins
    • A23L33/19Dairy proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/16Otologicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2300/00Processes
    • A23V2300/30Ion-exchange
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2300/00Processes
    • A23V2300/34Membrane process
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Nutrition Science (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA2750701A 2009-01-28 2010-01-28 Method for production of lactoferrin Expired - Fee Related CA2750701C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20208809P 2009-01-28 2009-01-28
US61/202,088 2009-01-28
PCT/IB2010/000149 WO2010112988A1 (en) 2009-01-28 2010-01-28 Method for production of lactoferrin

Publications (2)

Publication Number Publication Date
CA2750701A1 CA2750701A1 (en) 2010-10-07
CA2750701C true CA2750701C (en) 2018-02-13

Family

ID=41818728

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2750701A Expired - Fee Related CA2750701C (en) 2009-01-28 2010-01-28 Method for production of lactoferrin

Country Status (12)

Country Link
US (1) US9115211B2 (enExample)
EP (1) EP2391225B1 (enExample)
JP (1) JP5718254B2 (enExample)
CN (1) CN102348387B (enExample)
AU (1) AU2010231075B2 (enExample)
CA (1) CA2750701C (enExample)
DK (1) DK2391225T3 (enExample)
ES (1) ES2805279T3 (enExample)
NZ (1) NZ594212A (enExample)
PL (1) PL2391225T3 (enExample)
RU (1) RU2579661C2 (enExample)
WO (1) WO2010112988A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2013204858B2 (en) * 2012-10-08 2015-06-25 Saputo Dairy Australia Pty Limited Improved process for purifying milk proteins and products thereof
AU2013204850B2 (en) * 2012-10-08 2015-06-25 Murray Goulburn Co-Operative Co. Limited Improved process for purifying milk proteins and products thereof
RO130063A8 (ro) 2014-08-28 2017-06-30 Romvac Company S.A. Producerea şi utilizarea ovotransferinei moderne ()
JPWO2016136904A1 (ja) * 2015-02-26 2017-12-07 味の素株式会社 チーズの製造方法及びチーズ改質用の製剤
FR3046603B1 (fr) 2016-01-11 2017-12-29 Michelin & Cie Procede de modification d'un caoutchouc naturel et caoutchouc naturel modifie
CN117942405A (zh) 2016-02-25 2024-04-30 应用生物实验室公司 保护空气传播的病原体和刺激物的组合物和方法
US12447166B2 (en) * 2016-02-25 2025-10-21 Applied Biological Laboratories, Inc. Compositions and methods for protecting against airborne pathogens and irritants
CN112996806A (zh) * 2018-11-06 2021-06-18 安赫尔工程建模有限责任公司 从奶、初乳和酸乳清或甜乳清中制备高纯度乳铁蛋白和乳过氧化物酶的方法
JPWO2021153508A1 (enExample) 2020-01-30 2021-08-05
AU2020203454B1 (en) * 2020-05-26 2021-07-22 HPS Tech Pty Ltd Processing protein
FR3115037B1 (fr) 2020-10-12 2025-02-21 Cie Laitiere Europeenne Procédé de purification de fraction de protéines cationiques et fraction ainsi obtenue
UY39909A (es) * 2021-08-23 2023-03-31 Lactea Therapeutics Llc Composiciones de lactoferrina y métodos de uso
IL311036A (en) * 2021-08-23 2024-04-01 Lactea Therapeutics Llc Lactoferrin compositions and methods of use
US20250136666A1 (en) * 2021-11-16 2025-05-01 Noumi Limited A method for producing a lactoferrin powder and uses thereof
DE202023102334U1 (de) 2023-04-28 2023-06-07 Mercurius Production Gmbh Lactoferrin und Vorrichtung zu dessen Herstellung
PL444766A1 (pl) * 2023-05-07 2024-11-12 Polmlek Spółka Z Ograniczoną Odpowiedzialnością Sposób uzyskiwania laktoferyny w proszku z surowego mleka

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE61701B1 (en) * 1986-07-17 1994-11-30 Morinaga Milk Industry Co Ltd Process for producing bovine lactoferrin in high purity
US5571697A (en) * 1989-05-05 1996-11-05 Baylor College Of Medicine Texas Medical Center Expression of processed recombinant lactoferrin and lactoferrin polypeptide fragments from a fusion product in Aspergillus
JP2686831B2 (ja) * 1989-09-22 1997-12-08 雪印乳業株式会社 鉄結合性蛋白質を分離、精製し、採取する方法
US6096870A (en) * 1994-01-05 2000-08-01 Sepragen Corporation Sequential separation of whey
JPH09509165A (ja) * 1994-02-16 1997-09-16 ファーミング ベスローテン フェンノートシャップ ミルクからのラクトフェリンの分離
JPH08217693A (ja) * 1995-02-17 1996-08-27 Yoshihisa Naito 新規医薬組成物
JP2974604B2 (ja) * 1996-01-23 1999-11-10 雪印乳業株式会社 塩基性タンパク質組成物、塩基性ペプチド組成物及びその利用
JPH1059864A (ja) * 1996-08-15 1998-03-03 Morinaga Milk Ind Co Ltd 経口がん転移抑制剤
JP2002326950A (ja) * 2001-05-02 2002-11-15 Meiji Milk Prod Co Ltd 炎症性サイトカイン産生抑制剤
US20030096736A1 (en) * 2001-05-09 2003-05-22 Kruzel Marian L. Lactoferrin for age related disorders in humans
WO2003094952A1 (en) * 2002-05-10 2003-11-20 Agennix Incorporated Intratumorally administered lactoferrin in the treatment of malignant neoplasms and other hyperproliferative diseases
AU2003233583A1 (en) * 2002-05-24 2003-12-12 Agennix Incorporated Oral lactoferrin in the treatment of respiratory disorders
CA2542291A1 (en) * 2004-02-03 2005-08-18 Kurume University Method for separating/refining cationic protein
CA2608281A1 (en) 2005-05-13 2006-11-16 Crea Biopharma Inc. New purification method of lactoferrin
JP5087297B2 (ja) * 2007-03-05 2012-12-05 森永乳業株式会社 インターロイキン−11産生促進剤
CN101117351B (zh) * 2007-04-30 2010-08-18 北京济普霖生物技术有限公司 一种从转基因牛乳中纯化重组人乳铁蛋白的方法
NZ583234A (en) 2007-07-10 2012-06-29 Glanbia Nutritionals Method for removing endotoxin from proteins

Also Published As

Publication number Publication date
NZ594212A (en) 2013-01-25
RU2011135536A (ru) 2013-03-10
RU2579661C2 (ru) 2016-04-10
DK2391225T3 (da) 2020-07-20
EP2391225B1 (en) 2020-05-06
EP2391225A1 (en) 2011-12-07
WO2010112988A1 (en) 2010-10-07
JP2012516319A (ja) 2012-07-19
JP5718254B2 (ja) 2015-05-13
CN102348387A (zh) 2012-02-08
CA2750701A1 (en) 2010-10-07
CN102348387B (zh) 2014-12-31
AU2010231075B2 (en) 2015-06-11
ES2805279T3 (es) 2021-02-11
AU2010231075A1 (en) 2011-08-18
US9115211B2 (en) 2015-08-25
PL2391225T3 (pl) 2020-11-16
US20110301077A1 (en) 2011-12-08

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EEER Examination request

Effective date: 20150119

MKLA Lapsed

Effective date: 20220128