CA2749802C - New stable formulations of recombinant human albumin-human granulocyte colony stimulating factor fusion protein - Google Patents

New stable formulations of recombinant human albumin-human granulocyte colony stimulating factor fusion protein Download PDF

Info

Publication number
CA2749802C
CA2749802C CA2749802A CA2749802A CA2749802C CA 2749802 C CA2749802 C CA 2749802C CA 2749802 A CA2749802 A CA 2749802A CA 2749802 A CA2749802 A CA 2749802A CA 2749802 C CA2749802 C CA 2749802C
Authority
CA
Canada
Prior art keywords
neutropenia
subject
neug
medicament
human
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2749802A
Other languages
English (en)
French (fr)
Other versions
CA2749802A1 (en
Inventor
Jason Benjamin Bock
Adam Carr Bell
Jeffrey Herpst
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teva Pharmaceutical Industries Ltd
Original Assignee
Teva Pharmaceutical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharmaceutical Industries Ltd filed Critical Teva Pharmaceutical Industries Ltd
Publication of CA2749802A1 publication Critical patent/CA2749802A1/en
Application granted granted Critical
Publication of CA2749802C publication Critical patent/CA2749802C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • A61K38/385Serum albumin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/193Colony stimulating factors [CSF]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38Albumins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/643Albumins, e.g. HSA, BSA, ovalbumin or a Keyhole Limpet Hemocyanin [KHL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA2749802A 2009-01-16 2010-01-15 New stable formulations of recombinant human albumin-human granulocyte colony stimulating factor fusion protein Expired - Fee Related CA2749802C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US14544009P 2009-01-16 2009-01-16
US14543609P 2009-01-16 2009-01-16
US61/145,440 2009-01-16
US61/145,436 2009-01-16
PCT/US2010/021241 WO2010083439A2 (en) 2009-01-16 2010-01-15 Recombinant human albumin-human granulocyte colony stimulating factor for the prevention of neutropenia

Publications (2)

Publication Number Publication Date
CA2749802A1 CA2749802A1 (en) 2010-07-22
CA2749802C true CA2749802C (en) 2016-08-23

Family

ID=42260335

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2749802A Expired - Fee Related CA2749802C (en) 2009-01-16 2010-01-15 New stable formulations of recombinant human albumin-human granulocyte colony stimulating factor fusion protein
CA2749786A Abandoned CA2749786A1 (en) 2009-01-16 2010-01-15 New stable formulations of recombinant human albumin-human granulocyte colony stimulating factor fusion protein

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2749786A Abandoned CA2749786A1 (en) 2009-01-16 2010-01-15 New stable formulations of recombinant human albumin-human granulocyte colony stimulating factor fusion protein

Country Status (16)

Country Link
US (4) US8323634B2 (cg-RX-API-DMAC7.html)
EP (2) EP2387420A2 (cg-RX-API-DMAC7.html)
JP (2) JP5753095B2 (cg-RX-API-DMAC7.html)
KR (2) KR20110132326A (cg-RX-API-DMAC7.html)
CN (2) CN102395379B (cg-RX-API-DMAC7.html)
AU (2) AU2010204552B2 (cg-RX-API-DMAC7.html)
BR (2) BRPI1005159A2 (cg-RX-API-DMAC7.html)
CA (2) CA2749802C (cg-RX-API-DMAC7.html)
EA (2) EA201190079A1 (cg-RX-API-DMAC7.html)
IL (2) IL214052A0 (cg-RX-API-DMAC7.html)
MX (2) MX2011007582A (cg-RX-API-DMAC7.html)
NZ (2) NZ594055A (cg-RX-API-DMAC7.html)
SG (3) SG196821A1 (cg-RX-API-DMAC7.html)
UA (2) UA103221C2 (cg-RX-API-DMAC7.html)
WO (2) WO2010083434A2 (cg-RX-API-DMAC7.html)
ZA (1) ZA201105171B (cg-RX-API-DMAC7.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010083434A2 (en) * 2009-01-16 2010-07-22 Teva Biopharmaceuticals Usa, Inc. New stable formulations of recombinant human albumin-human granulocyte colony stimulating factor
EP2384759A1 (en) 2010-05-06 2011-11-09 Suomen Punainen Risti Veripalvelu Sulphated hyaluronic acid in combination with G-CSF for use in mobilising blood stem cells
KR20180037303A (ko) * 2010-06-07 2018-04-11 암젠 인크 약물 전달 장치
CN102628869B (zh) * 2012-04-19 2014-04-02 上海蓝怡科技有限公司 提高甲胎蛋白抗体冻干稳定性的制剂
WO2014113359A1 (en) * 2013-01-15 2014-07-24 Teva Pharmaceutical Industries Ltd. Formulations of albu-bche, preparation and uses thereof
US20140271538A1 (en) 2013-03-15 2014-09-18 Teva Pharmaceutical Industries Ltd. Recombinant Human Albumin-Human Granulocyte Colony Stimulating Factor for the Prevention of Neutropenia in Pediatric Patients
MA40904A (fr) * 2014-11-03 2017-09-12 Hygeia Tech Inc Compositions d'ester de phorbol et procédés pour traiter ou réduire la durée d'une cytopénie
JP6769982B2 (ja) 2015-03-06 2020-10-14 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド Ras変異と関連するがんの治療方法
BE1023343B1 (nl) * 2015-05-20 2017-02-09 Mycartis Nv Opslagbuffer
CN108026075B (zh) 2015-07-13 2021-06-29 大连万春布林医药有限公司 普那布林组合物
JP2018522030A (ja) * 2015-07-30 2018-08-09 エンドール テクノロジーズ, エス.エレ.Endor Technologies, S.L. 膵癌又は大腸癌の治療用コロニー刺激因子
RU2753543C1 (ru) 2016-02-08 2021-08-17 Бейондспринг Фармасьютикалс, Инк. Композиции, содержащие тукаресол или его аналоги
EP3463337A4 (en) 2016-06-06 2020-02-12 Beyondspring Pharmaceuticals, Inc. COMPOSITION AND METHOD FOR REDUCING NEUTROPENIA
CN106222221A (zh) * 2016-08-05 2016-12-14 山东科兴生物制品有限公司 制备重组人粒细胞刺激因子原液的纯化方法
ES2985905T3 (es) 2016-11-22 2024-11-07 Lts Device Tech Ltd Aparato para suministrar una sustancia terapéutica
WO2018129381A1 (en) 2017-01-06 2018-07-12 Beyondspring Pharmaceuticals, Inc. Tubulin binding compounds and therapeutic use thereof
SG11201907023UA (en) 2017-02-01 2019-08-27 Beyondspring Pharmaceuticals Inc Method of reducing neutropenia
US20210088505A1 (en) * 2017-04-07 2021-03-25 La Jolla Institute For Allergy And Immunology Unipotent Neutrophil Progenitor Cells, Methods of Preparation, and Uses Thereof
CN109420159A (zh) * 2017-08-23 2019-03-05 江苏泰康生物医药有限公司 一种重组蛋白药物的新型稳定制剂
BR112020014960A2 (pt) 2018-01-24 2020-12-22 Beyondspring Pharmaceuticals, Inc. Composição e método para redução de trombocitopenia
CN112105363A (zh) * 2018-02-01 2020-12-18 大连万春布林医药有限公司 用于通过施用普那布林和g-csf剂来减少化学疗法诱导的嗜中性白血球减少症的组合物和方法
US11583633B2 (en) 2018-04-03 2023-02-21 Amgen Inc. Systems and methods for delayed drug delivery
ES2986346T3 (es) 2018-10-05 2024-11-11 Lts Device Tech Ltd Secuencia de activación
CN111383745A (zh) * 2018-12-29 2020-07-07 医渡云(北京)技术有限公司 计算机数据处理方法、装置、存储介质及设备
US11267858B2 (en) * 2019-05-31 2022-03-08 Spectrum Pharmaceuticals, Inc. Methods of treatment using G-CSF protein complex
US11684655B2 (en) * 2019-05-31 2023-06-27 Spectrum Pharmaceuticals, Inc. Methods of treating neutorpenia using G-CSF protein complex
CN112316120A (zh) * 2019-08-05 2021-02-05 天津派格生物技术有限公司 使用低动员型g-csf有效且安全治疗粒细胞减少症的方法
WO2021112654A1 (en) * 2019-12-05 2021-06-10 Hanmi Pharm. Co., Ltd. Methods of treating chemotherapy or radiotherapy induced neutropenia
KR102485892B1 (ko) * 2020-04-09 2023-01-09 주식회사 에이프릴바이오 고양이 과립구 집락 자극인자 및 혈청 알부민에 대한 항원 결합 단편을 포함하는 융합 단백질 및 이의 용도
CN111751552B (zh) * 2020-06-18 2022-09-16 广州市伊川生物科技有限公司 一种缺血修饰白蛋白测定试剂盒及其使用方法
JP2024513505A (ja) 2021-04-09 2024-03-25 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド 腫瘍を治療するための組成物及び方法
US11723955B1 (en) 2022-05-13 2023-08-15 Allgenesis Biotherapeutics Inc. VEGFR fusion protein pharmaceutical composition

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3888381T2 (de) * 1987-04-09 1994-07-28 Delta Biotechnology Ltd Hefevektor.
JPH01215289A (ja) 1988-02-22 1989-08-29 Toa Nenryo Kogyo Kk 遺伝子組換えによる正常ヒト血清アルブミンaの製造方法
FR2649991B2 (fr) 1988-08-05 1994-03-04 Rhone Poulenc Sante Utilisation de derives stables du plasmide pkd1 pour l'expression et la secretion de proteines heterologues dans les levures du genre kluyveromyces
FR2686899B1 (fr) 1992-01-31 1995-09-01 Rhone Poulenc Rorer Sa Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
FR2686900B1 (fr) * 1992-01-31 1995-07-21 Rhone Poulenc Rorer Sa Nouveaux polypeptides ayant une activite de stimulation des colonies de granulocytes, leur preparation et compositions pharmaceutiques les contenant.
DE4242863A1 (de) * 1992-12-18 1994-06-23 Boehringer Mannheim Gmbh Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF
DE19549232C2 (de) * 1995-12-20 1998-05-20 Boehringer Mannheim Gmbh Verwendung von G-CSF in Kombination mit einem Chemotherapeutikum bei der Behandlung von Erkrankungen, die eine periphere Stammzelltransplantation erfordern
US7321023B2 (en) 1997-11-07 2008-01-22 Incyte Corporation SP16 protein
EP1060746A4 (en) * 1998-03-06 2002-06-19 Chugai Pharmaceutical Co Ltd PROTEIN-FREE PREPARATIONS
US6831158B2 (en) * 2000-01-10 2004-12-14 Maxygen Holdings Ltd. G-CSF conjugates
US6555660B2 (en) * 2000-01-10 2003-04-29 Maxygen Holdings Ltd. G-CSF conjugates
EP1803730A1 (en) 2000-04-12 2007-07-04 Human Genome Sciences, Inc. Albumin fusion proteins
US7229645B2 (en) * 2001-06-08 2007-06-12 Powderject Research Limited Spray freeze-dried compositions
AU2002364586A1 (en) * 2001-12-21 2003-07-30 Delta Biotechnology Limited Albumin fusion proteins
WO2003076567A2 (en) 2002-03-05 2003-09-18 Eli Lilly And Company Heterologous g-csf fusion proteins
CN1241946C (zh) 2002-07-01 2006-02-15 美国福源集团 对多种细胞具刺激增生作用的人血清白蛋白重组融合蛋白
EP1594530A4 (en) 2003-01-22 2006-10-11 Human Genome Sciences Inc HYBRID PROTEINS OF ALBUMIN
US20070041987A1 (en) 2003-03-19 2007-02-22 Daniel Carter Fragments or polymers of albumin with tunable vascular residence time for use in therapeutic delivery and vaccine development
US6972332B1 (en) * 2004-05-20 2005-12-06 Acura Pharmaceuticals, Inc. Process for the production of opiates
BRPI0614761A2 (pt) * 2005-08-12 2009-05-19 Human Genome Sciences Inc proteìnas de fusão de albumina
CA2584927C (en) * 2006-04-13 2011-02-08 Wix Filtration Corp. A body for actuating a standpipe of a replaceable filter element
JP2008146587A (ja) * 2006-12-13 2008-06-26 Sony Corp 表示装置、表示プログラム、表示方法、画像提供装置、画像提供プログラム、画像提供方法及び記録媒体
WO2010083434A2 (en) 2009-01-16 2010-07-22 Teva Biopharmaceuticals Usa, Inc. New stable formulations of recombinant human albumin-human granulocyte colony stimulating factor

Also Published As

Publication number Publication date
SG196821A1 (en) 2014-02-13
IL214051A0 (en) 2011-08-31
KR20110132326A (ko) 2011-12-07
JP2012515222A (ja) 2012-07-05
SG172941A1 (en) 2011-08-29
CN102395379B (zh) 2015-07-22
WO2010083439A2 (en) 2010-07-22
BRPI1004940A2 (pt) 2018-06-19
NZ594055A (en) 2013-03-28
EA023344B1 (ru) 2016-05-31
MX2011007583A (es) 2011-12-14
AU2010204547A1 (en) 2011-07-28
IL214052A0 (en) 2011-08-31
UA105201C2 (uk) 2014-04-25
SG172940A1 (en) 2011-08-29
KR20110132327A (ko) 2011-12-07
UA103221C2 (uk) 2013-09-25
WO2010083439A3 (en) 2010-09-10
MX2011007582A (es) 2011-12-14
US20150202268A1 (en) 2015-07-23
US20100297062A1 (en) 2010-11-25
AU2010204552A1 (en) 2011-08-04
EP2387420A2 (en) 2011-11-23
JP2012515221A (ja) 2012-07-05
BRPI1005159A2 (pt) 2018-04-03
EP2387419A2 (en) 2011-11-23
AU2010204552B2 (en) 2014-05-01
CA2749802A1 (en) 2010-07-22
WO2010083434A2 (en) 2010-07-22
US20100227818A1 (en) 2010-09-09
AU2010204547B2 (en) 2014-01-23
CA2749786A1 (en) 2010-07-22
NZ594056A (en) 2013-03-28
ZA201105171B (en) 2015-12-23
US8323634B2 (en) 2012-12-04
EA201190080A1 (ru) 2014-03-31
EA201190079A1 (ru) 2013-02-28
JP5753095B2 (ja) 2015-07-22
CN102378635A (zh) 2012-03-14
CN102395379A (zh) 2012-03-28
US20130129669A1 (en) 2013-05-23
WO2010083434A3 (en) 2010-09-10
US8993519B2 (en) 2015-03-31

Similar Documents

Publication Publication Date Title
CA2749802C (en) New stable formulations of recombinant human albumin-human granulocyte colony stimulating factor fusion protein
Rogers et al. Recombinant human serum albumin fusion proteins and novel applications in drug delivery and therapy
CN105209054A (zh) 使用白细胞介素-10治疗疾病和病症的方法
JP2008528621A (ja) 腎細胞ガンを処置するための方法
CN116133676A (zh) Il-2序列及其用途
JP2022553370A (ja) Il-2受容体作動薬の投与方法
WO2021214658A1 (en) Pharmaceutical compositions and pharmaceutical products of heterodimeric human interleukin-15 (hetil-15)
KR20220110747A (ko) 화학 요법 또는 방사선 요법으로 유도된 호중구감소증을 치료하는 방법
US20240350647A1 (en) Sting sensitizing agents
AU2014208224A1 (en) New Stable Formulations of Recombinant Human Albumin-Human Granulocyte Colony Stimulating Factor Fusion Protein
AU2014202190B2 (en) New Stable Formulations of Recombinant Human Albumin-Human Granulocyte Colony Stimulating Factor Fusion Protein
US20140271538A1 (en) Recombinant Human Albumin-Human Granulocyte Colony Stimulating Factor for the Prevention of Neutropenia in Pediatric Patients
US20060269514A1 (en) Methods and compositions for the modulation of immune responses and cancer diseases
GB2415904A (en) Interleukin-2 composition
US20240245752A1 (en) Methods for effective and safe treatment of neutropenia using de-mobilized g-csf
WO2010008561A2 (en) Methods and compositions for protecting against cytotoxic therapy

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20140820

MKLA Lapsed

Effective date: 20180115